姓名 李俊 职称 教授 所在
部门 药理学系 研究
方向 功能基因组与生物信息学
办公室 基础研究中心501 办公
电话 电子
邮箱 mulin0424.li@gmail.com
教育背景
2012.06~2015.10 香港大学生物医学科学学院　博士
2014.04~2015.04 哈佛大学计算机生物学系　　交换博士
2006.09~2009.06 中国科学技术大学　　　　　硕士
2002.09~2006.06 安徽科技学院　　　　　　　学士

工作经历
2016.09~今　　　　天津医科大学，功能基因组与生物信息学，教授
2015.10~2016.09 香港大学医学院，生物信息学，博士后
2014.04~2015.04　Broad Institute，计算机表观遗传学，研究科学家
2010.03~2012.05　香港大学，生物信息学，助理研究员
2009.01~2010.02　金斯瑞生物科技有限公司，生物信息学软件工程师
2007.09~2009.01　Applied Biosystems，生物学软件工程师

研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　

论文 　1.Dandan Huang*, Xianfu Yi,* Shijie Zhang, ZhanyeZheng, Panwen Wang, ChenghaoXuan, Pak Chung Sham, Junwen Wang, Mulin Jun Li; GWAS4D: multidimensional analysis of context-specific regulatory variant for human complex diseases and traits, Nucleic Acids Research,2018, 46(1): 114–120
　2.Li MJ, Yao H, Huang D, Liu H, Liu Z, Xu H, Qin Y, Prinz J, Xia W, Wang P, Yan B, Tran NL, Kocher JP, Sham PC, Wang J. mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers.Nucleic Acids Research. 2017 May 8.
　3.Li MJ, Zhang J, Liang Q, Xuan C, Wu J, Jiang P, Li W, Zhu Y, Wang P, Fernandez D, Shen Y, Chen Y, Kocher JA, Yu Y, Sham PC, Wang J, Liu JS, Liu XS. Exploring genetic associations with ceRNA regulation in the human genome.Nucleic Acids Research. 2017 May 2.
　4.Li MJ, Li M, Liu Z, Yan B, Pan Z, Huang D, Liang Q, Ying D, Xu F, Yao H, Wang P, Kocher JA, Xia Z, Sham PC, Liu JS, Wang J. cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes.Genome Biology. 2017 Mar 16;18(1):52.
　5.Li MJ, Pan Z, Liu Z, Wu J, Wang P, Zhu Y, Xu F, Xia Z, Sham PC, Kocher JP, Li M, Liu JS, Wang J. Predicting regulatory variants with composite statistic.Bioinformatics. 2016 Sep 15;32(18):2729-36.
　6. Cheng TH, Thompson DJ, O'Mara TA, Painter JN, Glubb DM, Flach S, Lewis A, French JD, Freeman-Mills L, Church D, Gorman M, Martin L; National Study of Endometrial Cancer Genetics Group (NSECG)., Hodgson S, Webb PM; Australian National Endometrial Cancer Study Group (ANECS)., Attia J, Holliday EG, McEvoy M, Scott RJ, Henders AK, Martin NG, Montgomery GW, Nyholt DR, Ahmed S, Healey CS, Shah M, Dennis J, Fasching PA, Beckmann MW, Hein A, Ekici AB, Hall P, Czene K, Darabi H, Li J, D?rk T, Dürst M, Hillemanns P, Runnebaum I, Amant F, Schrauwen S, Zhao H, Lambrechts D, Depreeuw J, Dowdy SC, Goode EL, Fridley BL, Winham SJ, Nj?lstad TS, Salvesen HB, Trovik J, Werner HM, Ashton K, Otton G, Proietto T, Liu T, Mints M, Tham E; RENDOCAS.; CHIBCHA Consortium.,Li MJ, Yip SH, Wang J, Bolla MK, Michailidou K, Wang Q, Tyrer JP, Dunlop M, Houlston R, Palles C, Hopper JL; AOCS Group., Peto J, Swerdlow AJ, Burwinkel B, Brenner H, Meindl A, Brauch H, Lindblom A, Chang-Claude J, Couch FJ, Giles GG, Kristensen VN, Cox A, Cunningham JM, Pharoah PD, Dunning AM, Edwards SL, Easton DF, Tomlinson I, Spurdle AB. Five endometrial cancer risk loci identified through genome-wide association analysis.Nature Genetics. 2016 Jun;48(6):667-74.
　7.Li MJ, Liu Z, Wang P, Wong MP, Nelson MR, Kocher JP, Yeager M, Sham PC, Chanock SJ, Xia Z, Wang J. GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.Nucleic Acids Research. 2016 Jan 4;44:D869-76.
　8. Nelson MR, Tipney H, Painter JL, Shen J, Nicoletti P, Shen Y, Floratos A, Sham PC,Li MJ, Wang J, Cardon LR, Whittaker JC, Sanseau P. The support of human genetic evidence for approved drug indications.Nature Genetics. 2015 Aug;47(8):856-60.
　9.Li MJ, Deng J, Wang P, Yang W, Ho SL, Sham PC, Wang J, Li M. wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders.Human Mutation. 2015 May;36(5):496-503.
　10.Li MJ, Wang J. Current trend of annotating single nucleotide variation in humans--A case study on SNVrap.Methods. 2015 Jun;79-80:32-40.
　11.Li MJ, Yan B, Sham PC, Wang J. Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression.Briefing in Bioinformatics. 2015 May;16(3):393-412.
　12.Li MJ, Wang LY, Xia Z, Wong MP, Sham PC, Wang J. dbPSHP: a database of recent positive selection across human populations.Nucleic Acids Research. 2014 Jan;42:D910-6.
　13.Li MJ, Wang LY, Xia Z, Sham PC, Wang J. GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications.Nucleic Acids Research. 2013 Jul;41:W150-8.
　14. Xu F, Wang W, Wang P,Li MJ, Chung Sham P, Wang J. A fast and accurate SNP detection algorithm for next-generation sequencing data.Nature Communications. 2012;3:1258.
　15.Li MJ, Sham PC, Wang J. Genetic variant representation, annotation and prioritization in the post-GWAS era.Cell Research. 2012 Oct;22(10):1505-8.
　16.Li MJ, Wang P, Liu X, Lim EL, Wang Z, Yeager M, Wong MP, Sham PC, Chanock SJ, Wang J. GWASdb: a database for human genetic variants identified by genome-wide association studies.Nucleic Acids Research. 2012 Jan;40:D1047-54.
　17.Li MJ, Sham PC, Wang J. FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution.Bioinformatics. 2010 Nov 15;26(22):2897-9.
（#:第一作者；*:通讯作者）

科研
项目 　1、国家自然科学基金青年科学基金，整合策略预测组织细胞特异调控变异和系列生物信息学工具开发，2018年-2020年，项目负责人。
　2、天津市自然科学基金重点项目，基于泛癌基因组的长非编码RNA 海绵效应位点研究，2018-04 至2021-03，项目负责人。
　3、国家自然科学基金面上项目，复杂疾病致病调控变异及其靶基因预测方法研究，2019-01至2022-12，项目负责人。

荣誉奖励
2015年香港大学杰出研究奖
2018年天津市青年科技优秀人才

其他事项
研究领域：
1) 人遗传变异/突变的基因组功能注释：包括开发高效准确的注释算法，预测功能/有害/致病突变，以及设计和开放相关生物信息学数据库和工具；
2) 调控基因组学研究：包括使用大规模遗传、基因组和表观遗传组学数据，开发新的生物信息学方法预测和鉴定人类基因组调控元件和变异；使用CRISPR-cas9相关技术筛选和精确鉴定遗传疾病相关变异和肿瘤驱动突变；
3) 肿瘤药物基因组学研究：包括预测肿瘤突变与肿瘤靶向药物的响应，利用遗传学证据寻找可复用的肿瘤药物。