姓　名 李娇
职　称 副教授
所在系别 生物医学工程
行政职务 院长助理
所属课题组 生物医学光子学
联系电话
电子邮件 jiaoli@tju.edu.cn
办公地址 天津大学第十七教学楼431室
主讲课程 生物医学光子学
导师类型 硕士生导师，团队博士生导师
通讯地址 天津市南开区卫津路92号天津大学精仪学院
邮政编码 300072

个人经历或学术经历
2004-2008 天津大学精密仪器与光电子工程学院，生物医学工程专业，学士
2008-2010 天津大学精密仪器与光电子工程学院，生物医学工程专业，硕士
2010-2013 天津大学精密仪器与光电子工程学院，生物医学工程专业，博士
2013-2018 天津大学精密仪器与光电子工程学院，生物医学工程专业，讲师
2018-至今 天津大学精密仪器与光电子工程学院，生物医学工程专业，副教授
2015-2016 慕尼黑工业大学公派，访问****
2018.9-12 加州大学洛杉矶分校，访问****


研究方向
生物医学光子学；
生物医学光学成像；
生物医学测量方法与系统;


科研项目、成果和专利
科研项目

1. 国家自然科学基金面上项目，**，面向人源异位移植肺癌动物模型的多参数量化光声介观成像先进方法，2018/01-2021/12，50万元，在研，主持
2. 国家自然科学基金青年基金项目，**，基于扩散光学层析支持的小动物定量光声层析成像方法研究， 2015.1-2017.12，23万，结题。主持
3. 国家自然科学基金面上项目，面向光动力治疗在体测评的空间频率域成像方法研究，**，57万，2019.1-2022.12，在研，参加，第三
4. 国家自然科学基金面上项目，面向早期乳腺癌诊断的锥束相衬XCT/XLCT双模态成像先进方法，**，60万，2016.1-2019.12，在研，参加，第四
5. 国家自然科学基金面上项目，面向视觉脑功能探测的高灵敏度与定量化近红外光谱成像关键方法，**，63万，2016.1-2019.12，在研，参加，第四
6. 国家自然科学基金面上项目，**，面向光动力治疗在体测评的空间频率域成像方法研究， 2015.1-2018.12，80万，在研，参加，第四
7. 国家自然科学基金面上项目，**，面向肿瘤恶性生物学研究的小动物全身XCT/DOT/FMT多模态成像先进方法，2014.1-2017.12，100万，结题，参加，第七
8.国家自然科学青年基金项目，**，基于辐射传输方程高阶近似的时域荧光分子层析方法，2012.1-2014.12，25万，结题，参加，第五
9.天津市科技计划重点项目，15JCZDJC31800，基于XCT/DOT支持的定量小动物FMT方法及集成多模态系统，015.04.01-2018.03.31，20万，结题，参加，第五
发明专利

[1]高峰，李娇，赵会娟，张丽敏。仿CT扫描模式多光谱时域荧光分子层析测量系统，中国发明专利，专利号：3.X（2011年6月22日授权）。
[2]高峰，李娇，张丽敏，赵会娟。重构混浊介质光学参数的时间分辨测量系统及方法，中国发明专利，专利号：8.1（2011年12月14日授权）。
[3]高峰，王欣，李娇，马文娟，赵会娟。光子计数型动态扩散荧光断层成像方法及装置，中国发明专利，专利号：5.0 （2013年8月28日授权）
[4]高峰，陈琛，朱苹苹，李娇，赵会娟。混沌介质光学参数多波长空间分辨锁相测量方法与装置，中国发明专利，专利号：7.5 （2014年7月2日授权）
[5]高峰，张伟，武林会，李娇，马文娟，周仲兴，张丽敏，赵会娟。荧光-光学联合断层成像系统及测量方法，中国发明专利，专利号： 5.7。（2014年11月26日授权）


论文、专著
期刊论文

1.Yihan Wang #, Tong Lu #, Jiao Li*, WenboWan, Wenjuan Ma, Limin Zhang, Zhongxing Zhou, Jingying Jiang, Huijuan Zhao and Feng Gao*, "Enhancing sparse-view photoacoustic tomography with combined virtually parallel projecting and spatially adaptive filtering", Biomedical Optics Express, 2018,9(9):4569-4587, SCI, 二区, IF: 3.482
2.Lingling Liu, Wenbo Wan, Jiao Li*, Huijuan Zhao and Feng Gao*, "Simultaneous recovery of a full set of optical properties in turbid media using incomplete P5 approximation to CW radiance", Optics Letters, 2018, 43(17):4188-4191, SCI, 二区, IF: 3.589
3.Yidan Wang, Xiaojuan Pang, Jinping Wang, Yu Cheng, Yilin Song, Qi Sun, Qing You, Fengping Tan, Jiao Li* and Nan Li*, “Magnetically-targeted and near infrared fluorescence/magnetic resonance/photoacoustic imaging-guided combinational anti-tumor phototherapy based on polydopamine-capped magnetic Prussian blue nanoparticles”, J. Mater. Chem. B 6: 2460-2473. (2018), SCI, 一区, IF: 4.714
4.Yu Cheng, Xiaoxiao Tan, Jinping Wang, Yidan Wang, Yilin Song, Qing You, Qi Sun, Li Liu, Siyu Wang, Fengping Tan, Jiao Li*, Nan Li*, “Polymer-based gadolinium oxide nanocomposites for FL/MR/PA imaging guided and photothermal/photodynamic combined anti-tumor therapy”, Journal of Controlled Release 277: 77–88. (2018), SCI, 一区, IF: 7.644
5.Yihan Wang, Jie He, Jiao Li *, Tong Lu, Yong Li, Wenjuan Ma, Limin Zhang, Zhongxing Zhou, Huijuan Zhao and Feng Gao*,“Toward whole-body quantitative photoacoustic tomography of small-animals with multi-angle light-sheet illuminations”, Biomedical Optics Express, 2017, 8(8): 3778-3795. SCI, 二区, IF: 3.443
6.Yihan Wang#, Jiao Li#, *, Tong Lu, Limin Zhang, Zhongxing Zhou, Huijuan Zhao, and Feng Gao?,“Combined diffuse optical tomography and photoacoustic tomography for enhanced functional imaging of small animals: a methodological study on phantoms,” Applied Optics 56(2): 303-311 (2017). SCI, 三区, IF: 1.677
7.Bingyuan Wang, Wenbo Wan, Yihan Wang, Wenjuan Ma, Limin Zhang, Jiao Li, Zhongxing Zhou, Huijuan Zhao(*), Feng Gao(*), “An Lp(0≤p≤1)-norm regularized image reconstruction scheme for breast DOT with non-negative-constraint”, BioMedical Engineering OnLine, 2017, 16(1), SCI, 三区, IF: 1.497
8.Lu Tong, Wang Yihan, Zhang Songhe, Li Jiao*, “Photoacoustic mesoscopy: pushing toward the depth limit in the high-resolution optical imaging for biomedical applications and clinical potentials”, Instrumentation, 2016, 3(4): 29-41.
9.Wenbo Wan, Lingling Liu, Yihan Wang, Jiao Li, Limin Zhang, Zhongxing Zhou, Huijuan Zhao, and Feng Gao, “Region-based diffuse optical tomography with registered atlas: in vivo acquisition of mouse optical properties,” Biomedical Optics Express, Vol. 7(12): 5066-5080, 2016
10.Mengyu Jia, Huijuan Zhao, Jiao Li, Lingling Liu, Limin Zhang, Jingying Jiang, and Feng Gao, “Coupling between radiative transport and diffusion approximation for enhanced near-field photon-migration modeling based on transient photon kinetics,” Journal of Biomedical Optics, Vol. 21(5): 050501, 2016.
11.Xin Wang, Yanqi Zhang, Limin Zhang, Jiao Li, Zhongxing Zhou, Huijuan Zhao, and Feng Gao, “Direct reconstruction in CT-analogous pharmacokinetic diffuse fluorescence tomography: two-dimensional simulative and experimental validations,” Journal of Biomedical Optics, Vol. 21(4): 046007, 2016.
12.Linhui Wu, Wenbo Wan, Xin Wang, Zhongxing Zhou, Jiao Li, Limin Zhang, Huijuan Zhao, and Feng Gao, “Shape-parameterized diffuse optical tomography holds promise for sensitivity enhancement of fluorescence molecular tomography,” Biomedical Optics Express, Vol. 5(10): 3640-3659, 2014. (WOS: 031; Ei: 3)
13.Limin Zhang, Xi Yi, Jiao Li, Zhao, Huijuan Zhao, and Feng Gao, “ Analytical Green's function for the fluorescence simplified spherical harmonics equations in turbid medium”, J. Biomed. Opt., 19 (7): 070503. (2014)
14.Limin Zhang, Jiao Li, Xi Yi, Huijuan Zhao, and Feng Gao , “Analytical solutions to the simplified spherical harmonics equations using eigen-decompositions”, Optics Letters, 38(24): 5462-5465. (2013)
15.Jiao Li, Xi Yi, Xin Wang, Yiming Lu, Limin Zhang, Huijuan Zhao, and Feng Gao, “ Overlap time-gating approach for improving time-domain diffuse fluorescence tomography based on the IRF-calibrated Born normalization”, Optics Letters, 38(11): 1841-1843.(2013)
16.Wei Zhang, Linhui Wu, Jiao Li, Xi Yi, Xin Wang, Yiming Lu, Weiting Chen, Zhongxing Zhou, Limin Zhang, Huijuan Zhao, and Feng Gao, Combined hemoglobin and fluorescence diffuse optical tomography for breast tumor diagnosis: a pilot study on time-domain methodology, Biomedical Optics Express, 4(2):331-348. (2013)
17.Jiao Li, Xin Wang, Xi Yi, Limin Zhang, Zhongxing Zhou, Huijuan Zhao, and Feng Gao, "Towards pH-sensitive imaging of small animals with photon-counting difference diffuse fluorescence tomography," J. Biomed. Opt., 17(9): 096011. (2012)
18.Feng Gao, JiaoLi, Wei Zhang, XiYi, XinWang, Limin Zhang, Zhongxing Zhou and Huijuan Zhao, “A CT-analogous scheme for time-domain diffuse fluorescence tomography”, Journal of X-Ray Science and Technology, 20(1): 91-105. (2012)
19.Wenjuan Ma, Wei Zhang, Xi Yi, Jiao Li, Linhui Wu, Xin Wang, Limin Zhang, Zhongxing Zhou, Huijuan Zhao and Feng Gao, “Time-domain fluorescence- guided diffuse optical tomography based on the third-order simplified harmonics approximation,” Applied Optics, 51(36): 8656-8668. (2012)
20.Feng Gao, Jiao Li, Limin Zhang, Patrick Poulet, Huijuan Zhao, and Yukio Yamada, “Simultaneous fluorescence yield- and lifetime-tomography from time-resolved transmittances of a small-animal-stimulating phantom”, Applied Optics, 49(16): 3163-3172. (2010)
21.李娇，张燕，赵会娟，张丽敏，高峰，“基于多级小波域变换的时域扩散荧光层析成像方法,” 生命科学仪器，2014，12(6)：45-50。
22.李娇，高峰，易茜，张丽敏，赵会娟； “基于二维圆域解析模型的时域扩散荧光层析原理与实验研究”；中国激光；37(11)；2010年11月； 2743-2748.
23.高峰，李娇，张丽敏，赵会娟； “基于透射解析模型的时域扩散荧光层析原理与实验研究”；天津大学学报；43(6) ；2010年6月；557-561.
24.金蒙，高峰，李娇，赵会娟，“二维辐射传输方程的有限差分求解法”，光子学报， 2010年9月，39(9)：1594~1601。
25.赵会娟，王婷婷，李娇，高峰，“基于时间相关单光子计数的非接触式荧光层析成像系统”， 纳米技术与精密工程， 2012年5月，10(3)：243~248。 (EI: 044)
26.马文娟、高峰、张伟、易茜、李娇、武林会, “基于辐射传输方程三阶简化球谐近似模型的时域荧光扩散层析图像重建方法”, 光学学报，Vol. 31(5): **, 2011。(Ei: 539)
27.王欣、高峰、李娇、赵会娟，“仿CT扫描模式扩散荧光层析成像方法”，天津大学学报(自然科学与工程技术版)，Vol. 46(12): 1106-1113, 2013。(Ei: 20**3)
28.高峰、李峰辉、李娇、易茜、陈琛，“一种基于光子计数技术的时间分辨荧光免疫分析系统设计”，天津大学学报(自然科学与工程技术版), Vol. 47(6): 518-523, 2014。(Ei: 20**3)
29.高峰、陈琛、赵会娟、李娇、李峰辉,“一种双波长数字锁相光学拓扑成像系统”，纳米技术与精密工程，Vol.12(1): 7-14, 2014。
30.高峰、段临晶、李娇、张伟、易茜、武林会、王欣,“时域光学拓扑成像方法的模拟和实验研究”, 天津大学学报(自然科学与工程技术版), Vol. 47(9): 829-835, 2014。(Ei: 8) 31.张丽敏、高峰、李娇、赵会娟，“基于透射和反射时间分辨测量数据的荧光参数三维重建”，中国激光，Vol. 36(10): 2552-2556, 2009。(Ei: 169)
会议论文

1.Jiao Li, Songhe Zhang, Andrei Chekkoury, Sarah Glasl, Paul Vetschera, Benno Koberstein -Schwarz, Murad Omar and Vasilis Ntziachristos*. “Three-dimensional optoacoustic mesoscopy of the tumor heterogeneity in vivo using high depth-to-resolution multispectral optoacoustic tomography”, Proc. SPIE, Photons Plus Ultrasound: Imaging and Sensing 2017, 10064:100643C, San Francisco, CA, USA, 2017.01.29-02.01.
2.Yihan Wang, Feng Gao, Wenbo Wan, Yan Zhang, Jiao Li＊, Photoacoustic tomography guided diffuse optical tomography for small-animal model, Proc. of SPIE, Multimodal Biomedical Imaging X, 2015, 9316: 93160P.
3.Wenbo Wan, Jiao Li＊, Lingling Liu, Yihan Wang, Yan Zhang, Feng Gao, Acquisition of priori tissue optical structure based on non-rigid image registration, Proc. of SPIE, Multimodal Biomedical Imaging X, 2015, 9316: 93160O.
4.Yan Zhang, Limin Zhang, Meng Jin, Huijuan Zhao, Feng Gao, Jiao Li＊, In vivo experimental validation for a featured-data time-domain diffuse fluorescence tomography based on the radiative transfer equation, Proc. of SPIE, Optical Tomography and Spectroscopy of Tissue XI, 2015, 9319: 93191S.
5.Yihan Wang, Limin Zhang, Huijuan Zhao, Feng Gao and Jiao Li*, “ Diffuse fluorescence tomography based on the radiative transfer equation for small animal imaging”, in Multimodal Biomedical Imaging IX, F. S. Azar, X. Intes, eds, Proc. of SPIE Vol.8937: art. no. 89370W, 2014.
6.Jiao Li, Feng Gao, Linjing Duan, Xin Wang, Limin Zhang, and Huijuan Zhao, “PH-sensitive fluorescence detection by diffuse fluorescence tomography”, in Multimodal Biomedical Imaging VII, F. S. Azar, X. Intes, eds, Proc. of SPIE Vol.8216: art. no. 821606, 2012.
7. Jiao Li, Feng Gao, Qingzhen Zhu, Fenghui Li, Xin Wang, Limin Zhang, and Huijuan Zhao, “A CT-analogous method for high-resolution fluorescence molecular tomography”, in Multimodal Biomedical Imaging VII, F. S. Azar, X. Intes, eds, Proc. of SPIE Vol.8216: art. no. 82160W,2012.
8.Jiao Li, Feng Gao, Xi Yi, Xin Wang , Linhui Wu, Pingping Zhu, Limin Zhang , and Huijuan Zhao, “A pilot characterization of quantitative time-domain fluorescence diffuse optical tomography”, in Optical Tomography and Spectroscopy of Tissue IX, B. J. Tromberg, A. G. Yodh, M. Tamura, E. M. Sevick-Muraca, R. R. Alfano, eds, Proc. of SPIE Vol. 7896: art. no.78961G, 2011.
9.Jiao Li , Feng Gao , Xin Wang , Limin Zhang , and Huijuan Zhao, “An analytic scheme for time-domain diffuse fluorescence tomography in circular geometry: methodology and validation”, in Optics in Health Care and Biomedical Optics IV, Q. M. Luo, Y. Gu, X. D. Li, eds., Proc. of SPIE Vol. 7845: art. no. 78451W, 2010.
10.Limin Zhang, Jiao Li, Feng Gao, Huiyuan He, and Huijuan Zhao, “Time-domain fluorescence molecular tomography based on experimental data,” in Optical Tomography and Spectroscopy of Tissue VIII (BiOS2009), B.J. Tromberg, A.G. Yodh, M. Tamura, E.M. Sevick-Muraca, R.R. Alfano, eds., Proc. SPIE 7174: 71741O, 2009. (Ei: 543)
11.Feng Gao, Limin Zhang , Patrick Poulet, Jiao Li, Huijuan Zhao, and Yukio Yamada, “Simultaneously reconstructing fluorescent yield and lifetime from measured time-resolved transmittance of a small-animal-stimulating phantom,” in Diffuse Optical Imaging II, R. Cubeddu, A.H. Hielscher, Eds., Proc. SPIE 7369: 73691H, 2009. (Ei: 003)
12.Limin Zhang, Feng Gao, Jiao Li, and Huijuan Zhao, “Reconstructing fluorescent parameters using time-resolved data based on experimental measurement,” in Multimodal Biomedical Imaging V, F.S. Azar, X. Intes, eds., Proc. SPIE 7557: 75570Q, 2010. (Ei: 307)
13.Feng Gao, Meng Jin, Jiao Li, Farouk Nouizi, Patrick Poulet, Limin Zhang, and Huijuan Zhao, “A fiber-based, non-contact scheme for time-domain diffuse fluorescence tomography: methodology and simulative validation,” in Multimodal Biomedical Imaging V, F.S. Azar, X. Intes, eds., Proc. SPIE 7557: 75570O, 2010. (Ei: 305)
14.Linhui Wu, Yiming Lu,Wei Zhang, Xi Yi, Wenjuan Ma, Jiao Li, Xin Wang, Huijuan Zhao, and Feng Gao, “Time-domain diffuse fluorescence tomography using BEM forward solver,” Proc. SPIE 8216: 82160X, 2012. (Ei: 017)
15.Feng Gao, Weiting Chen, Jiao Li, Wei Zhang, Xi Yi , Xin Wang, Limin Zhang , Zhongxing Zhou, and Huijuan Zhao, “Time-domain diffuse fluorescence tomography of CT-analogous scheme: an experimental validation,” Proc. SPIE 8216: 82160Y, 2012. (Ei: 018)
16.Xi Yi, Weiting Chen, Linhui Wu, Wenjuan Ma, Wei Zhang, Jiao Li, Xin Wang, and Feng Gao, “GPU-accelerated Monte-Carlo modeling for fluorescence propagation in turbid medium,” Proc. SPIE 8216: 82160U, 2012. (Ei: 014)
17.Xin Wang, Jiao Li, Xi Yi, Linhui Wu, Wenjuan Ma, Wei Zhang, and Feng Gao, “A high-sensitive diffuse fluorescence tomography system with CT-analogous scanning mode,” Proc. SPIE 8216: 82160V, 2012. (Ei: 015)
18.Hui Guo, Wei Meng, Tingting Wang, Jiao Li;, Huijuan Zhao, and Feng Gao, "A time domain noncontact fluorescence tomography system for breast cancer diagnosis," Proc. SPIE 8216: 82160Z, 2012. (Ei: 019)
19.Limin Zhang, Wei Zhang, Feng Gao, Jiao Li, and Huijuan Zhao, "Fluorescence guided diffusion optical tomography based on wavelet transform and singular value decomposition," Proc. SPIE 8216: 821610, 2012. (Ei: 020)
20.Linhui Wu, Xi Yi, Wei Zhang, Jiao Li, Xin Wang, Limin Zhang, Huijuan Zhao, and Feng Gao "Experimental investigation on region-based diffuse optical tomography", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85782T, 2013. (Ei: 20**1)
21.Limin Zhang, Wei Zhang, Feng Gao, Jiao Li, and Huijuan Zhao, "Analytical solutions of the simplified spherical harmonics equations for infinite and semi-infinite scattering medium based on Eigen method", Proc. SPIE8578, Optical Tomography and Spectroscopy of Tissue X, 85782G, 2013. (Ei: 20**0)
22.Linjing Duan, Xin Wang, Jiao Li, Xi Yi, Linhui Wu, Limin Zhang, and Feng Gao, "Time-domain schemes of optical topography: methodology, simulative and experimental validation", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740P, 2013. (Ei: 20**5)
23.Xi Yi, Weiting Chen, Linhui Wu, Wei Zhang, Jiao Li, Xin Wang, Limin Zhang, and Feng Gao, "Towards diffuse optical tomography of arbitrarily heterogeneous turbid medium using GPU-accelerated Monte-Carlo forward calculation", Proc. SPIE8574, Multimodal Biomedical Imaging VIII, 85740O, 2013. (Ei: 20**4)
24.Feng Gao, Pengxi Liu; Wenbo Wan, Jiao Li, and Huijuan Zhao, “ IRF-calibrated Born normalization scheme for time-domain diffuse fluorescence tomography based on overlap time-gating,” Proc SPIE 8937, MULTIMODAL BIOMEDICAL IMAGING IX, 89370O, 2014. (Ei: 20**9)


学术、社会团体任职情况
1. 中国光学学会---生物医学光子学专业委员会,青年委员
2. 中国生物医学工程学会---生物医学光子学分会,青年委员
3. 天津光学学会，理事
4. 担任Journal of Biomedical Optics, Journal of Medical Imaging等国际著名期刊活跃审稿人


奖励、荣誉和学术兼职
1. 2016年 获天津市 “131”创新型人才培养工程第三层次人才荣誉
2. 2015年 获天津大学北洋青年骨干教师荣誉
3. 2014年 获天津大学优秀博士学位论文荣誉
4. 2011年 获天津大学优博基金提名奖