个人简介

杨力权，生物信息学博士，教授，云南省****青年拔尖人才。
科研兴趣
研究领域和方向: 结构生物信息学；蛋白质结构动力学和功能研究。
研究课题和兴趣：极端环境酶适应机制；人类疾病相关蛋白的结构动力学和功能研究。
项目成果
1. 国家自然科学基金项目 《基于自由能图谱的极端温度α-淀粉酶温度适应机理研究》；
2. 国家自然科学基金项目 《HIV-1抗体中和表型差异的分子机制研究》；
3. 云南省科技厅面上项目《嗜冷胰蛋白酶低温耐受机理研究》；
4. 云南省科技厅面上项目《HIV-1 对CD4 依赖性差异机制的计算生物学研究》。
代表性论文
1.Sang Peng, Tian Shu-Hui, Meng Zhao-Hui, Yang Li-Quan*. Anti-HIV drug repurposing against SARS-CoV-2. RSC advances , 2020, 10, 15775.
2.Peng Sang; Shu-Qun Liu; Li-Quan Yang*. New Insight into Mechanisms of Protein Adaptation to High Temperatures: A Comparative Molecular Dynamics Simulation Study of Thermophilic and Mesophilic Subtilisin-Like Serine Proteases, International Journal of Molecular Sciences , 2020, 21(9).
3.Yi-Rui Yin; Peng Sang; Feng-Li Yang; Tao Li; Run-Feng Yang; Hong-Yan Liu; Zong-Long Luo; Wen-Jun Li; Li-Quan Yang*; Characterization of a Cu2+, SDS, alcohol and glucose tolerant GH1 b-glucosidase from Bacillus sp. CGMCC 1.16541, Antonie van Leeuwenhoek, 2020, 113(3)：1467-1477.
4.Li Yi，Zhang Xiao-Ling，Yuan Xue，Hou Jiang-Chun，Sang Peng，Yang Li-Quan*，Probing intrinsic dynamics and conformational transition of HIV gp120 by molecular dynamics simulation, RSC Advances , 2020, 10(51)：30499-30507.
5.Li Yi，Guo Yu-Chen，Zhang Xiao-Ling，Deng Lei，Sang Peng，Yang Li-Quan*，Shu-Qun Liu*，CD4-binding obstacles in conformational transitions and allosteric communications of HIV gp120, BBA - Biomembranes , 2020, 1862(6)：183217.
6.Li-Quan Yang; Yi-Rui Yin; Jian-Xin Shen; Yi Li; Shu-Qun Liu; Peng Sang. Insight derived from molecular dynamics simulation into cold-adaptation mechanism of trypsins, Journal of Biomolecular Structure and Dynamics, 2019, 38(10). SCIE.
7.Yang Li-Quan, Chen Gui-Yuan, Li Yi, Zhang Ruo-Peng, Liu Shu-Qun, Sang Peng, Insight derived from molecular dynamics simulation into dynamics and molecular motions of cuticle-degrading serine protease Ver112. Journal of Biomolecular Structure & Dynamics , 2018, 1-28.
8.Yang Li-Quan, Sang Peng, Zhang Ruo-Peng, Liu Shu-Qun, Substrate- induced changes in dynamics and molecular motions of cuticle-degrading serine protease PL646: a molecular dynamics study. RSC Advances , 2017, 7(67): 42094-42104.