姓名 张健 职称 副教授 所在
部门 药理学系 研究
方向 血管重构
办公室 基础研究中心306 办公
电话 电子
邮箱 zhangjian07@tmu.edu.cn
教育背景
2005.09~2009.07，河北大学，生物科学专业，理学学士；
2009.09~2014.07，中国科学院大学，生物化学与分子生物学方向，理学博士。

工作经历
2017.01~至今，天津医科大学，基础医学 院药理学系，副教授
2014.03~2016.12月，中国科学院生命科学研究院营养科学研究所，博士后

研究成果（本人具有代表性的论著、论文及主持的科研项目）
论著
及编
著 　2014年10月，《血管生物学（第二版）》，北京大学医学出版社，第二十六章前列腺素与心血管疾病.

论文 　1. Guizhu Liu^#, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang*, Ying Yu*. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. Brit J Pharmacol. 2018; 175:1205–1216.
　2. Guizhu Liu^#, Yanjun Gong^#, Rui Zhang, Lingjuan Piao, Xinzhi Li, Qian Liu, Shuai Yan, Yujun Shen, Shumin Guo, Mingjiang Zhu, Huiyong Yin, Colin D. Funk, Jian Zhang*, Ying Yu*. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration. FASEB J. 2018; 32(10):5413-5425.
　3. Mulin Jun Li^#, Jian Zhang^#, Jiexing Wu, Peng Jiang, Wei Li, Yun Zhu, Daniel Fernandez, Russell J. H. Ryan, Yiwen Chen , Junwen Wang* , Jun S. Liu*, X. Shirley Liu*. Exploring genetic associations with ceRNA regulation in the human genome. Nucleic Acids Research. 2017 Jun 2;45(10):5653-5665.
　4. Jian Zhang^#, Fangfang Zou, Juan Tang, Qianqian Zhang, Yanjun Gong, Qingsong Wang, YujunShen, Lixia Xiong, Richard M. Breyer, Michael Lazarus, Colin D. Funk, Ying Yu*. Cyclooxygenase-2–derived prostaglandin E2 promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circulation Research. 2013;113(2):104-114.
　5. Jian Zhang^#, Yanjun Gong, Ying Yu*. PGF2alpha receptor: a promising therapeutic target for cardiovascular disease. Frontiers in Pharmacology. 2010; 1(116):1-7.
　6.Yu Hu He^#, Xiao Qun Wang, Jian Zhang, Zhu Hui Liu, Wen Qi Pan, Ying Shen, Zheng Bin Zhu, Ling Jie Wang, Xiao Xiang Yan, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding*, Lin Lu*. Association of serum HMGB2 levels with in-stent restenosis: HMGB2 promotes neointima hyperplasia in mice with femoral artery injury and proliferation and migration of VSMCs. Arteriosclerosis Thrombosis and Vascular Biology. 2017 Apr;37(4):717-729.
　7. Guilin Chen^#, Shengkai Zuo, Juan Tang, Caojian Zuo, Daile Jia, Qian Liu, Guizhu Liu, Qian Zhu, Yuanyang Wang, Jian Zhang, Yujun Shen, Dongrui Chen, Ping Yuan, Zhiqiang Qin, Chengchao Ruan, Jue Ye, Xiao-Jian Wang, Yuping Zhou, Pingjin Gao, Peng Zhang, Jinming Liu, Zhi-Cheng Jing, Ankang Lu, Ying Yu*. Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. J Exp Med. 2018; 215(8):2175-2195.
　8.Shengkai Zuo^#, Deping Kong, Chenyao Wang, Jiao Liu, Yuanyang Wang, Qiangyou Wan, Shuai Yan, Jian Zhang, Juan Tang, Qianqian Zhang, Luheng Lyu, Xin Li, Zhixin Shan, Li Qian, Yujun Shen*, Ying Yu*. CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyteapoptosis through m-calpain. EMBO Mol Med. 2018; 10(3). pii: e8237.
　9.Juan Tang^#, Yujun Shen, Guilin Chen, Qiangyou Wan, Kai Wang, Jian Zhang, Jing Qin, Guizhu Liu, Shengkai Zuo, Bo Tao, Yu Yu, Junwen Wang, Michael Lazarus, Ying Yu*. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat Commun. 2017; 8:14656.
　10.Di Chen^#, Juan Tang, Qiangyou Wan, Jian Zhang, Kai Wang, Yujun Shen*, Ying Yu*. E-prostanoid 3 receptor mediates sprouting angiogenesis through suppression of the protein kinase A/β-catenin/Notch pathway. Arterioscler Thromb Vasc Biol. 2017; 37(5):856-866.
　11. Yujun Shen^#, Shengkai Zuo^#, Yuanyang Wang, Hongfei Shi, Shuai Yan, Di Chen, Bing Xiao, Jian Zhang, Yanjun Gong, Maohua Shi, Juan Tang, Deping Kong, Luheng Lu, Yu Yu, Bin Zhou, Sheng-Zhong Duan, Claudio Schneider, Colin D. Funk, Ying Yu*. Thromboxane governs the differentiation of adipose-derived stromal cells toward endothelial cells in vitro and in vivo. Circulation Research. 2016 Apr 15;118(8):1194-207 .
　12. Ankang Lv^#, Caojian Zuo^#, Yuhu He^#, Guilin Chen, Lingjuan Piao, Jian Zhang, Bing Xiao, Yujun Shen, Juan Tang,Deping Kong, Sara Alberti, Di Chen, ShenkaiZuo, Qianqian Zhang, Shuai Yan, Xiaochun Fei, Fei Yuan, Bin Zhou, Shengzhong Duan, Yu Yu, Michael Lazarus, Yunchao Su, Richard M. Breyer, Colin D. Funk, Ying Yu*. EP3 receptor deficiency attenuates pulmonary hypertension through suppressing Rho/TGFβ1 pathway. Journal of Clinical Investigation. 2015;125(3):1228-42.
　13. Shuai Yan^#, Qianqian Zhang^#, Xiaojing Zhong, Juan Tang, Yuanyang Wang, Junjie Yu, Yi Zhou, Jian Zhang, Liu Yong, Feifan Guo, FitzGerald GA, Ying Yu*. I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT. Diabetes. 2014;63(9):2911-23.
　14. Yanjun Gong^#, Minghui Lin^#, Lingjuan Piao, Xinzhi Li, Fei Yang, Jian Zhang, Bing Xiao, Qianqian Zhang, Wenliang Song, Huiyong Yin, Li Zhu, Colin D. Funk, Ying Yu*. Aspirin Enhances Protective Effect of Fish Oil against Thrombosis and Injury-induced Vascular Remodeling. British Journal of Pharmacology. 2015 Dec;172(23):5647-60.
　
（#:第一作者；*:通讯作者）

科研
项目 　1.2018-2020，前列腺素与血管重构，天津市青年人才托举工程，主持，45万；
　2.2018-2021，EP3受体在巨噬细胞介导的老年性肥胖和褐脂化中的作用及其机制研究，国家自然科学基金面上项目，主持(Grant No.**)，54万元；
　3.2017-2020，DP1受体在机械损伤诱导的血管重塑中的作用机制研究，天津市自然科学基金面上项目，主持(Grant No.17JCYBJC26800)，10万；
　4.2017-2020，脂代谢异常和动脉粥样硬化的分子调控机制与防治新靶点，动脉粥样硬化与心力衰竭的动态演变特征和分子基础研究，国家重点研发计划，参与(2017YFC**)，212万；
　5.2015-2017，前列腺素E2受体亚型3在肺动脉高压中的作用机制研究，国家自然科学基金青年基金，主持(Grant No.**)，23万；
　6.2014-2016，RvE1在机械损伤诱导的血管重塑中的作用机制研究，第56批中国博士后科学基金面上资助，主持(Grant No.2014M561534)，5万；
　7.2014-2016，RvE1在心梗后心肌修复中的作用机制研究，中国科学院博士后科研基金，主持 (Grant No.2014KIP316)，15万。

荣誉奖励
2018年天津市青年人才托举工程;
2018年天津市青年科技优秀人才;
2017年天津市131创新型人才培养工程第二层次人才。

其他事项