姓名：李玉皓
职称：教授
一、教育经历
1999/09-2002/07天津医科大学，医学博士
1996/09-1999/07天津医科大学，医学硕士
1991/09-1996/07天津医科大学，医学学士
二、工作经历
2017/12 -今 南开大学医学院，教授
2009/06 - 2010/10 美国密歇根大学，访问****
2005/12 - 2017/12 南开大学医学院，副教授
2002/07 - 2005/12 南开大学医学院，讲师
三、研究方向（包括承担课题项目）
1.人类疾病斑马鱼模型构建与机制研究；
2.纳米材料的生物毒性评价及体内外成像。
承担课题项目：
1.国家自然科学基金，**，利用斑马鱼模型研究白细胞介素7受体在髓鞘脱失和形成中的作用机制，2017/01-2020/12，主持。
2.国家自然科学基金，**，小胶质细胞调控Müller glia基础上感光细胞再生的机制，2014/01-2016/12，主持。
3.国家自然科学基金，**，利用转基因斑马鱼研究小胶质细胞在视网膜感光细胞损伤及再生中的作用，2013/01-2013/12，主持。
4.国家科技支撑计划，2012BAI08B06，视神经炎的临床研究——斑马鱼动物模型研究（子项目），2012/01-2014/12，子项目主持。
5.天津市应用基础与前沿技术研究计划，15JCYBJC24400，利用转基因斑马鱼筛选髓鞘损伤中的关键调控基因，2015/04-2018/03，主持。
6.天津市应用基础与前沿技术研究计划，08JCYBJC07100，甲状腺相关性眼病的分子遗传学研究，2008/04-2011/03，主持。
7.教育部留学回国人员科研启动基金，2012-1707，小胶质细胞在视网膜发育和损伤再生中的调控作用，2013/01-2015/12，主持。
四、学术兼职
1.国家自然科学基金委，基金项目同行评议专家
2.天津市免疫学会，会员
五、近五年发表的学术论文
Ya-Kun Dou, Yang Chen, Xi-Wen He, Wen-You Li*,Yu-Hao Li*, YuKui Zhang. Synthesis of water-dispersible Mn²⁺functionalized silicon nanoparticles under room temperature and atmospheric pressure for fluorescence and magnetic resonance dual-modality imaging. Anal Chem, 2017; 89: 11286-11292. (*Corresponding author)
Xudan Lei, Shijiao Cai, Yang Chen, Jianlin Cui, Yajie Wang, Zongjin Li,Yuhao Li*. Down regulation of interleukin 7 receptor contributes to the demyelination of central nervous system. Oncotarget, 2017; 8 (17): 28395-28407.
Ya-jie Wang, Shi-jiao Cai, Jian-lin Cui, Yang Chen, Xin Tang*,Yu-hao Li*. Correlation between photoreceptor injury-regeneration process and behavior in a zebrafish model. Neural Regen Res,2017; 12 (5): 795-803.
Wei Liu, Yong-Mei Wang,Yu-Hao Li, Shi-Jiao Cai, Xue-Bo Yin*, Xi-Wen He, Yu-Kui Zhang. Fluorescent imaging-guided chemotherapy-and-photodynamic dual therapy with nanoscale porphyrin metal–organic framework. Small, 2017; 13 (17): **.
Ji-Chun Yang, Yang Chen,Yu-Hao Li, and Xue-Bo Yin*. Magnetic Resonance Imaging-Guided Multi-Drug Chemotherapy and Photothermal Synergistic Therapy with pH and NIR-Stimulation Release. ACS applied materials & interfaces,2017; 9 (27): 22278-22288.
Hui Zhang,Yu-Hao Li, Yang Chen, Man-Man Wang, Xue-Sheng Wang, Xue-Bo Yin*. Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites. Sci Rep-Uk,2017;7: 44153.
Hong-Li Ye, Shi-Jiao Cai, Si Li, Xi-Wen He, Wen-You Li*,Yu-Hao Li*, Yu-Kui Zhang. One-pot microwave synthesis of water-dispersible, high fluorescence silicon nanoparticles and their imaging applications in vitro and in vivo. Anal Chem, 2016; 88: 11631-11638.
Yan Sun, Gong Zhang, Zizi He, Yajie Wang, Jianlin Cui*,Yuhao Li*. Effects of copper oxide nanoparticles on developing zebrafish embryos and larvae. Int J Nanomed, 2016; 11: 905-918.
Xu-Dan Lei, Yan Sun, Shi-Jiao Cai, Yang-Wu Fang, Jian-Lin Cui*,Yu-Hao Li*. Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination. Int J Ophthalmol, 2016; 9 (6): 831-837.
Yangwu Fang, Xudan Lei, Xiang Li, Yanan Chen, Fei Xu, Xizeng Feng*, Shihui Wei*,Yuhao Li*. A novel model of demyelination and remyelination in a GFP-transgenic zebrafish.Biol Open,2015; 4(1): 62-68.
Yan-Fei Kang, Yang-Wu Fang,Yu-Hao Li, Wen Li, Xue-Bo Yin*. Nucleus-stainingwithbiomolecule-mimickingnitrogen-dopedcarbondotspreparedby afastneutralizationheatstrategy.Chem Commun (Camb).2015; 51 (95): 16956-16959.
Yan-Fei Kang,Yu-Hao Li,Yang-Wu Fang,Yang Xu,Xiao-Mi Wei,Xue-Bo Yin*. Carbon quantum dots for zebrafish fluorescence imaging. Sci Rep, 2015; 5: 11835.
Yajie Wang, Zizi He, Yangwu Fang, Yang Xu, Yanan Chen, Guanqun Wang, Yongqiang Yang, Zhuo Yang*,Yuhao Li*. Effect of titanium dioxide nanoparticles on zebrafish embryos and developing retina. Int J Ophthalmol, 2014; 7 (6): 917-923.
Qian-Qian Shi^?,Yuhao Li^?, Yang Xu, Yue Wang, Xue-Bo Yin*, Xi-Wen He and Yu-Kui Zhang. High-yield and high-solubility nitrogen-doped carbon dots: formation, fluorescence mechanism and imaging application. RSC Advances, 2014; 4: 1563-1566.(^?Equal contribution)
Yike Yuan, Yaguang Zhang, Shaohua Yao*, Huashan Shi, Xi Huang,Yuhao Li, Yuquan Wei, Shuo Lin. The translation initiation factor Eif3i upregulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.J Biol Chem,2014; 289 (41): 28310-28123.
Yang Xu,Yu-Hao Li, Yue Wang, Jian-Lin Cui, Xue-Bo Yin*, Xi-Wen He, Yu-Kui Zhang.¹³C-engineered carbon quantum dots for in vivo magnetic resonance and fluorescence dual-response.Analyst,2014; 139 (20): 5134-5139.
Xiao-Mi Wei, Yang Xu,Yu-Hao Li, Xue-Bo Yin*, Xi-Wen He. Ultrafast synthesis of nitrogen-doped carbon dots via neutralization heat for bioimaging and sensing applications.RSC Adv, 2014;4:44504-44508.
Yang Xi, DongyanChen, LeiSun,YuhaoLi*, LeiLi*. Characterization of zebrafish mutants with defects in bone calcification during development.Biochem Biophys Res Commun,2013; 440: 132-136.
Tao Huang, Jianlin Cui, Lei Li, Peter F. Hitchcock,Yuhao Li*. The role of microglia in the neurogenesis of zebrafish retina. Biochem Biophys Res Commun, 2012; 421: 214-220.

六、讲授课程
1.口腔组织病理学
2.病理学
3.病理学实验
七、荣誉和奖励
1.纳米氧化钛颗粒对斑马鱼胚胎和视网膜发育的作用，第十三届“挑战杯”天津市大学生课外学术科技作品竞赛特等奖，优秀指导教师，2015
2.医学与人类健康，大学素质教育优秀通选课，获奖人：李玉皓、刘文、张京玲、王德坤，中国高等教育学会大学素质教育研究分会，2014
3.第九届天津市青年教师教学基本功大赛，优秀奖，2008
八、联系方式
1.通讯地址：300071天津市南开区卫津路94号 南开大学医学院
2.电话：
3. E-mail：liyuhao@nankai.edu.cn