lgchen@tju.edu.cn
药物化学
未公开
教授
基于“亚胺离子脱质子化活化”模型的有机小分子催化不对称反应

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近红外光/磁双模态肿瘤靶向显影剂的研究

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羰基化合物的绿色还原工艺

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新型受阻胺类光稳定剂的设计、合成与应用性能评价

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精细化学品技术开发

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氟氯苯胺的技术开发

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2.6一二甲基苯胺技术开发与产业化

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环氮乙烷的技术开发

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光稳定剂新产品技术开发

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氮杂环丙烷衍生物的技术开发

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HS-808的技术开发

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HS-430的技术开发

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光稳定剂系列产品的研究与开发

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2,2,6,6-四甲基哌啶酮合成新工艺

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含氮精细化工产品技术开发
哌嗪副产物合成三乙烯二胺的方法

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新型受阻胺光稳定剂及其合成方法

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制备2-氨基-1-烷基醇的方法及催化剂制备方法

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一种苯并三唑类化合物的合成方法

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具有抗组胺活性的三环类化合物、制备方法及用途

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催化氢化法连续合成苯并三唑类紫外线吸收剂

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2,2,6,6-四甲基-4-哌啶酮连续合成方法

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具有抗组胺活性的手性三环类化合物、制备方法及用途

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本发明公开了一种苯并三咄类化合物的合成方法，包括如下步骤：将加氢-固体碱双功能催化剂装入固定床反应器中；将式(I)所示化合物的溶液持续通入固定床反应器，并通入氢气，加热；反应液持续从固定床反应器下端流出，流出的反应液冷却至室品、气液分离、液体过滤、滤液浓缩除去溶剂，纯化，得式(II)的苯并三咄类化合物；本发明采用加氢-固体碱双功能催化剂进行催化氢化合成苯并三咄类化合物。

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具有抗组胺活性的三环类化合物、制备方法及用途

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催化氢化法连续合成苯并三唑类紫外线吸收剂

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本发明公开了一种2,2,6,6-四甲基-4-哌啶酮连续合成方法，包括如下步骤：（1）在固定床反应器中装入酸型树脂，加热使固定床反应器温度在40~70℃；（2）将丙酮和氨气按照摩尔比为3~9:1的比例，通入所述固定床反应器，丙酮的体积空速为0.15~1.17h-1，氨气的体积空速为5.25~124.20h-1，生成物经冷却得到2,2,6,6-四甲基-4-哌啶酮粗品。本发明工艺简单、成本低廉、适用于工业连续化生产，无需用有机溶剂或水作溶剂，避免了因使用有机溶剂而对环境造成的污染

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Multi-responsive red solid emitter: Detection of trace water and sense of relative humidity

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Cobalt entrapped in N, S-codoped porous carbon: Catalysts for transfer hydrogenation with formic acid

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Study on adsorptive behavior of pyrolytic nitrogen-doped graphene gel

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A novel Pd-Ni bimetallic synergistic catalyst on ZIF-8 for Sonogashira coupling reaction

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An organocatalytic synthesis of chiral pyrano[2,3-d]pyrimidines through [3+3] annulation of 1,3-dimethyl-barbituric acid with

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Stimuli-responsive 2,6-diarylethene-4H-pyran-4-one derivatives: Aggregation induced emission enhancement, mechanochromism and

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Several fluorescent probes based on hemicyanine for the detection of SO2 derivatives

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Two-dimensional imine-linked covalent organic frameworks as a platform for selective oxidation of olefins

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Alkoxy substituted D-π-A dimethyl-4-pyrone derivatives: Aggregation induced emission enhancement, mechanochromic and solvatoc

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Post-modified acid-base bifunctional MIL-101(Cr) for one-pot deacetalization-Knoevenagel reaction

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Piezochromic luminescence and aggregation induced emission of 9,10-bis[2-(2-alkoxynaphthalen-1-yl)vinyl]anthracene derivative

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Synthesis and evaluation of anthranilamide-based derivatives as FXa inhibitors

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3D nitrogen-doped graphene gels as robust and sustainable adsorbents for dyes

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Controllable magnetic 3D nitrogen-doped graphene gel: Synthesis, characterization, and catalytic performance

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Enantioselective synthesis of chiral 4H-pyran derivatives through [3+3] tandem reaction over a squaramide catalyst

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Michael–michael addition reactions promoted by secondary amine-thiourea: stereocontrolled construction of barbiturate-fused t

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Catalytic hydrogenation of 2-nitro-2'-hydroxy-5'-methylazobenzene over solid base-hydrogenation bifunctional catalysts: Effec

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A near-infrared fluorescent probe for rapid and selective detection of hydrosulfide and imaging in live cells

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Mechanically strong fully biobased anisotropic cellulose aerogels

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An efficient method for the synthesis of laquinimod

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A novel near-infrared colorimetric probe for fluoride anions based on a heptamethine dye

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Efficient continuous kinetic resolution of racemic 2-aminobutanol over immobilized penicillin G acylase

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Reductive cyclization of 2-nitro-2′-hydroxy-5′-methylazobenzene to benzotriazole over K-doped Pd/γ-Al2O3

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An efficient synthesis of N,N,N’,N’,N″-pentamethyldipropylenetriamine

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Controlled release strategy of paclitaxel by conjugating to matrix metalloproteinases-2 sensitive peptide

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Enhanced AIE and different stimuli-responses in red fluorescent (1,3-dimethyl)barbituric acid-functionalized anthracenes

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An efficient method for synthesis of tofacitinib citrate

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(1R, 2R)-(+)-1,2-DPEN-modified Wang resin: An efficient catalyst for the asymmetric Michael addition of acetone to beta-nitro

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(1R, 2R)-(+)-1,2-DPEN-modified Wang resin: An efficient catalyst for the asymmetric Michael addition of acetone to beta-nitro

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A near-infrared multifunctional fluorescent probe with an inherent tumor-targeting property for bioimaging

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(1R, 2R)-(+)-1,2-DPEN-modified Wang resin: An efficient catalyst for the asymmetric Michael addition of acetone to beta-nitro

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A comparative study on iron modified or unmodified tungstophosphoric acid supported on titania for Friedel-Crafts acylation

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Iron(III)-Modified Tungstophosphoric Acid Supported on Titania Catalyst: Synthesis, Characterization, and Friedel-Craft Acyla

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Effect of Alkali Treatment of HY Zeolite on Continuous Synthesis of Triacetonamine

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Construction of 2-(2′-Hydroxy-5′-methylphenyl) benzotriazole over Pd/γ-Al2O3 by a Continuous Process

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Facile and efficient reductive N-alkylation of nitrobenzenes with alcohols catalyzed by Cu–Cr/γ-Al2O3

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A Sensitive Colorimetric and Ratiometric Chemosensor for Trivalent Metal Cations

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Continuous asymmetric Michael addition of ketones to beta-nitroolefins over (1R,2R)-(+)-1,2-DPEN-modified sulfonic acid resin

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Design, synthesis, and biological evaluations of several Y‐26732 analogues

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Significant effect of alkyl chain length on fluorescent thermochromism of 9,10-bis(p-alkoxystyryl)anthracenes

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Regulating the piezofluorochromism of 9,10-bis(butoxystyryl)anthracenes by isomerization of butyl groups

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Hydrogenation of aromatic aldehydes to aromatic hydrocarbons over (*) Cu-HZSM-5 catalyst

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An efficient Fe2O3/HY catalyst for (*) Friedel-Crafts acylation of m-xylene with benzoyl chloride

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Synthesis and biological (*) evaluation of novel pazopanib derivatives as antitumor agents

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Resin-immobilized pyrrolidine-based chiral organocatalysts for asymmetric Michael additions of ketones and aldehydes to nitro

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Glucosamine modified near-infrared (*) cyanine as a sensitive colorimetric fluorescent chemosensor for aspartic and glutamic

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Near-infrared aminocyanine dyes: (*) synthesis, optical properties, and application to the preparation of fluorescent microsp

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Efficient (*) Hydrodeoxygenation of Aliphatic Ketones over an Alkali-Treated Ni/HZSM-5 Catalyst

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Design, (*) synthesis and biological activity evaluation of desloratadine analogues as H-1 receptor antagonists

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Total synthesis of padanamides A and B

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A fluorescent chemosensor for fluoride anions based on a (*) hemicyanine dye

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One-Pot Enantioselective Synthesis of (*) 3-Nitro-2H-chromenes Catalyzed by a Simple 4-Hydroxyprolinamide with 4-Nitrophenol

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Preparation of a pH-sensitive polystyrene (*) fluorescent microsphere based on a cyanine dye

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The reductive amination of (*) cyclohexanone with 1,6-diaminohexane over alumina B modified Cu-Cr-La/gamma-Al2O3

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Proline (*) -based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael additi

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Synthesis and antihistamine evaluations of novel loratadine analogues

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Synthesis and antihistamine evaluations of novel loratadine analogues