姓名：山长亮
职称：教授 南开大学百名青年学科带头人
学科方向：肿瘤药理、分子生物学和细胞生物学
研究方向：肿瘤代谢酶表观调控与化学干预
通讯地址：天津市津南区同砚路38号南开大学药学院102室
电子邮件：changliangshan@nankai.edu.cn
教师简介：
教育背景
2011年 获南开大学 生物化学与分子生物学 博士
2006年 获鲁东大学 生物技术 本科
工作经历
2018年12月~至今 南开大学药学院 教授 博导
2015年6月~2018年11月 暨南大学生物医学转化研究院 研究员 博导
2015年1月~2015年5月 上海药物研究所 客座研究员
2011年9月~2014年12月 美国Emory 大学医学院 博后


个人专长
山长亮博士长期从事肿瘤代谢酶表观调控与化学干预研究。发表学术论文50余篇，其中以第一（共同）和通讯作者发表论文17篇，包括Nature Cell Biology， Nature Chemistry，Molecular Cell（2篇），Cancer Letters，J. Biol. Chem，Cell Research，Biochemical Pharmacology，Cell Death & Disease（2篇）， Carcinogenesis（2篇），European Journal of Medicinal Chemistry FEBS Lett.和Front. Pharmacol（3篇）。
学术兼职
中国抗癌协会抗癌药物专业委员会第六届委员会委员
中国抗癌协会肿瘤标志专业委员会青年委员
中国细胞生物学学会肿瘤细胞生物学学会分会委员
中国细胞生物学学会细胞代谢分会委员
中国抗癌协会肿瘤细胞代谢分会委员
中国抗癌协会非编码RNA与肿瘤研究专家委员会常委
代表性论文：（#通讯作者*第一作者）
1. Feng, Q., Li, X., Sun, W., Sun, M., Li, Z., Sheng, H., Xie, F., Zhang, S (#)., Shan, C (#). Targeting G6PD Reverses Paclitaxel Resistance in Ovarian Cancer by Suppressing GSTP1. Biochem Pharmacol. (2020) Jun 11:114092. doi: 10.1016/j.bcp.2020.114092.
2. Li, Y*., Liang, R*., Sun, M*., Li, Z., Sheng, H., Wang, J., Xu, P., Liu, S., Yang, W., Lu, B., Zhang, S (#)., Shan C (#). AMPK-Dependent Phosphorylation of HDAC8 Triggers PGM1 Expression to Promote Lung Cancer Cell Survival under Glucose Starvation. Cancer Lett. (2020) Mar 20; 478:82-92. doi: 10.1016/j.canlet.2020.03.007
3. Sheng, H., Li, Z., Su, S., Sun, Wen., Zhang, X., Li, L., Li, J., Liu, S., Lu, B., Zhang, S (#)., Shan, C (#).YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. (2019) Sep 5. pii: bgz152. doi: 10.1093/carcin/bgz152.
4. Shan, C^*, (#)., Lu, Z*., Li, Z*., Hao, S., Fan, J.,Qi, Q., Liu, S^#., Zhang, S^#. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death & Disease. (2019), Jul 8;10(7):525. doi: 10.1038/s41419-019-1756-1.
5. Li, Y., Liang, R., Zhang, X., Wang, J., Shan, C (#)., Liu, S#., Li, L#., Zhang, S#. Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling. Front Pharmacol. 2019, Apr 5;10:356. doi: 10.3389/fphar.2019.00356. eCollection 2019.
6. Zhang, S (*)., Sheng, H., Zhang, X., Qi, Q., Chan, C., Li L., Shan, C (#)., Ye, K (#). Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation, Cell Death & Disease. (2019), Mar 4;10(3):222. doi: 10.1038/s41419-019-1452-1.
7. Huang, K (*)., Jinag, L (*)., Liang (*)., Li, H., Ruan, X., Shan, C (#)., Ye, D (#); Zhou, L (#). Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment, European Journal of Medicinal Chemistry. (2019). Apr 15;168: 45-57.doi: 10.1016/j.ejmech.2019.01.085.
8. Lu, Z., Guo Y, Zhang, X., Li, J., Li, L., Zhang, S^#., Shan, C (#). ORY-1001 suppresses cell growth and induces apoptosis in lung cancer through triggering HK2 mediated Warburg effect. Frontiers in Pharmacology. (2018), Dec 4;9:1411. doi: 10.3389/fphar.2018.01411. eCollection 2018.
9. Zheng, W., Feng, Q., Liu, J., Guo, Y., Gao, L., Li, R., Xu, M., Yan, G., Yin, Z., Zhang, S., Liu, S., Shan, C (#). Inhibition of 6-phosphogluconate dehydrogenase reverses cisplatin resistance in ovarian and lung cancer. Frontiers in Pharmacology. (2017), DOI: 10.3389/fphar.2017.00421.
10. Lin, R*., Elf, S*., Shan, C*., Kang, H.-B., Ji, Q., Zhou, L., Hitosugi, T., Zhang, L.,Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J.,Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J.,Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S.,Fan, J. , and Chen, J. 6-phosphogluconate dehydrogenase linksoxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling. Nature Cell Biology. (2015), DOI: 10.1038/ncb3255.
11. Wang, J*., Luo, C*.,Shan, C*., You, Q*., Elf, S., Lu, Y., Zhou, Y., Wen, Y., Vinkenborg, J.L., Fan, J., Kang,H., Han, D., Karpus, J., Xie, Y., Ouyang, S., Luan, C., Zhang, N., Merkx, M.,Liu, H., Chen, J., Jiang, H., He, C. Inhibition of humancopper trafficking significantly attenuates tumor growth. Nature Chemistry. (2015), DOI:10.1038/nchem.2381.
12. Shan, C*., Elf, S*., Ji, Q., Kang,H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu,T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P.,Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye,K., Boggon, T.J., He, C., Kang, S., Fan, J. , and Chen, J. Lysine acetylation activates 6-phosphogluconatedehydrogenase to promote tumor growth. Molecular Cell. (2014), 55(4):552-65.
13. Shan, C^*., Kang, H.-B., Elf, S., Xie,J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T,-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M.,Boggon, T. and Fan,J. Tyr-94 Phosphorylation Inhibits PyruvateDehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem. (2014), 289(31):21413-22.
14. Fan, J*., Shan, C*., Kang, H.-B*., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S.,Chen, H., Mohannadi, M., Britton, L-M P., Garcia, BA. Aleckovic, M., Kang, Y.,Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, JH., Lonial, S., Gaddh, M.,Arellano, M., Khoury, HJ., Khuri, FR., Boggon, TJ., Kang, S., and Chen, J. Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvatedehydrogenase complex. Molecular Cell. (2013), 53(4):534-48.
15. Shan, C^*., Zhang, S., Cui, W., You, X., Kong, G., Du, Y., Qiu, L., Ye,L., Zhang, X. Hepatitis B virus X protein activates CD59involving DNA binding and let-7i in protection of hepatoma and hepatic cellsfrom complement attack. Carcinogenesis. (2011), 32(8):1190-7.
16. Shan, C^*., Xu, F. Zhang, S., You, J., You, X., Qiu, L., Zheng, J., Ye, L., Zhang, X. Hepatitis B virus X protein promotes livercell proliferation via a positive cascade loop involving arachidonic acidmetabolism and p-ERK1/2.Cell Res. (2010), 20(5):563-75.
17. Zhang,S*., Shan, C*., Cui, W., You, X., Du,Y., Kong, G., Gao, F., Ye, L., Zhang, X. Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46. FEBSLett. (2013), 587(6):645-51.