姓　　名:
熊文勇
学　　科:
药理学
电话/传真:
**/**
电子邮件:
xiong.wenyong@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:


简历：
1995年9月-1999年7月，陕西师范大学，学士

1999年9月-2004年7月，中国科学院昆明动物研究所，博士

2004年9 月-2007年7月，美国南加州大学医学院 (University of Southern California) ，博士后

2007年7月-2010年 12 月，美国康乃尔大学医学院（Cornell University），博士后

2010年12月-至今，中国科学院昆明植物研究所，植物化学与西部植物资源持续利用国家重点实验室，研究员
研究领域：
1. 治疗2型糖尿病和肥胖的药物活性筛选及作用机制研究

2. 治疗2型糖尿病天然药物研发

3. 脂肪细胞生成的调控

4. 胰岛素受体信号通路调控的GLUT4膜转运
社会任职：

获奖及荣誉：
1999年 陕西师范大学优秀毕业生

2012年 中国科学院百人计划

2013年 云南省高端科技人才
代表论著：
1. L. Amanda Sadacca, Joanne Bruno, Jennifer Wen, Wenyong Xiong, and Timothy E. McGraw^*. Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs. Molecular Biology of the Cell. 24(16): 2544-2557. (2013)

2. Cheng-Qin Liang, Jing Hu, Rong-Hua Luo, Yi-Ming Shi, Shan-Zhai Shang, Zhong-Hua Gao, Rui-Rui Wang, Yong-Tang Zheng, Wen-Yong Xiong, Hong-Bin Zhang, Wei-Lie Xiao^*, Han-Dong Sun^*. Six new lignans from the leaves and stems of Schisandra sphenanthera. Fitoterapia. 86:171–177. (2013)

3. Liang, Cheng-Qin; Hu, Jing; Shi, Yi-Ming; Shang, Shan-Zhai; Du, Xue; Zhan, Rui; Wang, Wei-Guang; Xiong, Wen-Yong; Xiao, Wei-Lie; *Zhang, Hong-Bin; *Sun, Han-Dong. Five New Nortriterpenoids from the Stems of Schisandra neglecta. Helvetica Chimica Acta, 96(7), pp 1376-1385, 2013/7. (2013)

4. Cheng-Qin Liang, Jing Hu, Yi-Ming Shi, Shan-Zhai Shang, Xue Du, Rui Zhan, Wen-Yong Xiong, Hong-Bin Zhang, Wei-Lie Xiao^*, Han-Dong Sun^*. Schisphenlignans A–E: Five New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera. Chemical and Pharmaceutical Bulletin. 61(1):96-100. (2013)

5. Wenyong Xiong, Ingrid Jordens, Eva Gonzalez and Timothy McGraw. GLUT4 is sorted into vesicles whose accumulation beneath and insertion to the plasma membrane is differentially regulated by insulin and selectively by insulin resistance. (2010) Molecular Biology of the Cell. 21(8):1375-86.

6. Ingrid Jordens , Dorothee Molle*, Wenyong Xiong* (*equal contribution) and Timothy McGraw. IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles. (2010) Molecular Biology of the Cell. 21(12):2034-44.

7. Darren J Michael*, Wenyong Xiong*(*co-first author), Xuehui Geng, Peter Drain and Robert H Chow. Human Insulin Vesicle Dynamics During Pulsatile Secretion. (2007) Diabetes. 56(5):1277-1288.

8. Pyrko P, Kardosh A, Wang W, Xiong Wenyong, Sch?nthal AH, Chen TC. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. (2007) Cancer Research. 67(22):10920-8.

9. Peter Pyrko, Adel Kardosh, Yen-Ting Liu, Nathaniel Soriano, Wenyong Xiong, Robert H Chow, Jasim Uddin, Nicos A Petasis, Austin K Mircheff, Robert A Farley, Stan G Louie, Thomas C Chen, Axel H Sch?nthal. Calcium-induced ER stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib (DMC), a non-coxib derivative of celecoxib. (2007) Molecular Cancer Therapy. 6(4):1262-75.

10. Darren J Michael, Haijiang Cai, Wenyong Xiong, Justin Ouyang and Robert H Chow. Mechanisms of peptide hormone secretion. TRENDS in Endocrinology and Metabolism. (2006) 17(10):408-415.

11. Wenyong Xiong, Huiming Wei, Xiaojun Xiang, Zhifang Dong, Jun Cao, Yongfu Wang, Tianle Xu and Lin Xu. The Effect of Acute Stress on LTP and LTD Induction in the Hippocampal CA1 Region of Anesthetized Rats at Three Different Ages. (2004) Brain Research. 1005(1-2): 187-192.

12. Wenyong Xiong, Yuexiong Yang, Jun Cao, Huiming Wei, Chongli Liang, Shangchuan Yang, Lin Xu. The stress experience dependent long-term depression disassociated with stress effect on spatial memory task. (2003) Neuroscience Research. 46(4): 415-421.
承担科研项目情况：
1. 云南省科技厅-高端科技人才项目（2014-2016）

2. 中国科学院-百人计划项目（2013-2015）

3. 国家自然科学基金委-面上项目（2013-2016）