\r张 欣¹，谢 闯^{1, 2}，陈 峰³，王静康\r^{1, 2}\r
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AuthorsHTML:\r张 欣¹，谢 闯^{1, 2}，陈 峰³，王静康\r^{1, 2}\r
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AuthorsListE:\rZhang Xin¹，Xie Chuang^{1, 2}，Chen Feng³，Wang Jingkang\r^{1, 2}\r
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AuthorsHTMLE:\rZhang Xin¹，Xie Chuang^{1, 2}，Chen Feng³，Wang Jingkang\r^{1, 2}\r
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Unit:\r\r1. 天津大学化工学院，天津 300072；\r
\r\r2. 天津化学化工协同创新中心，天津 300072；
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\r3. 天津药业研究院有限公司，天津 300000\r
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Unit_EngLish:\r1．School of Chemical Engineering and Technology，Tianjin University，Tianjin 300072，China；
2．Collaborative Innovation Centre of Chemical Science and Engineering(Tianjin)，Tianjin 300072，China；
3．Tianjin Pharmaceuticals Research Institute Co.，Ltd，Tianjin 300000，China\r
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Abstract_Chinese:\r采用离子凝胶法制备了壳聚糖-三聚磷酸钠(CS-TPP)亚微米颗粒，并以其为稳定剂，制备了内含聚乳酸-羟基乙酸共聚物(PLGA)和布洛芬(IBU)药物的o/w 型Pickering 乳液;采用溶剂挥发法制备了CS-TPP 亚微米颗粒包覆的载药微胶囊，并通过静电作用包覆羧甲基纤维素钠(CMC)．利用SEM、光学显微镜、荧光共聚焦显微镜、红外光谱等对载药微胶囊进行了表征．以IBU 为模型药物，在模拟胃液(SGF，pH＝1.2)和模拟肠液(SIF，pH＝6.8)中进行载药微胶囊的体外药物释放实验．结果表明：所得载药微胶囊在SIF 中释放速率为其在SGF 中的约12 倍，表现出良好的pH 响应性．\r
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Abstract_English:\rNovel pH-responsive microcapsules loaded with ibuprofen were facilely fabricated through solvent evaporation of Pickering emulsion stabilized by chitosan(CS)-tripolyphosphate(TPP)submicron particles．The CS-TPP particles were synthesized using the ionic gelation technique．The o/w Pickering emulsion containing poly(D，Llactic-co-glycolic acid)(PLGA)and ibuprofen(IBD) was prepared，and the oil phase was dried using the solvent evaporation method．Then，the microcapsules were coated with sodium carboxymethyl cellulose(CMC)through inter-ionic interactions．The drug-containing microcapsules were characterized by SEM，optical microscopy，fluorescence confocal microscopy，and FTIR．Finally，the in vitro releasing behaviors of microcapsules in an acidic simulated gastric fluid(SGF，pH＝1.2)and in a simulated intestinal fluid(SIF，pH＝6.8)were determined．The cumulative release rate of the drug carrier microcapsule in SIF was about 12 times of that in SGF，exhibiting good pH responsiveness.\r
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Keyword_Chinese:pH 响应；载药微胶囊；壳聚糖-三聚磷酸钠；Pickering 乳液\r

Keywords_English:pH-responsiveness；drug carrier microcapsule；chitosan-tripolyphosphate(CS-TPP)；Pickering emulsion\r


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