姓　　名
周传政 性　　别
男
出生年月
1978 籍　　贯
湖北省枝江市
学　　历
博士毕业院校
瑞典乌普萨拉大学
职　　称
研究员管理职务

学科专业
化学生物学 系所单位
元素有机化学研究所
特殊人才称号
国家青年千人
通讯地址
天津市卫津路94号南开大学化学理化楼320室
电话
**
电子邮件
chuanzheng.zhou@nankai.edu.cn
课题组网站

研究领域
化学生物学
药物化学
有机化学

教育及科研经历
2010-2014 美国约翰霍普金斯大学，博士后 (With Marc M. Greenberg)
2004-2010 瑞典乌普萨拉大学，获得生物有机化学博士学位，导师：Jyoti Chattopadhyaya
2001-2004 南开大学，获得有机化学硕士学位，导师：席真 教授
1997-2001 南开大学，获得理学学士学位，导师：杨华铮 教授
荣誉和奖励
2009 国家优秀自费留学生奖学金
2015 国家“青年****”

科研成果与代表作
1. Weng, L.; Zhou, C.; Greenberg, M.M. “Probing Interactions Between Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis” ACS Chem. Biol. 2015, 10, 620-630. [Featured in Chemical Research in Toxicology Spotlights: Chem. Res. Toxicol. 2015, 28, 2?3]
2. Zhou, C. and Greenberg, M. M.“DNA Damage by Histone Radicals in Nucleosome Core Particles” J. Am. Chem. Soc. 2014, 136, 6562-6565.
3. Zhou, C. and Chattopadhyaya J. (2013) “Challenges in the Chemistry of Small Interfering RNA as Potential Therapeutics to Inhibit Cellular mRNA Expression” In Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering; Reedijk, J. (Ed.) Elsevier: Waltham, MA; 11-Sep-13 doi: 10.1016/B978-0-12-409547-2.05337-3.
4. Zhou, C., Sczepanski, J. T. and Greenberg, M. M. “Histone modification vis rapid cleavage of C4’-oxidized abasic sites in nucleosome core particles” J. Am. Chem. Soc. 2013, 135, 5274-5277. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2013, 135, 5933]
5. Sczepanski, J. T., Zhou, C. and Greenberg, M. M. “Nucleosome core particle catalyzed strand scission at abasic sties” Biochemistry, 2013, 52, 2157–2164.
6. Zhou, C, Sczepanski, J. T. and Greenberg, M. M. “Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles” J. Am. Chem. Soc. 2012, 134, 16734-16741.
7. Zhou, C and Greenberg, M. M. “Histone catalyzed cleavage of nucleosomal DNA containing 2-deoxyrionolactone” J. Am. Chem. Soc. 2012, 134, 8090?8093. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2012, 134, 9021]
8. Zhou, C. and Chattopadhyaya, J. “Intramolecular Free-Radical Cyclization Reactions on Pentose-Sugars for Synthesis of carba-LNA and carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics” Chem. Rev. 2012, 112, 3808-3832.
9. Zhou, C. and Chattopadhyaya, J.“Why carba-LNA Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to that of the LNA Modified or the Native Counterparts : A Michaelis-Menten Kinetic Analysis” J. Org. Chem. 2010, 75, 2341-2349.
10. Zhou, C. and Chattopadhyaya, J.“The synthesis of therapeutic locked nucleos(t)ides” Curr. Opin. Drug Discov. Devel. 2009, 12, 876-898.
11. Zhou, C.; Plashkevych, O.; Chattopadhyaya, J. “Double Sugar and Phosphate Backbone-constrained Nucleotides: Synthesis, Structure, Stability and Their Incorporation into Oligodeoxynucleotides” J. Org. Chem. 2009, 74, 3248-3265. [JOC Featured Article]
12. Zhou, C.; Liu, Y.; Andaloussi, M.; Badgujar, N.; Plashkevych, O.; Chattopadhyaya, J. “Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′, 4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties” J. Org. Chem. 2009, 74, 118-134.
人才培养
在读博士生4名
硕士生5名