wgliu@tju.edu.cn
国家****基金获得者
教授
负载内皮抑制素基因的胶原基互穿聚合物网络角膜替代物

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功能生物墨水体系构建

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基于重组人III 型胶原构建活性复合角膜替代物

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新发突发传染病应急处置帐篷式防控系统研究

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离子诱导的形状记忆水凝胶设计及其在动脉瘤栓塞中的应用探索

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具有集成功能的高强度光敏水凝胶的基础研究

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生物材料

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离子/光响应的高强度形状记忆水凝胶的研究

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生物材料及功能高分子研究

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生物材料

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生物医用高分子材料

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负载内皮抑制素基因的胶原基复合角膜替代物的开发研究

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离子驱动的形状记忆高强度水凝胶的构建及其医学应用

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重要生命器官构建的工程化技术研究

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静脉注射导电纳米凝胶诱导低氧微环境促进心肌功能重建的研究

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高强度水凝胶作为结构生物医用材料的基础研究

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负载可递送内皮抑制素基因的胶原基复合角膜替代物
具有生物活性的胶原基复合角膜替代物及其制备方法

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胶原基互穿聚合物网络组织工程角膜替代物及其制备方法

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一种具有抗吸附功能的高强度水凝胶及其制备方法

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基于环糊精交联的二氨基三嗪氢键增强水凝胶及其制备方法和应用

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一种微量离子响应水凝胶及其制备方法

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一种组氨修饰的胍基丁胺基线性聚合物转基因载体及其制备方法与应用

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基于甲基丙烯酰基甘氨酰胺的水凝胶及其作为自动修复材料的应用

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高强度温度敏感水凝胶及制备方法和应用

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具有抗撕裂的高强度形状记忆水凝胶及其制备方法

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高强度光敏感水凝胶及其制备方法和应用

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一种具有CO2响应性的形状记忆抗撕裂水凝胶及其制备方法

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一种具有高度稳定性、热塑性和可自修复的高强度超分子水凝胶的制备方法

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一种光敏型水凝胶及其制备方法和应用

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含有ZnO 量子点载体/DNA 复合物的胶原基复合角膜替代物及其制备方法和应用
本发明提供了一种具有生物活性的胶原基复合角膜替代物及其制备方法。它主要是以胶原、3－(甲基丙烯酰胺)丙基－二甲基(3－磺丙)胺(MPDSAH)为原料，以水为溶剂。以零长度交联剂碳二亚胺(EDC)对胶原进行交联；以Irgacure 2959为光引发剂，聚乙二醇二丙烯酸酯(PEGDA)为交联剂对MPDSAH进行引发聚合并交联。混合均匀后，注入模具内固化成型。上述复合角膜替代物冷冻干燥后，具有三维多孔结构，可以吸附大量角膜细胞生长因子，而且冻干角膜替代物可以长期存放，

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本发明公开了一种具有抗吸附功能的高强度水凝胶及其制备方法，它以丙烯腈和甲基丙烯酰氧乙基磷酸胆碱为原料，在交联剂和引发剂存在下共聚制成，单体丙烯腈和甲基丙烯酰氧乙基磷酸胆碱的质量比为6-9∶1。本发明的水凝胶具有很强的抗拉伸和抗压缩能力，具有良好的生物相容性和光学性能。并且该水凝胶表面具有抗大分子蛋白吸附和良好耐疲劳性能。其制备方法简单，产品易于长期保存和长途运输。

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发明了氢键增强的水凝胶

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发明了锌离子交联的高强度凝胶方法

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发明了高效低毒转基因载体

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本发明公开基于甲基丙烯酰基甘氨酰胺的水凝胶及其作为自修复材料的应用，由以甲基丙烯酰基甘氨酰胺为单体的聚合物和水组成，每个重复单元的侧链上设有两个酰胺基团和一个侧甲基基团。由于其聚合物分子链的侧链上带有两个酰胺基团以及侧链带有的甲基结构，分子间的温和的分子间的氢键作用以及氢键强度趋于相同，从而形成的物理交联作用使得甲基丙烯酰基甘氨酰胺凝胶具有不错的力学强度，并且由于这种由双酰胺基团和甲基的作用形成的氢键可以在较低温度（室温及以下）下实现破坏和重建，凝胶具有了自修复和热塑性的功能。

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本发明涉及一种高强度温度敏感水凝胶及制备方法和应用，它以2-乙烯基-4，6-二氨基-1，3，5-三嗪和N-异丙基丙烯酰胺为原料，在交联剂和引发剂存在下共聚制成，单体2-乙烯基-4，6-二氨基-1，3，5-三嗪和N-异丙基丙烯酰胺的质量比为0.2-2∶1。本发明具有很强的抗拉伸和抗压缩能力，具有良好的生物相容性和光学性能。并且该水凝胶表面具有吸附DNA转染细胞的能力以及通过温度调节细胞的贴附和脱贴附行为，其制备方法简单，产品易于长期保存和长途运输。

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本发明公开具有抗撕裂的高强度形状记忆水凝胶及其制备方法，以丙烯腈、丙烯酰胺和2-丙烯酰胺-2-甲基丙磺酸为原料，在交联剂和引发剂存在下无规共聚制成，具有很强的抗拉伸和抗压缩能力的同时可以抗撕裂、耐缺口，并在体温刺激下具有形状记忆功能。其制备方法简单，产品易于长期保存和长途运输。

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本发明公开了高强度光敏感水凝胶及其制备方法和应用，由聚乙二醇甲基丙烯酸酯，2-乙烯基-4，6-二氨基-1，3，5-三嗪和带有螺吡喃结构的含双键单体通过自由基聚合共聚而成，将这三种单体和引发剂溶解在溶剂中，通过引发剂引发它们分子上的不饱和键，通过自由基聚合反应制备出水凝胶。本发明的光敏感性水凝胶具有较高的抗拉伸和抗压缩能力，具有良好的生物相容性。并且该水凝胶具有吸附DNA转染细胞的能力以及通过光照调节细胞的贴附和脱贴附行为。

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本发明公开了一种具有CO2响应性的形状记忆抗撕裂水凝胶及其制备方法，它以2-乙烯基-4,6-二氨基-1,3,5-三嗪、N,N-二甲基丙烯酰胺为单体，以聚乙二醇二丙烯酸酯为交联剂在引发剂的作用下共聚制成。凝胶在单体质量比为(2：1)-(3：1)组分下具有很强的抗拉伸、抗压缩，以及抗撕裂、耐缺口能力，在单体质量比为3：2时，凝胶具有很强的抗拉伸，抗压缩能力同时对CO2具有刺激响应性，并且在其刺激下具有形状记忆功能。

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本发明公开了一种具有高度稳定性、热塑性和可自修复的高强度超分子水凝胶的制备方法，它以丙烯酰基甘氨酰胺为原料，在引发剂的存在下以自由基聚合制备成不同单体浓度的聚丙烯酰基甘氨酰胺凝胶。本发明的水凝胶可以通过改变单体浓度具有不同的性能，这种水凝胶具有很强的拉伸、压缩的同时能够抗撕裂，在较高温下能够实现热塑性和自修复的功能，并且很好的生物相容性。我们实现了一种简单可行的制备高强度超分子水凝胶，产品易于长期保存和长途运输。

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本发明公开了一种具有光致自变形性及宏观/微观打印性质的光敏型水凝胶及其制备方法，以丙烯酰胺、N-丙烯酰（三羟甲基）氨基甲烷为单体，在引发剂的存在下以自由基聚合制备成不同组分含量的光敏型水凝胶。本发明的水凝胶对365 nm波长的紫外光具有响应性质，这种水凝胶能够在紫外光照射下发生变形行为，从二维的平面材料转变成一系列三维形状，并且能够利用光掩模板实现无接触的宏观和微观图案的打印。这种水凝胶制备方法简单，产品易于长期保存和长途运输。

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本发明涉及一种含有ZnO量子点载体/DNA复合物的胶原基复合角膜替代物及其制备方法和应用。它是胶原/MPDSAH IPN角膜替代物吸附ZnO量子点载体/DNA复合物制备而成。角膜替代物与ZnO量子点载体/DNA复合物重量比约425∶1，ZnO量子点载体与DNA的重量比25∶1。本发明具有良好的生物相容性，可诱导和促进角膜再生，并随角膜再生而生物降解；
An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits

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Stiffness Self-Tuned Shape Memory Hydrogels for Embolization of Aneurysm

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A smart indwelling needle with on-demand switchable anticoagulant and hemostatic activities

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Polymerization of N-acryloylsemicarbazide: a facile and versatile strategy to tailor-make highly stiff and tough hydrogels

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Wound dressing change facilitated by spraying zinc ions

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Coadministration of an Adhesive Conductive Hydrogel Patch and an Injectable Hydrogel to Treat Myocardial Infarction

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Water-Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

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Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Sca

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Conductive Hydrogen Sulfide-Releasing Hydrogel Encapsulating ADSCs for Myocardial Infarction Treatment

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An Injectable Supramolecular Polymer Nanocomposite Hydrogel for Prevention of Breast Cancer Recurrence with Theranostic and M

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High-strength smart hydrogels as a versatile platform for surface-mediated gene delivery

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3D-Printed High Strength Bioactive Supramolecular Polymer/Clay Nanocomposite Hydrogel Scaffold for Bone Regeneration

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Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect

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Repair of volumetric bone defects with a high strength BMP-loaded-mineralized hydrogel tubular scaffold

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Bioinspired fabrication of high strength hydrogels from non-covalent interactions

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Opinion on the recent development of injectable biomaterials for treating myocardial infarction

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Methyl matters: An autonomic rapid self-healing supramolecular poly(N-methacryloyl glycinamide) hydrogel

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Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries

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NIR-responsive cancer cytomembrane-cloaked carrier-free nanosystems for highly efficient and self-targeted tumor drug deliver

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An injectable conductive hydrogel encapsulating plasmid DNA-eNOs and ADSCs for treating myocardial infarction

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A high strength semi-degradable polysaccharide-based hybrid hydrogel for promoting cell adhesion and proliferation

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Poly(N-acryloyl glycinamide): a fascinating polymer that exhibits a range of properties from UCST to high-strength hydrogels

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Poly(vinyl diaminotriazine): From Molecular Recognition to High-Strength Hydrogels

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Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis

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A Mechanically Robust, Stiff, and Tough Hyperbranched Supramolecular Polymer Hydrogel

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Rebuilding Postinfarcted Cardiac Functions by Injecting TIIA@PDA Nanoparticle-Cross-linked ROS-Sensitive Hydrogels

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A pH-Responsive Biodegradable High-Strength Hydrogel as Potential Gastric Resident Filler

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An Autolytic High Strength Instant Adhesive Hydrogel for Emergency Self-Rescue

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A highly tough and stiff supramolecular polymer double network hydrogel

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NIR-Activated Polydopamine-Coated Carrier-Free "Nanobomb" for In Situ On-Demand Drug Release

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Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

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Carrier-free nanodrug-based virus-surface-mimicking nanosystems for efficient drug/gene co-delivery

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Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

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Direct neural stem cell differentiation on polyaniline-coated high strength hydrogels

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ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging

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Double hydrogen-bonding pH-sensitive hydrogels retaining high-strengths over a wide pH range

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Highly luminescent carbon nanodots by microwave-assisted pyrolysis

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Temperature-tuned DNA condensation and gene transfection by PEI-g-(PMEO(2)MA-b-PHEMA) copolymer-based nonviral vectors

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High-strength hydrogels with integrated functions of H-bonding and thermoresponsive surface-mediated reverse transfection and cell detachment

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The biocompatibility of fatty acid modified dextran-agmatine bioconjugate gene delivery vector

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High-Strength Photoresponsive Hydrogels Enable Surface-Mediated Gene Delivery and Light-Induced Reversible Cell Adhesion/Deta

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Gene-modified cell detachment on photoresponsive hydrogels strengthened through hydrogen bonding

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Redox-cleavable star cationic PDMAEMA by arm-first approach of ATRP as a nonviral vector for gene delivery

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Water-soluble and phosphorus-containing carbon dots with strong green fluorescence for cell labeling

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Polycation-b-Polyzwitterion Copolymer Grafted Luminescent Carbon Dots As a Multifunctional Platform for Serum-Resistant Gene

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UV light-triggered unpacking of DNA to enhance gene transfection of azobenzene-containing polycations

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PDMAEMA-b-polysulfobetaine brushes-modified epsilon-polylysine as a serum-resistant vector for highly efficient gene delivery

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Combining magnetic field/temperature dual stimuli to significantly enhance gene transfection of nonviral vectors

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Zinc ion-triggered two-way macro-/microscopic shape changing and memory effects in high strength hydrogels with pre-programme

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Fenton reaction-initiated formation of biocompatible injectable hydrogels for cell encapsulation

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Intermolecular hydrogen bonding strategy to fabricate mechanically strong hydrogels with high elasticity and fatigue resistan

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A facile and versatile approach to biocompatible "fluorescent polymers'' from polymerizable carbon nanodots

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Zinc ion uniquely induced triple shape memory effect of dipole-dipole reinforced ultra-high strength hydrogels

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Redox-Triggered Self-Rolling Robust Hydrogel Tubes for Cell Encapsulation

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Dipole–Dipole and H‐Bonding Interactions Significantly Enhance the Multifaceted Mechanical Properties of Thermoresponsive Sha

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Fabrication of a shape memory hydrogel based on imidazole-zinc ion coordination for potential cell-encapsulating tubular scaf

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An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung

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Enhanced gene transfection and serum stability of polyplexes by PDMAEMA-polysulfobetaine diblock copolymers

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High-strength hydrogel as a reusable adsorbent of copper ions

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Controlled Heterogeneous Stem Cell Differentiation on a Shape Memory Hydrogel Surface

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Co-delivery of doxorubicin and tumor-suppressing p53 gene using a PUSS-based star-shaped polymer for cancer therapy

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Photoactive Self-Shaping Hydrogels as Noncontact 3D Macro/Microscopic Photoprinting Platforms

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Enhanced Therapeutic siRNA to Tumor Cells by a pH-Sensitive Agmatine-Chitosan Bioconjugate

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Hydrogen bonded and ionically crosslinked high strength hydrogels exhibiting Ca2+-triggered shape memory properties and volum

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Nano-silver in situ hybridized collagen scaffolds for regeneration of infected full-thickness burn skin

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A nucleoside responsive diaminotriazine-based hydrogen bonding strengthened hydrogel

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Hydrogen-Bonding Toughened Hydrogels and Emerging CO2-Responsive Shape Memory Effect

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High Strength Multifunctional Multiwalled Hydrogel Tubes: Ion-Triggered Shape Memory, Antibacterial, and Anti-inflammatory Ef

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A Mechanically Strong, Highly Stable, Thermoplastic, and Self-Healable Supramolecular Polymer Hydrogel

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Sea Cucumber-Inspired Autolytic Hydrogels Exhibiting Tunable High Mechanical Performances, Repairability, and Reusability

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A thermoresponsive supramolecular copolymer hydrogel for the embolization of kidney arteries

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A robust, highly stretchable supramolecular polymer conductive hydrogel with self-healability and thermo-processability

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A Mineralized High Strength and Tough Hydrogel for Skull Bone Regeneration

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A pi-pi conjugation-containing soft and conductive injectable polymer hydrogel highly efficiently rebuilds cardiac function a

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A high strength pH responsive supramolecular copolymer hydrogel

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Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence