个人简介
赵新锋，教授，博士生导师。中国药学会药物分析专业委员会委员，陕西省药学会药物分析专委会委员，陕西省中药产业技术创新战略联盟理事，《Chinese Medicine》、《药物分析》和《世界科学技术-中医药现代化》等杂志编委。2010年至2011年在英国剑桥大学药理学系进行博士后研究，2017年在美国普渡大学访学。近年来，主要致力于药物分析新方法的创建及其应用研究，开展了以药物活性成分多靶点辨识为目标的受体色谱创建研究和应用研究。主持国家自然科学基金项目4 项，陕西省重点研发计划重点产业创新链（群）项目1项；参与国家“重大新药创制”重大专项项目等国家级项目6项及其他省部级重大科研项目21 项；在Science, Journal of the American Chemical Society, Chemical Science和Analytical Chemistry等国际权威期刊上发表学术论文50余篇；获中国发明专利授权6项，提交国际PCT专利申请3份，获软件著作权1项；获陕西省科学技术一等奖2项、陕西高等学校科学技术一等奖4项；获西部药学之星、陕西省中青年科技创新领军人才和西安青年科技人才等荣誉称号。
受教育经历：
1. 2006/03-2009/05，西安交通大学，医学院，博士
2. 2003/09-2005/07，西安交通大学，理学院，硕士
3. 1997/09-2001/07， 西北大学，化学系，学士
研究工作经历：
1. 2017/02-2018/03，美国普渡大学，化学系，高级访问****
2. 2016/01-至 今，西北大学，生命科学学院，教 授
3. 2013/05-2015/12，西北大学，生命科学学院，副教授
4. 2010/10-2011/11，英国剑桥大学，药理学系，博士后
5. 2009/07-2013/05，西北大学，生命科学学院，讲 师
承担的科研项目
国家自然科学基金面上项目，**，别构响应型受体色谱方法建立及评价，2020/01-
2023/12，在研，主持
陕西省重点研发计划重点产业创新链（群）项目，2020ZDLSF05-07，止嗽口服液止咳祛痰靶向功效
物质三位一体智能辨识与研发，2020/01-2022/12，在研，主持
国家自然科学基金面上项目，**，基于G-蛋白偶联受体信号转导通路的复杂体系药
物活性成分色谱筛选方法，2018/01-2021/12，在研，主持
国家自然科学基金面上项目，**，固定化O6-烷基鸟嘌呤-DNA甲基转移酶标签重组
蛋白构象表征新方法的建立及应用，2015/01-2016/12，结题，主持
国家自然科学基金青年项目，**，固定化功能蛋白质取向及构象表征和调控色谱新
方法，2011/01-2013/12，已结题，主持
主要研究成果
一、研究论文：
2020年
1. Qian Li, Longfei Liu, Dake Mao, Yuyan Yu, Xinfeng Zhao*, Chengde Mao*, ATP-triggered, allosteric self-assembly of DNA nanostructures, Journal of the American Chemical Society, 2020, 142(2): 665-668.
2. Xinfeng Zhao*, Yahui Jin, Xinyi Yuan, Zhaoling Hou, Ziyue Chen, Xiaoying Fu, Qian Li, Jing Wang, Yajun Zhang*, Covalent inhibitor-based one-step method for endothelin receptor A immobilization: from ligand recognition to lead identification, Analytical Chemistry, 2020, 92, 13750-13758.
3. Qi Liang, Xiaoying Fu, Jianfeng Zhang, Jiaxue Hao, Gangjun Feng, Jing Wang, Qian Li, Faizan Ahmad, Xinfeng Zhao*, Immobilized angiotensin II type I receptor: A powerful method of high throughput screening for antihypertensive compound identification through binding interaction analysis, Journal of Chromatography A, 2020, 1622, 461003.
4. Juan Gao, Zhongman Chang, Rui Tian, Ping Li, Faizan Ahmad, Xiaoni Jia, Qi Liang, Xinfeng Zhao*, Reversible and site-specific immobilization of β2 -adrenergic receptor by aptamer-directed method for receptor-drug interaction analysis, Journal of Chromatography A, 2020, 1622, 461091.
2019年
1. Jing Wang, Yuxin Wang, Jiajun Liu, Qian Li, Guowei Yin, Yajun Zhang, Chaoni Xiao, Taiping Fan, Xinfeng Zhao*, Xiaohui Zheng. Site-specific immobilization of β2-AR using O6-benzylguanine derivative-functionalized supporter for high throughput receptor-targeting lead discovery. Analytical Chemistry, 2019, 91(11): 7385-7393.
2. Yuxin Wang, Weicang Wang, Haixia Yang, Derek Shao, Xinfeng Zhao*, Guodong Zhang*, Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of toll-like receptor 4 signaling. Free Radical Biology and Medicine, 2019, 131: 237-242.
3. Xiaoni Jia, Jiajun Liu, Baimei Shi, Qi Liang, Juan Gao, Gangjun Feng, Zhongman Chang, Qian Li, Xiaohong Zhang, Jianbo Chen, Xinfeng Zhao*, Screening bioactive compounds of Siraitia grosvenorii by immobilized β2-adrenergic receptor chromatography and druggability evaluation, Frontiers in Pharmacology, 2019, 10: 915.
2018年
1. Kaizhu Zeng, Qian Li, Jing Wang, Guowei Yin, Yajun Zhang, Chaoni Xiao, Taiping Fan, Xinfeng Zhao*, Xiaohui Zheng. One-step methodology for the direct covalent capture of GPCRs from complex matrices onto solid surfaces based on the bioorthogonal reaction between haloalkane dehalogenase and chloroalkanes, Chemical Science, 2018, 9(2): 446-456.
2. Qian Li, Xiaohui Ning, Yuxin An, Brett J. Stanley, Yuan Liang, Jing Wang, Kaizhu Zeng, Fuhuan Fei, Ting Liu, Huanmei Sun, Jiajun Liu, Xinfeng Zhao*, Xiaohui Zheng, Reliable analysis of the interaction between specific ligands and immobilized beta-2-adrenoceptor by adsorption energy distribution. Analytical Chemistry, 2018, 90(13): 7903-7911.
3. Yuan Liang, Jing Wang, Fuhuan Fei, Huanmei Sun, Ting Liu, Qian Li, Xinfeng Zhao*, Xiaohui Zheng, Binding kinetics of five drugs to beta2-adrenoceptor using peak profiling method and nonlinear chromatography, Journal of Chromatography A, 2018, 1538: 17-24.
4. Ting Liu, Yani Hou, Jiajun Liu, Qian Li, Jing Wang, Yuan Liang, Liujiao Bian, Xinfeng Zhao*, Screening bioactive compounds with multi-targets from Rhodiola crenulata by a single column containing co-immobilized beta2-adrenergic receptor and voltage dependent anion channel isoform 1, 1100: 76-82.
5. 刘嘉君, 贾晓妮, 王静, 曾凯竹, 李倩, 赵新锋*, 受体色谱: 中药靶向活性成分高效筛选技术, 世界科学技术:中医药现代化，2018，8：1476-1481.
2017年
1. Jing Wang, Fengwu Li, Kaizhu Zeng, Qian Li, Xinfeng Zhao*, Xiaohui Zheng, Bioactive compounds of Shuang–Huang–Lian prescription and an insight into its binding mechanism by β2‐adrenoceptor chromatography coupled with site-directed molecular docking, Journal of separation science, 2017, 40 (22): 4357-4365.
2. Zhenyu Sun, Jing Wang, Qian Li, Meimei Zhao, Yajun Zhang, Xunyu Xiong, Xinfeng Zhao*, Xiaohui Zheng, A fast affinity extraction methodology for rapid screening of bioactive compounds specifically binding to beta2-adrenergic receptor from Xie-Bai-San, Medicinal Chemistry Research, 2017, 26 (10): 2410-2419.
3. Guangxin Liu, Pei Wang, Chan Li, Jing Wang, Zhenyu Sun, Xinfeng Zhao*, Xiaohui Zheng, Confirming therapeutic target of protopine using immobilized β2-adrenoceptor coupled with site‐directed molecular docking and the target‐drug interaction by frontal analysis and injection amount–dependent method, Journal of Molecular Recognition, 2017, 30 (7): e2613.
4. Kaizhu Zeng, Jing Wang, Zhenyu Sun, Qian Li, Sha Liao, Xinfeng Zhao*, Xiaohui Zheng, Rapid analysis of interaction between six drugs and β2-adrenergic receptor by injection amount‐dependent method, Biomedical Chromatography, 2017, 31 (6): e3897.
2015年
1. Xinfeng Zhao, Xiaohui Zheng, Tai-Ping Fan*, Zijian Li, Youyi Zhang, Jianbin Zheng*, A novel drug discovery strategy inspired by traditional medicine philosophies, Science, 2015, 347 (6219): S38-S40.
2. Qian Li, Jing Wang, Yuqing Yuan Zheng, Lingjian Yang, Yajun Zhang, Liujiao Bian, Jianbin Zheng, Zijian Li, Xinfeng Zhao*, Youyi Zhang, Comparison of zonal elution and nonlinear chromatography in determination of the interaction between seven drugs and immobilised β2-adrenoceptor, Journal of Chromatography A, 2015 1401, 75-83.
3. Qian Li, Jing Wang, Guangxin Liu, Huanmei Sun, Liujiao Bian, Xinfeng Zhao*, Xiaohui Zheng, Screening bioactive compounds from Ligusticum chuanxiong by high density immobilized human umbilical vein endothelial cells, Analytical and bioanalytical chemistry, 2015, 407 (19): 5783-5792.
4. Qian Li, Jing Wang, Lingjian Yang, Xiaokang Gao, Hongwei Chen, Xinfeng Zhao*, Liujiao Bian, Xiaohui Zheng, Estimation of interaction between oriented immobilized green fluorescent protein and its antibody by high performance affinity chromatography and molecular docking, Journal of Molecular Recognition, 2015, 28 (7): 438-446.
5. Yuxin An, Xia Li, Huanmei Sun, Wenhai Bian, Zijian Li, Youyi Zhang, Xinfeng Zhao*, Xiaohui Zheng, Target‐directed screening of the bioactive compounds specifically binding to β2‐adrenoceptor in Semen brassicae by high‐performance affinity chromatography, Journal of Molecular Recognition2015, 28 (10): 628-634.
6. Jing Wang, Qian Li, Lingjian Yang, Yajun Zhang, Jie Yu, Xinfeng Zhao*, Jianbin Zheng, Youyi Zhang, Xiaohui Zheng, Binding interactions between prazosin and α 1A-adrenoceptor: investigation on the thermodynamic behaviors and the binding mechanism by high performance affinity chromatography, Analytical Methods, 2017, 7 (8), 3340-3346.
二、发明专利
1. 赵新锋，王静，李倩，袁心怡. 中药活性成分靶向筛选方法及试剂盒，中国发明专利，9.X，已受理
2. 赵新锋，李倩，王静. 止咳平喘中药活性成分靶向筛选方法及试剂盒，中国发明专利，0.6，已受理
3. 赵新锋，李倩，王静，曾凯竹. 基于halo-tag特异性脱卤反应的蛋白质一步定向固定化方法，中国发明专利，0.2，已受理
4. 赵新锋，常中满，张亚军，王静，李倩. 一种外用治疗痤疮的药物组合物及其制备方法，中国发明专利，3.8，已受理
5. 赵新锋, 郑晓晖, 于洁, 王世祥, 李倩. 一种高密度RGD肽修饰材料的合成及用途. 发明专利：ZL8.3
6. 赵新锋, 郑晓晖, 张亚军, 肖超妮, 王静. 定向固定化PEGA复合型树酯的制备方法及应用. 发明专利：ZL7.9
7. 郑晓晖, 王世祥, 赵新锋, 张群正. 取代β-苯基-α-羟基丙酸衍生物、其合成方法及其用途. 国际PCT专利：CN
8. 郑晓晖, 南叶飞, 赵新锋, 王世祥, 张群正. 取代的苯甲酸衍生物及其合成方法和用途. 发明专利: ZL 0.6
9. 于洁, 郑晓晖, 赵新锋, 王世祥. 丹参提取物纳米颗粒及其制备方法. 发明专利: ZL 5.0
10. 郑晓晖, 张群正, 王世祥, 赵新锋. β-(3,4-二羟基苯基)-α-羟基丙酸冰片酯、其合成方法和用途. 发明专利:ZL 7.3
三、软件著作
1. 蛋白质-药物相互作用分析软件，软著登字第**号
获得的教学和科研表彰
1. 陕西省科学技术进步奖一等奖，中药分子新药研发“合策略”的构建及基础应用，第二完成
人，陕西省人民政府，2019
2. 陕西高等学校科学技术奖一等奖，基于“良关系”的组合中药分子化学新药研发策略的构建及
基础应用，第二完成人，陕西省教育厅，2018
3. 陕西省科学技术奖一等奖，“君-使对药”有效成分群辨识技术研究，第二完成人，陕西省人民
政府，2014
4. 陕西高等学校科学技术奖一等奖，受体色谱的构建及应用基础研究，第二完成人，陕西省教
育厅，2014
5. 陕西高等学校科学技术奖一等奖，丹参素系列衍生物的合成及其医药用途基础研究，第二完
成人，陕西省教育厅，2011
6. 陕西省中青年科技创新领军人才，陕西省科学技术厅，2019
7. 西部药学之星，西部药学联合会，2019
8. 第四届西安科技人才奖，中共西安市委人才工作领导小组，2015