职　　务： 所长
学　　历：
电　　话： +86 ;**
传　　真： +86
电子邮件： yaoyg@mail.kiz.ac.cn
通讯地址： 云南省昆明市教场东路32号　中国科学院昆明动物研究所 动物模型与人类疾病机理重点实验室 650223
其他主页： http://mitotool.kiz.ac.cn/lab/index.html

简　　历

姚永刚，博士，研究员，博士生导师。1997年毕业于安徽师范大学生物系获学士学位，2003年于中国科学院昆明动物研究所获得理学博士学位，同年2月后赴约翰霍普金斯大学医学院(The Johns Hopkins University School of Medicine)从事博士后研究工作，2004年10月转至美国国家健康研究院心脏、肺、血液研究所(National Heart, Lung, and Blood Institute, National Institutes of Health)学习和工作，2007年12月回昆明动物研究所工作。现为疾病机理遗传学与进化医学学科组负责人。目前已在Am J Hum Genet、Autophagy、PNAS、Alzheimers Dement、Nat Commun等SCI期刊发表论文和评述200余篇，被SCI引用5170多次，h指数=38。先后获得国家自然科学奖二等奖（第二获奖人）、新世纪百千****才工程国家级人选、云南省有突出贡献优秀专业技术人才奖、朱李月华优秀教师奖等奖项与荣誉称号。2009年获得国家****基金和云南省高端科技人才计划资助，先后承担中科院战略性科技专项（B类）（子课题负责人）、973计划（课题负责人）、基金委重点和面上项目等。现担任“Journal of Genetics and Genomics” Editorial Board Member (2010- ), “Journal of Human Genetics” Associate Editor (2011- ), “PLoS ONE” Academic Editor (2012- ), “Infection, Genetics and Evolution” Receiving Editor (2012- ), “Scientific Reports” Editorial Board Member (2016- ), “Journal of Alzheimer’s Disease” Associate Editor (2018- ), “Zoological Research” Associate editor (2010.12 – 2012.08) and Editor-in-chief (2012.09- )。
　　2014.07 -中国科学院昆明动物研究所所长
　　2012.04 -2014.07中国科学院昆明动物研究所副所长（主持工作）
　　2010.04 - 2012.03中国科学院昆明动物研究所所长助理
　　2007.12 -至今中国科学院昆明动物研究所，疾病机理遗传学与进化医学研究组学科带头人
　　2004.10 - 2008.01美国国家健康研究院心脏、肺、血液研究所(National Heart, Lung, and Blood Institute, National Institutes of Health)，Visiting Fellow
　　2003.02 - 2004.09约翰霍普金斯大学医学院(The Johns Hopkins University School of Medicine)从事博士后研究工作
　　1997.09 - 2003.02中国科学院昆明动物研究所，获博士学位
　　2001.05 - 2001.08德国汉堡大学从事合作研究
　　1997.09 - 1998.07中国科学院研究生院学习
目前Yaolab开发的数据库：
AlzData: www.alzdata.org; Tree shrew database: www.treeshrewdb.org; Schizophrenia genetic research: www.szdb.org; mtDNA analysis: http://159.226.149.55/ or http://mitotool.kiz.ac.cn

研究方向

致力于人类疾病机理的遗传机制与进化医学研究，按照EAF (E = Evolutionary analysis; A = Association study; F = Functional assay)三层次，带领团队深入开展神经和免疫系统相关疾病的遗传易感解析和机制研究，通过对阿尔茨海默症、精神分裂症、LHON等神经精神疾病以及感染性疾病麻风的遗传易感性解析，试图阐明机体神经系统与免疫系统紊乱和病变导致的复杂临床表型的遗传基础与机理。力争将复杂纷繁的科研工作变得“Easier And Fun”。同时，集中开展实验动物树鼩基础生物学和品系创制研究。

承担科研项目

1）老年痴呆症、精神分裂症和麻风等疾病遗传易感与发病机制研究
2）线粒体、自噬与疾病
3）树鼩基础生物学

专家类别

研究员；****；百千****才
社会任职


获奖及荣誉

2014年 云南省科学技术奖励二等奖(自然科学奖); 项目名称: Leber遗传性视神经病遗传易感分析; 获奖人员: 姚永刚、张阿梅、余丹丹、毕蕊.
2012年 中国科学院 朱李月华优秀教师奖
2010年 云南省有突出贡献优秀专业技术人才奖 二等奖 （一等奖空缺）
2009年 新世纪百千****才工程国家级人选
2006年 国家自然科学奖二等奖; 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 获奖人员: 张亚平、姚永刚、孔庆鹏、丁远春、孙昌.
2005年 全国百篇优秀博士论文
2002年 中国科学院院长奖特别奖.

代表论著


1. Bi R*, Zhang W, Zhang D-F, Xu M, Fan Y, Hu Q-X, Jiang H-Y, Tan L, Li T, Fang Y, Zhang C, Yao Y-G*. 2018. Genetic association of the cytochrome c oxidase-related genes with Alzheimer’s disease in Han Chinese. Neuropsychopharmacology, in press
2. Ni H, Xu M, Zhan G-L, Fan Y, Zhou H, Jiang H-Y, Lu W-H, Tan L, Zhang D-F*, Yao Y-G*, Zhang C*. The GWAS risk genes for depression may be actively involved in Alzheimer’s disease. Journal of Alzheimer’s Disease, in press
3. Li X, Luo Z, Gu C, Hall LS, McIntosh AM, Zeng Y, Porteous DJ, Hayward C, Li M, Yao Y-G, Zhang C, Luo X-J; 23andMe Research Team7. 2018. Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder. Neuropsychopharmacology, in press, doi: 10.1038/s41386-018-0078-9
4. Wang D, Fan Y, Malhi M, Bi R, Wu Y, Xu M, Yu X-F, Long H, Li Y-Y, Zhang D-F*, Yao Y-G*. 2018. Missense variants in HIF1A and LACC1 contribute to leprosy risk in Han Chinese. American Journal of Human Genetics, 102: 794-805.
5. Yang C-P, Li X, Wu Y, Shen Q, Zeng Y, Xiong Q, Wei M, Chen C, Liu J, Huo Y, Li K, Xue G, Yao Y-G, Zhang C, Li M, Chen Y, Luo X-J. 2018. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nature Communications, 9: 838.
6. Fan Y, Luo R, Su L-Y, Xiang Q, Yu D, Xu L, Chen J-Q, Bi R, Wu D-D, Zheng P*, Yao Y-G*. 2018. Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer’s disease research? Journal of Alzheimer’s Disease, 61: 1015-1028 (doi: 10.3233/JAD-170594)
7. Luo M-T, Fan Y, Mu D, Yao Y-G, Zheng Y-T. 2018. Molecular cloning and characterization of APOBEC3 family in tree shrew. Gene, 646: 143-152
8. Peng M-S, Xu W, Song J-J, Chen X, Sulaiman X, Cai L, Liu H-Q, Wu S-F, Gao Y, Abdulloevich NT, Afanasevna ME, Ibrohimovich KB, Chen X, Yang W-K, Wu M, Li G-M, Yang X-Y, Rakha A, Yao Y-G, Upur H, Zhang Y-P. 2018. Mitochondrial genomes uncover the maternal history of the Pamir populations. European Journal of Human Genetics, 26:124-136 (doi: 10.1038/s41431-017-0028-8)
9. Xiao X, Zhang C, Grigoroiu-Serbanescu M, Wang L, Li L, Zhou D, Yuan T-F, Wang C, Chang H, Wu Y, Li Y, Wu D-D, Yao Y-G, Li M. 2018. The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Molecular Psychiatry, doi: 10.1038/mp.2017.243.
10. Zeng L, Ming C, Li Y, Su L-Y, Su Y-H, Otecko NO, Dalecky A, Donnellan S, Aplin K, Liu X-H, Song Y, Zhibin Z, Esmailizadeh A, Sohrabi SS, Nanaei HA, Liu H-Q, Wang M-S, Atteynine SA, Rocamora G, Brescia F, Morand S, Irwin DM, Peng M-S, Yao Y-G, Li H, Wu D-D, Zhang Y-P. 2018. Out of southern East Asia of the brown rat revealed by large scale genome sequencing. Molecular Biology and Evolution, 35: 149-158 (doi: 10.1093/molbev/msx276)
11. Xiao X, Zheng F, Chang H, Ma Y, Yao Y-G, Luo X-J, Li M. 2018. The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder. Neuropsychopharmacology, 43: 1128-1137 (doi: 10.1038/npp.2017.241)
12. Wang D*, Zhang D-F, Li GD, Bi R, Fan Y, Wu Y, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2018. A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China. British Journal of Dermatology, 178: 931-939.
13. Xu M, Zhang D-F*, Luo R, Wu Y, Zhou H, Kong L-L, Bi R, Yao Y-G*. 2018. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease. Alzheimer’s & Dementia, 14: 215-229 (doi: 10.1016/j.jalz.2017.08.012)
14. Bi R, Kong L-L, Xu M, Li G-D, Zhang D-F; Alzheimer’s Disease Neuroimaging Initiative., Li T, Fang Y, Zhang C, Zhang B, Yao Y-G*. 2018. The Arc gene confers genetic susceptibility to Alzheimer's disease in Han Chinese. Molecular Neurobiology, 55: 1217-1226 (doi: 10.1007/s12035-017-0397-6)
15. Xiao X, Wang L, Wang C, Yuan T-F, Zhou D, Zheng F, Li L, Grigoroiu-Serbanescu M, Ikeda M, Iwata N, Takahashi A, Kamatani Y, Kubo M, Preisig M, Kutalik Z, Castelao E, Pistis G, Amin N, van Duijn CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, N？then MM, Chang H, Luo X-J, Fang Y, Yao Y-G, Zhang C, Rietschel M, Li M; Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium. 2017. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. Translational Psychiatry, 7: 1273.
16. Zeng L, Ming C, Li Y, Su L-Y, Su Y-H, Otecko NO, Liu H-Q, Wang M-S, Yao Y-G, Li H-P, Wu D-D, Zhang Y-P. 2017. Rapid evolution of genes involved in learning and energy metabolism for domestication of the laboratory rat. Molecular Biology and Evolution, 34: 3148-3153 (doi: https://doi.org/10.1093/molbev/msx238)
17. Wang D, Li G-D, Fan Y, Zhang D-F, Bi R, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2017. The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China. Journal of Dermatological Science, 88: 349-356 (doi: http://dx.doi.org/10.1016/j.jdermsci.2017.09.001)
18. Zhang Y, Wu K, Su W, Zhang D-F, Wang P, Qiao X, Yao Q, Yuan Z, Yao Y-G, Liu G, Zhang C, Liu L, Chen C. 2017. Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα. Journal of Neuroscience, 37: 9741-9758 (doi: 10.1523/JNEUROSCI.0681-17.2017)
19. Rakha A, Fatima, Peng M-S, Adan A, Bi R, Yasmin M, Yao Y-G. 2017. mtDNA sequence diversity of Hazara ethnic group from Pakistan. Forensic Science International: Genetics, 30: e1-e5 (doi: 10.1016/j.fsigen.2017.07.004)
20. Su L-Y, Luo R, Liu Q, Su J-R, Yang L-X, Ding Y-Q, Xu L*, Yao Y-G*. 2017. Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine. Autophagy, 13: 1496-1511
21. Tang J, Fan Y, Li H, Xiang Q, Zhang D-F, Li Z, He Y, Liao Y, Wang Y, He F, Zhang F, Shugart YY, Liu C, Tang Y*, Chan RCK*, Wang C-Y*, Yao Y-G*, Chen X*. 2017. Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. Journal of Genetics and Genomics, 44: 295-306
22. Yao Y-G*. 2017. Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)? Zoological Research, 38: 118-126
23. Li G-D, Bi R, Zhang D-F, Xu M, Luo R, Wang D; Alzheimer's Disease Neuroimaging Initiative (ADNI)., Fang Y, Li T, Zhang C, Yao Y-G*. 2017. Female-specific effect of the BDNF gene on Alzheimer's disease. Neurobiology of Aging, 53: 192.e11 - 192.e19 (doi: 10.1016/j.neurobiolaging.2016.12.023)
24. Li C-H, Yan L-Z, Ban W-Z, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma Y-H, Nie W-H, Lv L-B, Yao Y-G*, Zhao X-D*, Zheng P*. 2017. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research, 27: 241-252
25. Wu Y, Yao Y-G*, Luo X-J*. 2017. SZDB: a database for schizophrenia genetic research. Schizophrenia Bulletin, 43: 459-471
26. Xiang Q, Bi R*, Xu M, Zhang D-F, Tan L, Zhang C, Fang Y, Yao Y-G*. 2017. Rare genetic variants of the Transthyretin gene are associated with Alzheimer's disease in Han Chinese. Molecular Neurobiology, 54: 5192-5200
27. Li H, Bi R, Fan Y, Wu Y, Tang Y, Li Z, He Y, Zhou J, Tang J*, Chen X*, Yao Y-G*. 2017. mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia. Molecular Neurobiology, 54: 4343-4352
28. Zhang A-M, Bi R, Hu Q-X, Fan Y, Zhang Q, Yao Y-G*. 2017. The OPA1 gene mutations are frequent in Han Chinese patients with suspected optic neuropathy. Molecular Neurobiology, 54: 1622-1630
29. Wang D, Zhang D-F, Feng J-Q, Li G-D, Li X-A, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2016. Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China. Scientific Reports, 6: 37086 (doi: 10.1038/srep37086)
30. Shen Q-K, Sulaiman X, Yao Y-G, Peng M-S, Zhang Y-P. 2016. Was ADH1B under selection in European populations? American Journal of Human Genetics, 99: 1217-1219
31. Rakha A, Peng M-S, Bi R, Song J-J, Salahudin Z, Adan A, Israr M, Yao Y-G. 2016. EMPOP-quality mtDNA control region sequences from Kashmiri of Azad Jammu & Kashmir, Pakistan. Forensic Science International: Genetics, 25: 125-131
32. Wang D, Li G-D, Zhang D-F, Xu L, Li X-A, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2016. Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China. Infection, Genetics and Evolution, 45: 105-110
33. Wang M-S, Huo Y-X, Li Y, Otecko NO, Su L-Y, Xu H-B, Wu S-F, Peng M-S, Liu H-Q, Zeng L, Irwin DM, Yao Y-G, Wu D-D, Zhang Y-P. 2016. Comparative population genomics reveals genetic basis underlying body size of domestic chickens. Journal of Molecular Cell Biology, 8: 542-552
34. Li G-D, Wang D, Zhang D-F, Xiang Q, Feng J-Q, Li X-A, Li Y-Y, Yao Y-G*. 2016. Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy. Journal of Dermatological Science, 84: 322-329 (doi: 10.1016/j.jdermsci.2016.09.018)
35. Huo Y-X, Huang L, Zhang D-F, Yao Y-G, Fang Y-R, Zhang C, Luo X-J. 2016. Identification of SLC25A37 as a major depressive disorder risk gene. Journal of Psychiatric Research, 83: 168-175
36. Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y-G*. 2016. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proceedings of the National Academy of Sciences of the United States of America, 113: 10950-10955
37. Wei J-K, Wang W-C, Zhai R-W, Zhang Y-H, Yang S-C, Rizak J, Li L, Xu L-Q, Liu L, Pan M-K, Hu YZ, Ghanemi A, Wu J, Yang L-C, Li H, Lv L-B, Li J-L, Yao Y-G, Xu L, Feng X-L, Yin Y, Qin D-D, Hu X-T, Wang Z-B. 2016. Neurons differentiated from transplanted stem cells respond functionally to acoustic stimuli in the awake monkey brain. Cell Reports, 16: 1016-1025
38. Wang M-S, Zhang R-W, Su L-Y, Li Y, Peng M-S, Liu H-Q, Zeng L, Irwin DM, Du J-L, Yao Y-G, Wu D-D, Zhang Y-P. 2016. Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication. Cell Research, 26: 556-573
39. Zhang C, Zhang D-F, Wu Z-G, Peng D-H, Chen J, Ni J, Tang W, Xu L, Yao Y-G*, Fang Y-R*. 2016. Complement factor H and susceptibility to major depressive disorder in Han Chinese. British Journal of Psychiatry, 208: 446-452
40. Yu D, Wu Y, Xu L, Fan Y, Peng L, Xu M, Yao Y-G*. 2016. Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis). Developmental and Comparative Immunology, 60: 127-138
41. Li M, Huang L, Li K, Huo Y, Chen C, Wang J, Liu J, Luo Z, Chen C, Dong Q, Yao Y-G, Su B, Luo X-J. 2016. Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations. Human Genetics, 135: 377-392
42. Bi R, Tang J, Zhang W, Li X, Chen S-Y, Yu D, Chen X, Yao Y-G*. 2016. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Schizophrenia Research, 171: 200-206
43. Zhang D-F*, Wang D, Li Y-Y, Yao Y-G*. 2016. Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile. Journal of Dermatological Science, 82: 18-27 (doi: 10.1016/j.jdermsci.2016.01.001)
44. Liu C, Saffen D, Schulze TG, Burmeister M, Sham PC, Yao Y-G, Kuo PH, Chen C, An Y, Dai J, Yue W, Li MX, Xue H, Su B, Chen L, Shi Y, Qiao M, Liu T, Xia K, Chan RC. 2016. Psychiatric genetics in China: achievements and challenges. Molecular Psychiatry, 21: 4-9 (doi: 10.1038/mp.2015.95)
45. Wang H-Z, Bi R, Zhang D-F, Li G-D, Ma X-H, Fang Y, Li T, Zhang C, Yao Y-G*. 2016. Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese. Molecular Neurobiology, 53: 4883-4892
46. Li M, Luo XJ, Landén M, Bergen SE, Hultman CM, Li X, Zhang W, Yao Y-G, Zhang C, Liu J, Mattheisen M, Cichon S, Mühleisen TW, Degenhardt FA, N？then MM, Schulze TG, Grigoroiu-Serbanescu M, Li H, Fuller CK, Chen C, Dong Q, Chen C, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Preisig M, Kutalik Z, Castelao E, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG; MooDS Consortium; Swedish Bipolar Study Group, Rietschel M, Liu C, Kleinman JE, Hyde TM, Weinberger DR, Su B. 2015. Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance. British Journal of Psychiatry, 208: 128-137
47. Zhang D-F, Li J, Wu H, Cui Y, Bi R, Zhou H-J, Wang H-Z, Zhang C, Wang D; Alzheimer's Disease Neuroimaging Initiative (ADNI), Kong Q-P, Li T, Fang Y, Jiang T*, Yao Y-G*. 2016. CFH variants affect structural and functional brain changes and genetic risk of Alzheimer's disease. Neuropsychopharmacology, 41: 1034-1045
48. Li M, Wu D-D, Yao Y-G, Huo Y-X, Liu JW, Su B, Chasman DI, Chu A-Y, Huang T, Qi L, Zheng Y; CHARGE Nutrition Working Group; DietGen Consortium, Luo X-J. 2016. Recent positive selection drives the expansion of a schizophrenia risk nonsynonymous variant at SLC39A8 in Europeans. Schizophrenia Bulletin, 42: 178-190
49. Wang H-Z, Bi R, Hu Q-X, Xiang Q, Zhang C, Zhang D-F, Zhang W, Ma X, Guo W, Deng W, Zhao L, Ni P, Li M, Fang Y, Li T, Yao Y-G*. 2016. Validating GWAS-identified risk loci for Alzheimer's disease in Han Chinese populations. Molecular Neurobiology, 53: 379-390
50. Zhang D-F, Fan Y, Wang D, Bi R, Zhang C, Fang Y, Yao Y-G*. 2016. PLD3 in Alzheimer's disease: a modest effect as revealed by updated association and expression analyses. Molecular Neurobiology, 53: 4034-4045
51. Zhang A-M, Hu Q-X, Liu F-L, Bi R, Yang B-Q, Zhang W, Guo H, Logan I, Zheng Y-T*, Yao Y-G*. 2016. Mitochondrial DNA haplogroup A decreases the risk of drug addiction but conversely increases the risk of HIV-1 infection in Chinese addicts. Molecular Neurobiology, 53: 3873-3881
52. Xiang Y-L, Zhang D-F, Wang D, Li Y-Y*, Yao Y-G*. 2015. Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China. Journal of Dermatological Science, 80: 133-141 (doi: 10.1016/j.jdermsci.2015.09.001)
53. Su L-Y, Li H, Lv L, Feng Y-M, Li G-D, Luo R, Zhou H-J, Lei X-G, Ma L, Li J-L, Xu L, Hu X-T*, Yao Y-G*. 2015. Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation. Autophagy, 11: 1745-1759
54. Yao Y-G*, Chen YB, Liang B. 2015. The 3rd symposium on animal models of primates - the application of non-human primates to basic research and translational medicine. Journal of Genetics and Genomics, 42: 339-341
55. Hu Q-X, Fan Y, Xu L, Pang W, Wang S, Zheng Y-T, Lv LB, Yao Y-G*. 2015. Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina. Gene, 571: 279-285 (doi: 10.1016/j.gene.2015.06.085)
56. Yao Y-G*, Kajigaya S, Young NS. 2015. Mitochondrial DNA mutations in single human blood cells. Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, 779: 68-77
57. Li X, Zhang W, Tang J, Tan L, Luo X-J, Chen X*, Yao Y-G*. 2015. Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations? Scientific Reports, 5: 11076 (doi: 10.1038/srep11076)
58. Xu L, Yu D, Peng L, Fan Y, Chen J, Zheng Y-T, Wang C, Yao Y-G*. 2015. Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis). Developmental and Comparative Immunology, 52: 58-68 (doi: 10.1016/j.dci.2015.04.014)
59. Li X, Zhang W, Lencz T, Darvasi A, Alkelai A, Lerer B, Jiang HY, Zhang D-F, Yu L, Xu X-F, Li M*, Yao Y-G*. 2015. Common variants of IRF3 conferring risk of schizophrenia. Journal of Psychiatry Research, 64: 67-73
60. Zhang C-C, Ren H-Y, Li M-L, Wang Q, Deng W, Guo WJ, Lei W, Xiang B, Zhao L-S, Ma X-H, Yao Y-G, Li T. 2015. Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese. Neuroscience Bulletin, 31: 368-370
61. Luo X-j, Huang L, van den Oord EJ, Aberg KA, Gan L, Zhao Z, Yao Y-G. 2015. Common variants in the MKL1 gene confer risk of schizophrenia. Schizophrenia Bulletin, 41: 715-727 (doi:10.1093/schbul/sbu156)
62. Peng M-S, Shi N-N, Yao Y-G, Zhang Y-P. 2015. Caveats about interpretation of ancient chicken mtDNAs from northern China. Proceedings of the National Academy of Sciences of the United States of America, 112: E1970- E1971
63. Luo X-J, Mattheisen M, Li M, Huang L, Rietschel M, B？rglum AD, Als TD, van den Oord EJ, Aberg KA, Mors O, Mortensen PB, Luo Z, Degenhardt F, Cichon S, Schulze TG, N？then MM; iPSYCH-GEMS SCZ working group; MooDS SCZ Consortium, Su B, Zhao Z, Gan L, Yao Y-G. 2015. Systematic integration of brain eQTL and GWAS identifies ZNF323 as a novel schizophrenia risk gene and suggests recent positive selection based on compensatory advantage on pulmonary function. Schizophrenia Bulletin, 41: 1294-1308
64. Peng M-S, Fan L, Shi N-N, Ning T, Yao Y-G, Murphy RW, Wang W-Z, Zhang Y-P. 2015. DomeTree: a canonical toolkit for mitochondrial DNA analyses in domesticated animals. Molecular Ecology Resources, 15: 1238-1242 (doi: 10.1111/1755-0998.12386)
65. Tian J-Y, Wang H-W, Li Y-C, Zhang W, Yao Y-G, van Straten J, Richards MB, Kong Q-P. 2015. A genetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road. Scientific Reports, 5: 8377 (doi: 10.1038/srep08377)
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173.Bandelt H-J, Olivieri A, Bravi C, Yao Y-G, Torroni A, Salas A. 2007. ‘Distorted’ mitochondrial DNA sequences in schizophrenic patients. European Journal of Human Genetics, 15: 400-402
174.Yao Y-G*, Ogasawara Y, Kajigaya S, Molldrem JJ, Falc？o RP, Pint？o M-C, McCoy JC, Jr, Rizzatti EG, Young NS*. 2007. Mitochondrial DNA sequence variation in single cells from leukemia patients. Blood, 109: 756-762
175.Yao Y-G*, Ellison FM, McCoy JP, Jr, Chen J, Young NS. 2007. Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background. Human Molecular Genetics, 16: 286-294
176.Lai S-J, Chen S-Y, Liu Y-P, Yao Y-G. 2007. Mitochondrial DNA sequence diversity and origin of Chinese domestic yak. Animal Genetics, 38: 77-80
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178.Wang C-Y, Kong Q-P, Yao Y-G*, Zhang Y-P. 2006. MtDNA mutation C1494T, haplogroup A, and hearing loss in Chinese. Biochemical and Biophysical Research Communications, 348: 712-715
179.Man X-Y, Yang X-H, Cai S-Q, Yao Y-G, Zheng M. 2006. Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis. Molecular Medicine, 12: 127-136
180.Yang X-H, Man X-Y, Cai S-Q, Yao Y-G, Bu Z-Y, Zheng M. 2006. Expression of VEGFR-2 on HaCaT cells is regulated by VEGF and plays an active role in mediating VEGF induced effects. Biochemical and Biophysical Research Communications, 349: 31-38
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185.Palanichamy MG, Agrawal S, Yao Y-G, Kong Q-P, Sun C, Khan F, Chaudhuri TK, Zhang Y-P. 2006. Comment on ‘‘Reconstructing the origin of Andaman islanders’’. Science, 311: 470; doi: 10.1126/science.** (comment)
186.Liu Y-P, Zhu Q, Yao Y-G*. 2006. Genetic relationship of Chinese and Japanese gamecocks revealed by mtDNA sequence variation. Biochemical Genetics, 44: 19-29
187.Liu Y-P, Wu G-S, Yao Y-G, Miao Y-W, Luikart G, Baig M, Beja-Pereira A, Ding Z-L, Palanichamy MG, Zeng F-T, Qiu X-P, Zhang Y-P. 2006. Multiple maternal origins of chickens: out of the Asian jungles? Molecular Phylogenetics and Evolution, 38: 12-19
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191.Yao Y-G, Yang HS, Cao Z, Danielsson J, Duh EJ. 2005. Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism. FEBS Letters, 579: 1227-1234
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198.Luan Y-X, Yao Y-G, Xie R-D, Yang Y-M, Zhang Y-P, Yin W-Y. 2004. Analysis of 18S rRNA gene of Octostigma sinensis (Projapygoidea: Octostigmatidae) supports the monophyly of Diplura. Pedobiologia, 48: 453-459
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200.Yao Y-G*, Macaulay V, Kivisild T, Zhang Y-P, Bandelt H-J. 2003. Mitochondrial DNA variation in Amerindians - Reply to Silva et al. American Journal of Human Genetics, 72: 1348-1349 (comment)
201.Yao Y-G, Zhang Y-P. 2003. Pitfalls in the analysis of ancient human mtDNA. Chinese Science Bulletin, 48: 826-830
202.Yao Y-G, Kong Q-P, Sun C, Zhang Y-P. 2003. Can the occurrence of rare insertion/deletion polymorphisms in human mtDNA be verified from phylogeny? Chinese Science Bulletin, 48: 663-667
203.Yao Y-G, Kong Q-P, Man X-Y, Bandelt H-J, Zhang Y-P. 2003. Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA. Molecular Biology and Evolution, 20: 214-219
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研究团队

工作人员
余丹丹　硕士　副研究员，yudandan@mail.kiz.ac.cn
毕　蕊　博士　副研究员，birui@mail.kiz.ac.cn　　　　　
许　凌　博士　副研究员，lingxu0502@yahoo.com
张登峰　博士　副研究员，zhangdengfeng@mail.kiz.ac.cn
苏凌燕　博士　副研究员，sulingyan@mail.kiz.ac.cn
范　宇　博士　助理研究员，fanyu@mail.kiz.ac.cn
杨禄秀　本科　助理实验师，yangluxiu@mail.kiz.ac.cn
研究生
武勇 罗荣灿 徐敏 古天乐 姚玉林 刘前进 李余 李桂瑜 焦利进 叶茂森 张金燕 阳静
郑全振 苗莹 曾春华 郑晓 李慧龙