一、个人简介
周乐，男，陕西蒲城人，教授，博士生生导师。2000年获得教育部第三届霍英东基金优秀教师奖。
1983.09?1987.06：西北大学化学系，获理学学士学位；
1987.09?1990.12：西北农业大学基础部，获理学硕士学位；
1990.09?1994.06：西北农业大学动物医学系，获农学博士学位；
2006.01?2007.01：美国宾夕法尼亚州立大学化学系，访问****
1990.12?1994.06：西北农业大学基础部，助教
1994.06?1996.06：西北农业大学基础科学系，讲师
1996.06?2001.06：西北农业大学基础科学系，西北农林科技大学，生命科学学院，副教授
2001.06至今：西北农林科技大学，生命科学学院，理学院，化学与药学院，教授
二、科研课题
1. 新型仿生咔啉类化合物的抗菌活性、构效关系及作用机制，国家自然科学基金面上项目（**），2019.01?2022.12，59万元
2. 新型仿生二氢异喹啉类化合物的杀螨活性及其构效关系研究，国家自然科学基金面上项目（**），2012.01?2015.12，60万元
3. 博落回生物碱杀螨活性分子及构效关系研究（**），国家自然科学基金面上项目（**），2008.01?2010.12，30万元
4. 新型天然双黄酮抗菌物质的构效关系研究，国家自然科学基金面上项目（**），2006.01?2008.12，26万元
5. 基于天然先导化合物的新型仿生酞嗪类农用抗菌剂的研究与开发，陕西省重点研发计划项目（2019NY-195），2019.01?2020.12，8.00万元
6. 新型生物农药—博落回抗菌剂的研究与开发，陕西省科技攻关项目（2016NY-171），2019.01?2020.12，10.00万元
7. 博落回生物碱的提取与分离工艺研发（横向课题），2018.06?2020.06，20万元
8. 曲虫综合防治技术研究与应用（横向课题），2018.12?2020.12，20万元
三、开设课程
有机化学，有机化学实验，有机化学波谱解析
四、研究方向
1. 天然药物活性分子的构效关系及结构优化
2. 基于天然活性分子的仿生药物研究与开发
3. 农用仿生抗菌剂的研究与开发
4. 植物和动物杀/驱虫剂的研究与开发
五、主要科研成果与学术论文
1. Bohang Zhou, Hui Li, Zhiming Cui, Ding Li, Huiling Geng, Jinming Gao, Le Zhou^?. Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase. Eur. J. Med. Chem. 2020, 200, 112415.
2. Zhiming Cui, Bohang Zhou, Chao Fu, Liu Chen, Juan Fu, Fangjun Cao, Xinjuan Yang, Le Zhou^?. Simple Analogues of quaternary benzo[100]phenanthridine alkaloids: discovery of a novel antifungal 2?phenylphthalazin-2-ium scaffold with excellent potency against phytopathogenic fungi. J. Agric. Food Chem. 2020, 68, 15418?15427.
3. Fangjun Cao, Mingxuan Xu, Bohang Zhou, Yisi Du, Junhu Yao, Le Zhou^?. Effects of 2-aryl-1-cyano-1,2,3,4-tetrohydroisoquinolines on apoptosis induction mechanism in NB4 and MKN-45 cells. Toxicol. in Vitro 2019, 54, 295-303.
4. Xingqiang Li, Bingyu Zhang, Wei Zhao, Shanshan Yang, Xinjuan Yang, Le Zhou*. New 2-aryl-6-methyl-3,4-dihydro-β-carbolin-2-iums as potential antifungal agents: Synthesis, bioactivity and structure-activity relationship. Sci. Rep. 2019, 9, 1941.
5. Bohang Zhou, Bingyu Zhang, Xingqiang Li, Xiuxiu Liu, Hui Li, Ding Li, Zhiming Cui, Huiling Geng, Le Zhou*. New 2-aryl-9-methyl-β-carbolinium salts as potential acetylcholinesterase inhibitor agents: synthesis, nioactivity and structure–activity relationship. Sci. Rep . 2018, 8, 1559.
6. Dongdong Chen, Ye Tian, Mingxuan Xu, Xinyuan Wang, Ding Li, Fang Miao, Xinjuan Yang, Le Zhou*. Design, bioactivity and structure-activity of 3-arylpropionate derivatives as potential high-efficient acaricides against Psoroptes Cuniculi . Sci. Rep. 2018, 8, 1797.
7. Dongdong Cheng, Bingyu Zhang, Xiuxiu Liu, Xingqiang Li, Xinjuan Yang, Le Zhou*. Bioactivity and structure–activity relationship of cinnamic acid derivatives and its heteroaromatic ring analogues as potential high-efficient acaricides against Psoroptes cuniculi . Bioorg. Med. Chem. Lett . 2018, 28, 1149–1153.
8. Kun Zhou, Dongdong Chen, Bingyu Zhang, Fang Miao, Le Zhou*. Bioactivity and structure-activity relationship of cinnamic acid esters and their derivatives as potential antifungal agents for plant protection. PLoS ONE 2017, 12(4): e**.
9. Fangjun Cao, Lifei Zhu§, Qian Kuang, Xingqiang Li, Bohang Zhou, Xinjuan Yang*, Le Zhou*. Cytotoxic activity, apoptosis induction and structure–activity relationship of 8-OR-2-aryl-3,4-dihydroisoquinolin-2-ium salts as promising anticancer agents. Bioorg. Med. Chem. Lett. 2017, 27, 55-60.
10. Lifei Zhou, Bohang Zhou, Bingyu Zhang, Mingxuan Xu, Huiling Geng, Zhou Le*. New 2-aryl-7,8-dimethoxy-3,4-dihydroisoquinolin-2-ium salts as potential antifungal agents: synthesis, bioactivity and structure-activity relationships. Sci. Rep. 2017, 7(1), 7537.
11. Lifei Zhu,Zhe Hou, Kun Zhou, Zongbo Tong, Qian Kuang, Huiling Geng, Le Zhou.* Synthesis, bioactivity and structure-activity relationships of new 2-aryl-8-OR-3,4-dihydroisoquinolin-2-iums salts as potential antifungal agents. Bioorg. Med. Chem. Lett. 2016, 26, 2413–2417.
12. Zhe Hou, Lifei Zhu, Xinchi Yu, Maqiang Sun, Fang Miao, Le Zhou.* Design, synthesis, and structure-activity relationship of new 2-aryl-3,4-dihydro-β-carbolin-2-ium salts as antifungal agents. J. Agric. Food Chem. 2016, 64, 2847-2854.
13. Dongdong Chen, Naixing Wang, Xingwang Lan, Wei Zhang, Cuibing Bai, Hui-Ling Geng, Le Zhou*, Yihe Li. Efficient synthesis of polysubstituted tetrahydrothiopyran sulfoxides by the reaction of α,β-unsaturated ketones and Na₂S. Curr. Org. Syn. 2016, 13(4), 651-655.
14. Zhaofeng Gao, Bohang Zhou, Jieyu Zhao, Fangjun Cao, Le Zhou*, Huiling Geng . Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters. Int. J. Mol. Sci. 2015, 16, 9119-9133.
15. Rui Yang, Zhaofeng Gao, Jieyu Zhao, Weibo Li, Le Zhou, Fang Miao. New class of 2-aryl-6-chloro-3,4-dihydroisoquinolinium salts as potential antifungal agents for plant protection: synthesis, bioactivity and structure-activity relationships. J. Agric. Food Chem. 2015, 63(7):1906-1914.
16. Fangjun Cao, Rui Yang, Chao Lv, Qun Ma, Ming Lei, Huiling Geng, Le Zhou*. Pseudocyanides of sanguinarine and chelerythrine and their series of structurally simple analogues as new anticancer lead compounds: cytotoxic activity, structure-activity relationship and apoptosis induction. Eur. J. Pharm. Sci. 2015, 67, 45-54.
17. Chao Lv, Zuolue Zheng, Fang Miao, Huiling Geng, Le Zhou *, Laping Liu. New New dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana Wall: isolation, identification and cytotoxicity against cancer cells, Int. J. Mol. Sci. 2014, 15 (6), 11111-11125.
18. Qiao Ruan, Le Zhou*, Bernhard Breit. New phosphorus self-assembling ligands for the tandem hydroformylation-Wittig olefination reaction of homoallylic alcohols - A key step for stereoselective pyran synthesis. Catal. Commun . 2014, 53, 87-90.
19. Rui Yang, Qiao Ruan, Bingyu Zhang, Zuolue Zheng, Fang Miao, Le Zhou,* Huiling Geng, A class of promising acaricidal tetrahydroisoquinoline derivatives: synthesis, biological evaluation and structure-activity relationships. Molecules 2014, 19, 8051-8066.
20. Zhe Hou, Rui Yang, Cen Zhang, Lifei Zhu, Fang Miao, Xinjuan Yang, Le Zhou*. 2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as novel antifungal lead compounds: biological evaluation and structure-activity relationships. Molecules , 2013, 18, 10413-10424.