蔡峻



招生专业： 微生物学
电话：

邮箱： caijun@nankai.edu.cn
办公地点： 生物楼111室







个人资料
性别： 男
部门： 微生物学系
联系电话：
通讯地址：
职称： 教授
电子邮箱： caijun@nankai.edu.cn
办公地址： 生物楼111室


教育经历
2000年毕业于浙江大学害虫综合治理专业，获博士学位。2000.9～2002.6,在南开大学生物学博士后流动站工作。2007.1～2008.1在丹麦哥本哈根大学分子生物学系访问学习。

工作经历



个人简介
教授，博士生导师。中国农业生物技术学会第5届理事会理事。主持国家自然科学基金、教育部出国留学人员科研启动基金、天津市自然科学基金等7项，参与国家、教育部、科技部、天津市科技攻关等项目5项。发表科研论文近60篇。2010年获国家科技进步二等奖（排名第2），2003年获教育部提名国家自然科学奖二等奖（排名第4），获得发明专利3项。现为国家精品视频公开课《生命科学漫谈》主持人，国家精品课《微生物发酵工程》课程组成员，教育部“科学素质教育系列公共课国家级教学团队”成员，校级精品课《基础生命科学》课程组主讲教师。2016年获“宝钢优秀教师奖”。


研究方向
研究方向：
1）生防微生物的杀虫、抗病的分子机理。
2）芽胞杆菌功能基因的表达调控。
3）芽胞杆菌合成生物学




科研成果
主持国家自然科学基金、教育部出国留学人员科研启动基金、天津市自然科学基金等7项，参与国家、教育部、科技部、天津市科技攻关等项目5项。发表科研论文近60篇。2010年获国家科技进步二等奖（排名第2），2003年获教育部提名国家自然科学奖二等奖（排名第4），获得发明专利3项。

代表论文：


1 Tong-tong Tan,Xu-dong Zhang,Zhen Miao, Ying Yu, Si-ling Du, Xiao-yue Hou, Jun Cai. A single point mutation in hmgA leads to melanin accumulation in Bacillus thuringiensis BMB181. Enzyme and Microbial Technology. 2019,120:91–97.
2..Kun Jiang, xiaoyue Hou, Lu Han, Tongtong Tan, Zhanglei Cao, Jun Cai *.Fibroblast growth factor receptor, a novel receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa. Toxins. , 2018, 10(12), 546; https://doi.org/10.3390/toxins**.
3.Kun Jiang, Xiao-yue Hou, Tong-tong Tan, Zhang-lei Cao, Si-qi Mei, Bing Yan, Jin Chang, Lu Han, Dan Zhao, Jun Cai*. Scavenger receptor-C acts as a receptor for Bacillus thuringiensisvegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis. PLOS Pathogens. 2018，14(10):e**，DOI: 10.1371/journal.ppat.**
4.Zhang-lei Cao, Tong-tong Tan, Yan-li Zhang, Lu Han, Xiao-yue Hou, Hui-yong Ma，Jun Cai*. NagRBt is a pleiotropic and dual transcriptional regulator in Bacillus thuringiensis. Frontiers in Microbiology, 2018, https://doi.org/10.3389/fmicb.2018.01899
5.Zhang-lei Cao, Tong-tong Tan, Kun Jiang, Si-qi Mei, Xiao-yue Hou, Jun Cai*. Complete genome sequence of Bacillus thuringiensisL-7601, a wild strain with high production of melanin. Journal of Biotechnology .2018, 275(10): 40–43
6.Kun Jiang, Si-qi Mei, Ting-ting Wang, Jin-hua Pan, Yue-hua Chen, Jun Cai*.Vip3Aa induces apoptosis in culturedSpodoptera frugiperda(Sf9) cells. Toxicon, 2016,120 :49-56
7.Yinyue Deng, Jien Wu, Wenfang Yin, Peng Li, Jianuan Zhou, Shaohua Chen, Fei He,Jun Cai, and Lian-Hui Zhang. Diffusible signal factor family signals provide a fitness advantage toXanthomonas campestrispv.campestrisin interspecies competition. Environmental Microbiology, 2016, 18(5)：1534–1545
8.Kun Jiang, Li-na Li, Jin-hua Pan, Ting-ting Wang, Yue-hua Chen, Jun Cai*. YvoA and CcpA Repress the Expression of chiB in Bacillus thuringiensis. Applied and Environmental Microbiology,2015，81（19）:6548-6555
9.Xie Chi Chu, Jin Shi, Hai Yun Jia, Peng Fei Li,Yang Luo, Jun Cai , Yue Hua Chen. Characterization of regulatory regions involved in the inducible expression of chiB in Bacillus thuringiensis. Archives of Microbiology. 2015, 197 (1): 53-63
10.Yingde Shen, Ruibin Liu, Yuehua Chen, Jun Cai*. Identification of an Antifungal Bacillus Strain and Studies on Its Antifungal Active Ingredients. Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012), Lecture Notes in Electrical Engineering. Volume 251, 2014, pp 1637-1644
11.Xiao Liang, Chuan Liu, Xie Chi-chu, Jun Cai* , Yue-hua Chen*. The direct repeat sequence upstream of Bacillus chitinase genes is cis-acting elements that negatively regulate heterologous expression in E. coli. Enzyme and Microbial Technology, 2012,50:280-286.
12.Xie Chi-Chu, Yang Luo, Yue-Hua Chen*, Jun Cai. Construction of a Promoter-probe Vector for Bacillus thuringiensis: the Identification of cis-acting Elements of the chiA Locus. Current Microbiology, 2012,64(5):492-500.
13.Xueyong Zhou, Wei Qi, Jianbo Zhang, Tingting Zou , Guo Chen , Jun Cai*, and Xiang Huang .Spectroscopic investigation of the structure of protoxin protein isolated from Bacillus thuringiensiscontacted with minerals. Biocontrol Science and Technology, 2010,20(8)841 – 852
14.Dong Liu, Jun Cai, Chi-chu Xie, Chuan Liu and Yue-hua Chen. Purification and partial characterization of a 36-kDa chitinase fromBacillus thuringiensis subsp. colmeri, and its biocontrol potential. Enzyme and Microbial Technology. 2010,46:252–25646
15.Liang Xiao, Chi-chu Xie, Jun Cai, Zhi-Jie Lin and Yue-Hua Chen. Identification and Characterization of a Chitinase-Produced Bacillus Showing Significant Antifungal Activity. Current Microbiology. 2009 ,58(5):528-33
16.Zhang, J. Cai, J. Deng, Y. Chen, Y. Ren, G.Characterization of Melanin produced by a wild-type strain of Bacillus cereus. Frontiers of Biology in China, 2007. 2: 26～29
17.Jun Cai*, Liang Xiao, Bing Yan, Yinyue Deng, Yuehua Chen, Gaixin Ren.Vip3A is responsible for the potency of Bt9816C culture supernatant against Helicoverpa armigera and Spodoptera exigua. Journal of General and Applied Microbiology. 2006，52（2）83－89
18.Zhong Zhang, Gong-yin Ye, Jun Cai, Cui Hu. Comparative venom toxicity betweenPteromalus puparumand Nasonia vitripennis(Hymenoptera: Pteromalidae) toward the hemocytes of their natural hosts, non-target insects and cultured insect cells. Toxicon. 2005, 46(3):337-49
19.Jun Cai*, Rui-Bin Liu, Gai-Xin Ren. The toxicity of Bacillus thuringiensis9816C toSpodoptera exiguarelated to the binding sites on BBMV. Insect Science. 2005, 12:429-433
20.Jun Cai, Gong-yin Ye, Cui Hu.Parasitization of Pieris rapae (Lepidopetera) by the pupal endoparisitoid Pteromalus puparum(Hymenoptera: Pteromalidae), suppresses haemocyte encapsulation. Journal of Insect Physiology. 2004,50:315-322
21.Yuehua Chen, Yinyue Deng, Jinhong Wang, Jun Cai, Gaixin Ren. Characterization of melanin produced by a wild-type strain of Bacillus thuringiensis. Journal of General and Applied Microbiology. 2004, 50: 183-188.




社会兼职
中国农业生物技术学会第5届理事会理事


教学经历
目前承担本科生课程：基础生命科学，发育生物学，生命科学概要；承担研究生课程：分子微生物学。
参与编译专著3部。
现为国家精品视频公开课《生命科学漫谈》主持人，国家精品课《微生物发酵工程》课程组成员，教育部“科学素质教育系列公共课国家级教学团队”成员，校级精品课《基础生命科学》课程组主讲教师。
获“第十届天津市高校青年教师教学基本功竞赛”二等奖，“南开大学青年教师教学基本功竞赛”一等奖。指导本科生获南开大学本科生创新科研项目一等奖。2011年12月荣获南开大学第四届“良师益友”评选活动优秀导师，2016年获“宝钢优秀教师奖”。



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