副教授



满淑丽，博士，天津科技大学生物工程学院 副教授。
主讲课程：
本科生：天然药物学、免疫学、生物制药工艺学等。
研究生：天然药物学、免疫学等。
科研领域及方向
[1]天然产物提取分离及活性开发
[2]中药成分鉴定及体内外代谢研究
[3]中药组方配伍机制研究
科研情况
[1] 国家自然科学基金项目：基于肿瘤微环境干预的重楼皂苷抗转移性肺癌作用机制及物质基础研究，项目负责人，2017-2020.
[2] 国家自然科学基金项目：基于代谢调控网络干预的重楼总皂苷组分配伍机制研究，项目负责人，2013-2015.
[3] 天津市自然科学基金项目：基于细胞周期阻滞的楼黄配伍作用机制研究，项目负责人，2013-2016.
主要学术成果
先后以第一作者或通讯作者发表SCI三十余篇，累积影响因子97，其中一、二区论文10篇，单篇最高引用二百余次，参编专著1部，授权或申请发明专利6项。部分发表论文如下：
[1] Man SL, Li J, Qiu PY, et al. Inhibition of lung cancer in diethylnitrosamine- induced mice by Rhizoma paridis saponins. Molecular Carcinogenesis. 2017.
[2] Qiu PY, Sun JC, Man SL*, et al. Curcumin attenuates N- nitrosodiethylamine induced liver injury in mice by utilizing the method of metabonomics. J Agric Food Chem. 2017.
[3] Qiu PY, Man SL*, Li J, et al. Overdose taking curcumin initiating the unbalanced state of bodies. J Agric Food Chem. 2016; 64: 2765-2771.
[4] Man SL, Ma J, Wang CX, et al. Chemical composition and hypoglycemic effect of polyphenols extracts from Litchi chinensis seeds. J Funct Foods. 2016; 22:313-24.
[5] Liu J, Liu Z, Man SL*, et al. Inhibition of urethane-induced lung carcinogenesis in mice by Rhizoma paridis saponins involved EGFR/PI3K/Akt pathway. RSC Advances. 2016; 6: 92330 - 92334.
[6] Li J, Man SL*, Qiu PY, et al. Toxicological risks of Rhizoma Paridis saponins in rats involved NF-κB and Nrf2 signaling. RSC Advances. 2016; 6: 31889-31897.
[7] Qiu PY, Man SL*, Yang H, et al. Metabolic regulatory network alterations revals different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice. RSC Advances. 2016, 6, 115029 - 115038.
[8] Man SL, Li YY, Fan W, Gao WY, Liu Z, Li N, Zhang Y, Liu CX. Curcuma increasing antitumor effect of Rhizoma paridis saponins through absorptive enhancement of paridis saponins. Int J Pharm. 2013; 454:296-301.
[9] Man SL, Wang J, Gao WY, Guo SB, Li YY, Zhang LM, Xiao PG. Chemical analysis and anti-inflammatory comparison of the cell culture of Glycyrrhiza with its field cultivated variety. Food Chem. 2013; 136:513-517.
[10] Man SL, Qiu PY, Li J, et al. Global metabolic profiling for the study of Rhizoma Paridis Saponins induced hepatotoxicity in rats. Environmental Toxicology. 2017; 32:99-108.
[11] Liu J, Man SL*, Liu Z, et al. A synergistic antitumor effect of Polyphyllin I and Formosanin C on hepatocarcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2016; 26: 4970-5.
[12] Qiu PY, Man SL*, Yang H, et al. Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. Chemico-biological interactions. 2016;256:55-63.
[13] Man SL, Li J, Liu J, et al. Curcumin alleviated the toxic reaction of Rhizoma paridis saponins in a 45-day subchronic toxicological assessment of rats. Environmental Toxicology. 2016;31:1935-43.
[14] Zhang LL, Man SL*, Wang YS, et al. Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells. Chemico-Biological Interactions. 2016; 253: 125-133.
15] Man SL, Li J, Fan W, et al. Inhibition of pulmonary adenoma in diethylnitrosamine- induced rats by Rhizoma paridis saponins. J Steroid Biochem Mol Biol, 2015; 154, 62-67.
[16] Man SL, Chai HY, Qiu PY, et al. Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice. Pathol Res Pract. 2015; 211:948-54.
[17] Li YY, Man SL*, Li J, et al. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chemico-Biological Interactions. 2014; 220C: 193-9.
[18] Man SL, Fan W, Liu Z, et al. Antitumor pathway of Rhizoma Paridis Saponins based on the metabolic regulatory network alterations in H22 hepatocarcinoma mice. Steroids. 2014; 84:17-21.
[19] Man SL, Li YY, Fan W, et al. Combination therapy of cyclophosphamide and Rhizoma Paridis Saponins on anti-hepatocarcinoma mice and effects on cytochrome p450 enzyme expression. Steroids. 2014; 80:1-6.
[20] Man SL, Fan W, Gao WY, et al. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats. J Ethnopharmacol. 2014; 151:407-412.
[21] Man SL, Guo SB, Gao WY, et al. Identification of metabolic profiling of cell culture of licorice compared with its native one. Anal Bioanal Chem. 2013; 405:3321-3329.
[22] Man SL, Gao WY, Wei CL. Anticancer drugs from Traditional toxic Chinese medicines. Phytother Res. 2012; 26:1449-1465.
[23] Man SL, Gao WY, Zhang YJ, et al. Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma. Cancer Biol Ther. 2011; 11(6):592-598.
[24] Man SL, Gao WY, Yan YJ, et al. Inhibition of matrix metalloproteinases related to metastasis by diosgenyl and pennogenyl saponins. J Ethnopharmacol. 2011; 137(3):1221-1227.
[25] Man SL, Gao WY, Zhang YJ, et al. Identification of chemical constituents in Rhizoma Paridis Saponins and their oral administration in rat plasma by UPLC/Q-TOF/MS. Biomed Chromatogr. 2011; 25(6):712-719.
[26] Man SL, Gao WY, et al. Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo. Arch Pharm Res. 2011; 34(1):43-50.
[27] Man SL, Gao WY, Zhang YJ, et al. Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC-MS/MS. J Chromatogr B. 2010; 878(29):2943-2948.
[28] Man SL, Gao WY, Zhang YJ, et al. Chemical study and Medical application of Saponins as Anti-cancer Agents. Fitoterapia. 2010; 81(7):703-714.
联系方式
办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院，
邮政编码：300457
办公电话：
传 真：
Email： msl@tust.edu.cn