姓名 李心乐 职称 讲师 所在
部门 人体解剖与组织胚胎学系 研究
方向 骨代谢性疾病治疗
办公室 教三楼218 办公
电话 电子
邮箱 lixinle@tmu.edu.cn
教育背景
2004.09–2008.07，南开大学，生命科学学院生物科学，学士
2008.09–2013.07，南开大学，医学院生物化学与分子生物学，博士
2010.09–2011.09，美国圣母大学，生物系，博士（联合培养，国家公派）

工作经历
2013.07–至今， 天津医科大学，基础医学院，讲师

研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　

论文 　1.Xinle Li, Daquan Liu, Jie Li, Shuang Yang, Jinfeng Xu , Hiroki Yokota, Ping Zhang*, Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model, FASEB J, 2019, 33(8):8913-8924.
　2.Weiwei Zheng^#, Xinle Li^#, Daquan Liu^#, Jie Li, Shuang Yang, Zhe Gao, Zhaonan Wang, Hiroki Yokota, Ping Zhang*, Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy, FASEB J, 2019, 33(3):4077-4088.
　3.Nian Tan^#, Xinle Li^#, Zhai L, Daquan Liu, Jie Li, Hiroki Yokota, Ping Zhang*, Effects of knee loading on obesity-related non-alcoholic fatty liver disease in an ovariectomized mouse model with high-fat diet, Hepatol Res, 2018, 48(10): 839-849.
　4.Daquan Liu, Yunlong Zhang, Xinle Li, Jie Li, Shuang Yang, Xiaoxue Xing, Guanwei Fan, Hiroki Yokota, Ping Zhang*, eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress, Sci Rep, 2017; 7(1): 5062.
　5.Xinle Li, Jing Yang, Daquan Liu, Jie Li, Kaijun Niu, Shiqing Feng, Hiroki Yokota, Ping Zhang*, Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis, Sci Rep, 2016, 6: 24668.
　6.Jie Li, Shuang Yang, Xinle Li, Daquan Liu, Zhaonan Wang, Jialu Guo, Nian Tan, Zhe Gao, Xiaoyu Zhao, Jiuguo Zhang, Fanlin Gou, Hiroki Yokota, Ping Zhang*, Role of endoplasmic reticulum stress in disuse osteoporosis, Bone, 2016, 16, 97: 2-14.
　7.Daquan Liu^#, Xinle Li^#, Jie Li, Jing Yang, Hiroki Yokota, Ping Zhang*, Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing, Bone, 2015, 81: 620-631.(共同第一作者)
　8.Xiang Li^#, Bo Liu^#, Xinle Li^#, Yixiang Li, Mingzhu Sun, Dongyan Chen*, Xin Zhao*, Xizeng Feng*, SiO2 nanoparticles change colour preference and cause Parkinson’s-like behaviour in zebrafish, Sci Rep, 2014, 4: 3810.(共同第一作者)
　9.Xinle Li, Jake Montgomery, Wesley Cheng, Jung Hyun Noh, David R Hyde, Lei Li*, Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish, PLoS One, 2012, 7(7): e4050.
　10.Xiaokai Wang, Luoxiu Huang, Yue Li, Xinle Li, Ping Li, John Ray, Lei Li*, Characterization of GFP-tagged GnRH-containing terminalis neurons in transgenic zebrafish, J Cell Physiol, 2011, 226(3): 608-615.
　11.Lei Li*, Yuhao Li, Dongyan Chen, Jinping Shao, Xinle Li, Cheng Xu, Fishing for age-related visual system mutants: behavioral screening of retinal degeneration genes in zebrafish, Curr Aging Sci, 2010, 3(1): 43-45.
（#:第一作者；*:通讯作者）

科研
项目 　1)国家自然科学基金青年项目，脊柱机械加载调控血管生成和骨重建治疗骨质疏松的机制研究（21万），**，2017/01 – 2019/12
　2)第60批中国博士后科学基金面上资助，SUMO化Wnt通路介导机械加载对骨质疏松治疗的机制研究（5万），2016M601275，2016/10 – 2017/12
　3)天津市自然科学基金青年项目，通过 Wnt 信号通路介导骨重建和血管生成治疗骨质疏松的机制研究（6万），18JCQNJC82200，2018/10-2021/09

荣誉奖励


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