ajdong@tju.edu.cn
材料学
未公开
教授
两亲性聚氨酯水分散体系超分子自组装及特性的研究

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纳米载体多级结构的精细化与免疫细胞内siRNA递送功效的最优化

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中药咳喘膏纳米透皮吸收新制剂的研究开发

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基于分子设计和组装开发新型药用高分子材料及纳米药物传递体

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中药纳米透皮吸收制剂高分子辅料的研制

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高分子多层次性结构对经皮给药功能性的调控作用

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高分子载体结构设计及其对艾滋病疫苗的黏膜免疫促进作用

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促进软骨再生修复功能的可注射支架材料及应用技术研究

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用于肿瘤介入治疗的纳米材料及其原位凝胶给药系统

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采用电纺丝技术优化经皮给药系统的结构组合及其功能性

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联合阻断HIV感染的新型多价生物预防技术研究

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通过纳米递送系统的功能性组装协调siRNA的负载、输运与释放

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肿瘤定位共输送siRNA与化疗药物的纳米粒温敏原位凝胶给药系统的研究

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持续定位输送模式下的多元协同促进纳米粒肿瘤内药物递送功效

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基于高分子自组装体系研究生物膜的分子自组装与功能性
聚乙二醇嵌段可生物降解聚酯梳型接枝共聚物及其制备方法和应用

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可再分散pH敏感型阳离子聚合物水凝胶亚微米粒及制备方法

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聚N-乙烯基吡咯烷酮与聚乙烯醇共混压敏胶及其应用

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一种pH与氧化还原双敏感的层交联纳米粒及其制备方法和应用

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有机硅交联的聚乙烯醇涂膜剂和制备方法及应用

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黏米淀粉/丙烯酸酯共聚物及其组合物和应用

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由化学键负载药物的温敏原位凝胶及制备

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两亲性可生物降解聚酯梳型接枝共聚物及其温敏原位凝胶体系
本发明涉及一种聚乙二醇嵌段可生物降解聚酯梳型接枝共聚物及其制备方法和应用，这种梳型接枝共聚物由聚乙二醇嵌段的可降解聚酯为疏水主链、聚酯嵌段侧链接枝可进行原子转移自由基聚合(ATRP)的单体的均聚物或共聚物，聚酯为内酯、交酯的均聚物或它们的共聚物。

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本发明公开了一类可再分散pH敏感型阳离子聚合物水凝胶亚微米粒及其制备方法，属于pH敏感型水凝胶高分子材料技术。该水凝胶亚微米粒中，含有亲水性非离子聚合物部分，阳离子聚合物部分，引发剂部分和交联剂部分。本发明所制得的水凝胶亚微米粒能再分散在纯水、生理盐水、缓冲液等；pH＜7时，水凝胶亚微米粒发生溶胀，而pH＞7时，水凝胶亚微米粒的粒径变化很小，是一种优良的药物控制释放载体材料

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本发明涉及一类聚N-乙烯基吡咯烷酮与聚乙烯醇共混压敏胶，该压敏胶至少包括：A.压敏胶的骨架成分，由至少两种分子量的聚N-乙烯基吡咯烷酮(PVP)和至少一种聚乙烯醇组成；B.液体增塑剂；C.5～50%的水；D.占骨架组分0～10%的交联剂；其中骨架成分占A、B、C总量的20～80%，液体增塑剂占A、B、C总量的10～60%。

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本发明公开了一种聚乙二醇-含环醚侧基的聚酯共聚物。该共聚物是由含环醚侧基的疏水性聚酯嵌段A，与亲水性聚乙二醇嵌段B，及与化合物C组成BAB型、(AB)1-40型、C-(AB)3-24型或C-(BA)3-24型的共聚物。该共聚物可以在水介质介质中自组装形成纳米粒，用于包载药物、蛋白质、多肽和多糖。又可以在水介质中，当共聚物的质量含量为10％～50％，在10℃～60℃形成原位凝胶，该凝胶用于原位注射给药的载体，也可为酶固定、细胞培养、组织工程提供凝胶基质。

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本发明公开了一种有机硅交联的聚乙烯醇涂膜剂及其应用，该涂膜剂是由有机硅交联的聚乙烯醇骨架成分、保湿剂和水为基本组分形成的具有可涂膜性的凝胶；其中聚乙烯醇占骨架成分的50～90％，涂膜剂中水含量为20～95％，保湿剂与骨架成分的质量比为0.3～1.5。该涂膜剂与药物、促透剂等配伍，在皮肤上涂敷并干燥成膜，可用于皮肤病、伤口或烫伤的敷料，作为面膜、化装用品，局部药物制剂以及其它涂膜制剂应用。

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本发明涉及一种黏米淀粉/丙烯酸酯共聚物及其组合物和应用，是用丙烯酸及其酯类单体与黏米淀粉进行共聚的产物，所述的黏米淀粉是糯米、黏大米、黏玉米、大黄米、小黄米、黏高梁米的淀粉及其改性淀粉的一种或多种混合物。所述的黏米淀粉/丙烯酸酯共聚物及其与淀粉或改性淀粉、交联剂形成的组合物作为吸水剂、增粘剂、黏合剂、增稠剂、增溶剂使用，以及作为药物制剂辅料用于药物片剂、胶囊剂、凝胶剂、乳剂、膏剂、膜剂、巴布剂和贴剂中

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该凝胶是由键合药物的聚乙二醇-聚酯嵌段共聚物分散于水体系中形成，所述的段共聚物是由亲乙二醇嵌段A，与聚酯嵌段B，及与药物C构成C/B-A-B/C型、A-B/C型、C/A-B型或C/A-B/C型的共聚物。制备过程包括，在辛酸亚锡催化下，聚乙二醇引发反应进行开环聚合聚乙二醇-聚酯；对聚乙二醇-聚酯进行端基改性；通过化学键键合药物C；键接药物的聚乙二醇-聚酯共聚物制成冻干粉再将其分散水介质中，当分散液质量为10％-50％、温度25-60℃转变为不流动的原位凝胶。

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本发明涉及一种两亲性可生物降解聚酯梳型接枝共聚物及其温敏原位凝胶体系，该梳型接枝共聚物由可降解聚酯为疏水主链、亲水温敏聚合物为侧链组成，主链为内酯、交酯的均聚物或它们的共聚物，侧链为N-取代或N，N-取代的(甲基)丙烯酰胺或N，N-取代的(甲基)丙烯酸酯的均聚物或它们的共聚物、或N，N-取代的(甲基)丙烯酸酯与聚乙二醇单甲醚(甲基)丙烯酸酯的共聚物。本发明在20～60℃能够形成水凝胶，在体内可生物降解，降解产物无毒无害，具有吸水性、通透性和生物相容性。
两性聚氨酯和磷脂自组装行为的研究

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Elaboration on the Distribution of Hydrophobic Segments in the Chains of Amphiphilic Cationic Polymers for Small Interfering

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Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy

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2.One simple and stable coating of mixed-charge copolymers on poly(vinyl chloride) films to improve antifouling efficiency

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One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid

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pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations

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Self-assembling nanowires of an amphiphilic camptothecin prodrug derived from homologous derivative conjugation

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Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release

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Co-delivery of doxorubicin and 131 I by thermosensitive micellar-hydrogel for enhanced in situ synergetic chemoradiotherapy

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Reactive oxygen species (ROS) responsive PEG–PCL nanoparticles with pH-controlled negative-to-positive charge reversal for in

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Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

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Thermo-sensitive nanoparticles for triggered release of siRNA

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A novel transdermal drug delivery system based on self-adhesive Janus nanofibrous film with high breathability and monodirect

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Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RA

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Toxicity and in vivo biological effect of the nanoparticular self-supported hydrogel of a thermosensitive copolymer for non-i

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Integrin-targeted zwitterionic polymeric nanoparticles with acid-induced disassembly property for enhanced drug accumulation

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Improving the oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanopa

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Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer

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Preparation and investigation of high solid content PTX-loaded nanoparticles dispersion via nanoprecipitation method

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Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluroni

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Sequential thermo-induced self-gelation and acid-triggered self-release process of drug-conjugated nanoparticles: A strategy

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Ternary complexes of poly(vinyl pyrrolidone)-graft-poly(2-dimethylaminoethyl methacrylate), DNA and bovine serum albumin for

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Intracellular Cleavable Poly (2-dimethylaminoethyl methacrylate) Functionalized Mesoporous Silica Nanoparticles for Efficient

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Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery

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Performance optimization of injectable chitosan hydrogel by combining physical and chemical triple crosslinking structure

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A reconstituted "two into one" thermosensitive hydrogel system assembled by drug-loaded amphiphilic copolymer nanoparticles f

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Poly(ether-ester anhydride)-based amphiphilic block copolymer nanoparticle as delivery devices for paclitaxel

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Poly(ethyleneglycol) -b-poly(ε-caprolactone-co-γ-hydroxyl-ε-caprolactone) bearing pendant hydroxyl groups as nanocarriers for

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Investigation on injectable, thermally and physically gelable poly(ethylene Glycol)/poly(octadecanedioic anhydride) amphiphil

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Controlled thermal gelation of poly(ε-caprolactone)/poly(ethylene glycol) block copolymers by modifying cyclic ether pendant

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Self-assembled cationic triblock copolymer mPEG-b-PDLLA-b-PDMA nanoparticles as nonviral gene vector

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Synthesis and properties of polycaprolactone-graft-Poly(2-(dimethylamino)ethyl methacrylate-co-methoxy polyethylene glycol mo

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Preparation and properties of thermoreversible hydrogels based on methoxy poly(ethylene glycol)-grafted chitosan nanoparticle

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Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacryl

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Methoxy poly(ethylene glycol)-b-poly(octadecanoic anhydride)-b-methoxy poly(ethylene glycol) amphiphilic triblock copolymer n

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Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanopart

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Ternary Complexes of Amphiphilic Polycaprolactone-graft-Poly (N,N-dimethylaminoethyl methacrylate), DNA and Polyglutamic acid

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Chitosan/alginate nanoparticles stabilized by poloxamer for controlled release of 5-Fluorouracil

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In vitro enhancement of lactate esters on the percutaneous penetration of drugs with different lipophilicity

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Pressure-sensitive adhesive properties of poly(N-vinyl pyrrolidone)/D,L-lactic acid oligomer/glycerol/water blends for TDDS

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Poly(ε-caprolactone)-graft-poly(2-(N,N-dimethylamino) ethyl methacrylate) nanoparticles: pH dependent thermo-sensitive multif

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The use of PEGylated poly [2-(N,N-dimethylamino) ethyl methacrylate] as a mucosal DNA delivery vector and the activation of i

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Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo

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Amphiphilic Methoxy Poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-dimethylaminoethyl methacrylate) Cationic Copolymer

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Thermoreversible gelation of poly(ethylene glycol)/poly(ester anhydride) triblock copolymer nanoparticles for injectable drug

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Thermosensitive behavior of poly(ethylene glycol)/poly(2-(N,N-dimethylamino) ethyl methacrylate) double hydrophilic block cop

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A Novel hydrophilic adhesive matrix with self-enhancement for

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Investigation on properties of P((MAA-co-DMAEMA)-g-EG) polyampholyte nanogels

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A new injectable thermogelling material: methoxy poly(ethylene glycol)-poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethyle

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VE醋酸酯两亲性嵌段共聚物纳米分散液的制备

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Controlled release of paclitaxel from amphiphilic copolymer hybrid assembly nanoparticles

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Amphiphilic poly{[α-maleic anhydride-ω- methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles

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Synthesis and application of RAFT agent p-xylylene di(N-carbazylcarbodithioate)

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Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone

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Stabilized micelles of amphoteric polyurethane formed by thermoresponsive micellization in HCl aqueous solution

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Synthesis and properties of O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers

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Methoxy poly(ethylene glycol)-block-poly(D,L-lactic acid) copolymer nanoparticles as carriers for transdermal drug delivery

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Characterization and in vitro degradation of poly(octadecanoic anhydride)

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Thermoresponsive degradable poly(ethylene glycol) analogues

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Influences of the content of POA on the properties of poly(sebacic acid-octadecanic diacid) copolyanhydrides

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Poly(ethylene glycol)/poly(ethyl cyanoacrylate) amphiphilic triblock copolymer nanoparticles as delivery vehicles for dexamet

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加氢裂化尾油评价试验与工业应用

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Complexation between Sodium Dodecyl Sulfate and Amphoteric Polyurethane Nanoparticles

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Preparation of Poly(MAA-g-EG) Hydrogel Nanoparticles by a Thermally Initiated Free Radical Dispersion Polymerizatiom

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Investigation on the properties of methoxy poly(ethylene glycol)/chitosan graft co-polymers

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Responsive catalysis of thermoresponsive micelle-supported gold nanoparticles

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亲水性聚氨酯压敏胶经皮给药应用性能研究

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纳米粒在经皮及黏膜给药系统中的应用

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高分子材料的结构与其在经皮给药系统中的作用

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水凝胶纳米粒及其在生物医药领域的应用

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用于透皮吸收制剂的亲水性压敏胶的制备与性能

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3-二甲胺基-1, 2-丙二醇的合成与表征

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紫杉醇的聚乙二醇单甲醚-b-聚(L-乳酸)二嵌段共聚物纳米粒的研究

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可生物降解聚合物纳米胶囊型药物载体及组合胶囊的药物控制释放

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紫杉醇的聚乙二醇单甲醚－b－聚（L－乳酸）二嵌段共聚物纳米粒的研究

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新型可生物降解医用高分子材料－聚膦腈

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聚乙二醇单甲醚－聚（D,L-乳酸）嵌段共聚物的研究

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Preparation and characterization of poly(ethylene glycol) grafted poly(ethyl cyanoacrylate) copolymer and nanoparticles

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聚乙二醇单甲醚接枝壳聚糖的合成与表征

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Methoxy Poly(ethylene glycol)-b-Poly(L-lactic acid) Copolymer Nanoparticles as Delivery Vehicles for Paclitaxel

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皮肤用亲水性聚氨酯压敏胶的制备及性能研究

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聚乙二醇甲醚-聚(D, L-乳酸)嵌段共聚物纳米胶束的制备

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聚乙二醇在新型药物制剂中的应用

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聚乙二醇/聚己内酯两亲性三嵌段共聚物纳米胶束的研究

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紫杉醇两亲嵌段共聚物纳米囊的研究

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超分子自组装模型体系在生物膜研究中的应用

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聚乙二醇/聚己内酯三嵌段共聚物的合成与表征

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粘度法研究壳聚糖与两性聚氨酯胶束间的相互作用

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低聚（L-乳酸）的合成

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Properties of Amphoteric Polyurethane Waterborne Dispersions II. Macromolecular Self-assembly Behavior

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壳聚糖—两性聚氨酯接枝共聚物的制备

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Properties of Amphoteric Polyurethane Waterborne Dispersions 1. Dependence on pH Value in salt Free Media

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Properties of Amphoteric Polyurethane Waterborne Dispersions III. Isoelectric points and Precipitation

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紫杉醇注射剂的研究

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载药聚乳酸纳米微粒的制备

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两性聚氨酯纳米水分散液的制备和性质

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Preparation and Morphology Studies of Core-Shell Type Waterborne Polyacrylate-Polyurethane Microspheres

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IR Spectra Studies of Core/Shell Type Waterborne Acrylic-Polyurethane Hybrid Microemulsions

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Structure-Property Relationships of Core-Shell Type Waterborne Polyacrylate-Polyurethane Microemulsions.

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核壳结构聚丙烯酸酯－聚氨酯微乳液膜的相行为

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水性丙烯酸－聚氨酯微乳液的制备及粒子形态