和媛
ename

gender
女
studentNo
employeeNo
**
idNo
610111**7
birth
1984-03-13
partyTime
2006-03-12
officeRoom
304
phone
**
email
yuanhe@nwu.edu.cn
political
中共党员
college
化学与材料科学学院,
collegeName
department
cardNo
nation
汉
placeOfDomicile
西安
hmtTrafficPermit

highestDegreeGetFromMatherSchool":0,"passport

state
在职
researchInterests
酶结构-功能；纳米酶；反应机理及活性调控；酶催化热动力学
idNoStartDatetime
2011-07-21
idNoEndDatetime
2031-07-21
passportStartDatetime
passportEndDatetime
hmtTrafficPermitStartDatetime
hmtTrafficPermitEndDatetime
resume
教师主页：http://faculty.nwu.edu.cn/YuanHe2/zh_CN/index.htm致力于采用化学生物学、酶学、结构生物学、材料科学等多学科手段，开展疾病相关靶酶催化反应机理与活性调控的基础应用研究（详见个人主页）。相关成果在包括Angew Chem Int Ed，J Am Chem Soc，Nanocale 等期刊共发表SCI论文26篇，完成国家自然科学基金1项，省部级科研项目3项，参与重大国际合作项目1项。入选第八批陕西省“****”。代表性科研成果：Lei, J. E., Wang, Q., Lin, Y., Li, F., Ma, C., He, Y.*, & Xu, J. R.* 2020. Rapid detection of extended-spectrum beta-Lactamases producers in Enterobacteriaceae using a calorimetry approach. J Appl Microbiol. doi: 10.1111/jam.14841Wasey, A., Yang, J., Sun, D., He, Y.*, & Zhang, C.* 2020. On-chip Carba NP test for accurate and high throughput detection of carbapenemase-producing Enterobacteriaceae. Talanta, 210, 120656. doi: 10.1016/j.talanta.2019.120656Liu, X., Yan, B., Li, Y., Ma, X., Jiao, W., Shi, K., Zhang, T., Chen, S., He, Y., Liang, X. J., & Fan, H. 2020. Graphene Oxide-Grafted Magnetic Nanorings Mediated Magnetothermodynamic Therapy Favoring Reactive Oxygen Species-Related Immune Response for Enhanced Antitumor Efficacy. ACS Nano, 14(2), 1936-1950. doi: 10.1021/acsnano.9b08320Liu, X., Peng, M., Li, G., Miao, Y., Luo, H., Jing, G., He, Y., Zhang, C., Zhang, F., & Fan, H. 2019. Ultrasonication-Triggered Ubiquitous Assembly of Magnetic Janus Amphiphilic Nanoparticles in Cancer Theranostic Applications. Nano Lett, 19(6), 4118-4125. doi: 10.1021/acs.nanolett.9b01524Peng, X., Wang, B., Yang, Y., Zhang, Y., Liu, Y., He, Y., Zhang, C., & Fan, H. 2019. Liver Tumor Spheroid Reconstitution for Testing Mitochondrial Targeted Magnetic Hyperthermia Treatment. ACS Biomater Sci Eng, 5(3), 1635-1644. doi: 10.1021/acsbiomaterials.8b01630Xiong, R., Zhang, W., Zhang, Y., Zhang, Y., Chen, Y., He, Y.*, & Fan, H.* 2019. Remote and real time control of an FVIO-enzyme hybrid nanocatalyst using magnetic stimulation. Nanoscale, 11(39), 18081-18089. doi: 10.1039/c9nr04289jWang, Q., He, Y.*, Lu, R., Wang, W. M., Yang, K. W.*, Fan, H. M., Jin, Y., & Blackburn, G. M. 2018. Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids. Biosci Rep, 38(2). doi: 10.1042/BSR**Xiang, Y., Chen, C., Wang, W. M., Xu, L. W., Yang, K. W.*, Oelschlaeger, P., & He, Y.* 2018. Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-beta-lactamase Inhibitors. ACS Med Chem Lett, 9(4), 359-364. doi: 10.1021/acsmedchemlett.7b00548Zhang, H., Liu, X. L., Zhang, Y. F., Gao, F., Li, G. L., He, Y., Peng, M. L., & Fan, H. M. 2018. Magnetic nanoparticles based cancer therapy: current status and applications. Sci China Life Sci, 61(4), 400-414. doi: 10.1007/s11427-017-9271-1Zhang, Y., Lei, J. E., He, Y.*, Yang, J., Wang, W., Wasey, A., Xu, J.*, Lin, Y., Fan, H., Jing, G., Zhang, C., & Jin, Y. 2018. Label-Free Visualization of Carbapenemase Activity in Living Bacteria. Angew Chem Int Ed, 57(52), 17120-17124. doi: 10.1002/anie.Li, G., Ma, P., He, Y., Zhang, Y., Luo, Y., Zhang, C., & Fan, H.* 2018. Enzyme-Nanowire Mesocrystal Hybrid Materials with an Extremely High Biocatalytic Activity. Nano Lett, 18(9), 5919-5926. doi: 10.1021/acs.nanolett.8b02620Wang, W. J., Wang, Q., Zhang, Y., Lu, R., Zhang, Y. L., Yang, K. W.*, Lei, J. E., & He, Y. * 2017. Characterization of beta-lactamase activity using isothermal titration calorimetry. Biochim Biophys Acta Gen Subj, 1861(8), 2031-2038. doi: 10.1016/j.bbagen.2017.04.011Cekic, N., Heinonen, J. E., Stubbs, K. A., Roth, C., He, Y., Bennet, A. J., McEachern, E. J., Davies, G. J., & Vocadlo, D. J. 2016. Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase. Chem Sci, 7(6), 3742-3750. doi: 10.1039/c6sc00370bMacauley, M. S., Kawasaki, N., Peng, W., Wang, S.-H., He, Y., Arlian, B. M., McBride, R., Kannagi, R., Khoo, K.-H., & Paulson, J. C. 2015. Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man. J Biol Chem, 290(50), 30066-30077. doi: 10.1074/jbc.M115.691337Rillahan, C. D., Macauley, M. S., Schwartz, E., He, Y., McBride, R., Arlian, B. M., Rangarajan, J., Fokin, V. V., & Paulson, J. C. 2014. Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas. Chem Sci, 5(6), 2398-2406. doi: 10.1039/C4SC00451EHe, Y., Roth, C., Turkenburg, J. P., & Davies, G. J. 2014. Three-dimensional structure of a Streptomyces sviceus GNAT acetyltransferase with similarity to the C-terminal domain of the human GH84 O-GlcNAcase. Acta Crystallogr D Biol Crystallogr, 70(Pt 1), 186-195. doi: 10.1107/S**29155Darby, J. F., Landstrom, J., Roth, C., He, Y., Davies, G. J., & Hubbard, R. E. 2014. Discovery of selective small-molecule activators of a bacterial glycoside hydrolase. Angew Chem Int Ed, 53(49), 13419-13423. doi: 10.1002/anie.Macauley, M. S., Chan, J., Zandberg, W. F., He, Y., Whitworth, G. E., Stubbs, K. A., Yuzwa, S. A., Bennet, A. J., Varki, A., Davies, G. J., & Vocadlo, D. J. 2012. Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular beta-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of beta-O-linked beta-N-acetylglucosaminidase. J Biol Chem, 287(34), 28882-28897. doi: 10.1074/jbc.M112.363721He, Y., Bubb, A. K., Stubbs, K. A., Gloster, T. M., & Davies, G. J. 2011. Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses. Amino Acids, 40(3), 829-839. doi: 10.1007/s00726-010-0700-6He, Y., Macauley, M. S., Stubbs, K. A., Vocadlo, D. J., & Davies, G. J. 2010. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. J Am Chem Soc, 132(6), 1807-1809. doi: 10.1021/ja**Martinez-Fleites, C., He, Y., & Davies, G. J. 2010. Structural analyses of enzymes involved in the O-GlcNAc modification. Biochim Biophys Acta, 1800(2), 122-133. doi: 10.1016/j.bbagen.2009.07.019Macauley, M. S., He, Y., Gloster, T. M., Stubbs, K. A., Davies, G. J., & Vocadlo, D. J. 2010. Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol, 17(9), 937-948. doi: 10.1016/j.chembiol.2010.07.006Marcelo, F., He, Y., Yuzwa, S. A., Nieto, L., Jimenez-Barbero, J., Sollogoub, M., Vocadlo, D. J., Davies, G. D., & Bleriot, Y. 2009. Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion. J Am Chem Soc, 131(15), 5390-5392. doi: 10.1021/ja809776rHe, Y., Martinez-Fleites, C., Bubb, A., Gloster, T. M., & Davies, G. J. 2009. Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase. Carbohydr Res, 344(5), 627-631. doi: 10.1016/j.carres.2008.12.007Balcewich, M. D., Stubbs, K. A., He, Y., James, T. W., Davies, G. J., Vocadlo, D. J., & Mark, B. L. 2009. Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Sci, 18(7), 1541-1551. doi: 10.1002/pro.137Martinez-Fleites, C., Macauley, M. S., He, Y., Shen, D. L., Vocadlo, D. J., & Davies, G. J. 2008. Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nat Struct Mol Biol, 15(7), 764-765. doi: 10.1038/nsmb.1443Yuzwa, S. A., Macauley, M. S., Heinonen, J. E., Shan, X., Dennis, R. J., He, Y., Whitworth, G. E., Stubbs, K. A., McEachern, E. J., Davies, G. J., & Vocadlo, D. J. 2008. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol, 4(8), 483-490. doi: 10.1038/nchembio.96Wang, Z.-F., He, Y., & Huang, L.-J. 2007. An alternative method for the rapid synthesis of partially O-methylated alditol acetate standards for GC-MS analysis of carbohydrates. Carbohydr Res, 342(14), 2149-2151. doi: 10.1016/j.carres.2007.05.028
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nativePlace
陕西西安"