姓　　名
苏循成 性　　别
男
出生年月
1972-08 籍　　贯
山东临沂莒南县
学　　历
博士毕业院校
南开大学
职　　称
教授管理职务

学科专业
化学生物学 系所单位
元素有机化学研究所
特殊人才称号

通讯地址
南开大学元素有机化学研究所
电话
**
电子邮件
xunchengsu@nankai.edu.cn
课题组网站

研究领域
本课题组主要从事化学生物学和生物有机化学合成研究。目前主要从事的研究方向有：
1.功能有机小分子探针设计、合成
2.蛋白质标记化学反应性和选择性
2.基于结构片段的蛋白药物设计和技术改进
3.生物大分子结构、功能与其分子动态间的关系
4.蛋白质无细胞合成
招生学科：有机化学、化学生物学
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教育及科研经历
2001年毕业于南开大学化学系获得博士学位（物理化学专业）
2001.8-2004.6 佛罗伦萨大学欧盟磁共振中心博士后(with Professor Ivano Bertini)
2004.8-2006.12 澳大利亚国立大学博士后(with Professor Gottfried Otting)
2006.12-2010.9 澳大利亚国立大学研究员
2010年9月到南开大学元素有机研究所组建独立课题组，从事化学生物学、结构生物学和有机合成化学研究。H-index 21.

在研项目：
1.国家自然科学基金“用于结构生物学和药物研发的蛋白质顺磁标记”（**，36万）
2. 国家自然科学基金“位点特异标记稀土金属离子在蛋白质构象分析中的应用”（**，80万）
3. 973国家“蛋白质研究”重大科学研究计划“蛋白质动态学研究的新技术新方法”（2013CB910200，230万）
荣誉和奖励
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科研成果与代表作
已发表论文50余篇，其中包括Immunity, Acc. Chem. Res., Proc. Natl. Acad. Sci. USA, J. Am. Chem. Soc., Nucl. Acids Res., J. Biol. Chem., J. Mol. Biol. 和 PLoS Neg.l Trop Dis. 等国际期刊. H-index 22.
16. Yang, Y.; Li, Q.F.;, Cao, C.; Huang, F.; Su, X.C.(2013) Site-specific labeling of proteins with a chemically stable, high-affinity tag for protein study. Eur. J. Chem. 19, 1097-1103.
15. Li, Q.F.; Yang, Y.; Maleckis, A.; Otting, G.; Su, X.C. (2012) Thiol-ene reaction: a versatile tool in site-specific labelling proteins with chemically inert tags for paramagnetic NMR. Chem. Commn. 48, 2704-2706.
14. Su, X.C., and Otting, G. (2010) Paramagnetic labelling of proteins and oligonucleotides for NMR. J. Biomol. NMR 46, 101-112.
13. Su, X.C., Ozawa, K., Qi, R., Vasudevan, S.G., Lim, P.L., and Otting, G. (2009) NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease. PLoS Negl. Trop. Dis. 3, e561.
12. Su, X.C., Liang, H., Loscha, K.V., and Otting, G. (2009) [Ln(DPA)3]3- is a convenient paramagnetic shift reagent for protein NMR studies. J. Am. Chem. Soc. 131, 10352-10353.
11. Ekonomiuk, D., Su, X.C., Ozawa, K., Bodenreider, C., Lim, S.P., Otting, G., Huang, D., and Caflisch, A. (2009) Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics J. Med. Chem. 52, 4860-4868.
10. Su, X.C., Ozawa, K., Yagi, J., Lim, S.P., Wen, D., Ekonomiuk, D., Huang, D., Keller, T.H., Sonntag, S., Caflisch, A., Vasudevan, S.G., and Otting, G. (2009) NMR study of complexes between low-molecular weight inhibitors and the West Nile virus NS2B-NS3 protease. FEBS J. 276, 4244-4255.
9. Su, X.C., Man, B., Beeren, S., Liang, H., Simonsen, S., Schmitz, C., Huber, T., Messerle, B.A., and Otting, G. (2008) A dipicolinic acid tag for rigid lanthanide tagging of proteins and paramagnetic NMR spectroscopy. J. Am. Chem. Soc. 130, 10486-10487.
8. Su, X.C., McAndrew, K., Huber, T., and Otting, G. (2008) Lanthanide-binding peptides for NMR measurements of residual dipolar couplings and paramagnetic effects from multiple angles. J. Am. Chem. Soc. 130, 1681-1687.
7. Su, X.C., Jergic, S., Keniry, M.A., Dixon, N.E., and Otting, G. (2007) Solution Structure of Domain V of the ? Subunit from Escherichia coli DNA Polymerase III and Interaction with the α Subunit. Nucl. Acids Res. 35, 2825-2832
6. Su, X.C, Jergic, S., Ozawa, K., Burns, N.D., Dixon, N.E., and Otting, G. (2007) Measurement of dissociation constants in high-molecular weight protein-protein complexes by transferred 15N-relaxation. J. Biomol. NMR 38, 65-72.
5. Pintacuda, G., John, M., Su, X.C., and Otting, G. (2007) NMR Structure determination of protein-ligand complexes by lanthanide labeling. Acc. Chem. Res. 40, 206-212.
4. Su, X.C., Schaeffer, P.M., Loscha, K.V., Gan, P.M., Dixon, N.E., and Otting, G. (2006) Monomeric solution structure of the helicase-binding domain of Escherichia coli DnaG primase. FEBS J. 273, 4997-5009.
3. Su, X.C., Huber, T., Dixon, N.E., and Otting, G. (2006) Site-specific labelling of proteins with a rigid lanthanide binding tag. ChemBioChem 7, 1599-1604.
2. Banci, L., Bertini, I., Ciofi-Baffoni, S., Kandias, N.G., Robinson, N.J., Spyroulias, G.A., Su, X.C., Tottey, S., and Vanarotti, M. (2006) The delivery of copper for thylakoid import observed by NMR. Proc. Natl. Acad. Sci. USA 103, 8320-8325.
1. Banci, L., Bertini, I., Ciofi-Baffoni, S., Su, X.C., Miras, R., Bal, N., Mintz, E., Catty, P., Shokes, J.E., and Scott, R.A. (2006) Structural basis for metal binding specificity: the N-terminal cadmium binding domain of the P1-type ATPase CadA. J. Mol. Biol. 356, 638-650.
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人才培养
本课题组有在读博士3名，在读硕士9名，研究助理1名
博士：杨茵， 陈家良， 曹婵
硕士：裴莹莹，左会会，王金涛，刘洪开，马飞贺，张琳琳，候萌萌，杨峰，赵宇
已毕业学生：魏珍，李庆锋，黄凤
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