姓名 周东明 职称 教授 所在
部门 病原生物学系 研究
方向 抗感染免疫与疫苗
办公室 主楼1103 办公
电话 电子
邮箱 dongmingzhou@hotmail.com
教育背景
1988.09 -1993.07 苏州医学院 预防医学 学士
1995.09 -1998.07 湖南医科大学 流行病学 硕士
1998.09 -2001.07 中南大学 病原生物学 博士

工作经历
2019.03 -至今 天津医科大学 教授
2010.09 -2019.02 中国科学院上海巴斯德研究所 研究员
2006.07 -2011.12 美国Wistar研究所疫苗研究中心 研究员
2006.07 -2007.11 美国Wistar研究所疫苗载体中心 主任
2004.08 -2006.06 美国Wistar研究所疫苗研究中心 博士后
2002.11 -2004.07 美国宾夕法尼亚大学 博士后
2002.01 -2002.10 美国田纳西大学健康科学中心 博士后


研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　

论文 　1. Xu K, Song Y, Dai L, Zhang Y, Lu X, Xie Y, Zhang H, Cheng T, Wang Q, Huang Q, Bi Y, Liu WJ, Liu W, Li X, Qin C, Shi Y, Yan J, Zhou D*, Gao GF*. Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage. J Virol. 2018 Jan 3. pii: JVI.01722-17. doi: 10.1128/JVI.01722-17.
　2. Dai W, Zhang C, Zhang X, Xiong P, Liu Q, Gong S, Geng L, Zhou D*, Huang Z*. A virus-like particle vaccine confers protection against enterovirus D68 lethal challenge in mice. Vaccine. 2017 Dec 30. pii: S0264-410X(17)31818-2. doi: 10.1016/j. vaccine.2017.12.057.
　3. Guo J, Mondal M, Zhou D*. Development of novel vaccine vectors: chimpanzee adenoviral vectors. Hum Vaccin Immunother. 2018 Jan 4:0. doi: 10.1080/**.2017.**.
　4. Wang CZ, Han HH, Tang XY, Zhou DM*, Wu C, Chen GR, He XP*, Tian H. Sialylglycan- Assembled Supra-dots for Ratiometric Probing and Blocking of Human-Infecting Influenza A Viruses. ACS Applied Materials & Interfaces. 2017, 9(30):25164-170.
　5. Chen T, Li D, Song Y, Yang X, Liu Q, Jin X, Zhou D*, Huang Z*. A heterologous prime-boost Ebola virus vaccine regimen induces durable neutralizing antibody responses and prevent Ebola virus-like particle entry in mice. Antiviral Res. 2017 145: 54-59.
　6. Tang X, Yang Y, Xia X, Zhang C, Yang X, Song Y, Dai X, Wang M, Zhou D*. Recombinant adenoviruses displaying matrix 2 ectodomain epitopes (M2e) on their fiber proteins as universal influenza vaccines. J. Virol. 2017, 91(7). pii: e02462-16.(Cover story).
　7. Wang X, Fu W, Yuan S, Yang X, Song Y, Liu L, Chi Y, Cheng T, Xing M, Zhang Y, Zhang C, Yang Y, Zhu C, Zhang X, Xiong S,*, Xu J*, Zhou D*. Both haemagglutinin-specific antibody and T cell responses induced by a chimpanzee adenoviral vaccine confer protection against influenza H7N9 viral challenge. Sci Rep, 2017, 7(1):1854.doi: 10.1038/s41598-017-02019-1.
　8. Song J, Tang X, Zhou DM※, Zhang W, James TD, He XP*, Tian H. A fluorgenic 2D glycosheet for the simultaneous identification of human- and avian-receptor specificity in influenza viruses. Mater. Horiz. 2017, doi: 10.1039/C6MH00571C.
　9. Zhang C, Chi Y, Zhou D*, Development of Novel Vaccines against Infectious Diseases Based on Chimpanzee Adenoviral Vector, Methods Mol Biol. 2017; 1581:3-13.
　10. Cheng T, Song Y, Zhang Y, Zhang C, Yin J, Chi Y, Zhou D*. A novel oncolytic adenovirus based on simian adenovirus serotype 24. Oncotarget 2017, 8(16): 26871-85.
　11. He XP*, Zeng YL, Tang XY, Li N, Zhou DM*, Chen GR, Tian H*. Rapid identification of the receiptor-binding specificity of influenza A viruses by fluorogenic glycofoldmaers. Angew Chem Int Ed Engl. 2016, 55(45):13995-13999.
　12. Xing M, Wang X, Chi Y, Zhou D*. Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab, Oncotarget 2016, 7(19): 28262-72.
　13. Tang X, Zhang H, Song Y, Zhou D*, Wang J*. Hemagglutinin-targeting artificial microRNAs expressed by adenovirus protect mice from different clades of H5N1 infection, Mol Ther Nucleic Acids 2016, doi: 10.1038/mtna.2016.25.
　14. Cheng T, Wang X, Song Y, Tang X, Zhang C, Zhang H, Jin X*, Zhou D*. Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1. Vaccine. 2016, 34(41):4875-83.
　15. Chi Y, Zhou D*, MicroRNA in colorectal carcinoma-from pathogenesis to therapy, J Exp Clin Cancer Res 2016, 35(1):43. doi: 10.1186/s13046-016-0320.
　16. Zhang C, Zhou D*. Adenoviral vector-based strategies against infectious disease and cancer, Hum Vaccin Immunother 2016, 12(8):2064-2074.
　17. Yang Y, Chi Y, Tang X, Ertl HC, Zhou D*, Rapid, Efficient, and Modular Generation of Adenoviral Vectors via Isothermal Assembly, Curr Protoc Mol Biol 2016, 113:16.26.1-16.26.18.
　18. Song Y, Wang X, Zhang H, Tang X, Li M, Yao J, Jin X, Ertl HC, Zhou D*. Repeated Low-dose Influenza Virus Infection Causes Severe Disease in Mice: a Model for Vaccine Evaluation. J Virol. 2015; 89(15):7841-51.
　19. Zhang H, Tang X, Zhu C, Song Y, Yin J, Xu J, Ertl HC, Zhou D*. Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge. Gene Ther. 2015; 22(8):653-62.
　20. Zhang C, Yang Y, Chi Y, Yin J, Yan L, Ku Z, Liu Q, Huang Z*, Zhou D*. Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71.Vaccine. 2015; 33(39):5087-94.
　21. Zhang C, Zhu R, Yang Y, Chi Y, Yin J, Tang X, Yu L, Zhang C*, Haung Z*, Zhou D*. Phylogenetic analysis of the major causative agents of hand, foot and mouth disease in Suzhou city, Jiangsu province, China, in 2012–2013. Emerg Microbes Infect. 2015,4:e12. doi:10.1038/emi.2015.12.
　22. Chi Y, Wang X, Yang Y, Zhang C, Ertl HC, Zhou D*.Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Mol Ther Nucleic Acids. 2014; 3:e208. doi: 10.1038/mtna.2014.59.
　23. Wang X, Xing M, Zhang C, Yang Y, Chi Y, Tang X, Zhang H, Xiong S*, Yu L*, Zhou D*. Neutralizing antibody responses to enterovirus and adenovirus in healthy adults in China. Emerg Microbes Infect 2014, 3: e30; doi: 10.1038/ emi.2014.30.
　24. Zhou D^#, Wu TL, Emmer KL, Kurupati R, Tuyishime S, Li Y, Giles-Davis W, Zhou X, Xiang Z, Liu Q, Ratcliffe SJ, Ertl HC. Hexon-modified Recombinant E1-deleted Adenovirus Vectors as Dual Specificity Vaccine Carriers for Influenza Virus. Mol Ther. 2013; 21(3):696-706.
　25. Wu TL^#, Zhou D^#. Viral delivery for gene therapy against cell movement in cancer. Adv Drug Deliv Rev. 2011; 63(8):671-7.
　26. Zhou D^#, Zhou X, Bian A, Li H, Chen H, Small JC, Li Y, Giles-Davis W, Xiang Z, Ertl HC. An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector. Nat Protoc. 2010; 5(11):1775-85.
　27. Zhou D^#, Wu TL, Lasaro MO, Latimer BP, Parzych EM, Bian A, Li Y, Li H, Erikson J, Xiang Z, Ertl HC. A Universal Influenza A Vaccine Based on Adenovirus Expressing Matrix-2 Ectodomain and Nucleoprotein Protects Mice From Lethal Challenge. Mol Ther. 2010; 18(12):2182-9.
　28. Zhou D^#, Cun A, Li Y, Xiang Z, Ertl HC. A chimpanzee-origin adenovirus vector expressing the rabies virus glycoprotein as an oral vaccine against inhalation infection with rabies virus. Mol Ther. 2006; 14(5):662-72.
　29. Zhou D^#, Ertl HC. Therapeutic potential of adenovirus as a vaccine vector for chronic virus infections. Expert Opin Biol Ther. 2006; 6(1):63-72.
　30. Zhou D^#, Herrick DJ, Rosenbloom J, Chaqour B. Cyr61 mediates the expression of VEGF, alphav-integrin, and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells. J Appl Physiol. 2005; 98(6):2344-54.
　31. Wang X, Yan Y, Gan T, Yang X, Li D, Zhou D, Sun Q, Huang Z, Zhong J. A trivalent HCV vaccine elicits broad and synergistic polyclonal antibody response in mice and rhesus monkey. Gut. 2017 Nov 27. pii: gutjnl-2017-314870. doi: 10.1136/gutjnl-2017-314870. [Epub ahead of print]
　32. Wu D, Luo Y, Guo W, Niu Q, Xue T, Yang F, Sun X, Chen S, Liu Y, Liu J, Sun Z, Zhao C, Huang H, Liao F, Han Z, Zhou D, Yang Y, Xu G, Cheng T, Feng X. Lkb1 maintains Treg cell lineage identity. Nat Commun. 2017; 8:15876.doi: 10.1038/ncomms15876.
　33. Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y, Lan K, Deng Q. Recombinant cccDNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model.Hepatology. 2017. doi: 10.1002/hep.29406.
　34. Wu H, Bao Y, Wang X, Zhou D, Wu W. Alkyl polyglycoside, a highly promising adjuvant in intranasal split influenza vaccines.Hum Vaccin Immunother. 2017; 13(6):1-9.
　35. Li D, Chen T, Hu Y, Zhou Y, Liu Q, Zhou D, Jin X, Huang Z. An ebola virus-like particle-based reporter system enables evaluation of antiviral drugs in vivo under non-BSL-4 conditions. J Virol. 2016 90(19):8720-8.
　36. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q, Lan K, Zhang C. Cocirculation of three hemagglutinin and two neuraminidase subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. J Virol. 2014; 88(11):6506-11.
　37. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML, Lan K, Deng Q. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection. J Virol. 2014; 88(5):3004-15.
　38. Han J, Zhang N, Zhang P, Yang C, Jin M, Yang J, Wu X, Liu G, Ji L, Zhang C, Zhou D, Lan K, Leng Q. Th2-type inflanmmation under conditions of pre-existing chronic disease is associated with liver damage in patients with avian influenza H7N9 virus. Microbes Infect. 2014: S1286-4579(14)00054-9.
　39. Han J, Jin M, Zhang P, Liu J, Wang L, Wen D, Wu X, Liu G, Zou Y, Lv X, Dong X, Shao B, Zhou D, Leng Q, Zhang C, Lan . Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May. 2013. Euro Surveill. 2013; 18(20).
　40. Han J, Niu F, Jin M, Wang L, Liu J, Zhang P, Xie B, Wu X, Wen D, Ji L, Liu G, Yang Z, Zhang C, Zhou D, Leng Q and Lan K. Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses. Emerging Microbes & Infections. 2013; (2), e23
　41. Li H, Tuyishime S, Wu TL, Giles-Davis W, Zhou D, Xiao W, High KA, Ertl HC..Adeno -associated Virus Vectors Serotype 2 Induce Prolonged Proliferation of Capsid-Specific CD8(+) T Cells in Mice. Mol Ther. 2011; 19(3):536-46.
　42. O Lasaro M, Haut LH, Zhou X, Xiang Z, Zhou D, Li Y, Giles-Davis W, Li H, Engram JC, Dimenna LJ, Bian A, Sazanovich M, Parzych EM, Kurupati R, Small JC, Wu TL, Leskowitz RM, Klatt NR, Brenchley JM, Garber DA, Lewis M, Ratcliffe SJ, Betts MR, Silvestri G, Ertl HC. Vaccine-induced T cells Provide Partial Protection Against High-dose Rectal SIVmac239 Challenge of Rhesus Macaques. Mol Ther. 2011; 19(2):417-26.
　43. Chen H, Xiang ZQ, Li Y, Kurupati RK, Jia B, Bian A, Zhou DM, Hutnick N, Yuan S, Gray C, Serwanga J, Auma B, Kaleebu P, Zhou X, Betts MR, Ertl HC. Adenovirus-based vaccines: comparison of vectors from three species of adenoviridae. J Virol. 2010; 84(20):10522-32.
　44. DiMenna L, Latimer B, Parzych E, Haut LH, T?pfer K, Abdulla S, Yu H, Manson B, Giles-Davis W, Zhou D, Lasaro MO, Ertl HC. Augmentation of primary influenza A virus-specific CD8+ T cell responses in aged mice through blockade of an immunoinhibitory pathway. J Immunol. 2010; 184(10):5475-84.
　45. Tatsis N, Lasaro MO, Lin SW, Haut LH, Xiang ZQ, Zhou D, Dimenna L, Li H, Bian A, Abdulla S, Li Y, Giles-Davis W, Engram J, Ratcliffe SJ, Silvestri G, Ertl HC, Betts MR. Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens. J Immunol. 2009; 182(10):6587-99.
　46. Li H, Lin SW, Giles-Davis W, Li Y, Zhou D, Xiang ZQ, High KA, Ertl HC.A preclinical animal model to assess the effect of pre-existing immunity on AAV-mediated gene transfer. Mol Ther. 2009; 17(7):1215-24.
　47. Tatsis N, Fitzgerald JC, Reyesl A, Harris KC, Hensley SE, Zhou D, Lin SW, Bian A, Xiang ZQ, Iparraguirre A, Lopez-Camacho C, Wherry EJ, Ertl HC. Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood. 2007; 110(6):1916-23.
　48. McCoy K, Tatsis N, Korioth-Schmitz B, Lasaro MO, Hensley SE, Lin SW, Li Y, Giles-Davis W, Cun A, Zhou D, Xiang Z, Letvin NL, Ertl HC. Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors. J Virol. 2007; 81(12):6594-604.
　49. Tatsis N, Blejer A, Lasaro MO, Hensley SE, Cun A, Tesema L, Li Y, Gao GP, Xiang ZQ, Zhou D, Wilson JM, Ertl HC. A CD46-binding chimpanzee adenovirus vector as a vaccine carrier. Mol Ther. 2007; 15(3):608-17.
　50. Liu L, He B, Liu WM, Zhou D, Cox JV, Zhang XA. Tetraspanin CD151 promotes cell migration by regulating integrin trafficking. J Biol Chem. 2007; 282(43):31631-42.
　
（#:第一作者；*:通讯作者）

科研
项目 　1. 天津医科大学人才引进启动项目
　2018.09-2023.08 ,300万， 课题负责人
　2. 黑猩猩型腺病毒作为疫苗载体的免疫学研究，国家自然科学基金面上项目，
　2019.01-2022.12，60万，在研， 主持
　3. 抗体介导的增强型溶瘤腺病毒AdC7的溶瘤功能及其机制研究，国家自然科学基金面上项目（**），
　2017.01-2020.12，60万，在研， 主持
　4. 基于多基因共表达载体的通用型流感疫苗研究，国家自然科学基金面上项目（**），
　2014.01-2017.12，结题，主持
　5. 人工合成新型腺病毒及其作为疫苗载体的研究，国家自然科学基金面上项目（**），
　2012.01-2015.12，结题， 主持
　6. 针对EBOV, MERS-CoV, ZIKV, DENV, CHIKV五种新发突发外来疫病的宿主和相关媒介的生物防控技术与产品的研发, 科技部重点研发项目,
　2016.07-2018.12，结题， 子课题负责人
　7. 重要治疗性生物大分子研发和无血清培养基的优化, 科技部“863”计划(2014AA021003),
　2014.01-2016.12，结题， 主持
　8. 新型狂犬病VLP疫苗研究,中国科学院STS项目(KFJ-EW-STS-027），
　2014.01-2016.12，结题， 主持
　9. 通用型流感疫苗研究,中国科学院“****”择优项目(Y316P11503),
　2012.01-2015.12，结题， 主持
　10. 中国科学院“知识创新工程”(Y014P31503),
　2010.10-2015.09，结题， 主持
　

荣誉奖励
1．周东明，中国科学院分子病毒与免疫重点实验室2016年度创新奖，2016年
2．中国科学院“****”入选，2012
3．易新元，曾宪芳，蔡春，陈欲晓，陈利玉，周东明。日本血吸虫病疫苗候选分子的克隆与鉴定，湖南省科学技术进步奖，二等奖，2005年。
4．易新元，曾宪芳，蔡春，陈欲晓，陈利玉，周东明，王敏，周金春，袁仁善，张冉。日本血吸虫病疫苗候选分子的克隆与鉴定，湖南省医学科技奖，一等奖，2004年。


其他事项
专利授权和申请：
1. 周东明，迟喻丹，邓飞，蓝柯.一种狂犬病疫苗及其制备方法（授权号：ZL1.8）
2. 周东明，万里明，宋宇峰，杨茜.基于黑猩猩腺病毒载体的埃博拉病毒疫苗（申请号：2.3）
3. 周东明，马小伟，成涛，朱睿，安文琪，潘若文.一种酵母细胞表达的狂犬病毒的病毒样颗粒及其制备方法（申请号：1.9）
4. 周东明，唐昕莹. 基于M2e表位的广谱型流感疫苗(申请号：8.8)
5. 周东明，邢嫚. 一种基于腺病毒载体表达全长西妥昔单抗基因治疗肿瘤的方法（申请号：.X）
6. 周东明，杨勇，丁妙.一种基于腺病毒AdC68的表达载体及其构建方法 （申请号：5.7）
7. 周东明，成涛.一种基于腺病毒AdC7的表达载体及其构建方法（申请号：8.2）
8. 冯晓明，周东明，邢嫚，吴万通，罗悦晨，方春敏. 一种用于预防和治疗高表达WT1肿瘤的黑猩猩腺病毒疫苗（申请号：1.6）
9. 贺晓鹏，周东明，陈国荣，林超奇，唐昕莹，曾亚丽. 含唾液酸糖基萘醛类化合物及其在流感检测中的应用（授权号：ZL1.6）
10. H.C.Ertl, Dongming Zhou. Universal influenza A vaccine. PCT/US2011/047900
11. H.C.Ertl, Dongming Zhou. Influenza vaccines containing modified adenovirus vectors. PCT/US2012/039051