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基本信息 The basic information
姓名: 曾华强

学院: 化学与化工学院


学历: 博士研究生毕业

学位: 理学博士


职称: 教授

职务:


学科:


邮箱: hqzeng@nwpu.edu.cn




教育经历 Education Experience
1996年7月：中国科学技术大学理学学士
2002年2月：美国纽约州立大学布法罗分校理学博士学位, 师从Gong Bing教授
2002年3月－2006年6月：美国斯克利普斯研究所博士后。师从美国科学院及医学院双院士Peter G. Schultz教授




工作经历 Work Experience
2006年7月－2014年6月：新加坡国立大学化学系助理教授及国立大学药物化学平台的核心成员
2014年7月－2019年3月：新加坡生物工程和纳米技术研究院课题组长/资深研究员
2019年4月－2020年9月：新加坡纳米生物国家实验室课题组长/资深研究员
2020年10月－现今: 西北工业大学教授





科学研究 Scientific Research


研究兴趣：生物有机功能超分子化学 (人工离子/水/DNA/质子通道)及在海水淡化，抗癌新药和第三代基因测序技术开发中的应用


个人谷歌学术主页：
https://scholar.google.com/citations?view_op=list_works&hl=zh-CN&user=4DzjlW0AAAAJ 或者
https://scholar.google.com/citations?user=4DzjlW0AAAAJ&hl=en&oi=ao



曾华强课题组在人工跨膜输运体的构筑和功能开发方面最主要的贡献如下：
1.大一统化的人工离子通道：创新性的构筑了一类可精准识别金属离子结构高度可调的五元环大环系统；以唯一通讯作者发表了5篇J. Am. Chem. Soc.和1篇Angew. Chem. Int. Ed.。


2.人工水通道：（1）创新性的在短的螺旋分子两端引入“粘性基团”用以驱动形成带空腔可让水选择性通过的纳米管（Chem. Sci. 2012, 3, 2042; J. Am. Chem. Soc. 2014, 136, 14270；Acc. Chem. Res. 2016, 49, 922；J. Am. Chem. Soc. 2020, 142, 10050; Angew. Chem. Int. Ed. 2020, 59, 13328）。（2）最近开发出的第二代人工水通道纳米管在保持高选择性的同时将水的通透性提高到水通道蛋白的2.5倍以上，为目前性能最好的海水反渗透膜了流速的8000倍，解决了人工水通道亟需解决的关键应用技术问题（Nature Nanotech., 已接收）。此类工作在有机功能超分子领域引起了国内外广泛的关注。尚未发表的第三代人工水通道纳米管在保持高选择性的同时将水的通透性提高到海水反渗透膜了流速的3万倍。


3.具有高选择性的人工离子通道：（1）将人工钾离子跨膜通道的钾/纳选择性提高到了16.3（J. Am. Chem. Soc. 2017, 139, 12338；Angew. Chem. Int. Ed. 2020, 59, 1440-1444），是从1982年第一篇离子通道论文的发表到至今的一个较大的突破。（2）开辟了可从液相选择性直接精准定制跨膜输运选择性的先河，解决了本领域40年来悬而未决的重大难题（J. Am. Chem. Soc. 2020, 142, 21082）。（3）具有高选择性的人工负离子通道：（J. Am. Chem. Soc. 2018, 140, 8817和Angew. Chem. Int. Ed. 2020, 59, 4806）。


4.全新跨膜输运机理：创新性的开发出了两类基于分子机器的人工跨膜运输体—分子秋千（Angew. Chem. Int. Ed. 2019, 58, 8034）和分子渔夫（J. Am. Chem. Soc. 2019, 141, 9788），为抗癌新药的研发开创了一个崭新的方向。


独立承担的主要科研项目:
(1) $3,498,800 from National Research Foundation Competitive Research Programme; Project title: Synthetic water channel-based biomimetic hybrid membranes for water desalination;expiry date: 30/09/2019
(2) $108,000 from The Faculty Research Committee (FRC) of NUS; Project title: Conformationally Switchable Fluorescent Oligophenol Foldamers as Amine/Ion Sensors; expiry date: 31/01/2015
(3) $150,000 from The Faculty Research Committee (FRC) of NUS; Project title: Water-binding aquafoldamers as synthetic water channels for water reuse and desalination; expiry date: 31/05/2014
(4) $68,000 from The Faculty Research Committee (FRC) of NUS; Project title: Novel Biosensors for sensitive and specific protein detection by the naked eyes; expiry date: 31/08/2013
(5) $25,000 from Cross-Faculty Research Grant of NUS; Project title: DNA‐based Nanosensors for Sensitive Detection and Rapid Monitoring of Environmental Contaminants; expiry date: 31/03/2012
(6) $155,000 from The Faculty Research Committee (FRC) of NUS; Project title: Tuning the Alkali Metal-Binding Affinities of Helical Oligoaromatic Foldamers; Expiry date: 30/06/2012
(7) $480,000 from Biomedical Research Council (BMRC); Project title: Synthesis and evaluation of planar pentavalent ligands targeting dimeric interface of serum amyloid P component for the therapeutic elimination of Alzheimer's disease; expiry date: 31/12/2011
(8) $179,987 from The Faculty Research Committee (FRC) of NUS; Project title: Synthetic Ion Channels with Tunable Interior Properties Derived from the Attachment of Circular Ion-Binding Units to A Linear, Rigid Scaffold; expiry date: 31/03/2011
(9) $179,960 from The Faculty Research Committee (FRC) of NUS; Project title: Chemical Models toward Protein β-Sheet/Turn Structures and Their Biological Implications; Expiry date: 31/08/2008




荣誉获奖 Awards Information
西北工业大学海外高层次领军人才


六项研究成果（J. Am. Chem. Soc. 2014, 136, 14270, Chem. Mater 2016, 28, 4001, J. Am. Chem. Soc. 2017, 139, 12338, Angew. Chem. Int. Ed. 2017, 56, 3847, J. Am. Chem. Soc. 2018, 140, 8817, Angew. Chem. Int. Ed. 2019, 58, 8034）被评为新加坡科技研究局最重要的年度科技进展并做新闻报道。其中，首次实现的常温下即可将水上泄漏的各类原油快速固化成易于打捞的悬浮胶状固体的"智能型"小分子胶凝剂被新加坡科技研究局做两次亮点报道并以”Superhero Supergelators”为电影题目被拍成微型电影，为新加坡科技研究局成立30年以来所拍的19部关于科技突破性进展的微型电影之一。


2011年10月，入选自然化学（Nature Chemistry，IF = 21.687）的Sceptical Chymist（指勇于推翻经典认知的怀疑派化学家）


2012年5月，受邀为美国化学会的化学和化工新闻杂志（Chemical & Engineering News）为发表在J. Am. Chem. Soc. 2012, 134, 8384上的人工水通道做新闻评述。


2013年，被化学主流期刊化学通讯（Chemical Communications）选为2013年度的"Emerging Investigators" (2013年共遴选出80多个研究小组，见Chem. Commun. 2013, 49, 4127)。


2015年，受邀为化学主流综述期刊（Acc. Chem. Res. ，IF = 21.661）撰写本课题组在人工水通道研究方面的综述（见：Acc. Chem. Res. 2016, 49, 922）





学术成果 Academic Achievements
2021
Shen, J.; Ye, R. J.; Zeng, H. Q.,* Crystal Packing-Guided Construction of Hetero-Oligomeric Peptidic Ensembles as Synthetic 3-in-1 Transporters. Angew. Chem. Int. Ed. 2021, in revision
Roy, A.; Shen, J.; Joshi, H.; Song, W.; Tu, Y.-M.; Chowdhury, R.; Ye, R. J.; Li, N.; Ren, C.; Kumar, M.; Aksimentiev, A.; Zeng, H. Q.,* Foldamer-Based Ultrapermeable and Highly Selective Artificial Water Channels that Exclude Protons. Nat. Nanotech. 2021, in press
Zhang, H.; Ye, R. J.; Mu, Y. G.; Li, T.; Zeng, H. Q.,* Small Molecule-Based Highly Active and Selective K⁺ Transporters with Potent Anticancer Activities. Nano Lett. 2021, 21, 1384–1391



2020
Li, N.; Shen, J.; Ang, G. K.; Ye, R. J.; Zeng, H. Q.,* Molecular Tetrahedrons as Selective and Efficient Ion Transporters via a Two-Station Swing-Relay Mechanism. CCS Chem. 2020, 2, 2269-2279
Li, N.; Chen, F.; Shen, J.; Zhang, H.; Wang, T.; Ye, R. J.; Li, T.; Loh, T.P.; Yang, Y.Y.; Zeng, H. Q.,* Buckyball-Based Spherical Display of Crown Ethers for De Novo Custom Design of Ion Transport Selectivity. J. Am. Chem. Soc. 2020, 142, 21082-21090
Shen, J.; Ye, R. J.; Romanies, A.; Lin, Y.; Roy, A.; Chen, F.; Ren, C. L., Liu, Z.; Zeng, H. Q.,* Aquafoldmer-Based Aquaporin-like Synthetic Water Channel. J. Am. Chem. Soc. 2020, 142, 10050-10058
Shen, J.; Fan, J.; Ye, R. J.; Li, N.; Mu, Y.; Zeng, H. Q.,* Polypyridine-Based Helical Amide Foldamer Channels: Rapid Transport of Water and Protons with High Ion Rejection. Angew. Chem. Int. Ed. 2020, 59, 13328-13334
Roy, A.; Joshi, H.; Ye, R. J.; Shen, J.; Chen, F.; Aksimentiev, A.*; Zeng, H. Q.,* Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels. Angew. Chem. Int. Ed. 2020, 59, 4806-4813
Chen, F.; Shen, J.; Li, N.; Roy, A.; Ye, R. J.; Ren, C. L.; Zeng, H. Q.,* Pyridine/Oxadiazole-Based Helical Foldamer Ion Channels with Exceptionally High K⁺/Na⁺ Selectivity. Angew. Chem. Int. Ed. 2020, 59, 1440-1444
Ye, R. J.; Jiang, C.-X.; Yuan, L.; Li, Y.; Hu, J.-F.*; Zeng, H. Q.,* Macrocyclic Pyridone Pentamers for Highly Selective High-Capacity Removal of Caesium Ions from Radioactive High Salinity Wastes. Chem. Asian J. 2020, 15, 4286-4290 (VIP paper)
Li, Z.; Luo, Z.; Zhou, J.; Ye, Z.; Ou, G.-C.; Huo, Y.; Yuan, L.*; Zeng, H. Q.,* Monopeptide-Based Powder Gelators for Instant Phase-Selective Gelation of Aprotic Aromatics and for Toxic Dye Removal. Langmuir 2020, 36, 9090-9098


2019
Ye, R. J.; Ren, C. L.; Shen, J.; Li, N.; Chen, F.; Roy, A.; Zeng, H. Q.,* Molecular Ion Fishers as Highly Active and Exceptionally Selective K⁺ Transporters. J. Am. Chem. Soc. 2019, 141, 9788-9792
Ren, C. L.; Chen, F.; Ye, R. J.; Ong, Y. S.; Lu, H. F.; Lee, S. S.; Ying, J. Y.-R.; Zeng, H. Q.,* Molecular swings as highly active ion transporters. Angew. Chem. Int. Ed. 2019, 58, 8034-8038 (Hot Paper)
Yuan, L.; Shen, J.; Ye, R. J.; Chen, F.; Zeng, H. Q.,* Structurally simple trimesic amides as highly selective anion channels. Chem. Commun. 2019, 55, 4797-4800
Zeng, F.; Liu, F.; Yuan, L.; Zhou, S.; Shen, J.; Li, N.; Ren, H.*; Zeng, H. Q.,* A Pore-Forming Tripeptide as an Extraordinarily Active Anion Channel. Org. Lett. 2019, 21, 4826-4830


2018
Ren, C. L.; Zeng, F.; Shen, J.; Chen, F.; Roy, A.; Zhou, S.; Ren, H.; Zeng, H. Q.,* Pore-Forming Monopeptides as Exceptionally Active Anion Channels. J. Am. Chem. Soc. 2018, 140, 8817–8826
Ren, C. L.; Ding, Z.; Roy, A.; Shen, J.; Zhou, S. Y.; Chen, F.; Li, S.; Ren, H. S..; Yang, Y. Y.; Zeng, H. Q.,* A halogen bond-mediated highly selective and active artificial chloride channel with high anticancer activity. Chem. Sci. 2018, 9, 4044-4051 (Front Cover)
Li, J.; Huo, Y.*; Zeng, H. Q.,* Combinatorial identification of a highly soluble phase-selective organogelator with high gelling capacity for crude oil gelation. J. Mater. Chem. A 2018, 6, 4044-4051
Li, J. T.; Huo, Y.*; Zeng, H. Q.,* Polar Solvent-Induced Unprecedented Supergelation of (Un)Weathered Crude Oils at Room Temperature. Langmuir 2018, 34, 8058-8064
S. Zhao, L. Zeng, G. Cheng, L. Yu,* Zeng, H. Q.,* "Ni/Co-based metal-organic frameworks as electrode material for high performance supercapacitors," Chin. Chem. Lett. 2018, 30, 605-609
J Li, J. T.; Huo, Y.*; Zeng, H. Q.,* "DMSO-accelerated rapid gelation of crude oils at room temperature," Supramol. Chem. 2018, 30, 1011-1016


2017
Ren, C. L.; Shen, J.; Zeng, H. Q.,* Combinatorial evolution of fast-conducting highly selective K⁺-channels via modularly tunable directional assembly of crown ethers J. Am. Chem. Soc. 2017, 139, 12338–12341
Shen, J.; Ren, C. L.; Zeng, H. Q.,* Surprisingly high selectivity and high affinity in mercury recognition by H-bonded cavity-containing aromatic foldarands. J. Am. Chem. Soc. 2017, 139, 5387–5396
Ren, C. L.; Shen, J.; Chen, F.; Zeng, H. Q.,* Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator. Angew. Chem. Int. Ed. 2017, 56, 3847-3851
Lee, K. H.; Zeng, H. Q.,* Aptamer-Based ELISA Assay for Highly Specific and Sensitive Detection of Zika NS1 Protein. Anal. Chem. 2017, 89, 12743-12748
Zhao, H. Q..; Shen, J.; Ren, C. L.; Zeng, W.; Zeng, H. Q.,* A Foldamer-Based Organocatalyst for Direct Arylations of Unactivated Arenes. Org. Lett. 2017, 19, 2190-2193
Lee, K. H.; Zeng, H. Q.,* A general double library SELEX strategy for aptamer selection using unmodified nonimmobilized targets. Anal. Bioanal. Chem. 2017, 409, 5081-5089
Li, J.; Huo, Y.*; Liu, M.; Zeng, H. Q.,* Phase-Selective Organogelators for Oil Spill Treatment. Prog. Chem. 2017, 29, 617-627


2016
Huo, Y. P.; Zeng, H. Q.,* “Sticky”-Ends-Guided Creation of Functional Hollow Nanopores for Guest Encapsulation and Water Transport Acc. Chem. Res. 2016, 49, 922–930
Shen, J.; Ren, C. L.; Zeng, H. Q.,* Tuning cation-binding selectivity and capacity via side chain-dependent molecular packing in the solid state. Chem. Commun. 2016, 52, 10361-10364
Ren, C.; Ng, G. H. B.; Wu, H.; Chan, K.-H.; Shen, J.; Teh, C.; Ying, J. Y.; Zeng, H. Q.,* Instant room-temperature gelation of crude oil by chiral organogelators. Chem. Mater 2016, 28, 4001–4008
Ren, C.; Chen, F.; Zhou, F.; Shen, J.; Su, H.; Zeng, H. Q.,* Low-Cost Phase-Selective Organogelators for Rapid Gelation of Crude Oils at Room Temperature. Langmuir 2016, 32, 13510-13516
Huo, Y. P.; Zeng, H. Q.*; Zhang, Y. G.,* Integrating Metabolic Engineering and Heterogeneous Chemocatalysis: New Opportunities for Biomass to Chemicals. ChemSusChem 2016, 9, 1078-1080

2015
Liu, Y.; Shen, J.; Sun, C.; Zeng, H. Q.,* Intramolecularly Hydrogen-Bonded Aromatic Pentamers as Modularly Tunable Macrocyclic Receptors for Selective Recognition of Metal Ions. J. Am. Chem. Soc. 2015, 137, 12055–12063
Ren, C. L..; Shen, J.; Zeng, H. Q.,* One-Pot Synthesis of Strained Macrocyclic Pyridone Hexamers and Their High Selectivity toward Cu²⁺ Recognition. Org. Lett. 2015, 17, 5946-5949
Ma, W. L.; Wang, C. Q.; Li, J. T.; Zhang, K.; Lu, Y.-J.; Huo, Y. P.; Zeng, H. Q.,* The Dynamics, energetics and selectivity of water chain-containing aquapores created by the self-assembly of aquafoldamer molecules. Org. Biomol. Chem. 2015, 13, 10613-10619


2014
Zhao, H. Q.; Sheng, S.; Hong, Y. H.; Zeng, H. Q.,* Proton Gradient-Induced Water Transport Mediated by Water Wires inside Narrow Aquapores of Aquafoldamer Molecules J. Am. Chem. Soc. 2014, 136, 14270-14276
Shen, J.; Ma, W. L.; Yu, L.; Li, J.-B.; Tao, H.-C.; Zhang, K.; Zeng, H. Q.,* Size-dependent patterned recognition and extraction of metal ions by a macrocyclic aromatic pyridone pentamer. Chem. Commun. 2014, 50, 12730
Fu, H. L.; Chang, H.; Shen, J.; Lu, Y.-J.; Qin, B.*; Zhang, K.*; Zeng, H. Q.,* An Unusual Macrocyclization Reagent for Highly Selective One-Pot Synthesis of Strained Macrocyclic Aromatic Hexamers. Chem. Commun. 2014, 50, 3582
Sun, C.; Liu, Y.; Liu, J. Q.; Lu, Y.-J.; Yu, L.; Zhang, K.; Zeng, H. Q.,* Computational Insights into Processes Underlying the Amine-Induced Fluorescence Quenching of a Stimuli-Responsive Phenol-Based Hexameric Foldamer Host. J. Org. Chem. 2014, 79, 2963
Liu, J. Q.; Sun, C.; Ma, W. L.; Lu, Y.-J.; Yu, L.; Zhanga, K.; Zeng, H. Q.,* A conformationally switchable fluorescent oligophenol foldamer for selective sensing of copper(II) ions. RSC Adv. 2014, 4, 54469.


2013
Sun, C.; Ren, C. L.; Wei, Y. C.; Qin, B.; Zeng, H. Q.,* Patterned Recognition of Amines and Ammonium Ions by a Stimuli-Responsive Foldamer-Based Hexameric Oligophenol Host Chem. Commun. 2013, 49, 5307.
Zhao, H. Q.; Shen, J.; Guo, J. J.; Ye, R. J.; Zeng, H. Q.,* A macrocyclic aromatic pyridone pentamer as a highly efficient organocatalyst for the direct arylations of unactivated arenes. Chem. Commun. 2013, 49, 2323.
Fu, H. L.; Liu, Y.; Zeng, H. Q.,* Shape-persistent H-bonded macrocyclic aromatic pentamers. Chem. Commun. 2013, 49, 4127 (Invited Feature Article for 2013 ChemComm Emerging Investigators Themed Issue)
Ong, W. Q.; Zeng, H. Q.,* Rapid construction of shape-persistent H-bonded macrocycles via one-pot H-bonding-assisted macrocyclization. J. Incl. Phenom. Macrocycl. Chem. 2013, 76, 1 (Invited Review)


2012
Zhao, H. Q.; Ong, W. Q.; Zhou, F.; Fang, X.; Chen, X. Y.; Li, S. F. Y.; Su, H. B.; Cho, N.-J.; Zeng, H. Q.,* Chiral crystallization of aromatic helical foldamers via complementarities in shape and end functionalities. Chem. Sci. 2012, 3, 2042.
Ong, W. Q.; Zhao, H. Q.; Sun, C.; Wu, J. E.; Wong, Z. C.; Li, S. F. Y.; Hong, Y. H.; Zeng, H. Q.,* Patterned Recognitions of Amines and Ammonium Ions by a Pyridine-Based Helical Oligoamide Host. Chem. Commun. 2012, 48, 6343 (Outside back cover).
Zhou, F, Fu, H. L.; Ong, W. Q.; Ye, R. J.; Yuan, W. X.; Lu, Y.-J.; Huo, Y.-P.; Zhang, K.; Su, H. B. and Zeng, H. Q.,* Locking high energy 1D chain of dichloromethane molecules containing abnormally short Cl···Cl contacts of 2.524 ？ inside organic crystals. Org. Biomol. Chem. 2012, 10, 5525 (hot paper)
Du, Z. Y.; Qin, B.; Sun, C.; Liu, Y.; Zheng, X.; Zhang, K.; Conney, A. H.; Zeng, H. Q.,* Folding-promoted TBAX-mediated selective demethylation of methoxybenzene-based macrocyclic aromatic pentamers. Org. Biomol. Chem. 2012, 10, 4164 (Inside front cover).
Zhao, H. Q.; Ong, W. Q.; Fang, X.; Zhou, F.; Hii, M. N.; Li, S. F. Y.; Su, H. B.; Zeng, H. Q.,* Synthesis, Structural Investigation and Computational Modelling of Water-Binding Aquafoldamers. Org. Biomol. Chem. 2012, 10, 1172 (hot paper; front cover).
Liu, Y.; Qin, B.; Zeng, H. Q.,* POCl₃-mediated H-bonding-directed one-pot synthesis of macrocyclic pentamers, strained hexamers and highly strained heptamers. Sci. China Chem. 2012, 55, 55 (front cover).


2011
Ren, C. L.; Maurizot, V.; Zhao, H. Q.; Shen, J.; Zhou, F.; Ong, W. Q.; Du, Z. Y.; Zhang, K.; Su, H. B.; Zeng, H. Q.,* Fivefold-symmetric macrocyclic aromatic pentamers: High affinity cation recognition, ion-pair induced columnar stacking and nanofibrillation. J. Am. Chem. Soc. 2011, 133, 13930.
Ren, C. L.; Zhou, F.; Qin, B.; Ye, R. J.; Shen, S.; Su, H. B.; Zeng, H. Q.,* Crystallographic realization of the mathematically predicted densest “All Pentamer” packing lattice by C5-symmetric “sticky” fluoropentamers. Angew. Chem. Int. Ed. 2011, 50, 10612.
Du, Z. Y.; Ren, C. L.; Ye, R. J.; Shen, J.; Lu, Y. J.; Wang, J.; Zeng, H. Q.,* BOP-mediated one-pot synthesis of C5-symmetric macrocyclic pyridone pentamers. Chem. Commun. 2011, 47, 12488.
Ong, W. Q.; Zhao, H. Q.; Du, Z. Y.; Yeh, J. Z. Y.; Ren, C. L.; Tan, L. Z. W.; Zhang, K.; Zeng, H. Q.,* Computational prediction and experimental verification of pyridine-based helical oligoamides containing four repeating units per turn. Chem. Commun. 2011, 47, 6416.
Qin, B.; Ong, W. Q.; Ye, R. J.; Du, Z. Y.; Chen, X. Y.; Yan, Y.; Zhang, K.; Su, H. B.; Zeng, H. Q.,* Highly selective one-pot synthesis of H-bonded pentagon-shaped circular aromatic pentamers. Chem. Commun. 2011, 47, 5419 (front cover).
Qin, B.; Jiang, L.; Shen, S.; Sun, C.; Yuan, W.; Li, S. F. Y.; Zeng, H. Q.,* Folding-Promoted TBACl-Mediated Chemo- and Regio-Selective Demethylations of Metoxybenzene-Based Macrocyclic Pentamers. Org. Lett. 2011, 13, 6212.
Ren, C. L.; Xu, S. Y.; Xu, J.; Chen, H. Y.; Zeng, H. Q.,* Planar macrocyclic fluoropentamers as supramolecular organogelators. Org. Lett. 2011, 13, 3840.
Ong, W. Q.; Zhao, H. Q.; Fang, X.; Woen, S.; Zhou, F.; Yap, W. L.; Su, H. B.; Li, S. F. Y.; Zeng, H. Q.,* Encapsulation of conventional and unconventional water dimers by water-binding foldamers. Org. Lett. 2011, 13, 3194.
Qin, B.; Sun, C.; Liu, Y.; Shen, J.; Ye, R. J.; Zhu, J.; Duan, X.-F.; Zeng, H. Q.,* One-pot synthesis of hybrid macrocyclic pentamers with variable functionalizations around the periphery. Org. Lett. 2011, 13, 2270.
Qin, B.; Shen, S.; Sun, C.; Du, Z. Y.; Zhang, K.; Zeng, H. Q.,* One-pot multi-molecular macrocyclization for the expedient synthesis of macrocyclic aromatic pentamers by a chain growth mechanism. Chem.Asian J. 2011, 3298 (inside cover).


2008-2010
Yan, Y.; Qin, B.; Ren, C. L.; Chen, X. Y.; Yip, Y. K.; Ye, R. J.; Zhang, D. W.; Su, H. B.; Zeng, H. Q.,* Synthesis, structural investigations, hydrogen？deuterium exchange studies, and molecular modeling of conformationally stablilized aromatic oligoamides. J. Am. Chem. Soc. 2010, 132, 5869.
Qin, B.; Ren, C. L.; Ye, R. J.; Sun, C.; Chiad, K.; Chen, X. Y.; Li, Z.; Xue, F.; Su, H. B.; Chass, G. A.; Zeng, H. Q.,* Persistently folded circular aromatic amide pentamers containing modularly tunable cation-binding cavities with high ion selectivity. J. Am. Chem. Soc. 2010, 132, 9564.
Yan, Y.; Qin, B.; Shu, Y. Y.; Chen, X. Y.; Yip, Y. K.; Zhang, D. W.; Su, H. B.; Zeng, H. Q.,* Helical organization in foldable aromatic oligoamides by a continuous hydrogen-bonding network. Org. Lett. 2009, 11, 1201.
Qin, B.; Chen, X. Y.; Fang, X.; Shu, Y. Y.; Yip, Y. K.; Yan, Y.; Pan, S. Y.; Ong, W. Q.; Ren, C. L.; Su, H. B.; Zeng, H. Q.,* Crystallographic evidence of an unusual, pentagon-shaped folding pattern in a circular aromatic pentamer. Org. Lett. 2008, 10, 5127.

Publications as co-author (2008-2020)

Yukun Zhang, et al, Folding and Assembly of Short α, β, γ-Hybrid Peptides: Minor Variations in Sequence and Drastic Differences in Higher-Level Structures. J. Am. Chem. Soc. 2019, 141, 14239-14248
Li, X. W.; Li, B.; Chen, L.; Hu, J.; Wen, C.; Zheng, Q.; Wu, L.; Zeng, H. Q.; Gong, B.; Yuan, L. H. Angew. Chem. Int. Ed. 2015, 54, 11147
He, Y. Z.; Xu, M.; Gao, R. Z.; Li, X. W.; Li, F. X.; Wu, X. D.; Xu, D. G.; Zeng, H. Q.; Yuan, L. H., Two-Component Supramolecular Gels Derived from Amphiphilic Shape-persistent Cyclo[6]aramide for Specific Recognition of Native. Arginine. Angew. Chem. Int. Ed. 2014, 53, 11834
Xu, W.; Xue, X.; Li, T.; Zeng, H. Q.; Liu, X., Ultrasensitive and Selective Colorimetric DNA Detection by Nicking, Endonuclease Assisted Nanoparticle Amplification. Angew. Chem. Int. Ed. 2009, 48, 6849.
Xiong, J.; Wang, L. J.; Qian, J. P.; Wang, P.; Wang, X. J.; Ma, G. L.; Zeng, H. Q.; Li, J.; Hu, J. F. Structurally Diverse Sesquiterpenoids from the Endangered Ornamental Plant Michelia shiluensis. J. Nat. Prod. 2018, 81, 2195-2204
Hu, X.; Chen, X.; Zhu, Y.; Deng, Y. F.; Zeng, H. Q.; Jiang, H. F.; Zeng, W. Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2–H/Csp3–Csp3 Activation. Org. Lett. 2017, 139, 3474-3477
Hong, N.; Li, M.; Yuan, Y.; Wang, T.; Yi, M.; Xu, H.; Zeng, H. Q.; Song, J.; Hong, Y. Stem Cell Reports 2016, 6, 411-421
Li, C.; Wu, L.; Chen, L.; Yuan, X.; Cai, Y.; Feng, W.; Liu, N.; Ren, Y.; Sengupta, A.; Murali, M. S.; Mohapatra, P. K.; Tao, G.; Zeng, H. Q.; Ding, S.; Yuan, L. Highly efficient extraction of actinides with pillar[5]arene-derived diglycolamides in ionic liquids via a unique mechanism involving competitive host-guest interactions. Dalton Transactions 2016, 45, 19299-19310
Hu, C.-L.; Xiong, J.; Gao, L.-X.; Li, J.; Zeng, H. Q.; Zou, Y.; Hu, J.-F. Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects. RSC Advances 2016, 6, 60467-60478
Meng, W.-J.; Xiong, J.; Wang, W.-X.; Zhang, H.-Y.; Zeng, H. Q.; Hu, J.-F. Phlefargesiine A, a C16N2 Lycopodium alkaloid with an unprecedented [6/7/6/6]-tetracyclic skeleton from Phlegmariurus fargesii. Tetrahedron Lett. 2016, 57, 3218-3221
Huo, Y. P.; Pan, C. Q.; Wang, S. Y.; Ji, S. M.; Kong, T. F.; Gao, L.; Cai, N.; Zeng, H. Q.* Color-Tunable Solid-State Emissions of Zn(II) and Cd (II) Complexes Derived from Cyano-modified 2-Substituted 8-Hydroxyquinolines. Polyhedron 2016, 119, 175-183
Teong, S. P.; Yi, G.; Zeng, H. Q.; Zhang, Y. The effects of emulsion on sugar dehydration to 5-hydroxymethylfurfural in a biphasic system. Green Chem. 2015, 17, 3751-3755
Xiong, J.; Hong, Z.-L.; Gao, L.-X.; Shen, J.; Liu, S.-T.; Yang, G.-X.; Li, J.; Zeng, H. Q.; Hu, J.-F., Chlorabietols A–C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhami. J. Org. Chem. 2015, 80, 11080-11085
Hu, J. C.; Chen, L.; Shen, J.; Luo, J.; Deng, P. C.; Ren, Y.; Zeng, H. Q.; Feng, W.; Yuan, L. H., Convergent heteroditopic cyclo[6]aramides as macrocyclic ion-pair receptors for constructing [2]pseudorotaxanes. Chem. Commun. 2014, 50, 8024
Zhao, H. B.; Hong, N.; Lu W. Q.; Zeng, H. Q.; Song, J. X.; Hong, Y. H., Fusion Gene Vectors Allowing for Simultaneous Drug Selection, Cell Labeling, and Reporter Assay in Vitro and in Vivo. Anal. Chem., 2012, 17, 84, 987.
Wu, S.-B.; Bao, Q.-Y.; Wang, W.-X.; Zhao, Y.; Xia, G.; Zhao, Z.; Zeng, H. Q.; Hu, J.-F., Cytotoxic Triterpenoids and Steroids from the Bark of Melia azedarach. Planta Med. 2011, 77, 922.
Du, Z. Y.; Ng, H. F.; Zhang, K.; Zeng, H. Q. and Wang, J.,* "Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: efficient synthesis of flavones under mild reaction". Org. Biomol. Chem. 2011, 9, 6930.
Fu, C.; Chen, W.; Quek, Y. L.; Ni, R.; Ghani, A. B. A.; Leong, W. W. Y.; Zeng, H. Q.; Huang, D., Sustainability from agricultural waste: chiral ligands from oligomeric proanthocyanidins via acid-mediated depolymerization. Tetrahedron Lett. 2010, 51, 6322.
Zhou, T.; Li, X.; Ng, M. T. T.; Guo, J.; Yuan, W.; Tan, C. H.; Zeng, H. Q.; Li, T., Synthesis and characterization of circular structures of i-motif tagged with fluoresceins. Bioconjug. Chem. 2009, 20, 644.



Undergraduate, graduate and postdoctoral research works (1997-2006)


Huaqiang Zeng, Jianmin Xie, and Peter G. Schultz.* Genetic introduction of a diketone-containing amino acid into proteins. Bioorg. Med. Chem. Lett. 2006, 16, 5356-5359.
Huaqiang Zeng, Xiaowu Yang, and Bing Gong,* etc. An extremely stable, self-complementary hydrogen-bonded duplex. Chem. Commun. 2003, 13, 1556–1557.
Huaqiang Zeng, Xiaowu Yang, Robert A. Flowers, II and Bing Gong.* A Non-Covalent Approach to Anti-Parallel β-Sheet Formation. J. Am. Chem. Soc. 2002, 124, 2903-2910.
Bing Gong,* Huaqiang Zeng, and Jin Zhu, etc. Creating nanocavities of tunable sizes: Hollow helices. Proc. Natl. Acad. Sci. USA, 2002, 99, 11583-11588.
Huaqiang Zeng, Harold Ickes, Robert A. Flowers, II, and Bing Gong.* Sequence-Specificity of Hydrogen-Bonded Molecular Duplexes. J. Org. Chem. 2001, 66, 3574-3583.
Huaqiang Zeng, Rebecca S. Miller, Robert A. Flowers, II, and Bing Gong.* A Highly Stable, Six-Hydrogen-Bonded Molecular Duplex. J. Am. Chem. Soc. 2000, 122, 2635 -2644.
Bing Gong,* Chong Zheng,* Huaqiang Zeng, and Jin Zhu. Polar Assembly of N,N'-Bis(4-substituted benzyl)sulfamides. J. Am. Chem. Soc. 1999, 121, 9766 -9767.
Lihua Yuan, Huaqiang Zeng, and Bing Gong,* etc. Helical Aromatic Oligoamides: Reliable, Readily Predictable Folding from the Combination of Rigidified Structural Motifs. J. Am. Chem. Soc. 2004, 126, 16528-16537.
Jin Zhu, Rubén D. Parra, Huaqiang Zeng, Ewa Skrzypczak-Jankun, Xiao Cheng Zeng, and Bing Gong.* A New Class of Folding Oligomers: Crescent Oligoamides. J. Am. Chem. Soc. 2000, 122, 4219 -4220.
Bing Gong,* Yinfa Yan, Huaqiang Zeng, Ewa Skrzypczak-Jankunn, Yong Wah Kim, Jin Zhu, and Harold Ickes. A New Approach for the Design of Supramolecular Recognition Units: Hydrogen-Bonded Molecular Duplexes. J. Am.Chem. Soc. 1999, 121, 5607 -5608.
Lihua Yuan, Adam R. Sanford, Wen Feng, Aimin Zhang, Jin Zhu, Huaqiang Zeng, Kazuhiro Yamato, Minfeng Li, Joseph S. Ferguson, and Bing Gong.* Synthesis of crescent aromatic oligoamides, J. Org. Chem. 2005, 70, 10660.
Rubén D. Parra, Huaqiang Zeng, Jin Zhu, Chong Zheng, Xiao Cheng.Zeng,* and Bing Gong.* Stable Three-Center Hydrogen Bonding in a Partially Rigidified Structure. Chem. Eur. J. 2001, 7, 4352-4357.
Jianmin Li,* Huaqiang Zeng, Jinhua Chen, Quanming Wang, and Xintao Wu. Crystal structure of a flexible self-assembled two-dimensional square network complex [Cu₂(C₃H₂O₄)₂(H₂O)₂(4,4’-bpy)]·H₂O. Chem. Commun. 1997, 13, 1213-1214.
Huaqiang Zeng, Min Yang, Xiaoying Huang, and Xueyuan Chen. The crystal and molecular structure of the complex diaquatetrakis(imidazole)copper(II) terephthalate. Cryst. Res. Tech. 1997, 32, 467-474.
Jianmin Li,* Huaqiang Zeng, Yanxiong Ke, and Quanming Wang. Synthesis and X-ray crystal structure analyses of Cu₂(CH₂CH₂COO)₄(OPph₃)₂, Cryst. Res. Tech. 1997, 32, 475-480.
Jianmin Li,* Huaqiang Zeng, and Min Xu. Spectroscopic properties of Cu(L-met)₂, Cu(DL-met)₂, Cu(L-ala)₂ and Cu(DL-ala)₂·H₂o and qualitative explanations to the magnetism and relative ordering of the one-electron energy levels. Spectro. Lett. 1997, 30, 545-557.






专利（2014-2020）




专利号
Patent number
专利名称
Name
授权日
Date Patent Granted
发明人
Inventors

国际专利WO/2020/159436
Water Channel and Method of Forming Same
2020.06.08
Huaqiang Zeng, Arudhati Roy, Feng Chen, Jie Shen

国际专利WO/2019/035763
Aptamers for Detection of Zika Flaviviral Protein
2019.02.21
Huaqiang Zeng, Kyung Hyun Lee

新加坡专利V
Synthetic proton channel and methods thereof
2019.01.31
Huaqiang Zeng, Fei Zeng

新加坡专利Y
Polyhydrazides-Based Superpermeable Synthetic Water Channels
2019.01.31
Huaqiang Zeng, Arudhati Roy, Feng Chen, Jie Shen

国际专利 WO2017/026944A1
An Organogelator Compound
2017.02.16
Huaqiang Zeng, Changliang Ren

新加坡专利P
A Powder Gelator And Method To Enhance Gelator’s Gelling Speed In The Powder Form
2017.01.20
Huaqiang Zeng, Changliang Ren

新加坡专利V
DNA Aptamers for Highly Specific and Sensitive Detection of Zika NS1 Protein in an ELISA Assay
2016.08.16
Huaqiang Zeng, Kyung Hyun Lee

国际专利 WO2016/036320A1
Highly Selective High-Capacity Cesium Removal Using Macrocycic Aromatic Pentamers
2016.03.10
Huaqiang Zeng

新加坡专利X
Highly Efficient Phase Selective Organogelators for Speedy Oil Spill Cleanup and Reclamation
2015.08.12
Huaqiang Zeng, Changliang Ren

新加坡专利X
Highly Selective High-Capacity Cesium Removal Using Macrocycic Aromatic Pentamers
2014.09.04
Huaqiang Zeng










学术文献 Academic Literature