个人简介 边六交，博士，教授，博士生导师，现在西北大学生命科学学院中药学系从事教学和科研工作。目前主要从事药用蛋白质分子的克隆表达和分离纯化研究、蛋白质与特异配体分子间的相互作用研究、生物工程和基因工程药物研究、基于DNA荧光探针的分子和离子检测研究以及微孔淀粉的制备和应用研究等。在中药生物工程和细胞生物工程两个方向招收博士和硕士研究生。

承担的科研项目 [1] 国家“重大新药创制”科技重大专项项目，基因重组血管生长抑制剂Kringle 5的中试生产工艺和药用研究。
[2] 国家自然科学基金面上项目，变性剂诱导的蛋白质分子展开过程稳定构象态分布和转化的理论模型及验证。
[3] 陕西省政府科技财政专项基金项目，基因重组血管生长抑制剂Kringle 5的中试生产工艺和药用研究。
[4] 陕西省科技攻关项目，马铃薯微孔淀粉的中试生产工艺研究。
[5] 陕西省科技统筹创新工程计划项目，微孔淀粉的规模化生产工艺及其止血剂和缓释剂的研究。

主要研究成果 发表论文
[1] Jianting Yang, Qian Li, Liujiao Bian. Spectroscopic analysis and docking simulation on the recognition and binding of TEM-1 β-lactamase with β-lactam antibiotics. Experimental and Therapeutic Medicine. 2017, 14: 3288-3298.
[2] Yeli Zhang, Pan Qiao, Shuaihua Li, Xuan Feng, Liujiao Bian. Molecular recognition and binding of beta‐lactamase II from Bacillus cereus with penicillin V and sulbactam by spectroscopic analysis in combination with docking simulation. Luminescence. 2017, 32: 932-941.
[3] Penghui Shi, Pan Qiao, Yeli Zhang, Shuaihua Li, Xuan Feng, Liujiao Bian. Spectroscopy analysis and molecular dynamics studies on the binding of penicillin V and sulbactam to beta-lactamase II from Bacillus cereus. Journal of Pharmaceutical and Biomedical Analysis, 2017, 138: 206–214.
[4] Qian Li,?Shuaihua Li,?Xiu Chen,?Liujiao?Bian. A G-quadruplex based fluorescent oligonucleotide turn-on probe towards iodides detection in real samples. Food Chemistry.?2017, 230: 432-440.
[5] Xiu Chen,?Yuhua Li,?Yan Zhang,?Jianting Yang,?Liujiao?Bian. Binding of TEM-1 beta-lactamase to beta-lactam antibiotics by frontal affinity chromatography. Journal of Chromatography B,?2017, 1051: 75-83.
[6] Qian Li,?Pan Qiao,?Xiu Chen,?Jing Wang,?Liujiao Bian, Xiaohui Zheng. Affinity chromatographic methodologies based on immobilized voltage dependent anion channel isoform 1 and application in protein-ligand interaction analysis and bioactive compounds screening from traditional medicine. Journal of Chromatography A,?2017, 1495: 31-45.
[7] 边文海，刘成程，李倩，王超展，边六交。玉米微孔淀粉制备止血剂研究，生物技术进展，2017, 7：320-326。
[8] 候晓苹，李丽，李蕊苹，李帅华，边六交。马铃薯微孔淀粉的中试生产制备工艺优化，中国医药工业杂志，2017, 47(11)：1627-1633。
[9] Q. Li, T. Zhang, L. Bian. Recognition and binding of β-lactam antibiotics to bovine serum albumin by frontal affinity chromatography in combination with spectroscopy and molecular docking. J. Chromatogr. B 2016, 1014: 90-101.
[10] Q. Li, M. Duan, S. Li, Y. Zhang, P. Qiao, L. Bian. Recognition and binding of voltage-dependent anion channel-1 with ATP and NADH by spectroscopic analysis and molecular docking. RSC Adv. 2016, 6: 13407-13417.
[11] Y. Liang, L. Bian. Voltage-dependent anion channel-1, a possible ligand of plasminogen Kringle 5, PLOE One, 2016, 11(10): e**.
[12] 杨文慧，冀旭，边六交。多方法组合分析脲诱导的淀粉液化芽孢杆菌α-淀粉酶去折叠和重折叠过程的构象转化，分析科学学报，2016，32(1)：8-14.
[13] L. Bian, Q. Li, X. Ji. Binding of angiogenesis inhibitor kringle 5 to its specific ligands by frontal affinity chromatography coupled with fluorescence spectra and molecular docking, Journal of Chromatography A. 2015, 1401:42-51.
[14] L. Bian, J. Yang, Y. Sun. Isolation and purification of monosialotetrahexosylgangliosides from pig brain by extraction and liquid chromatography, Biomedical Chromatography. 2015,29:1604-1611.
[15] Q. Li, J. Wang, L. Yang, X. Gao, H. Chen, X. Zhao, L. Bian, X. Zheng. Estimation of interaction between oriented immobilized green fluorescent protein and its antibody by high performance affinity chromatography and molecular docking, Journal of Molecular Recognition. 2015,28:438-46.
[16] Y. K. Liang, P. Wei, L. J. Bian, Cloning, expression and identification of an isoform of human stromal cell derived factor-1α, Experimental and Therapeutic Medicine, 2015, 9: 1751-1756.
[17] 杨文慧，冀 旭，边六交。多方法组合分析脲诱导的淀粉液化芽孢杆菌a-淀粉酶去折叠和重折叠过程的构象转化，分析科学学报，2015，31：1-8。
[18] 侯晓苹，赵娟，侯晓莉，李帅华，边六交。维生素C、茶碱和BSA在微孔淀粉上的吸附－释放动力学考察。中国医药工业杂志，2015，46：860-865。
[19] L. Bian, X. Ji, W. Hu. A novel single-labeled fluorescent oligonucleotide probe for silver(I) ion detection in water, drugs, and food, Journal of Agricultural and Food Chemistry, 2014, 62: 4870-4877.
[20] L. Bian, X. Ji. Distribution, transition and thermodynamic stability of protein conformations in the denaturant-induced unfolding of proteins. PLos One, 2014, 9: e91129-e91139.
[21] L. Bian, D. Wu, W. Hu. Temperature-induced conformational transition of bovine serum albumin in neutral aqueous solution by reversed-phase liquid chromatography. Biomedical Chromatography, 2014, 28: 295-301.
[22] L. Bian, X. Ji, W. Hu. Urea-induced dissociation of nerve growth factor from venom of Chinese cobra by SEC. Chromatographia, 2014, 77: 793-802.
[23] L. Bian, X. Ji, W. Hu. Isolation and purification of recombinant human plasminogen Kringle 5 by liquid chromatography and ammonium sulfate salting-out. Biomedical Chromatography, 2014, 28: 57-965.
[24] X. Guo, X. Wang, M. Li, Y. Yuan, Y. Chen, D. Zou, L. Bian, D. Li. PDX-1 mRNA-induced reprogramming of mouse pancreas-derived mesenchymal stem cells into insulin-producing cells in vitro, Clin. Exp.Med., 2014,10: 1591-1600.
[25] X. Ji, X. Ma, L. Bian. Spectral studies on the conformational transitions of bovine insulin during denaturant-induced unfolding. Chemical Research in Chinese Universities, 2014, 30: 222-227.
[26] 吴丹，边六交。光谱法研究变性剂诱导的猪胃蛋白酶和牛血清蛋白折叠中间态的分布和过渡，分析科学学报，2014，30：31-34。
[27] 冯瑄，张潭，边六交。盐酸胍诱导的变性卵清溶菌酶分子重折叠过程及其各稳定构象态的分布和过渡。高等学校化学学报，2013，34：336-345。
[28] 冀旭，边六交。Ca2+诱导的淀粉液化芽孢杆菌α-淀粉酶分子的生物活性和结构变化，高等学校化学学报，2013，34：2517-2523。
[29] 马丽娜，吴丹，边六交。基因重组可溶性非融合血管生成抑制剂Kringle 5的色谱分离和纯化，色谱，2012，30：822-826。
[30] 马晓娟，蔚萍，妙亮，边六交。可溶型非融合血管生长抑制因子Kringle 5基因工程菌发酵培养和诱导表达条件的优化，化学与生物工程，2012，29：27-31。
[31] J. Yang, T. Zhang, C. Lu, L. Bian. Distribution and transition of native and completely unfolded conformations in the unfolding of bovine heart cytochrome c induced by urea and guanidine hydrochloride. Chinese Journal of Chemistry, 2011, 29: 1939-1946.
[32] L. Bian, T. Zhang, X. Yang, L. Liu, X. Zheng. Unfolding of bovine heart cytochrome c induced by urea and guanidine hydrochloride. Chinese Journal of Chemistry, 2011, 29: 813-821.
[33] 张潭，边六交。脲和盐酸胍诱导的卵清溶菌酶分子去折叠过程中各稳定构象态的分布和过渡，高等学校化学学报，2011，32：1497-1505。
[34] 段栋，蔚萍，边六交。盐酸胍诱导的猪血红蛋白分子解离过程中各亚基的分布，分析科学学报，2011，27：688-692。
[35] 妙亮，徐立华，冀旭，边六交。可溶型三聚体血管生长抑制因子Kringle 5的克隆表达纯化及活性研究，中国生物工程杂志，2011，31：18-22。
授权专利
[1] 边六交，蔚萍，冀旭，侯俊。人源基质细胞衍生因子1α的表达载体、构建方法及应用，专利号：CN8.6。
[2] 边六交，刘成程，冀旭。一种高比表面积微孔淀粉的制备方法，专利号：CN2.1。
[3] 边六交，妙亮。一种高活性可溶型血管生长抑制剂Kringle 5三聚体的高效表达方法，专利号：CN1.5。
[4] 边文海，李倩，陈秀，王超展，边六交。一种快速止血剂，申请号：8.4。