姓名： 杨卓
职称： 教授
教授，博士生导师， 1983年天津医科大学获医学学士学位；1989年浙江大学医学院获医学硕士学位；1998年英国伯明翰大学医学院获博士学位。2003起至今为南开大学教授，从事生理学教学和科研工作。目前每年招收1-2名硕士生及博士生。
一、研究方向：
1围绕神经系统重大疾病，通过相关的动物模型，进行行为学、神经电生理、免疫组化及突触机制等研究。
2纳米材料在中枢神经系统的作用及其机制研究。
3 与肾发育有关的离子通道机制研究。
4海马神经通路的交互作用与神经元突触传递机制的研究。
承担项目：
国家自然科学基金项目，天津市应用基础与前沿技术研究计划重点项目等。
二、近3年主要论文
?Li Zhigui, Hao Shuang, Yin Hongqiang, Gao Jing, Yang Zhuo. Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice. Behavioural Brain Research. 2016; 305:265–277
?Lu Xiao, Chunhua Liu, Xiaoniao Chen, Zhuo Yang. Zinc oxide nanoparticles induce renal toxicity through reactive oxygen species. Food and Chemical Toxicology. 2016; 90:76–83
?Wen Li，Yuen-Ki Cheong，Hui Wang，Guogang Ren，Zhuo Yang. Neuroprotective effects of etidronate and 2,3,3-trisphosphonate against glutamate-induced toxicity in PC12 cells. Neurochem Res.2015; 41:844-854
?Jiajia Yang, Chunxiao Yang, Chunhua Liu, Tao Zhang, and Zhuo Yang, Paradoxical Effects of VEGF on Synaptic Activity Partially Involved in Notch1 Signaling in the Mouse Hippocampus. HIPPOCAMPUS 26:589–600 (2016)
?Wei Miaomiao, Liu Chunhua, Zhang Xiaochen, Chen Xiaoniao, Lin Hongli and Yang Zhuo. Autophagy is involved in regulating VEGF during high-glucose-induced podocyte injury. Mol. BioSyst., 2016, 12, 2202—2212
?Chunhua Liu, Xiaxia Xu, Jing Gao, Tao Zhang, Zhuo Yang. Hydrogen sulfide prevents synaptic plasticity from VD-induced damage via Akt/GSK-3β pathway and Notch signaling pathway in rats. Molecular Neurobiology, 2016; (53):4159–4172
?Xiaochen Zhang, Wen Li, Zhuo Yang. Toxicology of nanosized titanium dioxide: an update. Arch Toxico, 2015; Volume 89 (12): 2207–2217
?Chunhua Liu, Hongqiang Yin, Jing Gao, Xiaxia Xu, Tao Zhang, Zhuo Yang. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. Phytomedicine,2016:1638-1646
? Na Gao, Hui Wang, Xiaochen Zhang & Zhuo Yang. The inhibitory effect of angiotensin II on BKCa channels in podocytes via oxidative stress. Mol Cell Biochem (2015) 398:217–222
? Xuan Qin, Ye Liu, Minghui Zhu, Zhuo Yang, The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress. Behavioural Brain Research, 2015; 290:180–186
? Zhigui Li, Lifeng Wang, Jing Xu & Zhuo Yang.MiRNA expression profile and miRNA–mRNA integrated analysis (MMIA) during podocyte differentiation. Molecular Genetics and Genomics. Mol Genet Genomics, 2015;290:863–875
? Pengjuan Xu, Zhigui Li, Qinjun Xuan, Zhuo Yang.Different expressions of large-conductance Ca2+-activated K+ channels in mouse renal cortex and hippocampus during postnatal development. Applied Immunohistochemistry & Molecular Morphology: 2015;23(2):146-52
? Ye Liu, Chunhua Liu, Xuan Qin, Minghui Zhu, Zhuo Yang. The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6. Behavioural Brain Research, 2015;294:186–193
? Jing Gao, Xiaochen Zhang, Mei Yu, Guogang Ren, Zhuo Yang. Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway. Toxicology 337 (2015): 21–29
? Xiaochen Zhang, Wen Li & Zhuo Yang. Toxicology of nanosized titanium dioxide:an update. Archives of Toxicology. 2015; 89:2207–2217
? Minghui Zhu, Chunhua Liu, Xuan Qin, Zhuo Yang. Hyperforin alleviates mood deficits of adult rats suffered from early separation Neuroscience Letters. 608 (2015): 1–5
? Wei Miaomiao, Li Zhigui, Xiao Lu, Yang Zhuo*. Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury. Molecular Immunology, 2015;68:261–271
? Zhaowei Liu, Jiajia Yang, Xiaochen Zhang, Pengjuan Xu, Tao Zhang, Zhuo Yang.
Developmental Changes in the Expression and Function of TRPC6 Channels Related the F-actin Organization during Differentiation in Podocytes. Cell Calcium, 2015;58:541–548
? Chunhua Liu, Ye Liu, Zhuo Yang. Myocardial infarction induces cognitive impairment by increasing the production of hydrogen peroxide in adult rat hippocampus. Neuroscience Letters.2014; (560): 112-116
? Liu Zhaowei, Xie Yongling, Yang Jiajia & Yang Zhuo. The reduction of EPSC amplitude in CA1 pyramidal neurons by the peroxynitrite donor SIN-1 requires Ca2+ influx Via postsynaptic non-L-type voltage gated calcium channels. Neurochem Res. 2014;39:361-371
? Zhang Junsi, Li Yanna, Xu Jing, Yang Zhuo. The role of N-methyl-D-aspartate receptor in Alzheimer's disease. Journal of the Neurological Sciences. 2014;339:123-129
? Xu Lanju, Xu Jing, Liu Shichang, Yang Zhuo, Induction of apoptosis by antimycin A in differentiated PC12 cell line. Journal of Applied Toxicology. 2014; 651–657
? Miaomiao Wei, Zhigui Li, Zhuo Yang. Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes. Molecular and Cellular Biochemistry. 2014;394(1-2):261-273
? Weiwei Dai, Jiajia Yang, Ting Chen, Zhuo Yang. Protective Effects of Bexarotene against Aβ25-35-Induced Dysfunction in Hippocampal Neurons through Insulin Signaling Pathway. Neurodegenerative Diseases. 2014;14(2):77-84
? Pengjuan Xu, Zhigui Li, Xiaochen Zhang, Zhuo Yang. Increased response to oxidative stress challenge of nano-copper-induced apoptosis in mesangial cells. Journal of Nanoparticle Research, 2014; 16(12):2777,1-13
? Zhigui Li, Jing Xu, Pengjuan Xu, Shichang Liu, Zhuo Yang. Wnt/β-catenin signaling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes. Cell Prolif., 2013, 46, 76–85
三、讲授课程
1． 生理学
2． 专业英语
3． 若干研究生及硕士生课程
四、联系方式
1． 通讯地址：南开大学医学院（八里台校区）313室
2． E-mail：zhuoyang@nankai.edu.cn