刘娜
性 别：女
职 称：副研究员
所属部门：遗传学和细胞生物学系
招生专业：细胞生物学
研究方向：干细胞与发育生物学

::教师简介::
刘娜: 女，副研究员。2001年毕业于中国药科大学药理学专业，并获得理学学士学位。2003年考入中国医学科学院北京协和医学院，2008年毕业并取得博士学位。博士学位课题为Nanog在ES细胞自我更新中的作用机制研究。2008年进入南开大学生命科学学院任教，主要从事ES细胞、孤雌ES细胞等多能性干细胞的多能性维持机制研究、印记基因在ES细胞及早期胚胎分化发育中作用机制研究、以及胚胎干细胞多能性与端粒长度、端粒酶活性之间的关系研究等。目前主持自然科学基金一项，参与国家重大研究计划两项。先后于Journal of Cellular Biochemistry、Journal of Cellular Physiology、Journal of Molecular Cell Biology等杂志发表第一作者SCI文章五篇，已发表的文章被引用六十多次。联系方式：liuna@nankai.edu.cn**1.Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A*, Liu L*. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19. First Author2.Yu Yin, Na Liu, Xiaoying Ye, Renpeng Guo, Jie Hao, Fang Wang, Lin Liu. Telomere elongation in parthenogenetic stem cells. Protein Cell. 2014 5(1):8-11 First Author3.Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, Xiang R, Liu N*, Liu L*. , Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Current Molecular Medicine, 2014;14(6):737-48. Corresponding Author4.Zhenrong Zhao, Xinghua Pan, Lin Liu* and Na Liu*. Telomere Length Maintenance, Shortening, and Lengthening. J Cell Physiol. 2013 Dec 20. doi: 10.1002/jcp.24537. [Epub ahead of print] Corresponding Author5.Na Liu, Lin Liu & Xinghua Pan. Single cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos. Cell. Mol. Life Sci. (2014) 71:2707–2715 First Author6.Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. Genome-wide Gene Expression Profiling Reveals Aberrant MAPK and Wnt Signaling Pathways Associated with Early Parthenogenesis. J Mol Cell Biol. 2010, 2(6):333-344. First Author7.Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition. J Cell Biochem. 2009, 106(6):1041-1047. First Author8.Liu N, Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of Genes Regulated by Nanog Which Is Involved In ES Cells Pluripotency and Early Differentiation. J Cell Biochem. 2008, 104(6):2348-2362. First Author9.Liu N, Lu M, Tian X, Han Z. Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007, 211(2):279-286. First Author10.Liu N, Lu M. The signal transduction pathways and molecules for ES cells self-renewal，Chinese Science Bulletin. 2005, 50(8):721-726. First Author11.Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013, 23(1):162-6.12.Yin Y, Liu N, Keefe D, and Liu L. Parthenogenetic activation-induced pluripotent stem cells and potential applications. Stem Cells and Cancer Stem Cells. Volume 8. Hayat, MA (edt.) Springer, 2012, 235-246.13.Ji G, Liu K, Okuka M, Liu N, Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012 Dec 15; 13:36.14.Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J, Liu N, Liu L. Influences of lamin A levels on induction of pluripotent stem cells. Biol Open. 2012, 1(11):1118-27.15.Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2012, 97(2):208-18. 16.Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L. Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction. 2012; 27(5): 1411-1420.17.Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Research. 2012; 22(4): 757-768.18.Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L*. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research. 2011, 21(5):779-92.19.Fang ZH, Dong CL, Chen Z, Zhou B, Liu N, Lan HF, Liang L, Liao WB, Zhang L, Han ZC. Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy. J Cell Mol Med. 2009 13(8B):2039-52. 20.Feng XM, Liu N, Yang SG, Hu LY, Chen XL, Fang ZH, Ren Q, Lu SH, Liu B, Han ZC. Regulation of the classⅡ and classⅠMHC pathways in human THP-1 monocytic cells by interleukin-27. Biochem Biophys Res Commun. 2008 14;367(3):553-9.21.Feng XM, Chen XL, Liu N, Chen Z, Zhou YL, Han ZB, Zhang L, Han ZC. Interleukin-27 upregulates major histocompatibility complex class Ⅱ expression in primary human endoghelial cells through induction of major histocompatibility complex class Ⅱ trasactivator. Hum Immunol. 2007 68(12):965-72.
::主要学术论文::


::主要科研项目::