姓名： 刘成虎
职称： 副教授
一、教育经历
2003.8-2007.8 ，美国杜克大学博士
1993.9-2000.7, 南开大学临床医学硕士
二、工作经历
2007.8 至今 南开大学医学院副教授
2000.7-2003.7 南开大学医学院讲师
三、研究方向（包括承担课题项目）
1 CD8+T细胞抗肿瘤作用机制研究.
承担课题项目：
1 TLR4在肝癌中的作用,国家自然科学基金
四、近5年发表论文
1. Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.
Chang A, Chen Y, Shen W, Gao R, Zhou W, Yang S, Liu Y, Luo Y, Chuang TH, Sun P, Liu C, Xiang R.
J Infect Dis. 2015 Nov 1;212(9):1509-20. doi: 10.1093/infdis/jiv221.
2.Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53.
Bai N, Zhang C, Liang N, Zhang Z, Chang A, Yin J, Li Z, Luo N, Tan X, Luo N, Luo Y, Xiang R, Li X, Reisfeld RA, Stupack D, Lv D, Liu C.
Cancer Biol Ther. 2013 Jun;14(6):511-20. doi: 10.4161/cbt.24345.
3.ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes.
Zhang C, Bai N, Chang A, Zhang Z, Yin J, Shen W, Tian Y, Xiang R, Liu C.
Cell Mol Immunol. 2013 Jan;10(1):84-94. doi: 10.1038/cmi.2012.57. Epub 2012 Dec 17.
4.Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy.
Lu D, Chen S, Tan X, Li N, Liu C, Li Z, Liu Z, Stupack DG, Reisfeld RA, Xiang R.
Cancer Res. 2012 Jul 15;72(14):3451-6. doi: 10.1158/0008-5472.CAN-11-2536. Epub 2012 May 14.
5.Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma.
Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y, Liu C.
Cancer Biol Ther. 2012 Apr;13(6):435-42. doi: 10.4161/cbt.19295. Epub 2012 Apr 1.
6.TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus.
Zhang CY, Bai N, Zhang ZH, Liang N, Dong L, Xiang R, Liu CH.
Cell Mol Immunol. 2012 Jul;9(4):324-33. doi: 10.1038/cmi.2012.11. Epub 2012 May 28.
7. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell.
Jia X, Li X, Xu Y, Zhang S, Mou W, Liu Y, Liu Y, Lv D, Liu CH, Tan X, Xiang R, Li N.
J Mol Cell Biol. 2011 Aug;3(4):230-8. doi: 10.1093/jmcb/mjr002. Epub 2011 Mar 17.
五、讲授课程
1．人体寄生虫学
2. 肿瘤前沿进展
六、联系方式
1． 通讯地址：天津市南开区卫津路94号
2． 电话：**
3． E-mail： cl45@nankai.edu.cn