刘洋

职称/职务：教授
电话：
传真：
电子信箱：yliu@snnu.edu.cn
研究方向：动物分子进化
办公地点：长安校区格物楼2607
个人简介
2012年毕业于华东师范大学，获博士学位。陕西师范大学生命科学学院教授，博士生导师。多年来一直从事与动物分子进化相关的研究工作，通过基因序列、表达及蛋白功能等多个水平的研究揭示动物适应性进化的分子机制。研究工作主要集中在动物感官（视觉和听觉）和食性进化等方面。已发表学术论文20余篇，其中在PNAS杂志发表论文一篇、Current Biology两篇以及Molecular Biology and Evolution四篇。


主要研究领域
课题组目前的主要研究方向为脊椎动物视觉进化，包括明视觉和暗视觉两方面。脊椎动物的视网膜中具有视锥（cone）和视杆（rod）两类感光细胞，其中视锥细胞与明视觉或称色觉有关，而视杆细胞与暗视觉相关。视锥和视杆细胞中的感光物质是视色素，即视蛋白（opsin）结合生色团。早期脊椎动物具有五种视蛋白，其中四种（SWS1，SWS2，M/LWS和RH2）表达在视锥细胞中行使色觉功能，另外一种rhodopsin（RH1）表达在视杆细胞中行使暗视觉。因此，视色素的功能与脊椎动物的视觉直接相关。我们以脊椎动物视色素为对象，研究不同动物类群的色觉和暗视觉能力及其功能演变。通过基因序列分析（基因组大数据）与蛋白功能实验的结合，明确现生物种或远古脊椎动物祖先的视色素表型，进而揭示不同动物类群视觉功能的演化历史及生态学意义，并阐明其分子机理。


发表论文
1. He C^#, Wei Y^#, Zhu Y, Xia Y, Irwin DM, Liu Y^*. 2019. Adaptive evolution of c-type lysozyme in vampire bats. Journal of Molecular Evolution. 87(9-10): 309-316. (IF = 1.78)
2. Liu Y^*, Cui Y, Chi H, Xia Y, Liu H, Rossiter SJ^*, Zhang S^*. 2019. Scotopic rod vision in tetrapods arose from multiple early adaptive shifts in the rate of retinal release. Proc Natl Acad Sci USA. 116(26): 12627-12628. (IF = 9.58)
3. Li L, Chi H, Liu H, Xia Y, Irwin DM, Zhang S^*, Liu Y^*. 2018. Retention and losses of ultraviolet-sensitive visual pigments in bats. Scientific Reports. 8:11933. (IF = 4.01)
4. Liu Y^*, Chi H, Li L, Rossiter SJ, Zhang S^*. 2018. Molecular data support an early shift to an intermediate-light niche in the evolution of mammals. Molecular Biology and Evolution. 35(5): 1130-1134. (IF = 14.8)
5. Yokoyama S^*, Tada T, Liu Y, Faggionato D, Altun A. 2016. A simple method for studying the molecular mechanisms of ultraviolet and violet reception in vertebrates. BMC Evolutionary Biology. 16:64. (IF = 3.05)
6. Yokoyama S^*, Altun A, Jia H, Yang H, Koyama T, Faggionato D, Liu Y, Starmer WT. 2015. Adaptive evolutionary paths from UV reception to sensing violet light by epistatic interactions. Science Advances. 1: e**. (IF = 12.8)
7. Liu Y^#, He G^#, Xu H, Han X, Jones G, Rossiter SJ^*, Zhang S^*. 2014. Adaptive functional diversification of lysozyme in insectivorous bats. Molecular Biology and Evolution. 31(11): 2829-2835. (IF = 14.8)
8. Yokoyama S^*, Xing J, Liu Y, Faggionato D, Altun A, Starmer WT. 2014. Epistatic adaptive evolution of human color vision. PLoS Genetics. 10(12): e**. (IF = 5.22)
9. Yokoyama S^*, Starmer WT, Liu Y, Tada T, Britt L. 2014. Extraordinarily low evolutionary rates of short wavelength-sensitive opsin pseudogenes. Gene. 534(1): 93-99. (IF = 2.64)
10. Xu H, Liu Y^*, He G, Rossiter SJ, Zhang S^*. 2013. Adaptive evolution of tight junction protein claudin-14 in echolocating whales. Gene. 530(2): 208-214. (IF = 2.64)
11. Dong D^#*, Lei M^#, Liu Y^#, Zhang S^*. 2013. Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx). BMC Genomics. 14: 916. (IF = 3.5)
12. Pan YH^#, Zhang Y^#, Cui J, Liu Y, McAllan BM, Liao CC^*, Zhang S^*. 2013. Adaptation of phenylalanine and tyrosine catabolic pathway to hibernation in bats. PLoS ONE. 8(4): e62039. (IF = 2.78)
13. Xu H, Liu Y, Meng F, He B, Han N, Li G, Rossiter SJ^*, Zhang S^*. 2013. Multiple bursts of pancreatic ribonuclease gene duplication in insect-eating bats. Gene. 526(2): 112-117. (IF = 2.64)
14. Liu Y^#, Xu H^#, Yuan X, Rossiter SJ, Zhang S^*. 2012. Multiple adaptive losses of alanine-glyoxylate aminotransferase mitochondrial targeting in fruit-eating bats. Molecular Biology and Evolution. 29(6): 1507-1511. (IF = 14.8)
15. Liu Y^#, Han N^#, Franchini LF^#, Xu H, Pisciottano F, Elgoyhen AB, Rajan KE, Zhang S^*. 2012. The voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats. Molecular Biology and Evolution. 29(5): 1441-1450. (IF = 14.8)
16. Rossiter SJ^*, Zhang S, Liu Y. 2011. Prestin and high frequency hearing in mammals. Communicative & Integrative Biology. 4(2): 236-239.
17. Shen B, Avila-Flores R, Liu Y, Rossiter SJ^*, Zhang S^*. 2011. Prestin shows divergent evolution between constant frequency echolocating bats. Journal of Molecular Evolution. 73(3): 109-115. (IF = 1.78)
18. Liu Y, Rossiter SJ^*, Han X, Cotton JA, Zhang S^*. 2010. Cetaceans on a molecular fast track to ultrasonic hearing. Current Biology. 20(20): 1834-1839. (IF = 9.19)
19. Liu Y, Cotton JA^*, Shen B, Han X, Rossiter SJ^*, Zhang S^*. 2010. Convergent sequence evolution between echolocating bats and dolphins. Current Biology. 20(2): R53-R54. (IF = 9.19)
20. Mao X, Liu Y, Zhou Y, He B, Zhang S^*. 2009. Development of 19 polymorphic microsatellite loci for the intermediate horseshoe bat, Rhinolophus affinis (Rhinolophidae, Chiroptera). Conservation Genetics. 10(3): 709-711. (IF = 2.28)
21. Liu Y^#, Dong D^#, Han N, Zhao H, Zhang J, Li G, Racey PA, Zhang S^*. 2009. Molecular cloning and evolutionary analysis of hemoglobin alpha-chain genes in bats. Biochemical Genetics. 47(3): 257-265. (IF = 1.93)
^# 共同第一作者；^* 通讯作者


学习/工作机会
实验室长期招收有志于动物视觉进化研究的博士、硕士研究生；同时欢迎新毕业的博士（掌握基本的分子生物学实验技术，有真核或原核蛋白表达经验者优先）以常规补充或博士后形式加入课题组。