姓名 胡立志 职称 教授 所在
部门 病原生物学系 研究
方向 皮肤稳态
办公室 主楼1110 办公
电话 电子
邮箱 lizhihu@tmu.edu.cn
教育背景
1997/9 - 2002/7，内蒙古医科大学，临床医学，学士
2004/4 - 2006/3，日本神户大学，微生物免疫学，硕士
2006/4 - 2010/3，日本神户大学，分子生物学，博士

工作经历
2015/12-至今， 天津医科大学，基础医学院，教授
2013/3 -2015/12，天津医科大学，基础医学院，副教授
2011/2 -2013/1， 美国加州大学旧金山分校，博士后研究员
2010/4 -2011/2， 日本神户大学，医学系研究科，特聘助理教授

研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　

论文 　Publication （recent 3 years）
　1.Yoshizaki K*, Hu L*, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. 2014 Jun 20;9(6):e99991. doi: 10.1371 PLoS One 2014. (*co-first author)
　2.Hu L*, Oda Y, Bikle.D D. Reciprocal Roles of VDR and b-catenin in the Regulation of Keratinocyte Proliferation and Differentiation. J Steroid Biochem Mol Biol. 144PA:237-241. 2014. (first author)
　3.Man MQ, Hu L*, Elias PM. Herbal medicines prevent the development of atopic dermatitis by multiple mechanisms.Chin J Integr Med. 2016 Jan 6. (*corresponding author)
　4.Ning Z, Song S, Miao L, Zhang P, Wang X, Liu J, Liang Y , Liu L, Zhang J, Hu L, Huo M, Zhou Q. High prevalence of vitamin D deficiency in urban health checkup population. Clin Nutr. 08;35(4):859-63.2016
　5.Hu L*, Man H, Elias PM., Man MQ. Herbal medicines that benefit epidermal permeability barrier function. Dermatologica Sinica. 33:90-95; 2015 (*corresponding author)
　6.Ren J*, Hu L* ,Yang J, Yang L, Gao F, Lu P, Fan M, Zhu Y, Liu J, Chen L, Gupta S, Yang X, Liu P. Novel T-cell epitopes on Schistosoma japonicum SjP40 protein and their preventive effect on allergic asthma in mice. Eur J Immunol. 2016 Feb 3. (*co-first author)
　7.Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. J Biol Chem. 2017 Aug18;292(33):13531-13540
　8.Hu L*, Man H, Elias PM., Man MQ. Herbal medicines that benefit epidermal permeability barrier function. Dermatologica Sinica. 33:90-95; 2015 (*corresponding author)
　9.Oda Y*, Hu L*, Nguyen T, Fong C, Bikle DD. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization. Endocrinology. 2017 Jun 1;158(6):1929-1938. (*co-first author)
　10.Zhu X, Sun Y, Mu X, Guo P, Gao F, Zhang J, Zhu Y, Zhang X, Chen L, Ning Z, Bai Y, Ren J, Man M, Liu P, Hu L*. Phospholipase Cε deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice. Biochem Biophys Res Commun. 2017 Feb 26;484 (1):144-151. (*corresponding author)
　11.Hu L*, Mauro TM, Dang E, Man G, Zhang J, Lee D, Wang G, Feingold KR, Elias PM, Man MQ. Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum Inflammatory Cytokines. J Invest Dermatol. 2017 Jun;137(6):1277-1285. (corresponding author)
　12.Li Z, Hu L*, Elias PM, Man MQ. Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin. Contact Dermatitis. 2018 Feb;78(2):151-158. (*co-first author)
　13.Oda Y*, Hu L*, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD. Vitamin D receptor is required for proliferation, migration and differentiation of epidermal stem cells and progeny during cutaneous wound repair. J Invest Dermatol. 2018 May 19. (18)31971-7. (*co-first author)
　14.Yao Y, Guo P, Feng X, Shen C, Huang J, Zhang J, Elias PM, Hu L*, Man MQ. A topical heparinoid-containing product improves epidermal permeability barrier homeostasis in mice. Exp Dermatol. 2019 Aug;28(8):956-960. (*corresponding author)
　15.P Guo, J Huang, J Zhang, CMeng, S Zhang,Y Bai, Z Ning, Hu L*,The potential role of circRNA_004229 in hair/epidermal regulation after MED1 ablation in keratinocytes RSC Adv., 2019,9, 19095-19103 (*corresponding author)
　
（#:第一作者；*:通讯作者）

科研
项目 　1.国家自然科学面上项目，**，转录共激活因子MED1和SRC3差异化调控VDR信号通路在表皮自我更新及其稳态维持中作用机制的研究，2020.1-2013.12，在研，主持人。
　2.国家自然科学面上项目，**，VDR及其转录辅激活因子MED1对表皮干细胞的调控机制研究；2016/01-2019/12，在研，主持人。
　3.国家自然科学基金青年项目，**，磷脂酶 Cε（PLCε）在皮肤真皮及表皮细胞中调控炎症细胞因子的机制研究，2014/01-2016/12，已结题，主持人。
　4.天津医科大学科研基金面上项目，2013ky06，PLCε对IL-17在皮肤成纤维细胞中有的炎症细胞因子的影响及其机制研究，2014/01-2015/12，已结题，主持人。

荣誉奖励


其他事项
天津医科大学党外知识分子联谊会副秘书长
中华医学会热带病与寄生虫学会分会委员
天津市医学会感染病学分会常务委员