姓 名:
张萍性 别:
女
职 务:
功能食品研究组组长职 称:
研究员(自然科学)
通讯地址:
云南勐腊勐仑
邮政编码:
666303电子邮件:
zhangping@xtbg.org.cn

中文简历：




姓名: 张萍 博士, 女, 北京人

生日: 1970 年 6月

职称: 研究员

职务: 功能食品研究组组长

地址: 云南勐腊勐仑

　　 中国科学院西双版纳热带植物园热带植物资源开放实验室

邮编：666303　　

电话：**

电子邮件：zhangping@xtbg.org.cn





教育:

Texas A&M University, College Station, TX

Ph.D., Nutrition　2005　　　　　　　　　　　 　　　　　　　 Lund University, Lund, Sweden

Master of Science, Food Science and Biotechnology; 1998

中国人民大学经济学硕士　1996　

中国人民大学经济学学士　 1993　

　　　　　　　　　　　　　　　　　　　　 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 　　　　　　　　　　　　

研究经历:　　　　　　

杜克大学医学中心儿科, 2008. 8 – Present

参与美国卫生部NIH 项目, Pompe disease基因治疗中的免疫调节

参与美国卫生部NIH 项目DGK 酶对T细胞的调节以及对自身免疫性肝炎的影响　



俄克拉河马大学医学中心病原微生物与免疫系 2006.9 – 2008.7

参与美国卫生部NIH 项目心肌炎自身免疫反应致病机理研究

协助导师写NIH项目申请报告, 获得NIH经费两百万美元.



Wake Forest University, Winston-Salem, NC 　　2005.8 – 2006.8　参与美国卫生部NIH 项目Echium Oil 对血脂代谢和动脉粥样硬化的影响



Texas A&M University, College Station, Texas 　2000.8-2005.8

参与美国农业部USDA资助项目饮食中的多不饱和脂肪酸对T细胞分化的影响.



学术报告:

Oral presentation at the 13th gene therapy meeting, 2010, Washington DC.

Invited talk at center for genetics, National Jewish Health, CO. Oct, 2009.

Poster presentation at the annual department of pediatrics research retreat, Duke University Medical Center, Durham, NC, June, 2009.

Invited talk at Dept. of Immunology, St Jude Children’s hospital, Memphis, TX. Feb, 2008.

Poster presentation at the 94th AAI meeting 2007, Miami.

Poster presentation at 7th annual conference on arteriosclerosis, thrombosis and vascular biology. 2006. Denver.

Invited talk at Wake Forest University School of Medicine, Winston-Salem, NC, June 2005.

Invited talk at Gladstone Institute, UCSF, San Francisco, May 2005.

Invited talk at Baylor College of Medicine Dept. of Immunology, Houston, Texas, Mar. 2005.

Experimental Biology Conference 2005, San Diego; oral and poster presentation.

Texas Agriculture Conference, Feb 2005, poster presentation.

First Research Symposium, Faculty of Nutrition, TAMU, 2004, Oral presentation.

Experimental Biology Conference 2004, Washington, DC, Poster presentation.



学术组织:

American Society for Nutrition (ASN).

American Association of Immunologists (AAI).

American Society of Gene and Cell Therapy (ASGCT).
英文简历：

研究领域：
营养与免疫；功能性食品开发
社会任职：

获奖及荣誉：

代表论著：
发表论文: Deficiency in MyD88 signaling results in decreased antibody responses to adeno-associated virus vector containing a CMV enhancer/chicken β-actin cassette in murine Pompe disease. Ping Zhang, Xiaoyan Luo, Andrew Bird, Songtao Li & Koeberl DD. 2012. BioResearch Open Access. Vol1, No.3, 109-114.



Immunodominant, liver-specific expression suppresses transgene-directed immune responses in murine Pompe disease. Zhang, P., Sun, B., Osada T., Rodriguiz R., Yang X., Luo X, Kemper, A.R., Clay, T.M., and Koeberl, D.D. Hum Gene Ther 2012 Mar 29 (Epub ahead of print).



The role of TSC1 in regulating innate immunity. Pan, H.J., O’Brien, T., Zhang, P., & Zhong, X.P. J. Immunol 2012 Mar (Epub ahead of print).



Rescue administration of a helper-dependent adenovirus vector with a long-term efficacy in dogs with glycogen storage disease type 1a. Gene Ther. 2012. Apr; 19 (4) 443-52. Crane B, Luo X, Demaster A, Williams KD, Kozink

DM, Zhang P, Brown TT, Pinto CR, Oka K, Sun F, Jackson MW, Chan L, Koeberl DD



Cutting edge: Cardiac myosin activates innate immune responses through TLRs. Zhang, P., Cox C.J., Alvarez, K.M., Cunningham, M.W. 2009. The Journal of Immunology. Jul 1; 183(1):27-31.

Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-LDL receptor knockout mice. Zhang, P., Boudyguina, E., Wilson, M.D., Gebre, A.K. & Parks, J.S. 2008. J. Nutr. Biochem. 19(10): 655-663.



Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansion. 2006. Zhang, P., Kim, W., Zhou, L., Wang, N., Ly, L.H., McMurray, D.N. & Chapkin, R.S. Journal of Nutrition. 136, 2391-2398.



Dietary n-3 polyunsaturated fatty acids modulate Th1/Th2 balance in vitro towards Th2 pole by suppression of Th1 development. 2005. Zhang, P., Smith, R., Chapkin, R.S. & McMurray, D.N. Journal of Nutrition. 135:1745-1751.



In revision for Nature Medicine:

Rishu Guo, Chi-Keung Wan, Ping Zhang, Shudan Shen, Thomas O'Brien, Carpenter,Chenhu Liu, Yingxian Li, Balachandra Gorentla, A. J. Harris, Wesley Burks, and Xiao-Ping Zhong (2012). Synergistic control of regulatory T cell function and self-tolerance to the liver by diacylglycerol kinases alpha and zeta.



Submitted to the Journal of Immunology:

Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1. 2012 Jinwook Shin, Ping Zhang, Ziqiang Guan, and Xiao-Ping Zhong.





发表会议文摘:

Deficiency in MyD88 signaling results in decreased antibody responses to adeno-associated virus vector containing a CMV enhancer/chicken β-actin cassette in murine Pompe disease. Ping Zhang, Andrew Birdy, and Dwight Koeberl. Sbumitted to the 15th gene therapy meeting, Philadelphia, May2012.



Differential activation of innate immune responses and T cell proliferation by adeno-associated virus vectors containing different regulatory cassettes in murine Pompe disease. Ping Zhang, PhD, Takuya Osada, PhD, Andy Bird, BS, Songtao Li, BS, Timothy Clay, PhD, and Dwight Koeberl, MD, PhD. Abstract to be presented at the 14th gene therapy meeting, Seattle, May 2011.



Differential ability to transducer dendritic cells by AAV vectors expressing hGAA with different regulatory cassettes impacts efficacy in Pompe disease. Sun, B.D., Zhang, P., Yang, X., Li, S., Bird, A., Clay, T.M., and Koeberl, D.D. Abstract presented at the 13th gene therapy meeting, Washington DC, 2010.



Loss of DGKαζ results on autoimmune hepatitis. Zhang, P and Zhong, XP. Abstract presented at the annual department of pediatrics research retreat, Duke University Medical Center, 2009.



Human cardiac myosin (HCM) activates Toll-like recetors2, 7 and 8. Zhang, P., Alvarez, K.M., Hauser, J.S., Cunningham, M.W. Abstract presented at the 94th AAI meeting, Miami, 2007.



Dietary Echium Oil supplementation lowers plasma triglycerides in mice as effectively as fish oil. Zhang, P., Boudyguina, E., Wilson, M.D., Gebre, A.K. & Parks, J.S.Abstract presented at the 7th annual conference on arteriosclerosis, thrombosis and vascular biology, Denver, 2006.



Dietary fish oil suppresses clonal expansion during antigen-stimulated murine Th1 differentiation. Zhang, P., Smith, R., Chapkin, R.S. & McMurray, D.N. Abstract presented at Experimental Biology Conference 2005, San Diego. The FASEB Journal 2005, vol. 19, No.5 A744.1.



Dietary fish oil does not affect proliferation or cytokine production in murine CD4+ T cells polarized toward a Th2 phenotype in vitro. Zhang, P., Smith, R., Chapkin, R.S. & McMurray, D.N. Abstract presented at Experimental Biology Conference 2004, Washington, DC. The FASEB Journal 2004, vol. 18, No.4 A133.3.
承担科研项目情况：