姓名 李津 职称 教授 所在
部门 细胞生物学系 研究
方向 生物信息学基因组学及人类疾病的遗传学基础
办公室 主楼206 办公
电话 ** 电子
邮箱 jli01@tmu.edu.cn
教育背景
2008-2012, 理学硕士,生物统计学, 美国德克萨斯大学,休斯顿健康科学中心,公共卫生学院 (UT Health ScienceCenter at Houston, School of Public Health)
2000-2007, 理学博士, 遗传学, 美国康奈尔大学 (Cornell University)
1994-1998, 理学学士, 生物科学与技术, 清华大学

工作经历
2017年9月- 至今　　　　教授 天津医科大学细胞生物学系　
2011年2月-2017年8月　　研究科学家（Research Scientist）美国费城儿童医院 (Children’s Hospital of Philadelphia)
2007年8月-2011年2月　　博士后, 美国德克萨斯大学,安德森癌症研究中心 (UT MD Anderson Cancer Center)

研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　

论文 　1.Sun Y, Yao X, March ME, M X, Li J, Wei Z, Sleiman PMA, Hakonarson H, Xia Q*, Li J*, Target Genes of Autism Risk Loci in Brain Frontal Cortex, (*co-contact authors) 09 August 2019 | https://doi.org/10.3389/fgene.2019.00707.
　2.Li J, Yuan X, March ME, Yao X, Sun Y, Chang X, Hakonarson H, Xia Q, Meng X*, Li J*, Identification of Target Genes at Juvenile Idiopathic Arthritis GWAS Loci in Human Neutrophils.. Frontiers in Genetics, Front Genet. (*co-contact authors)2019 Mar 27;10:181. doi: 10.3389/fgene.2019.00181. eCollection 2019.
　3.Li J^#, J?rgensen SF^#, Maggadottir SM^#, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, et al., Karlsen TH, Grimbacher B, Hakonarson H, Hammarstr?m L, Ellinghaus E, Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nature Communications, 2015 Apr 20;6:6804. PMID:**.
　4.Maggadottir SM^#, Li J^#, Glessner JT^#, Li YR, Wei Z, Chang X, Mentch FD, Thomas KA, Kim C, Zhao Y, Hou C, et al., Hakonarson H. Rare variants at 16p11.2 are associated with common variable immunodeficiency. (^#co-first authors) Journal of Allergy and Clinical Immunology, 2015 Jun;135(6):1569-77. PMID: **. (the Editor’s Choice)
　5.van Ingen G^#, Li J^#, , Goedegebure A, Li YR, Jaddoe VWV, March ME, Mentch FD, et al., de Jong B, Sleim????an PM, van der Schroeff MP, Hakonarson H, Genome-wide Association Study for Acute Otitis Media in Children Identifies Disease Contributing Gene. (^#co-first authors) 2016 Sep 28;7:12792, Nature Communications
　6.Li YR, Li J, Zhao SD, Bradfield J, Mentch F, Maggadottir MS, Abrams D, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Thomas K, Wei Z, et al..., Keating B, Hakonarson H. Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nature Medicine. 2015 Sep;21(9):1018-27. PMID: **
　7.Glessner JT^#, Li J^#, Wang D, March M, Lima L, Desai A, Hadley D, Kao C, Gur RE, Cohen N, Sleiman PMA, Li Q, Hakonarson H; Janssen-CHOP Neuropsychiatric Genomics Working Group. Copy number variation meta-analysis reveals a novel duplication at 9p24 associated with multiple neurodevelopmental disorders. (^#co-first authors) Genome Med. 2017 Nov 30;9(1):106. doi: 10.1186/s13073-017-0494-1.
　8.Li J, Glessner JT, Zhang H, Hou C, Wei Z, Bradfield JP, Mentch FD, Guo Y, Kim C, Xia Q, Chiavacci RM, Thomas KA, Qiu H, Grant SF, Furth SL, Hakonarson H, Sleiman PM. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Human Molecular Genetics. 2013 Apr 1;22(7):1457-64. PMID:**.
　9.Glessner JT, Li J, Hakonarson H. ParseCNV integrative copy number variation association software with quality tracking. Nucleic Acids Research. 2013 Mar 1;41(5):e64. PMID:**
　10.Cook-Sather S^#, Li J^#, Goebel TK, Sussman EM, Rehman MA, Hakonarson H. TAOK3, a novel GWAS locus associated with morphine sulfate dose requirement and postoperative pain in a pediatric day surgery population. (^#co-first authors) Pain. 2014 Sep;155(9):1773-83. PMID: **.
　11.Dajani R^#, Li J^#, Wei Z, Glessner J, Chang X, Hakooz N, Khader Y, Sheshani A, Zandaki D, Hakonarson H. CNV analysis suggests AKNAD1 associated with type-2 diabetes in the Circassian and the Chechan populations of Jordan. (^#co-first authors) Scientific Reports 2015 Aug 21;5:13391. PMID: **.
　12.Li J, Fung IN, Glessner JT, Wei Z, Mentch FD, Pellegrino R, Kim C, Wang T, Hou C, Chiavacci RM, Thomas KA, Spergel J, Sleiman PMA, Hakonarson H. Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy. Journal of Immunology 2015 Aug 15;195(4):1599-607., PMID: **.
　13.Li J, Wei Z, Chang X, Cardinale CJ, Kim C, Baldassano R, Hakonarson H on behalf of The International IBD Genetics Consortium. Pathway based genome-wide association studies reveal the association between growth factor activity and inflammatory bowel disease. Inflammatory Bowel Diseases. 2016 Apr 21. PMID: **.
　14.Li J, Wei Z, Li YR, Maggadottir SM, Chang X, Hakonarson H, Understanding the genetic and epigenetic basis of common variable immunodeficiency through omics approaches. Biochim Biophys Acta. 2016 Jun 14. pii: S0304-4165(16)30219-7. doi: 10.1016/j.bbagen.2016.06.014.
　15.Li J, Kim J. Molecular profiles of finasteride effects on prostate carcinogenesis. Cancer Prevention Research (Phila). 2009 Jun;2(6):518-24. PMID: **.
　16.Li J, Wei Z, Zhang J, Hakonarson H, Cook-Sather SD, Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits. The Pharmacogenomics Journal. 2019 Feb 14. doi: 10.1038/s41397-019-0074-4
　17. Li J, Wei Z, Zhang J, Hakonarson H, Cook-Sather SD. Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits. Pharmacogenomics J. 2019 Feb 14. doi: 10.1038/s41397-019-0074-4.
　18.Li J, Maggadottir SM, Hakonarson H. Are genetic tests informative in predicting food allergy? Curr Opin Allergy Clin Immunol. 2016 Apr 11. PMID: **
　19.Li J, Kim H, Aceto DG, Hung J, Aono S, Kemphues KJ. Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans. Developmental Biology. 2010 Apr 1;340(1):88-98. PMID: **.
　20.Glessner JT^#, Li J^#, Desai1 A, Palmer M, Kim D, Lucas AM, Chang X, Connolly JJ, Almogeura B, Harley JB, Jarvik GP, Ritchie MD, Sleiman PMA, Roden DM, Crosslin D, Hakonarson H, CNV Association of Diverse Clinical Phenotypes from eMERGE Reveals Novel Disease Biology Underlying Cardiovascular Disease, (^#co-first authors) International Journal of Cardiology, (in press),
　21.Purkey MT^#, Li J^#, Mentch F, Grant SFA, Hakonarson H, Toskala E. Genetic variation in genes encoding airway epithelial potassium channels are associated with chronic rhinosinusitis in a pediatric population. (^#co-first authors) PLoS One, 2014 Mar 3;9(3):e89329. PMID: **.
　22.Ong BA^#, Li J^#, McDonough JM, Wei Z, Kim C, Chiavacci R, Mentch F, Caboot JB, Spergel J, Allen JL, Sleiman PMA, Hakonarson H. Gene network analysis in a pediatric cohort identifies novel lung function genes. (^#co-first authors) PLoS One, 2013 Sep 2;8(9):e72899. PMID: **.
　23.Li J, Ding Z, Wang Z, Lu JF, Maity SN, Navone NM, Logothetis CJ, Mills GB, Kim J. Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. PLoS One. 2011;6(12):e28840. PMID: **.
　24.Finkel TH^#, Li J^#, Wei Z^#, Wang W, Zhang H, Behrens EM, Reuschel EL, Sophie M. Limou SM, Wise C, et al.,…, Ellis JA, Hakonarson H, Variants in CXCR4 associate with Juvenile Idiopathic Arthritis susceptibility, BMC Med Genet. 2016 Mar 22;17:24. PMID: ** (^#co-first authors)
　25.Li J, Wei Z, Hakonarson H. Application of computational methods in genetic study of inflammatory bowel disease. World J Gastroenterol. 2016 Jan 21;22(3):949-60. PMID: **.
　26.Dajani R, Li J, Wei Z, March ME, Xia Q, Khader Y, Hakooz N, Fatahallah R, El-Khateeb M, Arafat A, Saleh T, Dajani AR, Al-Abbadi Z, Abdul Qader M, Shiyab AH, Bateiha A, Ajlouni K, Hakonarson H. Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations. PeerJ. 2017 Aug 17;5:e3618. doi: 10.7717/peerj.3618. eCollection 2017.
　27.Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J, Genome-wide association study of methadone dose identifies major locus upstream of OPRM1, Molecular Psychiatry, 2017 Jan 24. doi: 10.1038/mp.2016.257. PMID: **
　28.Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab m, Steel L, et al., Li H, Keating BJ, Hakonarson H, Genetic Sharing and Heritability of Pediatric Age of Onset Autoimmune Diseases. Nature Communications. 2015 Oct 9;6:8442. PMID: **
　29.Cook-Sather S, Li J, Hakonarson H. Modulatory effects of TAOK3 variants on morphine requirement in acute postoperative pain: An early genome wide association study contribution to the field of pediatric pain. Pain, 2014 November. 155 (2014) 2432–2437. PMID: **
　30.Cook-Sather SD, Adamson PC, Li J, and Hakonarson H, CYP2B6^#6 or not CYP2B6^#6 – that remains a question for precision medicine and ketamine! Anesthesiology, 2016 Oct 20.
　31.Cook-Sather SD, Li J, Hakonarson H, Pain versus Analgesia: TAOK3 as a Pharmacogene, Pain 2017 Aug;158(8):1622-1623. doi: 10.1097/j.pain.0946
　32.Chang X, Li J, Guo Y, Wei Z, Mentch FD, Hou C, Zhao Y, Qiu H, Kim C, Sleiman PM, Hakonarson H. Genome-wide association study of serum minerals levels in children of different ethnic background. PLoS One. 2015 Apr 17;10(4):e**. PMID:**
　33.Cardinale CJ, Wei Z, Li J, Zhu J, Gu M, Baldassano RN, Grant SF, Hakonarson H, Transcriptome profiling of human ulcerative colitis mucosa reveals altered expression of pathways enriched in genetic susceptibility loci. PLoS One, 2014 May 1;9(5):e96153. PMID:**
　34.Yang P, Cartwright CA, Li J, Wen S, Prokhorova IN, Shureiqi I, Troncoso P, Navone NM, Newman RA, Kim J., Arachidonic acid metabolism in human prostate cancer. International Journal of Oncology,2012 41(4):1495-503. PMID:**
　35.Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One. 2010 Mar 26;5(3):e9910. PMID: **. 影响因子: 3.73
　36.Wang Y, Li J, Kolon TF, Olivant Fisher A, Figueroa TE, et al., Abrams DJ, Stabley D, Kim CE, Sol-Church K, Hakonarson H, Devoto M, Barthold JS, Genomic copy number variation association study in Caucasian patients with nonsyndromic cryptorchidism. BMC Urol. 2016 Oct 21;16(1):62.PMID: **
（#:第一作者；*:通讯作者）

科研
项目 　

荣誉奖励


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