王淑芳



招生专业： 高分子化学与物理,生物化学与分子生物学,生物工程
电话：

邮箱： wangshufang@nankai.edu.cn
办公地点： 南开大学分子生物学研究所







个人资料
性别： 女
部门： 生物材料与组织工程系
联系电话：
通讯地址： 天津市南开区卫津路94号
职称： 教授
电子邮箱： wangshufang@nankai.edu.cn
办公地址： 南开大学分子生物学研究所


教育经历
2001-2004：南开大学化学学院高分子化学与物理专业 博士研究生1988-1991：南开大学化学系高分子化学与物理专业 硕士研究生1982-1986：南开大学化学系高分子化学与物理专业 本科生

工作经历
2007-今：南开大学生命科学学院 生物活性材料教育部重点实验室 教授1998-2007：南开大学戈德研究院 高级工程师/教授级高级工程师1995-1998：南开大学戈德防伪技术公司 工程师1991-1995：南开大学科技发展总公司新材料研究所 工程师1986-1988：天津制药学校（天津医药教育中心）教师


个人简介
王淑芳, 1963年出生，理学博士，教授，博士生导师；毕业于南开大学化学学院高分子化学与物理专业；现就职于南开大学生命科学学院生物活性材料教育部重点实验室，从事生物材料的结构与功能关系及其应用研究。主持或参加国家级、省部级科研项目四十余项。获得了国家科技进步三等奖、天津市自然科学二等奖、天津市技术发明二等奖等奖项。还获得南开大学优秀教育工作者和南开大学优秀硕士论文指导教师等称号。


研究方向
生物功能高分子材料的结构与性能关系及其应用研究（包括血管组织工程支架材料构建，新型生物降解高分子材料的药物控释及载药新技术研究，功能性水凝胶的制备及其在皮肤创伤修复材料中的应用）。
目前承担科研项目：
1.主持国家自然科学基金项目（**）利用生物反应器体外培养hiPSCs来源的SMCs构建ECM人工血管，2019.1-2022.12
2.主持国家自然科学基金项目（**）原位催化生成NO的人工血管材料炎症反应调控及其对血管再生行为的影响，2017.1-2020.12
3.参加国家重点研发计划“生物医用材料研发与组织器官修复替代”重点专项——新型响应性智能水凝胶的设计、制备及工程化技术（2017YFC**），2017.7-2020.12，任课题组长。
4. 主持天津市自然科学基金重点项目（16JCZDJC37600）小口径人工血管的炎症反应与血管再生功能调控研究，2016.4-2019.3
5.主持其他横向科研项目多项



科研成果

1.Lin Zhang, Yina Ma, Xiaochen Pan, Siyuan Chen, Huahong Zhuang, Shufang Wang* A composite hydrogel of chitosan/heparin/poly (γ-glutamic acid) loaded with superoxide dismutase for wound healing. Carbohydrate Polymers 2018, 180, 168–174.
2.Jingchen Gao, Li Jiang, Qinge Liang, Jie Shi, Ding Hou, Di Tang, Siyuan Chen, Deling Kong and Shufang Wang*.The grafts modified by heparinization and catalytic nitric oxide generation used for vascular implantation in rats. Regenerative Biomaterials, 2018, 5(2), 105-114
3.Di Tang, Siyuan Chen, Ding Hou, Jingchen Gao, Li Jiang, Jie Shi, Qinge Liang, Deling Kong, Shufang Wang*. Regulation of macrophage polarization and promotion of endothelialization by NO generating and PEG-YIGSR modified vascular graft. Materials Science and Engineering: C, 2018, 84, 1-11.
4.Jingchen Gao, Yaping Wang, Siyuan Chen, Di Tang, Li Jiang, Deling Kong and Shufang Wang*. Electrospun poly-3-caprolactone scaffold modified with catalytic nitric oxide generation and heparin for small-diameter vascular graft. RSC Advances, 2017, 7,18775-18784.
5.Yuanyuan Wang, Siyuan Chen, Yiwa Pan, Jingchen Gao, Di Tang, Deling Kong, Shufang Wang*. Rapid in situ endothelialization of small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion. Journal of Materials Chemistry B. 2015.3.9212-9222
6.Jun An, Kai Wang, Siyuan Chen, Meimei Kong, Yuxin Teng, Lianyong Wang, Cunjiang Song, Deling Kong and Shufang Wang*. Biodegradability, cellular compatibility and cell infiltration of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in comparison with poly(e-caprolactone) and poly(lactide-co-glycolide). Journal of Bioactive and Compatible Polymers. 2015.30(2): 209-221.
7.Jun An, Siyuan Chen, Jingchen Gao, Xu Zhang, Yuanyuan Wang, Yandong Li, Sergey Mikhalovsky, Deling Kong, Shufang Wang. Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly. Science China, Life Sciences.2015,58(8):765-772.
8.Huahong Zhuang, Yanhang Hong, Jingchen Gao, Siyuan Chen, Yina Ma, Shufang Wang* . A Poly (g-Glutamic Acid)-Based Hydrogel Loaded with Superoxide Dismutase for Wound Healing. Journal of Applied Polymer Science. 2015.132(23): DOI: 10.1002/app.42033
9.Jun Feng, Yanyan Gu, Yufen Quan, Wei Zhang, Mingfeng Cao, Weixia Gao, Cunjiang Song, Chao Yang & Shufang Wang. Recruiting a new strategy to improve levan production in Bacillus amyloliquefaciens. Scientific Reports 2015. | 5:13814 | DOi: 10.1038/srep13814.
10.Siyuan Chen , Jun An , Lei Weng , Yandong Li , Han Xu , Yaping Wang , Dan Ding , Deling Kong , Shufang Wang*. Construction and biofunctional evaluation of electrospun vascular grafts loaded with selenocystamine for in situ catalytic generation of nitric oxide. Materials Science and Engineering C, 2014, 45:491-496.
11.Jun Feng, Weixia Gao, Yanyan Gu, Wei Zhang, Mingfeng Cao, Cunjiang Song*, Peng Zhang, Min Sun, Chao Yang, Shufang Wang*. Functions of poly-gamma-glutamic acid (g-PGA) degradation genes in g-PGA synthesis and cell morphology maintenance. Appl Microbiol Biotechnol. 2014.98: 6397-6407
12.Wenbin Guo, Jingjing Duan, Weitao Geng, Jun Feng, Shufang Wang*, Cunjiang Song*. Comparison of medium-chain-length polyhydroxyalkanoates synthases from Pseudomonas mendocina NK-01 with the same substrate speci?city. Microbiological Research, 2013, 168(4), 231-237.
13.Jun Feng, Yanyan Gu, Jingqiang Wang, Cunjiang Song*, Chao Yang, Hui Xie, Wei Zhang, Shufang Wang*. Curing the Plasmid pMC1 from the Poly (g-glutamic Acid) Producing Bacillus amyloliquefaciens LL3 Strain Using Plasmid Incompatibility. Appl Biochem Biotechnol. 2013, 171:532-542. (IF 1.893)
14.Qing Ji, Suai Zhang, Jimin Zhang, Zhihong Wang, Jianing Wang, Yun Cui, Liyun Pang, Shufang Wang, Deling Kong, and Qiang Zhao*, Dual Functionalization of Poly(e-caprolactone) Film Surface through Supramolecular Assembly with the Aim of Promoting In Situ Endothelial Progenitor Cell Attachment on Vascular Grafts. Biomacromolecules, 2013, 14 (11), pp 4099-4107.
15. Qian Li, Zhihong Wang, Suai Zhang, Wenting Zheng, Qiang Zhao *, Jun Zhang, Lianyong Wang *, Shufang Wang, Deling Kong.Functionalization of the surface of electrospun poly(epsilon-caprolactone) mats using zwitterionic poly(carboxybetaine methacrylate) and cell-specific peptide for endothelial progenitor cells capture. Mater Sci Eng C-Mater Biol Appl 2013, 33, 1646-1653.
16.Wenbin Guo, Jian Tao, Chao Yang, Cunjiang Song*, Weitao Geng, Qiang Li, Yuanyuan Wang, Meimei Kong, Shufang Wang*. Introduction of Environmentally Degradable Parameters to Evaluate the Biodegradability of Biodegradable Polymers. PLoS ONE, 2012, 7(5), e38341.
17.Wenbin Guo, Jun Feng, Weitao Geng, Cunjiang Song*, Yuanyuan Wang, Ning Chen, Shufang Wang*. Augmented production of alginate oligosaccharides by the Pseudomonas mendocina NK-01 mutant. Carbohydrate Research, 2012, 352,109-116.
18.Qiang Zhao, Shufang Wang*, Meimei Kong, Weitao Geng, Robert K. Y. Li, Cunjiang Song*, Deling Kong. Phase morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends. Journal of Biomedical Materials Research B: Applied Biomaterials. 2012, 100B (1): 23-31.
19.Wenbin Guo, Cunjiang Song*, Meimei Kong, Weitao Geng, Yuanyuan Wang, Shufang Wang*. Simultaneous production and characterization of medium-chain-length polyhydroxyalkanoates and alginate oligosaccharides by Pseudomonas mendocina NK-01. Applied Microbiology and Biotechnology. 2011, 92, 791-801.
20.Wenbin Guo, Yuanyuan Wang, Cunjiang Song*, Chao Yang, Qiang Li, Baobin Li, Wenping Su, Xiumei Sun, Dongfang Song, Xiaojuan Yang, and Shufang Wang*. Complete Genome of Pseudomonas mendocina NK-01, Which Synthesizes Medium-Chain-Length Polyhydroxyalkanoates and Alginate Oligosaccharides. Journal of Bacteriology, 2011, 193(13):3413-3414.
21.Li Q, Wang ZH, Zhao Q*, Wang LY, Wang SF, Kong DL*. Tissue engineering scaffold electrospun from poly(e-caprolactone)-b-poly(sulfobetaine methacrylate). E-Polymers. 2012, 050: 1-12.
22.Congxin Li, Tianying Guo, Dezhong Zhou, Yuling Hu, Hao Zhou, Shufang Wang, Jiatong Chen, Zhengpu Zhang. A novel glutathione modified chitosan conjugate for efficient gene delivery. Journal of Controlled Release 2011, 154, 177-188.
23.Qiang Zhao, Shufang Wang, Xinjian Cheng, Richard CM. Yam, Deling Kong*, Robert KY Li, Surface Modification of Cellulose Fiber via Supramolecular Assembly of Biodegradable Polyesters by the aid of Host-Guest Inclusion Complexation. Biomacromolecules, 2010, 11(5), 1364-1369.
24.Wenbin Guo, Jian Tao, Chao Yang, Qiang Zhao, Cunjiang Song*, Shufang Wang*, The rapid evaluation of material biodegradability using an improved ISO 14852 method with a microbial community, Polymer Testing, 2010, 29, 832-839.
25.Mingfeng Cao , Cunjiang Song*, Yinghong Jin, Li Liu , Jing Liu, Hui Xie, Wenbin Guo, Shufang Wang* Synthesis of Poly (g-glutamic acid) and Heterologous Expression of pgsBCA Genes, Journal of Molecular Catalysis B: Enzymatic, 2010, 67, 111-116.
26.Mingfeng Cao, Weitao Geng, Li Liu, Congjiang Song*, Hui Xie, Wenbin Guo, Yinghong Jin, Shufang Wang*. Glutamic acid independent production of poly(g-glutamic acid) by Bacillus amyloliquefaciens LL3 and cloning of pgsBCA genes. Bioresource technology, 2011, 102(5), 4251-4257.
27.Lei Zhang, Kai Wang, Qiang Zhao, Wenting Zheng, Zhihong Wang, Shufang Wang*, Deling Kong*. Core-shell fibrous vascular graft with nitric oxide releasing property, Science in China Series B: Chemistry, 2010, 53(3): 528-534.
28.Wenting Zheng, Zhihong Wang, Lijie Song, Qiang Zhao, JunZhang, Dong Li, Shufang Wang, Jihong Han, Xi-Long Zheng, Zhimou Yang, Deling Kong,* Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials. 2012, 33(10): 2880-2891.
29.Min Zhang, Zhexiang Wang, Zefang Wang, Shuren Feng, Haijin Xu, Qiang Zhao, Shufang Wang, Jianxin Fang,MingqiangQiao*,DelingKong*.Immobilizationofanti-CD31antibodyonelectrospun poly(e-caprolactone)scaffoldsthroughhydrophobinsforspecificadhesionofendothelialcells. Colloids Surf B Biointerfaces. 2011, 85 (1): 32-39.
30.Zhihong Wang, Huaimin Wang, Wenting Zheng, Jun Zhang, Qiang Zhao , Shufang Wang , ZhimouYang , Deling Kong. Highly stable surface modifications of poly(e-caprolactone) (PCL) films by molecular self-assembly to promote cells adhesion and proliferation. Chem Commun 2011, 47: 8901-8903.
31.Ding, L.; Wang, S. F.; Wu, W. J.; Hu, Y. H.; Yang, C. H.; Tan, M.; Kong, D. L. and Yang, Z. M.*. A Supramolecular Hydrogel Inspired by Elastin. Chin. J. Chem. 2011, 29(10): 2182-2186.
32.Qian Li, Zhihong Wang, Qiang Zhao, Lianyong Wang, Shufang Wang , Deling Kong. Synthesis and characterization of a zwitterionic copolymer poly(e-caprolactone)-b-poly(carboxybetaine methacrylate) with good cell affinity. Chinese J Biomed Eng 2011, 20: 47-54.
33.Jian Tao; Cunjiang Song; Cao Mingfeng; Dan Hu; Li Liu; Na Liu; Shufang Wang*. Thermal Properties and Degradability of Poly (propylene carbonate) / Poly (b-hydroxybutyrate-co-b-hydroxyvalerate) (PPC / PHBV) Blends. Polymer Degradation and Stability, 2009, 94(4):573-583.




社会兼职
中国复合材料学会理事、天津生物医学工程学会口腔生物医学工程专业委员会副主任委员、天津生物医学工程学会组织工程专业委员会委员、中国生物材料学会会员、中国化学会会员。



教学经历
本科生课程：
2011-2018：生物工程下游技术
2009-2018：创新与创业实践
2008-2018：实践教学II
硕士生课程：
2011-2018：生物工程下游分离与纯化



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