姓　　名:
肖伟烈
学　　科:
药物化学
电话/传真:
**
电子邮件:
xwl@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:


简历：
主要从事植物次生代谢产物及其生物学功能研究，从五味子等科属的植物中发现了系列结构新奇的三萜、二萜、环烯醚萜等类型及具有生物活性的化合物。在国际学术刊物Nat. Prod. Rep., Chem. Eur. J., Org. Lett., Tetrahedron Lett., J. Nat. Prod.等杂志上共发表共论文130余篇；以第一作者发表22篇和以通讯作者或联合通讯作者发表20余篇，其中8篇论文发表在影响因子5以上的杂志上，19篇论文发表在本学科领域Top15%刊物上；申请专利10余项；获得国家、科学院及云南省等10余项课题的资助及多项奖励。



1995.9－1999.7,淮北煤炭师范学院,生物学,学士
1999.9－2002.7,南京农业大学,植物学,硕士
2002.9－2005.7,中科院昆明植物研究所,植物化学,博士
2005.7－2006.7,中科院昆明植物研究所, 助理研究员

2006.7－2011.12,中科院昆明植物研究所, 副研究员

2008-2010，美国纽约Memorial Sloan Kettering Cancer Center 以及

City University of New York博士后研究

2012.1－至今，中科院昆明植物研究所, 研究员
研究领域：
天然药物化学、植物化学，以抗艾滋病、抗肿瘤等活性为主要研究目标的新药研发等
社会任职：

获奖及荣誉：
1. 2005年：获得“中科院优秀院长奖学金奖学金”。

2. 2005年：获得“云南省青年科技红河奖”。

3. 2006年：博士论文《四种药用植物的化学成分和生物活性研究》被评为

中国科学院50篇优秀博士学位论文称号。

4. 2007年：博士论文获全国百篇优秀博士论文提名奖。

5. 2007年：获得“第十届中国药学会施维雅青年药物化学奖”。

6. 2008年：获中国科学院卢嘉锡青年人才工作奖。

7. 2006年：入选云南省第九批中青年学术和技术带头人后备人才培养计

划资助，并于2011年12月顺利出站，获得证书。

8. 2007年：博士论文《四种药用植物的化学成分和生物活性研究》被评为

云南省优秀博士学位论文之一。

9. 2007年：入选中国科学院西部之光人才培养计划资助。

10. 2007年：论文Kadlongilactones A and B, Two Novel Triterpene Dilactones

from Kadsura longipedunculata Possessing a Unique Skeleton，Org. Lett.,

2005, 7 (22), 5079-5082 获 云南省科协优秀科技论文（云锡）奖二等奖，

第二作者。

11. 2008年：“有机合成与药物化学中的（量子）计算化学研究”获云南

省科学技术自然科学奖二等奖，排名第5。

12. 2009年：第一作者论文Triterpenoids from the Schisandraceae family,

Nat. Prod. Rep. 2008, 25, 871-891. 获云南省优秀科技论文一等奖。

13. 2010年，入选中科院青年创新会会员，并获得40万元经费资助。

14. 2011年，建党90周年纪念活动中，获得“中国科学院昆明植物研究所

优秀共产党员”荣誉称号。
代表论著：
1. Wei-Lie Xiao, Hua-Jie Zhu, Yun-Heng Shen, Rong-Tao Li, Sheng-Hong Li, Han-Dong Sun*, Yong-Tang Zheng, Rui-Rui Wang, Yang Lu, Cheng Wang, Qi-Tai Zheng, Lancifodilactone G: A unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity, Org. Lett., 2005, 7(11), 2145-2148.

2. Wei-Lie Xiao, Rong-Tao Li, Sheng-Hong Li, Xiao-Li Li, Han-Dong Sun*, Yong-Tang Zheng, Rui-Rui Wang, Yang Lu, Cheng Wang, Qi-Tai Zheng, Lancifodilactone F: A novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity, Org. Lett., 2005, 7(7), 1263-1266.

3. Wei-Lie Xiao, Sheng-Hong Li*, Xue-Mei Niu, Yu Zhao, Han-Dong Sun*, Rapulasides A and B: two novel intermolecular rearranged biiridoid glucosides from the roots of Heracleum rapula, Tetrahedron Lett., 2005, 46, 5743-5746.

4. Wei-Lie Xiao, Sheng-Hong Li*, Yun-Heng Shen, Xiao-Li Li, Han-Dong Sun*, Four new coumarin glucosides from the roots of Heracleum rapula, Heterocycles, 2005, 65(5), 1189-1196.

5. Wei-Lie Xiao, Liu-Meng Yang, Ning-Bo Gong, Li Wu, Rui-Rui Wang, Jian-Xin Pu, Xiao-Li Li, Sheng-Xiong Huang, Yong-Tang Zheng, Rong-Tao Li, Yang Lu, Qi-Tai Zheng, Han-Dong Sun*, Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities, Org. Lett., 2006, 8(5), 991-994.

6. Wei-Lie Xiao, Jian-Xin Pu, Ying Chang, Xiao-Li Li, Sheng-Xiong Huang, Liu-Meng Yang, Li-Mei Li, Yang Lu, Yong-Tang Zheng, Rong-Tao Li, Qi-Tai Zheng, Han-dong Sun*, Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera, Org. Lett., 2006, 8(7), 1475-1478.

7. Wei-Lie Xiao, Ren-Rong Tian, Jian-Xin Pu, Xian Li, Li Wu, Yang Lu, Sheng-Hong Li, Rong-Tao Li, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun*，Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity, J. Nat. Prod., 2006, 69(2), 277-279.

8. Wei-Lie Xiao, Sheng-Xiong Huang, Li Zhang, Ren-Rong Tian, Li Wu, Xiao-Li Li, Jian-Xin Pu, Yong-Tang Zheng, Yang Lu, Rong-Tao Li, Qi-Tai Zheng, Han-Dong Sun*, Nortriterpenoids from Schisandra lancifolia, J. Nat. Prod., 2006, 69(4), 650-653.

9. Wei-Lie Xiao, Xiao-Li Li, Rui-Rui Wang, Liu-Meng Yang, Li-Mei Li, Sheng-Xiong Huang, Jian-Xin Pu, Yong-Tang Zheng, Rong-Tao Li, Han-Dong Sun*, Triterpenoids from Schisandra rubriflora, J. Nat. Prod., 2007, 70(6), 1056-1059.

10. Wei-Lie Xiao, Liu-Meng Yang, Li-Mei Li, Jian-Xin Pu, Sheng-Xiong Huang, Zhi-Ying Weng, Chun Lei, Jing-Ping Liu, Rui-Rui Wang, Yong-Tang Zheng, Rong-Tao Li, Han-Dong Sun*, Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera, Tetrahedron Lett., 2007, 48(31), 5543-5546.

11. Wei-Lie Xiao, Jian-Xin Pu, Rui-Rui Wang, Liu-Meng Yang, Xiao-Li Li, Sheng-Hong Li, Rong-Tao Li, Sheng-Xiong Huang, Yong-Tang Zheng, Han-Dong Sun*, Isolation and structure elucidation of nortriterpenoids from Schisandra rubriflora, Helv. Chim. Acta, 2007, 90(8), 1505-1513.

12. Wei-Lie Xiao, Sheng-Hong Li*, Yun-Heng Shen, Xue-Mei Niu, Han-Dong Sun*, Two new coumarin glucosides from the roots of Angelica apaensis and their anti-platelet aggregation activity, Arch. Pharm. Res., 2007, 30(7), 799-802.

13. Wei-Lie Xiao, Rong-Tao Li, Sheng-Xiong Huang, Jian-Xin Pu, Han-Dong Sun*, Triterpenoids from the Schisandraceae family, Nat. Prod. Rep., 2008, 25, 871-891.

14. Wei-Lie Xiao, Chun Lei, Jie Ren, Tou-Gen Liao, Jian-Xin Pu, Charles U. Pittman Jr., Yang Lu, Yong-Tang Zheng, Hua-Jie Zhu*, Han-Dong Sun*, Structure elucidation and theoretical investigation of key steps in the biogenetic pathway of schisanartane nortriterpenoids by using DFT methods, Chem. Eur. J., 2008, 14(36), 11584-11592.

15. Wei-Lie Xiao, Sheng-Xiong Huang, Rui-Rui Wang, Jia-Liang Zhong, Xue-Mei Gao, Fei He, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun*, Nortriterpenoids and lignans from Schisandra sphenanthera, Phytochemistry, 2008, 69, 2862-2866.

16. Wei-Lie Xiao, Chun-Ling Luo, Ya-Hua Chen, Zhen-Guo Shen*, Xiang-Dong Li, Bioaccumulation of heavy metals by wild plants growing on copper mine spoils in China, Commun. Soil Sci. Plant Anal., 2008, 39, 315–328.

17. Wei-Lie Xiao, Yan-Qing Gong, Rui-Rui Wang, Zhi-Ying Weng, Xiao Luo, Xiao-Nian Li, Fei He, Jian-Xin Pu, Liu-Meng Yang, Yong-Tang Zheng, Yang Lu, Han-Dong Sun*, Bioactive nortriterpenoids from Schisandra grandiflora, J. Nat. Prod., 2009, 72(9), 1678–1681.

18. Wei-Lie Xiao, Shi-Ying Yang, Liu-Meng Yang, Guang-Yu Yang, Rui-Rui Wang, Hai-Bo Zhang, Wei Zhao, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng and Han-Dong Sun*, Chemical constituents from the leaves and stems of Schisandra rubriflora, J Nat Prod., 2010, 73(2), 221-225.

19. Wei-Lie Xiao, Liu-Meng Yang Hai-Bo Zhang Yong-Bo Xue, Guang-Yu Yang, Jian-Xin Pu, Rui-Rui Wang, Yong-Tang Zheng, and Han-Dong Sun*, Chemical constituents from the leaves and stems of Schisandra lancifolia, Chem. & Pharm. Bull., 2010, 58(6), 852-855.

20. Wei-Lie Xiao, Rui-Rui Wang , Wei Zhao, Ren-Rong Tian, Shan-Zhai Shang, Liu-Meng Yang , Jian-Hong Yang, Jian-Xin Pu , Yong-Tang Zheng and Han-Dong Sun*, Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora, Arch. Pharm. Res., 2010, 33(5), 697-701.

21. Wei-Lie Xiao, Ying-Li Wu, Shang-Shan Zhai, Fei-He, Xiao Luo, Guang-Yu Yang, Jian-Xin P^{u ,} Guo-Qiang Chen, and Han-Dong Sun*, Four new nortriterpenoids from Schisandra lancifolia, Helv. Chim. Acta, 2010, 93,1975-1982.

22. Wei-Lie Xiao, Timothy J. Motley, Uchenna J. Unachukwu, Clara Bik San Lau, Bei Jiang, Feng Hong, Ping-Chung Leung, Qing-Feng Wang, Philip O. Livingston, Barrie R. Cassileth, Edward J. Kennelly*, Chemical and genetic assessment of variability in commercial Radix Astragali (Astragalus spp.) by ion trap LC-MS and nuclear ribosomal DNA barcoding sequence analyses, J. Agric. Food Chem., 2011, 59, 1548-1556.

23. Xue-Mei Gao, Jian-Xin Pu, Wei-Lie Xiao*, Sheng-Xiong Huang, Li-Guang Lou, Han-Dong Sun*, Kadcoccilactones K–R, triterpenoids from Kadsura coccinea, Tetrahedron, 2008, 64, 11673-11679.

24. Xue-Mei Gao, Jian-Xin Pu, Sheng-Xiong Huang, Liu-Meng Yang, Hao Huang, Wei-Lie Xiao*, Yong-Tang Zheng, Han-Dong Sun*, Lignans from Kadsura angustifolia, J. Nat. Prod., 2008, 71(4), 558-563.

25. Guang-Yu Yang, Wei-Lie Xiao*, Ying Chang, Rui-Rui Wang, Jian-Xin Pu, Xue-Mei Gao, Chun Lei, Yang Lu, Yong-Tang Zheng, Han-Dong Sun*, Nortriterpenoids from Schisandra wilsoniana, Helv. Chim. Acta, 2008, 91(10), 1871-1878.

26. Xiao-Nian Li, Jian-Xin Pu, Xue Du, Liu-Meng Yang, Hui-Mei An, Chun Lei, Fei He, Xiao Luo, Yong-Tang Zheng, Yang Lu, W Wei-Lie Xiao*, Han-Dong Sun*, Lignans with anti-HIV activity from Schisandra propinqua var. sinensis, J. Nat. Prod., 2009, 72(6), 1133-1141.

27. Xiao Luo, Ying Chang, Xing-Jie Zhang, Jian-Xin Pu, Xue-Mei Gao, Ying-Li Wu, Rui-Rui Wang, Wei-Lie Xiao*, Yong-Tang Zheng, Yang Lu, Guo-Qiang Chen, Qi-Tai Zheng, Han-Dong Sun*, Schilancidilactones A and and B: two novel tetranortriterpenoids with an unprecedented skeleton from Schisandra lancifolia, Tetrahedron Lett., 2009, 50, 5962-5964.

28. Guang-Yu Yang, Wei-Bo Fen, Chun Lei, Wei-Lie Xiao*, Han-Dong Sun*, Study on determination of pentacyclic triterpenoids in Chaenomeles by high-performance liquid chromatography coupled with evaporative light scattering detection, J. Chrom. Sci., 2009, 47, 718-723.

29. Guang-Yu Yang, Wei-Bo Fen, Chun Lei, Wei-Lie Xiao*, Han-Dong Sun,Study on solid phase extraction and gr aphite furnace atomic absorption spectrometry for the determination of nickel, silver, cobalt, copper, cadmium and lead with MCI GEL CHP 20Y as sorbent, J. Hazard. Mater., 2009, 162(1), 44-49.

30. Guang-Yu Yang, Peng Fan, Rui-Rui Wang, Jing-Li Cao, Wei-Lie Xiao*, Liu-Meng Yang, Jian-Xin Pu, Yong-Tang Zheng, and Han-Dong Sun*, Dibenzocyclooctadiene lignans from Schisandra lancifolia and their anti-human immunodeficiency virus-1 activities, Chem. & Pharm. Bull., 2010, 58(5), 734-737.

31. Guang-Yu Yang, Yin-Ke Li, Rui-Rui Wang, Xiao-Nian Li , Wei-Lie Xiao*, Liu-Meng Yang, Jian-Xin Pu , Yong-Tang Zheng, Han-Dong Sun*, Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities, J. Nat. Prod., 2010, 73(5), 915-919.

32. Guang-Yu Yang, Yin-ke Li, Rui-Rui Wang, Wei-Lie Xiao*, Liu-Meng Yang , Jian-Xin Pu, Yong-Tang Zheng, Han-Dong Sun, Dibenzocyclooctadiene lignans from the fruits of Schisandra wilsoniana and their anti-HIV-1 activities, J. Asian Nat. Prod. Res., 2010, 12(6), 470-476.

33. Xing-Jie Zhang, Guang-Yu Yang, Rui-Rui Wang, Jian-Xin Pu, Han-Dong Sun, Wei-Lie Xiao*, and Yong-Tang Zheng*, 7,8-seco-Lignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities, Chem. Biodivers., 2010, 7, 2692-2701.

34. Yi-Ming Shi, Xing-Yao Li, Xiao-Nian Li, Xiao Luo, Yong-Bo Xue, Cheng-Qin Liang, Juan Zou, Ling-Mei Kong, Yan-Li, Jian-Xin Pu, Wei-Lie Xiao*, Han-Dong Sun*, Schicagenins A-C: three cagelike nortriterpenoids from leaves and stems of Schisandra chinensis, Org. Lett., 2011, 13(15), 3848-3851.

35. Yuan-Xing Duan, Jing-Li Cao, Rong-Rong Wen, Guang-Yu Yang, Jian-Xin Pu, Han-Dong Sun, Wei-Lie Xiao*, Gan-Peng Li*, Dibenzocyclooctadiene lignans from Schisandra neglectaand their anti-HIV-1 activities, J. Asian Nat. Prod. Res., 2011, 13(7), 592-598.

36. Huai-Xue Mu, Xue-Sen Li, Peng Fan, Guang-Yu Yang, Jian-Xin Pu, Han-Dong Sun, Qiu-Fen Hu*, Wei-Lie Xiao*, Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities, J. Asian Nat. Prod. Res., 2011, 13(5), 393-399.

37. Jing-Jiao Xue, Jing-Li Cao, Guang-Yu Yang, Jian-Xin Pu, Han-Dong Sun, Qiu-Fen Hu*, Wei-Lie Xiao*, Lignans from Schisandra lancifolia, J. Asian Nat. Prod. Res., 2011, 13(6), 492-497.

38. Guang-Yu Yang, Rui-Rui Wang, Huai-Xue Mu, Yin-Ke Li, Wei-Lie Xiao*, Liu-Meng Yang, Jian-Xin Pu, Yong-Tang Zheng, Han-Dong Sun*, Neolignans from Schisandra wilsoniana and their anti-human immunodeficiency virus-1 activities. Chem. Pharm. Bull., 2011, 59(11), 1344-1347.

39. Guang-Yu Yang, Yin-Ke Li, Xing-Jie Zhang, Xiao-Nian Li, Liu-Meng Yang, Yi-Ming Shi, Wei-Lie Xiao*, Yong-Tang Zheng, Han-Dong Sun*, Three new nortriterpenoids from Schisandra wilsoniana and their anti-HIV-1 activities, Natural Products and Bioprospecting, 2011, 1, 33-36.

40. Xiao Luo, Jian-Xin Pu, Peng Fan, Yi-Ming Shi, Guang-Yu Yang, Xiao-Nian Li, Chun Lei, Xue-Mei Gao, Hai-Bo Zhang, Wei-Lie Xiao*, Han-Dong Sun*, Four new dibenzocyclooctadiene lignans from Schisandra rubriflora, Chin. J. Nat. Med., 2011, 9(3), 167-172

41. Fei He , Xing-Yao Li , Guang-Yu Yang , Xiao-Nian Li , Xiao Luo , Juan Zou , Yan Li , Wei-Lie Xiao*, Han-Dong Sun*,Nortriterpene constituents from Schisandra sphenanthera, Tetrahedron, 2012, 68, 440-446.

42. Juan Zou, Li-Bin Yang, Jing Jiang, Yan-Yan Diao, Xiao-Nian Li,1 Jin Huang, Jian-Hong Yang, Hong-Lin Li, Wei-Lie Xiao*, Xue Du, Shan-Zhai Shang, Jian-Xin Pu, and Han-Dong Sun*, Lanostane triterpenoids from the stems of Schisandra glaucescens, Planta. Med., 2012，online, DOI 10.1055/s-**.

43. Xiao Luo, Yi-Ming Shi, Rong-Hua Luo, Shi-Hong Luo, Xiao-Nian Li, Rui-Rui Wang, Sheng-Hong Li, Yong-Tang Zheng, Xue Du, Wei-Lie Xiao*, Jian-Xin Pu, and Han-Dong Sun*， Schilancitrilactones A-C: Three Unique Nortriterpenoids from Schisandra lancifolia，Org. Lett., 2012, 14(5), 1286-1289.
承担科研项目情况：
1. 国家自然科学基金青年项目（18万）－五种四川、西藏产五味子属药用植物的化学成分及抗艾滋病活性研究（项目批准号码：**），2009.1-2011.12，主持（结题）。

2. 中科院西部之光重点项目（25万）－几种西南地区五味子属药用植物的化学成分和生物活性的研究，2007.1-2009.12，主持（结题）。

3. 中科院优秀院长奖学金获得这启动经费（10万）－西藏三种五味子属药用植物的化学成分和抗艾滋病活性研究，2007.1-2009.12，主持（结题）。

4. 中科院优秀博士论文获得者科研启动经费（10万）－几种西南地区南五味子属植物的化学成分和生物活性研究(**)，2006.1-2008.12，主持（结题）。

5. 2006年入选云南省科技厅第九批中青年学术和技术带头人后备人才计划资助（12万），2007.1-2011.12，项目批准号2006PY01-47（结题）。

6. 云南省自然科学基金（5万）－两种南五味子属药用植物的化学成分和生物活性研究（2006B0042Q），2006.1-2008.12，主持（结题）。

7. 院方向性项目（25万）－参与“基于新信号分子的白血病细胞分化和凋亡机理和生物化学研究”，2007.10-2010.10，子课题负责人（结题）。

8. 中科院生命科学领域优秀青年科技专项（80万）－五味子科和木兰科药用植物的结构新颖化学成分及生物活性研究，2011.1-2013.12, 主持（执行）

9. 中国科学院青年创新促进会会员专项经费，2011.08-2015.12，40万元，项目负责人（执行）。

10. 院方向性项目（15万）－参与“天然小分子先导化合物的发现研究”（KSCX1-YW-R-24），2007.10-2010.10，青年骨干。

11. 国家自然科学基金重点（175万）－五味子科植物新奇化合物的发现及生物活性研究(**)，2009.1-2012.12，排名第2。

12. 与三金药业公司的合作项目（25万）－菝葜的化学成分研究，2006.1-2007.12，排名第2。

13. 云南省科技厅新药专项（100万）－治疗艾滋病中药、天然药物一类新药“五味子素”胶囊的临床前研究，2007.1-2011，排名第3。

14. NSFC-云南联合基金（重点项目）（180万）－云南特有香茶菜属植物中抗癌活性成分及其作用机制研究，2009.1-2012.12，参加。

15. 云南省科技计划项目（150万）－抗癌中药、天然药物一类新药毛萼乙素注射剂的临床前研究，2008.7-2011.12，参加。

16. 云南省民族药工程技术研究中心项目（390万）－抗炎、抗癌药物毛萼乙素的深度开发，2009.8-2013.10，参加。