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电话：一五八零二九二八七零三
地址：陕西省西安市雁塔西路76号，西安交通大学雁塔校区生化楼333
陕西省西安市长安区高桥街道，西安交通大学创新港校区19号楼19-4123
Email: silongxu@mail.xjtu.edu.cn
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Main page - 徐 四龙基本信息
Welcome to
The Silong Group
News of group
Contact information
电话：一五八零二九二八七零三
地址：陕西省西安市雁塔西路76号，西安交通大学雁塔校区生化楼333
陕西省西安市长安区高桥街道，西安交通大学创新港校区19号楼19-4123
Email: silongxu@mail.xjtu.edu.cn
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Prof. Silong - 徐 四龙Photos
Dr. Prof.Silong Xu(徐四龙)
With Prof. Zhengjie He (Nankai)
With Prof. Maimone (UC Berkeley)
Biographical Sketch
Silong Xu was born (1982) in the Hengnan county of Hunan province, China. He began undergraduate studies at the Hunan Normal University where he obtained his B.S. degree in chemistry in 2004. After working for two years as a middle school teacher, he joined the research group of Prof. Zhengjie He at Nankai University, Tianjin, China, where he obtained his MSc (2009) and PhD (2012) in Organic Chemistry. In July 2012, Silong moved to Xi’an Jiaotong University employed as a Lecturer. In December 2014, he was promoted to be an associated professor in the Department of Chemistry. During 2015.08-2016.08, he worked as a visiting scientist in the lab of Prof. Maimone at UC Berkeley, doing research in total synthesis of natural products.In January 2020, Silong was promoted as a full professor. He alsoacts as avice director in theDepartment of Chemistry,and anassistant dean of the School of Science.
Education and Positions
Since 2020.1 Professor,Doctoral Supervisor,at Xi’an Jiaotong University, China.
2015.8 - 2016.8 Visiting Scholar, at UC-Berkeley, USA
2014.12-2019.12 Associate Professor, at Xi’an Jiaotong University, China.
2012.7-2014.11 Lecturer & Post-doc, at Xi’an Jiaotong University, China.
2009.9-2012.6 Ph.D. in Organic Chemistry, at Nankai University, China.
2006.9-2009.7 M.S. in Organic Chemistry, at Nankai University, China.
2004.9-2006.7 Teacher, at No. 1 Middle School of Hengnan, China.
2000.9-2004.7 B.S. in Chemistry, at Hunan Normal University, China.
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2020.1-今 教授、博士生导师，西安交通大学化学学院（原理学院化学系）
2015.8-2016.8访问****，加州大学-伯克利分校
2014.12-2019.12 副教授、西安交通大学理学院化学系
2012.6-2014.11 讲师，西安交通大学理学院化学系
2006.9-2012.7 硕士、博士，南开大学化学学院，元素有机化学国家重点实验室，有机化学专业；
2004.9-2006.7 衡南一中，化学教师
2000.9-2004.7 本科，湖南师范大学化学化工学院，应用化学专业
Honors
Thieme Chemistry Journals Award, 2019
Outstanding PHD Graduates of Nankai University, 2012
Academic Star of Graduate Students at Nankai University, 2011
First-Class Scholarship of Nankai University, 2010
Excellence Scholarship of Nankai University, 2009
Contact
Department of Chemistry,SchoolofScience
Xi’anJiaotongUniversity
No.28,Xianning West Road,Xi'an,China, 710049
Tel: +86-
Email:silongxu@mail.xjtu.edu.cn
Home Page:http://gr.xjtu.edu.cn/web/silongxu
Research - 徐 四龙Research
The Silong Research Group is interested insynthetic organic chemistry focusing on the development of new synthetic methodology and total synthesis of natural products and pharmaceuticals.
Research Topics
l Phosphine-mediated transformations
l Lewis base catalysis for cyclopropane ring opening
l C-H activation via transition metal catalysis
l Total synthesis of complex bioactive natural product targets
Current research project
没有找到条目。
项目编号项目名称项目来源起讫时间承担角色项目类别
xzy 新冠状病毒肺炎药物Remdesivir(瑞德西韦)的高效合成方法研究 中央高校基本科研业务费专项资金 2020-1~ 负责人 纵向项目
超高弹性PBX粘结剂的合成 中国工程物理研究院化工材料研究所 2020-1~ 负责人 横向项目
** Lewis碱催化贫电子环丙烷的开环串联反应及在5/7/6环系紫杉烷二萜天然产物合成中的应用 国家自然科学基金项目 2019-1~ 负责人 纵向项目
** 高氮炸药TKX-50的光解反应的机理研究 中国工程物理研究院化工材料研究所 2019-1~ 负责人 横向项目
xjh 天然产物Taxchinin A的全合成及其抗肿瘤活性研究 中央高校基本科研业务费专项资金 2019-1~ 负责人 纵向项目
** 有机中间体合成工艺成果转化 西安宇特邦新材料科技有限公司 2018-1~ 负责人 横向项目
** 叔膦催化缺电子乙烯基环丙烷的环化反应研究 国家自然科学基金项目 2015-1~ 负责人 纵向项目
2015T81013 磷、氮路易斯碱催化缺电子乙烯基环丙烷的开环反应研究 中国博士后科学基金特别资助 2015-1~ 负责人 纵向项目
2014M550484 磷叶立德参与的有机合成串联新反应研究。 中国博士后科学基金面上项目一等 2014-5~ 负责人 纵向项目
NA 缺电子偶氮与磷叶立德的有机合成反应研究 陕西省博士后科学基金面上项目二等 2014-10~ 负责人 纵向项目
xjj** 有机小分子催化在手性药物合成中的应用研究 中央高校基本科研业务费专项资金 2013-1~ 负责人 纵向项目
xjtu 叔膦、叔胺催化的新的环化反应探索 西安交通大学“新教师科研支持计划”基金 2012-10~ 负责人 纵向项目
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Publications - 徐 四龙Publications@XJTU
37.Tang J.;Tang Y.; Wang X.; Wang Y.;Huang X.; Xu S.;Li Y.*,Regioselective cascade annulation of indoles with alkynediones for construction of functionalized tetrahydrocarbazoles triggered by Cp*RhIII-catalyzed C–H activation.Org. Chem. Front., 2021,DOI:10.1039/d1qo00616a.
36.Yan T.;Kaki, R. B.;Wu Y.;Li Y.;Tang Y.;Xu S.*,Phosphine-Catalyzed Cross-Coupling of Benzyl Halides and Fumarates.Org. Lett.2021,doi: 10.1021/acs.orglett.1c01214.
35.Han W.; Li Y.; Kaki, R. B.; Li J.; Tang Y.; Wu Y.*; Xu S.*, Catalyst-Free [3 + 3] Annulation/Oxidation of Cyclic Amidines with Activated Olefins: When the Substrate Olefin Is Also an Oxidant. J. Org. Chem. 2021, doi: 10.1021/acs.joc.1c00717.
33. Kaki, R. B.; Han, W.; Chen, J.-B.; Li, Y.; Tang, Y.; Zhang, W.; Xu, W.*; Xu, S.*, Three-Component Reaction of Phosphorus Ylides with Isocyanates: Facile Synthesis of 2-Amino-3-Carboxylate-4-Quinolones. Chem. Commun. 2020, 56, 5909-5912.
32. Kaki, R. B; He, X.;Xu, S.*, Lewis Base Catalysis Based on Homoconjugate Addition: Rearrangement of Electron-Deficient Cyclopropanes and Their Derivatives.Synlett2020,31(02), 117-124.
31. He, X.; Tang, Y.; Wang, Y.; Chen, J.-B.; Xu, S.*; Dou, J.; Li, Y.*, Phosphine-Catalyzed Activation of Alkylidenecyclopropanes: Rearrangement to Form Polysubstituted Furans and Dienones. Angew. Chem., Int. Ed. 2019, 58 (31), 10698-10702.
30. Li, Y.*; Shi, D.; He, X.; Wang, Y.; Tang, Y.; Zhang, J.; Xu, S.*, Redox-Neutral Annulation of Alkynylcyclopropanes with N-aryloxyamides via Rhodium(III)-Catalyzed Sequential C?H/C?C Activation. J. Org. Chem. 2019,84 (3),1588-1595.
29. Wei, W.; Tang, Y.; Zhou, Y.; Deng, G.; Liu, Z.; Wu, J.; Li, Y.; Zhang, J.; Xu, S.*, Recycling Catalyst as Reactant: A Sustainable Strategy To Improve Atom Efficiency of Organocatalytic Tandem Reactions. Org. Lett. 2018, 20 (20), 6559-6563.[PDF]
28. Li, Y.*;Xu, S.*, Transition Metal-Catalyzed C?H Functionalization for Construction of Quaternary Carbon Centers.Chem. Eur. J.2018, 24 (61), 16218-16245.[PDF]
27. Li, Y.*; Shi, D.; Tang, Y.; He, X.;Xu, S.*Rhodium(III)-Catalyzed Redox-Neutral C?H Activation/Annulation of N-Aryloxyacetamides with Alkynyloxiranes: Synthesis of Highly Functionalized 2,3-Dihydrobenzofurans.J. Org. Chem.2018, 83 (16), 9464-9470.[PDF]
26. Wu, J.; Tang, Y.; Wei, W.; Wu, Y.; Li, Y.; Zhang, J.; Zheng, Y.; Xu, S.*, Phosphine-Catalyzed Activation of Vinylcyclopropanes: Rearrangement of Vinylcyclopropylketones to Cycloheptenones. Angew. Chem. Int. Ed. 2018, 57 (21), 6284-6288.[PDF]
25. Wu, J.; Zhang, J.-Y.; Gao, P.; Xu, S.; Guo, L.-N., Copper-Catalyzed Redox-Neutral Cyanoalkylarylation of Activated Alkenes with Cyclobutanone Oxime Esters. J. Org. Chem. 2018, 83 (2), 1046-1055.[PDF]
24.Zhang, J.; Tang, Y.; Wei, W.; Wu, Y.; Li, Y.; Zhang, J.; Zheng, Y.; Xu, S.*, An Organocatalytic Cloke?Wilson Rearrangement: DABCO-Catalyzed Ring Expansion of Cyclopropyl Ketones to 2,3-Dihydrofurans. Org. Lett. 2017, 19(12), 3043-3046.[PDF]
23. Li, Y.*; Tang, Y.; He, X.; Shi, D.; Wu, J.;Xu, S.*, Rhodium(III)-Catalyzed Annulative Carbooxygenation of 1,1-Disubstituted Alkenes Triggered by C?H Activation.Chem. Eur. J.2017, 23(31), 7453-7457.[PDF]
22.Hu, X.;Xu, S.; Maimone, T. J., A Double Allylation Strategy for Gram-Scale Guaianolide Production: Total Synthesis of (+)-Mikanokryptin.Angew. Chem. Int. Ed.2017,56(6), 1624-1628.[PDF]
21.Xu, S.*; Chen, J.; Shang, J.; Qing Z.; Zhang, J.; Tang Y.*,Divergent Amine-Catalyzed [2+2] Annulation of Allenoates with Azodicarboxylates: Facile Synthesis of 1,2-Diazetidines.Tetrahedron Lett.2015,56(46), 6456–6459.[PDF]
20.Chen, R.;Xu, S.*; Fan, X.; Li, H.; Tang, Y.; He, Z.*, Construction of Dispirocyclohexanes via Amine-Catalyzed [2 + 2 + 2] Annulations of Morita-Baylis-Hillman Acetates with Exocyclic Alkenes.Org. Biomol. Chem.2015,13(2), 398-408.[PDF]
19.Xu, S.*; Zhu, S.; Shang, J.; Zhang, J.; Tang, Y.; Dou, J.*, Catalyst-Free Synthesis of Skipped Dienes from Phosphorus Ylides, Allylic Carbonates, and Aldehydes via a One-Pot SN2' Allylation-Wittig Strategy.J. Org. Chem.2014,79(8), 3696-3703.[PDF]
18.Xu, S.; Wang, L.; Tang, Y.; He, Z., Ethoxide-Mediated Condensation of γ-tert-Butylallenoate and Aldehydes: Facile Stereoselective Synthesis of Conjugated Dienes and Enynes.Synthesis2014,46(15), 2085-2092. [PDF]
17.Xu, S.*; Tang, Y.*, Catalytic Approaches to Stoichiometric Phosphine-Mediated Organic Reactions.Lett. Org. Chem.2014,11(7), 524-533. [PDF]
16.Xu, S.*; Shang, J.; Zhang, J.; Tang, Y.*, Regioselective SN2' Mitsunobu reaction of Morita–Baylis–Hillman alcohols: A facile and stereoselective synthesis of α-alkylidene-β-hydrazino acid derivatives.Beilstein J. Org. Chem.2014,10, 990-995.[PDF]
15.Xu, S.; He, Z., Progress on Vinylogous Organic Reactions of Allylic Phosphorus Ylides with Carbonyl Compounds.Chin. J. Org. Chem.2014,34, 2438-2447.[PDF]
14.Xu, S.; He, Z., Recent Advances in Stoichiometric Phosphine-Mediated Organic Synthetic Reactions.RSC. Adv.2013,3(38), 16885-16904.[PDF]
13.Chen, R.;Xu, S.*; Wang, L.; Tang, Y.; He, Z.*, Distinct Reactivity of Morita-Baylis-Hillman Acetates as A NovelC2Component in Amine-Catalyzed [2+2+2] and [2+4] Annulations.Chem. Commun.2013,49(34), 3543-3545.[PDF]
12. Wang, C.; Wang, L.; Zeng, S.;Xu, S.; He, Z., A New BINOL-Derived Chiral Bifunctional Phosphine Organocatalyst: Preparation and Application in Asymmetric (Aza)-Morita-Baylis-Hillman Reactions.Phosphorus, Sulfur Silicon Relat. Elem.2013,188(11), 1548-1554.
11. Qin, Z.; Ma, R.;Xu, S.; He, Z., Phosphine-Catalyzed Formal Vinylogous Aldol Reaction of γ-Methyl Allenoates with Aldehydes: Easy Access to 1,3-Dioxanes and Dienols.Tetrahedron2013,69(48), 10424-10430.
Publications@NKU
10.Xu, S.; He, Z. "Studies on Reactivity of in situ Generated Allylic Phosphorus Ylides with Aldehydes."Chin. J. Org. Chem.2012,32, 1159-1168.
9.Xu, S.; Chen, R.; Qin, Z.; Wu, G.; He, Z. "Divergent Amine-Catalyzed [4+2] Annulation of Morita-Baylis-Hillman Allylic Acetates with Electron-Deficient Alkenes."Org. Lett.2012,14, 996-999.
8.Xu, S.; Chen, R.; He, Z. "PBu3-Mediated Vinylogous Wittig Reaction of α-Methyl Allenoates with Aldehydes and Mechanistic Investigations."J. Org. Chem.2011,76, 7528-7538.
7.Ma, R.; Xu, S.; Tang, X.; Wu, G.; He, Z. "Phosphine-Mediated Diverse Reactivity of γ-Substituted Allenoates with Aldehydes: Syntheses of Highly Functionalized Chromans and (E,E)-1,3-Dienes."Tetrahedron2011,67, 1053-1061.
6.Xu, S.; Zou, W.; Wu, G.; Song, H.; He, Z. "Stereoselective Synthesis of 1,2,3,4-Tetrasubstituted Dienes from Allenoates and Aldehydes: An Observation of Phosphine-Induced Chemoselectivity."Org. Lett.2010,12, 3556-3559.
5.Xu, S.; Zhou, L.; Ma, R.; Song, H.; He, Z. "Phosphine-Mediated Stereoselective Reductive Cyclopropanation of α-Substituted Allenoates with Aromatic Aldehydes."Org. Lett.2010,12, 544-547.
4.Xu, S.; He, Z. "Reactivities of Allenoates with Aldehydes under the Mediation of Tertiary Phosphines."Sci. Sin. Chim.2010,40, 856-868.
3.Xu, S.; Zhou, L.; Zeng, S.; Ma, R.; Wang, Z.; He, Z. "Phosphine-Mediated Olefination between Aldehydes and Allenes: An Efficient Synthesis of Trisubstituted 1,3-Dienes with HighE-Selectivity."Org. Lett.2009,11, 3498-3501.
2.Xu, S.; Zhou, L.; Ma, R.; Song, H.; He, Z. "Phosphane-Catalyzed [3+2] Annulation of Allenoates with Aldehydes: A Simple and Efficient Synthesis of 2-Alkylidenetetrahydrofurans."Chem.Eur. J.2009,15, 8698-8702.
1. Zhang, B.; He, Z.; Xu, S.; Wu, G.; He, Z. "Nucleophilic Phosphine-Catalyzed [3+2] Cycloaddition of Allenes with N-(Thio)Phosphoryl Imines and Acidic Methanolysis of Adducts N-(Thio)Phosphoryl 3-Pyrrolines: A Facile Synthesis of Free Amine 3-Pyrrolines."Tetrahedron2008,64, 9471-9479.
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