姓　　名
王宝雷 性　　别
男
出生年月
1976-08 籍　　贯
安徽宿县砀山县
学　　历
硕士毕业院校
南开大学
职　　称
副研究员管理职务

学科专业
有机化学 系所单位
元素有机化学研究所
特殊人才称号

通讯地址
天津市卫津路94号南开大学元素有机化学研究所
电话
**
电子邮件
nkwbl@nankai.edu.cn
课题组网站

研究领域
具有生物活性物质的分子设计、合成与构效关系

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教育及科研经历
2001年毕业于新疆大学化学与化工学院，获有机化学硕士学位，并于同年考入南开大学化学学院元素有机化学研究所攻读农药学专业博士学位，师从李正名院士。2004年7月博士毕业留校任教。在李正名院士的领导下参加了美国DOW公司的合作研发项目，国家“863”、“973”计划项目，以及中澳国际合作项目，国家自然科学（重点）基金等课题的研究工作。先后承担教育部博士点基金1项，天津市自然科学基金1项，国家自然科学基金课题1项等。从事具有生物活性物质的分子设计、合成与构效关系的研究工作，并协助李正名院士指导研究生毕业论文以及课题组的部分管理工作。承担本科生《有机化学》、《有机化学实验》课程教学任务。已发表论文50余篇，授权专利1项。

荣誉和奖励

科研成果与代表作
部分文章如下：

[16] Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483–491.
[15] Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, Insecticidal Activities, and SAR Studies of Novel Pyridylpyrazole Acid Derivatives Based on Amide Bridge Modification of Anthranilic Diamide Insecticides. J. Agric. Food Chem., 2013, 61: 5483?5493.
[14] Zhang, Ji-Feng ; Liu, Chen; Ma, Yi; Wang, Bao-Lei*; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming*. Synthesis of Novel 3-Chloropyridin-2-yl-Pyrazole Derivatives and their Insecticidal, Fungicidal Activities and QSAR Study. LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10(6): 497-506.
[13] Wang Baolei, Ma Yi, Xiong Lixia, Li Zhengming. Synthesis and Insecticidal Activity of Novel N-Pyridylpyrazole Carbonyl Thioureas. Chin. J. Chem., 2012, 30: 815-821.
[12] Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea. J. Agric. Food Chem., 2012, 60: 7565-7572.
[11] Wang Bao-Lei, Liu Xing-Hai, Zhang Xiu-Lan, Zhang Ji-Feng, Song Hai-Bin, Li Zheng-Ming*. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety. Chem. Biol. Drug Des., 2011, 78: 42-49.
[10] Wang, B. L.; Shi, Y. X.; Ma, Y.; Liu, X. H.; Li, Y. H.; Song, H. B.; Li, B. J.; Li, Z. M., Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. Journal of Agricultural and Food Chemistry 2010, 58(9): 5515-5522.
[9] Wang, B. L.; Ma, R. D.; Li, Y. H.; Song, H. B.; Li, Z. M. Synthesis, Structure and Biological Activity of 2- 4-(5-Substituted-1,3,4-oxadiazol-2-yl)phenoxy Propanoate/Acetate. Chinese Journal of Organic Chemistry 2010, 30(1): 92-97.
[8] Wang, B. L.; Liu, X. H.; Li, Z. M., Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro- 1-arylaminoethyl) Phosphoramidothioates. Phosphorus Sulfur and Silicon and the Related Elements 2009, 184(9): 2281-2287.
[7] Bao-Lei Wang, Yong-Hong Li, Jian-Guo Wang, Yi Ma, Zheng-Ming Li. Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors. Chin. Chem. Letts., 2008, 19: 651-654
[6] WANG Bao-Lei, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles. Chem. J. Chin. U., 2008, 29(1): 90-94
[5] Bao-Lei Wang, Zheng-Ming Li, Yong-Hong Li, Su-Hua Wang. Syntheses and biological activities of ethyl N-
hydroxy-N-(substituted)phenyloxamates as KARI inhibitors. Chem. Res. Chin. U., 2007, 23(3): 280-283
[4] Bao-Lei Wang, Ronald G Duggleby, Zheng-Ming Li, Jian-Guo Wang, Yong-Hong Li, Su-Hua Wang, Hai-Bin Song.
Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction. Pest Management Science, 2005, 61: 407-412
[3] WANG Bao-Lei, WANG Jian-Guo, MA Yi, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Molecular Docking and 3D-QSAR Research of Amidines of KARI Inhibitor. Acta Chimica Sinica, 2006, 64(13): 1373-1378
[2] WANG Bao-Lei, LI Zheng-Ming, MA Yi, WANG Jian-Guo, LUO Xiao-Min, ZUO Zhi-Li. 3D-Database Searching Based on the Crystal Structure of Ketol-acid Reductoisomerase (KARI) Complex. Chin. J. Org. Chem., 2004, 24(8): 973-976
[1] Wang Bao-Lei, Ma Ning, Wang Jian-Guo, Ma Yi, Li Zheng-Ming, Li Yong-Hong. 3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity. Acta Physico-chimica Sinica, 2004, 20(6): 577-581

部分授权专利如下：
[1] 李正名, 王宝雷, 张吉凤, 徐俊英, 熊丽霞, 赵毓, 王刚. 吡唑甲酰基硫脲衍生物与制备方法和应用. 中国发明专利, 申请号: **5.7, 申请日: 2011年06月02日; 授权号: ZL **5.7, 授权日: 2013年11月06日.

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人才培养
指导硕士生，并协助李正名院士指导硕博士生，已毕业8人。