姓名： 刘 娜
职称： 副研究员
一、教育经历
1996.9-2001.6 中国药科大学 理学学士
2003.9-2008.5 中国医学科学院协和医科大学 博士学位
二、工作经历
2008-2011 南开大学生科院，讲师
2012-2016 南开大学生科院，副研究员
2013-2014 耶鲁大学，访问****
2016-至今 南开大学医学院，副研究员
三、研究方向：干细胞生物学


(一)研究领域：
1. 胚胎干细胞多能性维持机制
2. 干细胞分化调控机制研究及体内示踪
（二）主持及参与的科研课题：
1.国家自然科学基金：**，Lin28a调控ES细胞na?ve-primed状态转变机制研究，2018.1-2021.12 主持
2.国家自然科学基金：**，印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究，2011.1-2013.12，主持
3.天津市自然科学基金重点项目：14JCZDJC35200，先天性角化不良发病机制探究，2014.3-2017.4，主持
4.中央高校基本科研业务费专项资金：印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究， 2010.6-2012.5，主持
5.国家重点研发计划：不同胚层来源器官损伤后再生细胞命运及调控生理性修复的研究，2017.1-2021.8，参与
6.国家重大科学研究计划：端粒相关蛋白在基因表达调控及细胞分化中的作用，2012.1-2016.8，参与
7.国家重大科学研究计划：猪诱导多能干细胞（iPS）及其分化发育研究，2009.1-2013.8，参与
8.天津市自然科学基金重点项目：端粒相关蛋白在多能性干细胞中的作用及调控，2012.4-2015.3，参与
9.国际合作项目：单细胞技术研究肿瘤干细胞标志和新药研发，2013.1-2016.12，参与
四、学术兼职
1．2010-至今 中国细胞生物学学会 会员
五、发表论文：
第一及通讯作者文章：
[1]Wang D, Sang H, Zhang K, Nie Y, Zhao S, Zhang Y, He N, Wang Y, Xu Y, Xie X, Li Z*, Liu N*. Stat3 phosphorylation is required for embryonic stem cells ground state maintenance in 2i culture media. Oncotarget. 2017; 8(19): 31227-31237. Corresponding Author
[2]Liang L, Yue Z, Du W, Li Y, Tao H, Wang D, Wang R, Huang Z, He N, Xie X, Han Z, Liu N*,Li Z*. Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model. Cell Physiol Biochem. 2017;42(1):407-415. Corresponding Author
[3]Nie Y, Zhang K, Zhang S, Wang D, Han Z, Che Y, Kong D, Zhao Q, Han Z, He ZX, Liu N*,Ma F*, Li Z*.Nitric oxide releasing hydrogel promotes endothelial differentiation of mouse embryonic stem cells.Acta Biomater. 2017; 63:190-199. Corresponding Author
[4]Ningning He,Guowei Feng,Yang Li,Yang Xu,Xiaoyan Xie,Hui Wang,Yuebing Wang,Lailiang Ou, Xuetao Pei,Na Liu*, andZongjin Li*. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7(1):95 Corresponding Author
[5]Na Liu,Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, and Zongjin Li*. Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells.Sci Rep. 2016, 6:28739. First Author
[6]Dan J^#, Liu Y^#,Liu N^#,Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A*, Liu L*. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19.First Author
[7]Yu Yin^#, Na Liu^#,Xiaoying Ye, Renpeng Guo, Jie Hao, Fang Wang, Lin Liu. Telomere elongation in parthenogenetic stem cells. Protein Cell. 2014 5(1):8-11First Author
[8]Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, Xiang R,Liu N*, Liu L*. , Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Current Molecular Medicine, 2014; 14(6):737-48. Corresponding Author
[9]Zhenrong Zhao, Xinghua Pan, Lin Liu* and Na Liu*. Telomee Length Maintenance, Shortening, and Lengthening. J Cell Physiol. 2014; 229(10):1323-9. Corresponding Author
[10]Na Liu,Lin Liu & Xinghua Pan. Single?cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos. Cell. Mol. Life Sci. (2014) 71:2707–2715First Author
[11]Liu N,Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. Genome-wide Gene Expression Profiling Reveals Aberrant MAPK and Wnt Signaling Pathways Associated with Early Parthenogenesis. J Mol Cell Biol. 2010, 2(6):333-344. First Author
[12]Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition.J Cell Biochem. 2009, 106(6):1041-1047.First Author
[13]Liu N, Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of Genes Regulated by Nanog Which Is Involved In ES Cells Pluripotency and Early Differentiation. J Cell Biochem.2008, 104(6):2348-2362.First Author
[14]Liu N, Lu M, Tian X, Han Z.Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007, 211(2):279-286.First Author
[15]Liu N,Lu M. The signal transduction pathways and molecules for ES cells self-renewal, Chinese Science Bulletin. 2005, 50(8):721-726.First Author
非第一或通讯作者文章
[16]He N, Chen X, Wang D, Xu K, Wu L, Liu Y, Tao H, Zhao Q, Cao X, Li Y, Liu N, Qi X, Han Z, Kong D, Yang J, Li Z. VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway.Biomaterials. 2017 Dec 16;158:34-43.
[17]Liu Y, Song B, Wei Y, Chen F, Chi Y, Fan H, Liu N, Li Z, Han Z, Ma F.Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway.Cytotherapy. 2017 Dec 18. pii: S1465-3249(17)30733-8.
[18]Wang R, Zhang K, Tao H, Du W, Wang D, Huang Z, Zhou M, Xu Y, Wang Y, Liu N, Wang H, Li Z. Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence. Curr Pharm Biotechnol. 2017;18(5):422-428.
[19]Du W, Zhang K, Zhang S, Wang R, Nie Y, Tao H, Han Z, Liang L, Wang D, Liu J, Liu N,Han Z, Kong D, Zhao Q, Li Z. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017 Jul;133:70-81.
[20]Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, Fan N, Liu N,Ye X, Fu H, Zhou Z, Wang Y, Wei H, Liu Z, Li Z, Lai L, Wang X, Liu L. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS One. 2017 Mar 2;12(3):e**.
[21]Song X, Liu D, Cui J, Zhou M, Wang H, Liu N,Qi X, Li Z. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells Int. 2016;2016:**.
[22]Guowei Feng, Jimin Zhang, Yang Li, Yan Nie, Dashuai Zhu, Ran Wang, Jianfeng Liu, Jie Gao, Na Liu,Ningning He, Wei Du, Hongyan Tao, Yongzhe Che, Yong Xu, Deling Kong, Qiang Zhao, andZongjin Li*. IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI.J Am Soc Nephrol. 2016, 27(8):2357-69.
[23]Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N,Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015, 6(2):152-6.
[24]Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells.Cell Res. 2013, 23(1):162-6.
[25]Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N,Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey.Stem Cells. 2013 31(11):2538-50.
[26]Ji G, Liu K, Okuka M, Liu N,Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012 Dec 15; 13:36.
[27]Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J, Liu N,Liu L. Influences of lamin A levels on induction of pluripotent stem cells. Biol Open. 2012, 1(11):1118-27.
[28]Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N,Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res.2012, 97(2):208-18.
[29]Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N,Tang X, Baltz JM, Keefe DL, Liu L.Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction. 2012; 27(5): 1411-1420.
[30]Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N,Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell Research. 2012; 22(4): 757-768.
[31]Huang J, Wang F, Okuka M, Liu N,Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L*. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research. 2011, 21(5):779-92.
[32]Fang ZH, Dong CL, Chen Z, Zhou B, Liu N,Lan HF, Liang L, Liao WB, Zhang L, Han ZC. Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.J Cell Mol Med. 2009 13(8B):2039-52.
[33]Feng XM,Liu N,Yang SG, Hu LY, Chen XL, Fang ZH, Ren Q, Lu SH, Liu B, Han ZC.Regulation of the classⅡand classⅠMHC pathways in human THP-1 monocytic cells by interleukin-27. Biochem Biophys Res Commun. 2008 14;367(3):553-9.
[34]Feng XM, Chen XL, Liu N,Chen Z, Zhou YL, Han ZB, Zhang L, Han ZC.Interleukin-27 upregulates major histocompatibility complex class Ⅱexpression in primary human endoghelial cells through induction of major histocompatibility complex class Ⅱtrasactivator. Hum Immunol. 2007 68(12):965-72.
Books and Chapters:
[1]Yin Y, Liu N,Keefe D, and Liu L.Parthenogenetic activation-induced pluripotent stem cells and potential applications. Stem Cells and Cancer Stem Cells. Volume 8. Hayat, MA (edt.) Springer, 2012, 235-246.
[2]Yan Nie, Shuaiqiang Zhang, Na Liu,Zongjin Li, Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine.Composition and Function of the Extracellular Matrix in the Human Body. INTECH, 2016

六、讲授课程
1．细胞生物学
2．干细胞与再生医学


七、荣誉和奖励
1．2012年南开大学教学成果奖 二等奖
2．2016年南开大学青年教师教学基本功竞赛 二等奖
3．2016年天津市青年教师教学基本功竞赛 三等奖

八、联系方式
1． 通讯地址：天津市卫津路94号南开大学医学院304
2． 电话：
3．E-mail：liuna@nankai.edu.cn