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基本信息 The basic information
姓名: 张悦周

学院: 柔性电子研究院


学历: 博士研究生毕业

学位: 哲学博士


职称: 副教授

职务:


学科: 化学-有机化学,药学-药剂学,计算机科学与技术-计算机应用技术


邮箱: iamyzzhang@nwpu.edu.cn




工作经历 Work Experience
2019/01- 至今 副教授，西北工业大学柔性电子研究院
2016/12-2018/12 博士后，芬兰奥博学术大学
2015/06-2016/10 博士后，澳大利亚莫纳什大学
2015/03-2015/06 助理研究员，华中农业大学动物科技学院、动物医学院。





教育经历 Education Experience
2009/12-2014/12 芬兰赫尔辛基大学博士
2008/03-2009/12 西北工业大学博士学习
2005/09-2008/03 西北工业大学硕士
1999/09-2003/07 西安工程大学学士





招生信息 Admission Information
欢迎对纳米医学、数据发掘方向的同学加入本团队，尤其是具有有机化学、计算化学、高分子、数据挖掘背景的博士、硕士、本科生加入本课题组。



科学研究 Scientific Research
本课题组在药物化学，化学信息学，纳米医学，微流体技术等领域开展研究工作。其代表性成果有编写计算机程序从数据库中挖掘磷酸根生物等排体，并将获得的结果运用于新靶标活性小分子化合物的合成中。建立白桦醇同系物抗利什曼原虫的定量构效关系并预测其生物靶标。通过高通量筛选技术发现针对捻转血矛线虫的先导化合物，优化其结构获得药效和安全性俱佳的候选药物分子。以DNA为基础的药物递送系统的构建及其生物医学应用。多孔二氧化硅和硅材料的制备并赋予其靶向功能，基于多种具有协同作用抗癌药的前药纳米颗粒的制备。使用微流体技术制备纳米颗粒，对装载了药物的多孔材料进行包裹实现载体的控制释放。合成石墨烯增强的水凝胶吸附以及微/纳滤膜去除水体中的重金属污染。



学术成果 Academic Achievements
近年来以第一作者或通讯作者发表Adv. Mater.、Adv. Funct. Mater.、J.Chem.Inf.Model、J Cheminform.等国际著名学术期刊近20余篇，受邀为多家国际学术期刊的审稿人，并参与编写书籍章节3章。
代表性论文1. Yuezhou Zhang*, Huaguang Cui, Ruiqi Zhang, Hongbo Zhang* and Wei Huang*. Nanoparticulation of Prodrug into Medicines for Cancer Therapy. Advanced Science. 2021, (In press)
2. Jingyan Gao, Xiaodong Ma, Lirong Zhang, Jiaqi Yan, Huaguang Cui, Yuezhou Zhang,* Dongqing Wang,* and Hongbo Zhang.* Self-Assembled Disulfide Bond Bearing Paclitaxel-Camptothecin Prodrug Nanoparticle for Lung Cancer Therapy. Pharmaceutics. 2020, 12(12), 1169
3. Banfeng Ruan^⊥, Yuezhou Zhang^⊥, Solomon Tadesse^⊥, Sarah Preston, Aya C. Taki, Abdul Jabbar, Andreas Hofmann, Yaqing Jiao, Jose Garcia-Bustos, Jitendra Harjani, Thuy Giang Le, Swapna Varghese, Silvia Teguh, Yiyue Xie, Jephthah Odiba, Min Hu, Robin B. Gasser, Jonathan Baell*. Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus. European Journal of Medicinal Chemistry, 2020,190,112100
4. Xiaodong Ma^⊥, Yuezhou Zhang^⊥,* and Korbinian Weisensee. Conducting Polymeric Nanocomposites with a Three-Dimensional Co-flow Microfluidics Platform, Micromachines, 2019,10(6), 383
5. Xiaodong Ma, Ezgi zliseli, Yuezhou Zhang,* Guoqing Pan, Dongqing Wang,* and Hongbo Zhang.* Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy, Biomaterials Science, 2019, 7(2):634-644
6. Yuezhou Zhang, Henri Xhaard, Leo ghemtio*. Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors. Journal of Cheminformatics. 2018, 10(1):40
7. Yuezhou Zhang*, Jing Tu, Dongqing Wang, Haitao Zhu, Sajal Kumar Maity, Xiangmeng Qu, Bram Bogaert, Hao Pei, and Hongbo Zhang*. Programmable and Multifunctional DNA-Based Materials for Biomedical Applications. Advanced Materials. 2018, 30(24):**
8. Yuezhou Zhang, Alexandre Borrel, Leo Ghemtio, Leslie Regad, Gustav Boije af Genns, Anne-Claude Camproux, Jari Yli-Kauhaluoma, Henri Xhaard*. Structural isosteres of phosphate groups in the Protein Data Bank. Journal of Chemical Information and Modeling, 2017,57(3), 499-516
9. Xiuzhen Yang, Tengzhi Zhou, Bozhi Ren, Andrew Hursthouse, Yuezhou Zhang*. Removal of Mn (II) by Sodium Alginate/Graphene Oxide Composite Double-Network Hydrogel Beads from Aqueous Solutions. Scientific Reports. 2018, 8(1):10717
10. Yuezhou Zhang, Mikael Jumppanen, Mirko M. Maksimainen, Samuli Auno, Zulfa Awol, Léo Ghemtio, Hari Venkannagari, Lari Lehti, Jari Yli-Kauhaluoma, Henri Xhaard, Gustav Boije af Genns*. Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. Bioorganic & Medicinal Chemistry, 2018, 26(8): 1588-1597
11. Xiuzhen Yang, Yuezhou Zhang*, Liping Wang, Lili Cao, Kelin Li and Andrew Hursthouse. 2017, Preparation of a Thermally Modified Diatomite and a Removal Mechanism for 1-Naphthol from Solution. WATER, 2017, 9, (9), 651
12. Y.Z. Zhang, G.C. Zhang, X.F. Sun, He, Z and M. Rajaratnam. Properties and Microstructure Study of Polyimide Foam Plastic. Cellular Polymers, 2010, 29(4):211-226
13. Y.Z. Zhang, G.C. Zhang, Z. He, X.F. Sun, M. Rajaratnam. Visualization Study of Solid Poly (Ester-Amine Salt) Precursor Foaming Process. Cellular Polymers, 2010, 29(1):45-57
14. Feng Zhang^⊥, Yiran Zhang^⊥, LiKong^⊥, Huanhuan Luo, Yuezhou Zhang, ErmeiMkil, Jarno Salonen, Jouni T.Hirvonen, Yueqi Zhu, Yingsheng Cheng, Lianfu Deng, Hongbo Zhang*, Alexander Kros, Wenguo Cui*, Hélder A.Santos*. Multistage signal-interactive nanoparticles improve tumor targeting through efficient nanoparticle-cell communications. Cell Reports, 2021, 35, 109131
15. Meiling Chen, Chenxi Peng, Yaoquan Su, Xue Chen, Yuezhou Zhang, Yu Wang, Juanjuan Peng, Qiang Sun, Xiaowang Liu,* and Wei Huang*. A General Strategy for Hollow Metal-Phytate Coordination Complex Micropolyhedra Enabled by Cation Exchange. Angewandte Chemie International Edition. 2020, 59, (47):20988-20995
16. Minghua Yao, Ming Ma*, Hongbo Zhang, Yuezhou Zhang, Gang Wan, Jie Shen, Hangrong Chen*, Rong Wu*. Mesopore-Induced Aggregation of Cobalt Protoporphyrin for Photoacoustic Imaging and Antioxidant Protection of Stem Cell. Advanced Functional Materials, 2018, **
17. Yueqi Zhu^#, Hongbo Zhang^#, Yiran Zhang^#, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng, Minghua Li*, Hélder A. Santos*, Wenguo Cui*. Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Advanced Materials, 2018, **
18. Dongfei Liu*, Salvatore Cito, Yuezhou Zhang, Chang-Fang Wang, Tiina Sikanen and Hélder A. Santos*. A Versatile and Robust Microfluidic Platform towards High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties. Advanced Materials. 2015, 27 (14): 2298-2304
专著1.Yuezhou Zhang, Dongfei Liu, Hongbo Zhang and Hélder A. Santos*. chapter 7, Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery, Elsevier, 2019, 155-177
2.Yuezhou Zhang, Dhayakumar Rajan Prakash, Hongbo Zhang*. Nucleotide Aptamers as Theranostic Bionanomaterials, Theranostic Bionanomaterials, Elsevier, 2019, chapter 19, 423-446
3.Yuezhou Zhang, Luofeng Yu, Jianhong Zhang and Peng Li*. Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies. Polymeric Nanoparticulate Delivery Vehicles of Antimicrobials for Biofilm Eradication，Springer, 2020, Cham, 409-429

主持项目陕西省科学技术厅，面上项目，2020JM-141，微流控制备高载药基因药物连续流制备及形成机制研究，2020-01至2021-12，3万元
陕西省科学技术厅，高校联合项目-重点项目，2020GXLH-Z-017，基于线粒体质量控制的蛋白标志物研究，2020-01至2023-12，37万元，
宁波市科技局，自然科学基金重点项目，202003N4006，2020-11至2023-10，基于开源数据库的生物电子等排体网页服务器开发与应用研究，20万








学术文献 Academic Literature