个人简介
孙士生， Ph.D. 教授，博士生导师；suns@nwu.edu.cn
地址： 西北大学生命科学学院 西楼（原化材楼）221室，太白校区
教育和科研工作经历：
1）2011.06 西北大学 博士；2）2011.09 - 2017.01 约翰.霍普金斯大学 博士后；3）2017.02 西北大学 教授
主要研究方向：
1）糖蛋白质组学新技术、新软件；2）新的肿瘤标志物发现； 3）糖蛋白的功能和肿瘤发病机制；4）重要糖蛋白的功能研究；5）糖基化与男性不育
科研条件：
1）实验室拥有全套蛋白质组和糖蛋白质组学分析平台，其中包括Orbitrap Fusion Lumos三合一 质谱仪，HPLC 1260 (Agilent)及相应的数据分析软件，如Proteome Discoverer，MaxQuant，Byonic, GPQuest及自开发软件。 2）具有分子生物学实验平台，可进行分子功能研究； 3）与西安多家医院和计算机科研团队建立了稳定合作。4）科研团队成员具有生物学、医学、化学和计算机等多学科背景，便于科研合作和交流。
承担的科研项目
1. 科技部重点项目子课题 2020-2024 主持
2. 国家重大研究计划（培育） 2019-2021 主持
3. 中组部高层次人才项目 2018 -2020 主持
4. 国家自然科学基金（面上） 2018 - 2021 主持
5. 国家自然科学基金（青年） 2018 - 2020 主持
6. 陕西省自然科学基金（面上） 2018-2019 主持
主要研究成果
Selected publications: (共发表论文40余篇，引用1400余次，代表论文如下)
1. Liuyi Dang, Jiechen Shen, Ting Zhao, Fei Zhao, Li Jia, Bojing Zhu, Chen Ma, Danqian Chen, Yingyong Zhao, and Shisheng Sun*. Recognition of Bisecting N-Glycans on Intact Glycopeptides by Two Characteristic Ions in Tandem Mass Spectra. Analytical Chemistry. 2019, 91(9): 5478-5482. (IF=6.350)
2. Jian Shu, Liuyi Dang, Dandan Zhang, Punit Shah, Lijun Chen, Hui Zhang, Shisheng Sun. Dynamic analysis of proteomic alterations in response to N‐linked glycosylation inhibition in a drug‐resistant ovarian carcinoma cell line. FEBS Journal. 2019, 286(8): 1594-1605. (IF=4.739)
3. Liuyi Dang, Li Jia, Yuan Zhi, Pengfei Li, Ting Zhao, Bojing Zhu, Rongxia Lan, Yingwei Hu, Hui Zhang, Shisheng Sun*. Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry. Trends in Analytical Chemistry. 2019. 114: 143-150 (IF=8.428)
4. Bojing Zhu, Jiechen Shen, Ting Zhao, Haihai Jiang, Tianran Ma, Jie Zhang, Liuyi Dang, Ni Gao, Yingwei Hu, Yi Shi*, Shisheng Sun*. Intact glycopeptide analysis of influenza A/H1N1/09 neuraminidase revealing the effects of host and glycosite location on site‐specific glycan structures. Proteomics. 2019, **. (IF=3.5)
5. Shisheng Sun*, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang*. Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein. Analytical chemistry. 2018, 90 (10): 6292–6299. (IF=6.350)
6. Shisheng Sun, Punit Shah, Shadi Toghi Eshghi, Weiming Yang, Namita Trikannad, Shuang Yang, Lijun Chen, Paul Aiyetan, Naseruddin H?ti, Zhen Zhang, Daniel W. Chan, Hui Zhang*. Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nature Biotechnology. 2016, 34: 84-88. (IF=43.1)
7. Hui Zhang, Tao Liu, Zhen Zhang, Samuel H Payne, Bai Zhang, Jason E McDermott, Jian-Ying Zhou, Vladislav A Petyuk, Li Chen, Debjit Ray, Shisheng Sun, Feng Yang, Lijun Chen, Jing Wang, Punit Shah, Seong Won Cha, Paul Aiyetan, Sunghee Woo, Yuan Tian, Marina A Gritsenko, Therese R Clauss, Caitlin Choi, Matthew E Monroe, Stefani Thomas, Song Nie, Chaochao Wu, Ronald J Moore, ,Kun-Hsing Yu, David L Tabb, David Fenyo?, Vineet Bafna, Yue Wang, Henry Rodriguez, Emily S Boja, Tara Hiltke, Robert C Rivers, Lori Sokoll, Heng Zhu, Ie-Ming Shih, Akhilesh Pandey, Bing Zhang, Michael P Snyder, Douglas A Levine, Richard D Smith, Daniel W Chan, Karin D Rodland, and the CPTAC investigators. Integrated proteogenomic characterization of human high grade serous ovarian cancer. Cell. 2016, 166 (3): 755-765. (IF=28.7)
8. Shisheng Sun*, Hui Zhang. Identification and Validation of Atypical N-Glycosylation Sites. Analytical chemistry. 2015, 87 (24): 11948–11951. (IF=5.9)
9. Shisheng Sun, Hui Zhang*. Large-scale measurement of absolute protein glycosylation stoichiometry. Analytical chemistry. 2015, 87 (13): 6479-6482. (IF=5.9)
10. Shisheng Sun#, Bai Zhang#, Paul Aiyetan, Jian-Ying Zhou, Punit Shah, Weiming Yang, Douglas A Levine, Zhen Zhang, Daniel W Chan, Hui Zhang*. Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of proteome research. 2013, 12 (12): 5609-5615. (IF=5.0)