吴卫辉



招生专业： 微生物学
电话： **

邮箱： wuweihui@nankai.edu.cn
办公地点： 生物楼216







个人资料
性别： 男
部门： 微生物学系
联系电话： **
通讯地址：
职称： 教授
电子邮箱： wuweihui@nankai.edu.cn
办公地址： 生物楼216


教育经历
1994-1998 南开大学 理学学士1998-2001 南开大学 理学硕士2001-2006 美国佛罗里达大学 理学博士

工作经历
2006-2009 美国德克萨斯大学M.D.安德森癌症研究中心 博士后2009-2011 美国哈佛大学医学院布雷根及妇女医院Channing实验室 博士后2011-今 南开大学生命科学学院微生物系 教授


个人简介
吴卫辉, 1994年考入南开大学生命科学学院微生物学系，分别于1998年、2001年获得学士和硕士学位。随后赴美国佛罗里达大学医学院留学，于2006年获得免疫及微生物学博士学位。2006-2009年于美国德克萨斯大学M.D.安德森癌症中心分子及细胞肿瘤学系做博士后；2009-2011年于美国哈佛大学医学院布雷根及妇女医院做博士后；2011年至今任南开大学生命科学学院教授。曾获“美国微生物协会优秀学生展牌奖”（2005年）；“美国佛罗里达大学优秀国际学生奖”（2006年）；“美洲华人生物科学学会德克萨斯州分会基础研究奖，二等奖”（2008年）。吴卫辉教授从事病原细菌及免疫的研究，主要研究内容有：致病菌耐药机理研究；致病菌毒性基因的表达调控及作用机制；宿主在感染过程中的免疫反应。作为通讯作者或第一作者在Nature Immunology, American Journal of Respiratory and Critical Care Medicine, mBio, Molecular Microbiology, Antimicrobial Agents and Chemotherapy, Infect and Immunity, Journal of Bacteriology等期刊发表论文。


研究方向
主要致力于对细菌分子生物学和感染性疾病的研究，包括：
1. 铜绿假单孢菌耐药机理，致病基因表达调控；
2. 宿主的先天免疫中的信号传导；
3. 铜绿假单孢菌疫苗的研发。



科研成果


1.Jin Y, Zhang M, Zhu F, Peng Q, Weng Y, Zhao Q, Liu C, Bai F, Cheng Z, Jin S, Wu W. NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa. (2019) Front Microbiol. 10:85.
2.Song D, Meng J, Cheng J, Fan Z, Chen P, Ruan H, Tu Z, Kang N, Li N, Xu Y, Wang X, Shu F, Mu L, Li T, Ren W, Lin X, Zhu J, Fang X, Amrein MW, Wu W, Yan LT, Lü J, Xia T, Shi Y. Pseudomonas aeruginosaquorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution. (2019) Nat Microbiol. 4(1):97-111.
3.Zhang Y, Xia B, Li M, Shi J, Long Y, Jin Y, Bai F, Cheng Z, Jin S, Wu W. HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa. (2018) Toxins (Basel). 10(11).
4.Liu C, Pan X, Xia B, Chen F, Jin Y, Bai F, Priebe G, Cheng Z, Jin S, Wu W. Construction of a Protective Vaccine Against Lipopolysaccharide-Heterologous Pseudomonas aeruginosaStrains Based on Expression Profiling of Outer Membrane Proteins During Infection. (2018) Front Immunol. 9:1737.
5.Fan Z, Xu C, Pan X, Dong Y, Ren H, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Mechanisms of RsaL mediated tolerance to ciprofloxacin and carbenicillin in Pseudomonas aeruginosa. (2018) Curr Genet. Jun 27. doi: 10.1007/s00294-018-0863-3.
6.You J, Sun L, Yang X, Pan X, Huang Z, Zhang X, Gong M, Fan Z, Li L, Cui X, Jing Z, Jin S, Rao Z, Wu W, Yang H. Regulatory protein SrpA controls phage infection and core cellular processes in Pseudomonas aeruginosa. (2018) Nat Commun. 9(1):1846.
7.Shi J, Liu Y, Zhang Y, Jin Y, Bai F, Cheng Z, Jin S, Wu W. PA5470 Counteracts Antimicrobial Effect of Azithromycin by Releasing Stalled Ribosome in Pseudomonas aeruginosa. (2018) Antimicrob Agents Chemother. Jan 25;62(2).
8.He C, Zhou Y, Liu F, Liu H, Tan H, Jin S, Wu W, Ge B. Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation. (2017) Infect Immun. Aug 18;85(9).
9.Li K, Yang G, Debru AB, Li P, Zong L, Li P, Xu T, Wu W, Jin S, Bao Q. SuhB Regulates the Motile-Sessile Switch in Pseudomonas aeruginosathrough the Gac/Rsm Pathway and c-di-GMP Signaling. (2017) Front Microbiol. 8:1045.
10.Deng X, Li M, Pan X, Zheng R, Liu C, Chen F, Liu X, Cheng Z, Jin S, Wu W. Fis Regulates Type III Secretion System by Influencing the Transcription of exsA in Pseudomonas aeruginosa Strain PA14. (2017) Front Microbiol. 8:669
11.Pan X, Dong Y, Fan Z, Liu C, Xia B, Shi J, Bai F, Jin Y, Cheng Z, Jin S and Wu W. In vivo host environment alters Pseudomonas aeruginosa susceptibility to aminoglycoside antibiotics. (2017) Front. Cell. Infect. Microbiol.14;7:83.
12.Chen F, Chen G, Liu Y, Jin Y, Cheng Z, Liu Y, Yang L, Jin S, Wu W. Pseudomonas aeruginosa oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis. (2017) Antimicrob Agents Chemother. 61(3)
13.Weng Y, Chen F, Liu Y, Zhao Q, Chen R, Pan X, Liu C, Cheng Z, Jin S, Jin Y, Wu W. Pseudomonas aeruginosa Enolase Influences Bacterial Tolerance to Oxidative Stresses and Virulence. (2016) Front Microbiol. 15;7:1999.
14.Li M, Long Y, Liu Y, Liu Y, Chen C, Shi J, Zhang L, Jin Y, Yang L, Bai F, Jin S, Cheng Z, Wu W. HigB of Pseudomonas aeruginosa Enhances Killing of Phagocytes by Up-Regulating the Type III Secretion System in Ciprofloxacin Induced Persister Cells. (2016) Front. Cell. Infect. Microbiol. 6:125.
15.Chen G, Zhao Q, Zhu F, Chen R, Jin Y, Liu C, Pan X, Jin S, Wu W, Cheng Z. Oligoribonuclease is required for the type III secretion system and pathogenesis of Pseudomonas aeruginosa. (2016) Microbiol Res. 188-189:90-6.
16.Tan H, Zhang L, Zhao Q, Chen R, Liu C, Weng Y, Peng Q, Bai F, Cheng Z, Jin S, Wu W, Jin Y. DeaD contributes to Pseudomonas aeruginosa virulence in a mouse acute pneumonia model. (2016) FEMS Microbiol Lett. Oct;363(20).
17.Tan H, Zhang L, Weng Y, Chen R, Zhu F, Jin Y, Cheng Z, Jin S, Wu W. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa. (2016) Front Microbiol.7:317.
18.Chen R, Weng Y, Zhu F, Jin Y, Liu C, Pan X, Xia B, Cheng Z, Jin S, Wu W. Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa. (2016) Front Microbiol. 2;7:247.
19.Guo Q, Wei Y, Xia B, Jin Y, Liu C, Pan X, Shi J, Zhu F, Li J, Qian L, Liu X, Cheng Z, Jin S, Lin J, Wu W. Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa. (2016) Sci Rep. 6:19141.
20.Jin Y, Jin S, Wu W. Regulation of bacterial gene expression by ribosome stalling and rescuing.(2015) Curr Genet. Nov 26
21.Shi J, Jin Y, Bian T, Li K, Sun Z, Cheng Z, Jin S, Wu W. SuhB is a novel ribosome associated protein that regulates expression of MexXY by modulating ribosome stalling in Pseudomonas aeruginosa. (2015) Mol Microbiol. 98(2):370-83.
22.Bai F, Ho Lim C, Jia J, Santostefano K, Simmons C, Kasahara H, Wu W, Terada N, Jin S. Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors. (2015) Sci Rep.5:15014.
23.Jia J, Bai F, Jin Y, Santostefano KE, Ha UH, Wu D, Wu W, Terada N, Jin S. Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins. (2015) Stem Cells Transl Med.;4(8):913-26.
24.Neeld D, Jin Y, Bichsel C, Jia J, Guo J, Bai F, Wu W, Ha UH, Terada N, Jin S. Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system. (2014) Microbiology. 160(Pt 7):1417-26.
25.Jia J, Jin Y, Bian T, Wu D, Yang L, Terada N, Wu W, Jin S. (2014) Bacterial delivery of TALEN proteins for human genome editing.PLoS One. 11;9(3):e91547.
26.Sun Z, Shi J, Liu C, Jin Y, Li K, Chen R, Jin S, Wu W. PrtR homeostasis contributes to Pseudomonas aeruginosa pathogenesis and resistance against ciprofloxacin. (2014) Infect Immun. 82(4):1638-47.
27.Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, Jin S, Wu W. SuhB is a regulator of multiple virulence genes and essential for pathogenesis of Pseudomonas aeruginosa.(2013) MBio. 4(6):e00419-13.
28.Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. (2013) J Infect Dis. 207(1):39-49.
29.Wu, W, J Huang, B Duan, DC Traficante, H Hong, M Risech, S Lory, GP Priebe. Th17-stimulating Protein Vaccines Confer Protection against Pseudomonas aeruginosa Pneumonia. (2012) Am J Respir Crit Care Med. 186(5):420-7.
30.Bi, L., S. Gorjestani, W. Wu, YM. Hsu, J. Zhu, K. Ariizumi, X. Lin. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 20;285(34):25969-77.
31.Wu, W., YM. Hsu, L. Bi, Z. Songyang, X. Lin. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 10(11):1208-14.
32.Ha, U., J-H. Lim, W. Wu, S. Jin and J-D. Li. (2008) MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 283(45):30624-31.
33.Yang, H., Z. Shan, J. Kim, W. Wu, W. Lian, L. Zeng, L. Xing and S. Jin. (2007) Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa. J Bacteriol. 189(7):2599-609.
34.Jyot, J., A. Sonawane, W. Wuand R. Ramphal. (2007) Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol. 63(4):1026-38.
35.Wu, W. and S. Jin. (2005) PtrB of Pseudomonas aeruginosa Suppresses Type III Secretion System Under the Stress of DNA Damage. J Bacteriol. 187(17):6058-68.
36.Wu, W., Y. Song, S. Jin and S. Chen. (2006) An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome. Systems Biology and Regulatory Genomics of Lecture Notes in Computer Science. 4023: 1-10.
Wu, W., H. Badrane, S. Arora, H. Baker and S. Jin. (2004) MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol. 186(22):7575-85.



社会兼职



教学经历
2013-今 本科生专业选修课 微生物遗传学
2015-今 本科生专业必修课 微生物学



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