姓名：侯媛媛
职称：副教授
学科方向：生药学
研究方向：中药作用物质基础与机制研究
通讯地址：天津市津南区海河教育园区同砚路38号
电子邮件：houyy@nankai.edu.cn
教师简介：
1999年毕业于中国药科大学药物分析专业，获理学学士学位。
1999～2002年 任职于天津药业股份有限公司（金耀集团）。
2002～2007年 就读于四川大学华西药学院药物分析专业，硕博连读，获理学博士学位。
2007年7月到南开大学药学院工作。主要讲授本科生《药物分析》的理论课程。科研方面主要集中在筛选复方中药的生物活性成分及其作用机制的研究。先后主持南开大学青年教师研究资助项目、国家自然科学基金青年基金项目、国家自然科学基金面上项目等四项科研项目，并参与国家重大新药创制、国家自然科学基金、天津市重点项目、天津市科技支撑项目、教育部博士点基金项目等十余项科研课题的研究。近3年发表SCI论文10余篇。
代表性论文：
1.Jin Tao, Yuanyuan Hou*, Xiaoyao Ma, Dan Liu, Yongling Tong, Hong Zhou, Jie Gao, Gang Bai*. An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica – Fritillaria usuriensis dropping pills for pulmonary diseases. BMC Complement Altern Med. 2016 Jan 8; 16(1): 4.
2.Yuan Yuan Hou, Yan Nie, Bin Feng Cheng, Jin Tao, Xiao Yao Ma, Min Jiang, Jie Gao, Gang Bai*. Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways. Acta Pharmaceutica Sinica B, 2016, 6(3): 212-221.
3.Guoyu Ding, Baiqing Li, Yanqi Han, Aina Liu, Jingru Zhang, Jiamin Peng, Min Jiang,Yuanyuan Hou*, Gang Bai*. A rapid integrated bioactivity evaluation system based onnear-infrared spectroscopy for quality control of Flos Chrysanthemi. Journal of Pharmaceutical and Biomedical Analysis, 2016, 131: 391-399.
4.Guoyu Ding, Yuanyuan Hou*, Jiamin Peng, Yunbing Shen, Min Jiang, Gang Bai. On-line near-infrared spectroscopy optimizing and monitoring biotransformation process of γ-aminobutyric acid. Journal of Pharmaceutical Analysis, 2016, 6: 171-178.
5.Jiajia Wang, Yan Nie, Yunjuan Li, Yuanyuan Hou*, Wei Zhao, Jiagang Deng, Peng George Wang, and Gang Bai. Identification of Target Proteins of Mangiferin in Mice with Acute Lung Injury Using Functionalized Magnetic Microspheres Based on Click Chemistry. Journal of Agricultural and Food Chemistry, 2015, 63:10013-21.
6.Runping Fang, Qingxin Cui, Jixue Sun, Xixi Duan, Xiaoyao Ma, Weiya Wang, Binfeng Cheng, Yang Liu, Yuanyuan Hou*, Gang Bai. PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin. Allergy, 2015 Sep 3, 70: 1622-1632.
7.Guoyu Ding, Yan Nie, Yuanyuan Hou*, Zenghui Liu, Aina Liu, Jiamin Peng, Min Jianga, Gang Bai*. An integrated strategy of marker ingredients searching and near infrared spectroscopy rapid evaluation for the quality control of Chinese eaglewood. Journal of Pharmaceutical and Biomedical Analysis, 2015, 114: 462-470.
8.Ya-Nan Wang1, Yuan-Yuan Hou1, Ming-Zhu Sun1, Chun-Yang Zhang, Gang Bai*, Xin Zhao*, Xi-Zeng Feng*. Scientific Reports 2014, 16; 4: 5311.
9.Dan Sun, Mengge Zhou, Xuhui Ying, Binfeng Cheng, Yanqi Han, Yan Nie, Yuanyuan Hou*, Gang Bai. BMC Complementary and Alternative Medicine 2014, 14: 356.
10. Yuanyuan Hou, Binfeng Cheng, Mengge Zhou, Runping Fang, Min Jiang, Wenbin Hou, Gang Bai*. PLOS ONE 2014, 9 (11): e113104.
11. Xue Xiao, Yuanyuan Hou, Yang Liu, Yanjie Liu, Hongzhi Zhao, Linyi Dong, Jun Du, Yiming Wang, Gang Bai, Guoan Luo. Classification and analysis of corn steep liquor by UPLC/Q-TOF MS and HPLC. Talanta, 2013, 107: 344-8.
12. Cui Qingxin, Hou Yuanyuan, Hou Jie, Pan Pengwei, Bai Gang, Luo Guoan. Preparation and Optimization of Functionalized Alkynyl polyvinyl alcohol Magnetic Microspheres for the Selective Enrichment of Cell glycoproteins based on Click Chemistry. Biomacromolecules, 2013, 14(1): 124-31.
13. Yuanyuan Hou, Xuelin Cao, Linyi Dong, Liqiang Wang, Binfeng Cheng, Qian Shi, Xiaodong Luo, Gang Bai. Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β2AR agonist identification in alkaloidal extract of Alstonia scholaris. Journal of Chromatography A, 2012, 1227: 203-9.
14. Liqiang Wang, Jiamin Peng, Binfeng Cheng, Jie Gao, Min Jiang, Gang Bai, Yuanyuan Hou*. Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats. Pharmazie, 2012, 67(2):168-73.
15. Xiao X, Hou Y*, Du J, Liu Y, Liu Y, Dong L, Liang Q, Wang Y, Bai G, Luo G. Determination of main categories of components in corn steep liquor by near-infrared spectroscopy and partial least-squares regression. J Agric Food Chem, 2012, 60(32):7830-5.
16. Cheng B, Hou Y*, Wang L, Dong L, Peng J, Bai G. Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β(2)AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan. Analytical and Bioanalytical Chemistry, 2012, 404: 2445–52.
17. Qian Shi, Yuanyuan Hou*, Jie Hou, Penwei Pan, Ze Liu, Min Jiang, Gao Jie, Gang Bai. Glycyrrhetic acid synergistically enhances β2-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. PLoSONE, 2012, 7(9): e44921.
18. YuanyuanHou;XuelinCao;LiqiangWang;BinfengCheng;LinyiDong;XiaodongLuo;Gang Bai,WenyuanGao. Bioactivity integrated ultra performance liquid chromatography quadrupole time-of-flight massspectrometry forthe identification ofNuclearFactor-κBinhibitorsandβ2adrenergicreceptoragonistsinanalkaloidalextractofthefolkherbAlstoniascholaris. Chromatography B, 2012, 908:98-104.
申请专利：
1. 侯媛媛，白钢，王利强，白芳，彭佳敏，朱元元，王欣，聂万达，朱晓丹（2011）延缓α-糖苷酶抑制剂吸收及增强降糖药效的口服制剂，3.8
2. 白钢，侯媛媛，崔庆新，方润平，姜民，高洁（2014）一种用于治疗慢性呼吸系统疾病的药物及其制备方法，6.X