原续波 教授

Email: xbyuan@tju.edu.cn
研究所：先进高分子材料研究所

入选教育部新世纪人才
个人简历
教育背景：
· 1985.9 – 1989.7 北京理工大学化学工程系 工学学士
· 1992.9 – 1995.6 天津大学材料科学与工程系 工学硕士
· 1998.3 – 2001.6 天津大学材料科学与工程学院高分子系 工学博士
工作经历：
· 1989.7 – 1992.7 山西长治惠丰机械厂 助理工程师 副科长
· 1995.7 – 今 天津大学材料科学与工程学院讲师、副教授、教授
· 2002.9 – 2005.6 南开大学吸附与分离国家重点实验室，博士后
· 2010.1 – 2010.7 美国加州大学洛杉矶分校 访问****
研究方向
· 研究领域：
生物医用材料，生物纳米技术。
· 讲授课程：
材料现代研究方法，高分子材料科学基础，高分子物理。
承担项目
主要主持承担项目：
1.“治疗性抗体纳米微囊构建及恶性脑胶质瘤靶向免疫治疗研究”, 国家自然科学基金项目，2018～2021。
2.“靶向肿瘤微环境环境的功能蛋白、miRNA和阿霉素联合投递纳米微囊设计和肿瘤抑制研究”，国家自然科学基金项目，2015～2018。
3.“超支化星形聚合物单分子胶束介导紫杉醇和as-miR-21共传递抑制恶性脑胶质瘤”，国家自然科学基金项目，2011～2013。
4.“基因/药物同载时序性控制释放体系构建及肿瘤抑制研究”, 国家自然科学基金项目(合作),2012～2013
5.“功能纳米微粒介导基因治疗增效化疗”，教育部新世纪人才项目，2010～2012。
6.“载药超微粒表面多重生物功能因子组装介导药物跨血脑屏障靶向脑胶质瘤释放”，国家自然科学基金项目，2006～2008。
7.“可立体定位注射癌症缓释化疗制剂的产业化基础研究”，天津市科技攻关项目，2006～2009。
8.“可生物降解载药涂层冠状动脉支架研究”，校企横向合作项目 2006～2007。
9.“生物可降解PHB的化学合成关键问题研究”，天津市自然科学基金重点项目，2003～2005。
10.“载药超微粒表面生物功能化介导恶性脑胶质瘤靶向药物释放”，国家自然科学基金青年基金，2002～2004。
标志性成果
· 主要学术成就、获奖及荣誉：
1. 2009年获国家级教学成果二等奖
2. 2013年获天津市教学成果一等奖
· 发表文章、专著（代表作）：

1. Lei Han, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie Ren, Qixue Wang, Lixia Long, Yang Liu, Irvin Chen,Xubo Yuan*, Yunfeng Lu*, Chunsheng Kang*, Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Advanced Materials,2019: **. IF=25.809,Top期刊
2. Sidi Li, Luyang Chen, Kai Huang, Ning Chen, Qi Zhan, Kaikai Yi, Hongzhao Qi, Chaoyong Liu, Yanli Tan, Xin Hou, Yunfeng Lu, Jin Zhao*,Xubo Yuan*, Chunsheng* Kang, Tumor Microenvironment-Tailored Weakly Cell-Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function, Advanced Functional Materials,2019, **.IF=15.621,Top期刊
3. Hongzhao Qi, Chaoyong Liu, Lixia Long, Yu Ren, Shanshan Zhang, Xiaodan Chang, Xiaomin Qian, Huanhuan Jia, Jin Zhao, Jinjin Sun, Xin Hou*,Xubo Yuan*, Chunsheng Kang, Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy. ACS Nano,2016, 10(3): 3323-3333. IF=13.942,Top期刊
4. Chaoyong Liu, Jing Wen, Yubin Meng, Kailiang Zhang, Jialin Zhu, Yu Ren, Xiaomin Qian,Xubo Yuan*,Yunfeng Lu*, Chunsheng Kang*, Efficient Delivery of Therapeutic miRNA Nanocapsules for Tumor Suppression, Advanced Materials,2015, 27(2):292-297.IF=25.809,Top期刊
5. Xiaomin Qian, Lixia Long, Zhendong Shi, Chaoyong Liu , Mingzhe Qiu, Jing Sheng, Peiyu Pu,Xubo Yuan*, Yu Ren*, Chunsheng Kang*, Star-Branched Amphiphilic PLA-b-PDMAEMA Copolymers for Co-delivery of miR-21 Inhibitor and Doxorubicin to Treat Glioma, Biomaterials,2014, 35(7):2322-2335.IF=8.402, Top期刊
6.Qi Zhan, Kaikai Yi, Hongzhao Qi, Sidi Li, Xueping Li, Qixue Wang, Yunfei Wang, Chaoyong Liu, Mingzhe Qiu,Xubo Yuan, Jin Zhao*, Xin Hou*, Chunsheng Kang*, Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy. Theranostics,2020, doi:10.7150/thno.45028. IF=8.063,Top期刊
7.Sidi Li, Ning Chen, Xueping Li, Yang Li, Zhipeng Xie, Zhenyu Ma, Jin Zhao*, Xin Hou,Xubo Yuan. Bioinspired Double-Dynamic-Bond Crosslinked Bioadhesive Enables Post-Wound Closure Care. Advanced Functional Materials,2020: **.IF=15.621, Top期刊
8. Donglin Han, Yajing Han*, Jun Li, Xiangmei Liu*, Kelvin Wai Kwok Yeung, Yufeng Zheng, Zhenduo Cui, Xianjin Yang, Yanqin Liang, Zhaoyang Li, Shengli Zhu,Xubo Yuan, Xiaobo Feng, Cao Yang, Shuilin Wu*, Enhanced Photocatalytic Activity and Photothermal Effects ofCu-dopedMetal-organicFrameworks forRapidTreatment ofBacteria-InfectedWounds. Applied Catalysis B: Environmental, 2020, 261. IF=14.229,Top期刊
9. Meng Yubin, Li Xue, Li Zhaoyang, Liu Chaoyong, Zhao Jin, Wang Jianwei, Liu Yunde,Yuan Xubo, Cui Zhenduo, Yang Xianjin. Surface Functionalization of Titanium Alloy with miR-29b Nanocapsules To Enhance Bone Regeneration. ACS Applied Materials & Interfaces,2016, 8(9):5783-5793. IF=7.504,Top期刊
10. Meng Yubin, Liu Chaoyong, Zhao Jin, Li Xue, Li Zhaoyang, Wang Jianwei, Wang Renfeng, Liu Yunde,Yuan Xubo, Cui Zhenduo, Yang Xianjin. An Injectable miRNA-activated Matrix for Effective Bone Regenerationin vivo. Journal of Materials Chemistry B, 2016,4(43): 6942-6954. IF=4.543
11. Juanjuan Du, Jing Jin, Yang Liu, Jie Li, Talar Tokatlian, Zuhong Lu, Tatiana Segura, Xubo Yuan*, Xianjin Yang, Yunfeng Lu*, Gold-Nanocrystal-Enhanced Bioluminescent Nanocapsules, ACS Nano,2014, 8(10):9964-9969.IF=13.942,Top期刊
12. Yu Ren, Ruirui Wang, Yang Liu, Hua Guo, Xuan Zhou,Xubo Yuan, Chaoyong Liu, Jianguo Tian, Haifang Yin, Yinsong Wang*, Ning Zhang*, A Hematoporphyrin-based Delivery System for Drug Resistance Reversal and Tumor Ablation, Biomaterials,2014, 35(8):2462-2470.IF=8.402,Top期刊
13. Lijun Yang, Donglin Han, Qi Zhan, Xueping Li, Peipei Shan, Yunjie Hu, Han Ding, Yu Wang, Lei Zhang, Yuan Zhang, Sheng Xue, Jin Zhao, Xin Hou, Yin Wang, Peifeng Li,Xubo Yuan*, Hongzhao Qi*, Blood TfR+ Exosomes Separated by a pH-Responsive Method DeliverChemotherapeutics forTumorTherapy. Theranostics.2019,9(25):7680-7696. IF=8.063,Top期刊
14. Hongzhao Qi*, Lijun Yang, Xueping Li, Xiaolei Sun, Jin Zhao, Xin Hou , Zhaoyang Li*,Xubo Yuan*, Zhenduo Cui, Xianjin Yang, Systemic Administration of Enzyme-Responsive Growth Factor Nanocapsules for Promoting Bone Repair. Biomaterials Science,2019, 7, 1675-1685. IF=5.21
15. Xiaolei Sun, Xueping Li, Hongzhao Qi, Xin Hou, Jin Zhao, Xubo Yuan*, Xinlong Ma*, MiR-21 Nanocapsules Promote Early Bone Repair of Osteoporotic Fractures by Stimulating the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells. Journal of Orthopaedic Translation,2020. IF=3.063
16. Xueping Li, Qi Zhan, Hongzhao Qi, Donglin Han, Yaoyao Qin, Ning Chen, Lixia Long, Jin Zhao*, Xin Hou,Xubo Yuan*, Xianjin Yang, Paclitaxel Formulation with Stable Sustained-Release Behavior and Its Biological Safety Evaluation. Science China Technological Sciences,2019, 62(7). IF=2.18
专著：
《材料分析方法》，杜希文，原续波，天津大学出版社，2006. "十二五"普通高等教育本科国家级规划教材，普通高等教育"十一五"国家级规划教材，教育部普通高等教育精品教材。