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基本信息 The basic information
姓名: 赵军锋

学院: 化学与化工学院


学历: 博士研究生毕业

学位: 哲学博士


职称: 教授

职务:


学科: 化学-有机化学





工作经历 Work Experience
2021 年至今，西北工业大学教授，博士生导师
2014 年至2020年，江西师范大学教授，博士生导师
2013 年至2014年，香港大学助理教授（研究）（Prof. Yang Dan）
2011年至2013年，洪堡****，德国波恩大学和明斯特大学（Prof. Studer Armido）
2010年至2011年，博士后，新加坡南洋理工大学生科院（Prof. Liu Chuanfa）



教育经历 Education Experience
2006年至2010年，博士，新加坡南洋理工大学理学院（Prof. Loh Teckpeng）
2005年至2006年，中科院成都有机化学研究所（导师：龚流柱教授）
2002年至2005年，硕士，华中师范大学（导师：丁明武教授）
2001年，学士，北京师范大学



招生信息 Admission Information
一、课题组研究定位：立足有机化学，面向化学生物学
二、研究方向：
1. 具有重要生物活性的多肽与蛋白质的化学合成与修饰
2. 不对称合成
3. 复杂多环分子的高效合成
4. 天然产物全合成
欢迎对有机合成化学与化学生物学感兴趣的博士研究生、硕士研究生和本科生加入到我们课题组来，在科研的道路上，我们共同奋斗、一起成长！
三、课题组学生培养目标：培养人格健全、素质全面、具有国际竞争力的科技人才。
我们看重的是学生锐意进取的拼搏精神，而不是他们的出身和基础--态度决定一切！我们相信在你愿意进取的情况下，我们有信心、有能力帮你重新打下坚实的基础，为你将来的辉煌人生做好起航准备！
课题组经费充足、设备一流！且与国外多个高水平实验室有密切的合作关系，我们将为成绩优秀，进取心强的学生提供到国外或者国内一流实验室去从事博士后研究、攻读博士学位或者其他合作交流及求职、深造的机会。
欢迎对有机合成化学与化学生物学感兴趣的博士研究生、硕士研究生和本科生加入到我们课题组来，在科研的道路上，我们共同奋斗、一起成长！
另外，课题组常年招聘有机化学与化学生物学方向副教授、博士后和研究助理。
联系方式：zhaojf@jxnu.edu.cn； QQ:
课题组主页链接：https://www.x-mol.com/groups/Zhao_Junfeng







荣誉获奖 Awards Information
2020 英国皇家化学会会士
2020 多肽青年科学家奖
2019 日本化学会杰出讲座奖
2019 莱佛士绿色制药创新奖
2018 “挑战杯”创业计划赛国家金奖第一指导教师
2018 第四届中国互联网+大赛国家银奖第一指导教师
2018 人社部高层次留学人才回国资助计划（人社部，全国共30名）
2018 第七届中国侨界贡献奖（中国侨联）
2018 Thieme Chemistry Journals Award (Thieme出版社)
2011 洪堡****奖学金 (Humboldt Foundation)
2011 Reaxys PhD Prize Finalist (Elsevier出版社)
2009 国家优秀自费留学生奖学金 (国家留学基金委)





科学研究 Scientific Research
一、课题组研究定位：立足有机化学，面向化学生物学
研究方向：
1. 多肽与蛋白质的化学合成与修饰
2. 多肽药物研发
3. 复杂多环分子的高效合成
二、主持科研项目
1. 国家自然科学基金重大研究计划（2019-2021，在研）
2. 人社部高层次留学人才回国资助计划（2018-2021，在研）
3. 国家自然科学基金面上项目（2017-2021，在研）
4. 江西省科技厅重点项目（2020-2023，在研）
5. 江西省教育厅重点项目（2016-2019，已结题）
6. 江西省****科学家项目（2015-2018，已结题）
7. 国家自然科学基金地区项目（2015-2018，已结题）
8. 江西省科技厅重大项目（2015-2017，已结题）





学术成果 Academic Achievements
论文独立工作后：
41. Long Hu, Silin Xu, Zhenguang Zhao, Yang Yang, Zhiyuan Peng, Ming Yang, Changliu Wang, Junfeng Zhao*, Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis, J. Am. Chem. Soc., 2016, 138, 13135–13138.（SCI一区Top, IF：14.357）
40. Jinhua Yang, Changliu Wang, Silin Xu, Junfeng Zhao*,Ynamide-Mediated Thiopeptide Synthesis, Angew. Chem. Int. Ed., 2019, 58, 1382 –1386.（SCI一区Top, IF: 12.5）
39. Liwen Fan, Chunyu Han, Xuerong Li, Jiasheng Yao, Zhengning Wang, Chaochao Yao, Weihao Chen, Tao Wang, Junfeng Zhao*,Enantioselective Polyene Cyclization Catalyzed by a Chiral Br？nsted Acid, Angew. Chem. Int. Ed., 2018, 57, 2115-2119.（SCI一区Top, IF: 12.5）
38. Ming Yang, Xuewei Wang, Junfeng Zhao*, Ynamide-Mediated Macrolactonization, ACS Catal. 2020, 10, 5230-5235.（SCI一区Top, IF: 12.2）
37. Jiasheng Yao, Xing Fan, Shiqiang Ma, Kai Wang, Zhou Wang, Zhixiang Yu*, Junfeng Zhao*, Ynamide Protonation-Initiated Cis-Selective Polyene Cyclization and Reaction Mechanism, CCS Chem. 2021, minor revision.
36. Zhengning Wang, Xuewei Wang, Penghui Wang, Junfeng Zhao*, Allenone-Mediated Amide Bond Formation and its Application in Peptide Synthesis, J. Am. Chem. Soc., 2021, in revision.
35. Tao Liu, Silin Xu, Junfeng Zhao*, Recent Advances in Ynamide Coupling Reagent, Chin. J. Org. Chem. 2021, DOI: 10.6023/cjoc, online.(invited account)
34. Yongliang Tu, Junfeng Zhao*, Recent Advances in the Pd-catalyzed Catalyzed Coupling of Arylhydrazines and Ammonium Salts via C–N Bond Cleavage, Chem. Record, 2021, submitted. (invited review)
33. Jinhua Yang, Huanan Huang, Junfeng Zhao*, Active ester enabled amide bond formation and its application in peptide synthesis, Org. Chem. Front. 2021, submitted. (invited review)
32. Tao Liu, Junfeng Zhao*, A Water-Removable Ynamide Coupling Reagent for Racemization-Free Synthesis of Peptide, Amide, and Ester without Column Chromatography, Green Chem. 2021, submitted.
31. Chaochao Yao; Jinhua Yang; Xiaobiao Lu; Shuyu Zhang; Junfeng Zhao*, Ynamide-Mediated Thionoester and Dithioester Syntheses, Org. Lett. 2020, 22, 6628–6631. (SCI一区, IF: 6.492)
30. Kai Wang, Chenghao Jiang, Zhenming Zhang, Chunyu Han, Xuewei Wang, Yaping Li, Kaiting Chen, Junfeng Zhao*, Cut and Sew: Benzofuran-Ring-Opening Enabled Cyclopentenone Ring Formation, Chem. Commun. 2020. 56, 12817-12820. (SCI一区，IF：6.290)
29. Xuewei Wang, Yang Yang, Yongli Zhao, Sheng Wang, Wenchang Hu, Jinmei Li, Zihao Wang, Fengling Yang*, Junfeng Zhao*, Ynamide-Mediated Intermolecular Esterification, J. Org. Chem. 2020, 85, 6188-6194.（SCI二区Top, IF: 4.7）
28. Zhenming Zhang, Bei Fu, Hui Wang, Han Chen, Yongliang Tu, and Junfeng Zhao*, Access to (Z)-1,2-Endiamides and 1,1-Endiamides via a Base-Promoted Tandem Reaction, J. Org. Chem. 2020, 85, 5245-5254.（SCI二区Top, IF: 4.7）
27. Changming You, Zhenming Zhang, Yongliang Tu, Hong Tang, Yuanfeng Wang, Da Long, and Junfeng Zhao*, Transition-Metal-Free Approach to Polysubstituted Furans, J. Org. Chem. 2020, 85, 3902-3010.（SCI二区Top, IF: 4.7）
26. Jinhua Yang, Changliu Wang, Chaochao Yao, Chunqiu Chen, Yafang Hu, Guifeng He, Junfeng Zhao*, Site-Specific Incorporation of Multiple Thioamide Substitutions into a Peptide Backbone via Solid Phase Peptide Synthesis, J. Org. Chem., 2020, 85, 1484-1494. （SCI二区Top, IF: 4.7）
25. Young career focus: Dr. Junfeng Zhao (Jiangxi Normal University). Synform 2019, 9, A144-A146.
24. Xianzhu Zeng,？ Yongliang Tu,？ ZhenmingZhang, Changming You, Jiao Wu, Zhiying Ye, and Junfeng Zhao*, Transition-Metal-Free One-Step Synthesis of Ynamides, J. Org. Chem., 2019, 84, 4458-4466.（SCI二区Top, IF: 4.7）
23. Chunyu Han, Zhenming Zhang, Silin Xu, Kai, Wang, Kaiting Chen, Junfeng Zhao*, Palladium-Catalyzed Hiyama Coupling of Benzylic Ammonium Salts via C？N Bond Cleavage, J. Org. Chem., 2019, 84, 16308-16313.（SCI二区Top, IF: 4.7）
22. Silin Xu, Zhenming Zhang, Chunyu Han, Wenkai Hu, Tiwen Xiao, Yanan Yuan, Junfeng Zhao*, Palladium-catalyzed Coupling of Terminal Alkynes with Benzyl Ammonium Salts, J. Org. Chem., 2019, 84, 12192-12197.（SCI二区Top, IF: 4.7）
21. Zhiyuan Peng, Zhenming Zhang, Xianzhu Zeng, Yongliang Tu, and Junfeng Zhao*, Regio- and Stereoselective Hydrophosphorylation of Ynamides: A Facile Approach to (Z)-β-Phosphor-Enamides, Adv. Syth. Catal. 2019, 19, 4489-4494. (SCI二区Top，IF：5.65)
20. Zhiyuan Peng, Zhenming Zhang, Yongliang Tu, Xianzhu Zeng, Junfeng Zhao*, Regio- and Stereo-Selective Intermolecular Hydroamidation of Ynamides: An Approach to (Z)-Ethene -1,2-Diamides, Org. Lett., 2018, 20, 5688-5691. (SCI一区，IF：6.58)
19. Silin Xu, Zhenguang Zhao, Junfeng Zhao*, Recent Advances in Enzyme-Mediated Peptide Ligation, Chin. Chem. Lett., 2018, 29, 1001-1008. (Invited review)
18. Jinhua Yang, Junfeng Zhao*, Recent developments in peptide ligation independent of amino acid side-chain functional group, Sci. China Chem., 2018, 61, 97-112 (Invited review，SCI一区, IF: 6.09).
17. Yongliang Tu, Xianzhu Zeng,Hui Wang, Junfeng Zhao*, A Robust One-Step Approach to Ynamides, Org. Lett., 2018, 20, 208-283. (SCI一区，IF：6.58)
16. Changliu Wang, Zhenming Zhang, Yongliang Tu, Ying Li, Jiale Wu, Junfeng Zhao*, Palladium-Catalyzed Oxidative Cross-Coupling of Arylhydrazines and Arenethiols with Molecular Oxygen as the Sole Oxidant, J. Org. Chem., 2018, 83,2389-2394.（SCI二区Top, IF: 4.7）
15. Zhenming Zhang, Hui Wang, Nianli Qiu, Yujing Kong, Wenjuan Zeng, Yongquan Zhang, Junfeng Zhao*, Synthesis of Triarylmethanes via Palladium-Catalyzed Suzuki Coupling of Trimethylammonium Salts and Arylboronic Acids, J. Org. Chem., 2018, 83,8710-8715.（SCI二区Top, IF: 4.7）
14. Liwen Fan, Zhenming Zhang, Tao Wang,* Qingjin Liang, Junfeng Zhao*, Copper-Catalyzed Oxidative Functionalization of Benzylic C–H Bonds with Quinazoline 3-Oxides, Org. Chem. Front. 2018, 5, 2492-2495.（SCI二区, IF: 5.08）
13. Zhiyuan Peng, Zhenming Zhang, Yongliang Tu, Xianzhu Zeng, Junfeng Zhao*, Regio- and Stereo-Selective Intermolecular Hydroamidation of Ynamides: An Approach to (Z)-Ethene-1,2-Diamides, Org. Lett., 2018, 20, 5688-5691. (SCI一区，IF：6.492)
12. Silin Xu, Zhenguang Zhao, Junfeng Zhao*, Recent Advances in Enzyme-Mediated Peptide Ligation, Chin. Chem. Lett., 2018, 29, 1001-1008. (Invited review, SCI三区, IF: 2.631)
11. Zhenguang Zhao, Zhiyuan Peng, Yongli Zhao, Hao Liu, Chongnan Li, Junfeng Zhao*, Hypervalent Iodine-Mediated Oxidative Rearrangement of N–H Ketimines: An Umpolung Approach to Amides, J. Org. Chem., 2017, 82, 11848-11853. (Invited contribution，SCI 二区Top, IF: 4.805）
10. Yongliang Tu, Zhenming Zhang, Tao Wang,* Jiamei Ke, Junfeng Zhao*, A Regioselective Approach to Tri-substituted Pyrazoles via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines, Org. Lett. 2017, 19, 3466-3469. (SCI一区，IF：6.492)
9. Long Hu, Junfeng Zhao*, Ynamide:ANewCouplingReagentforAmideandPeptide Synthesis, Synlett, 2017, 28, 1663-1670 (Invited SYPACT, SCI三区, IF: 2.369).
8. Tao Wang, Shuwu Yang, Silin Xu, Chunyu Han, Ge Guo, Junfeng Zhao*, Palladium catalyzed Suzuki cross-coupling of benzyltrimethylammonium salts via C–N bond cleavage, RSC Adv., 2017, 7, 15805-15808. (SCI三区, IF: 2.936).
7. Yongliang Tu, Lin Yuan, Tao Wang*, Changliu Wang, Jiamei Ke, Junfeng Zhao*, Palladium-Catalyzed Oxidative Carbonylation of Aryl Hydrazines with CO and O₂ at Atmospheric Pressure, J. Org. Chem., 2017, 82,4970-4976.（SCI二区Top, IF: 4.805）
6. Liwen Fan, Tao Wang,* Ying Tian, Fei Xiong, Simei Wu, Qingjin Liang, Junfeng Zhao*, Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines. Chem. Commun., 2016, 52, 5375-5378. (SCI一区，IF：6.290)
5. Long Hu, Christian Mück-Lichtenfeld, Tao Wang,* Guifeng He, Meng Gao, Junfeng Zhao*, Reaction between Azidyl Radical and Alkynes: A Straight forward Approach to NH-1, 2, 3-triazoles. Chem. Eur. J., 2016, 22, 911-915. (SCI二区, IF: 5.160)
4. Tao Wang, Lin Yuan, Zhenguang Zhao, Ailong Shao, Meng Gao, Yangfei Huang, Fei Xiong, Junfeng Zhao,* Direct oxidative amidation between methylarenes and amines in water. Green Chem., 2015, 17, 2741-2744. (SCI一区，IF：8.586)
3. Zhenguang Zhao, Tao Wang,* Lin Yuan, Fei Xiong, Hu Xu, Junfeng Zhao*. Oxidative Coupling between Methylarenes and Ammonia: A Direct Approach to Aromatic Primary Amides Adv. Synth.＆ Catal. 2015, 357, 2566-2570. (SCI一区，IF：5.65)
2. Zhenguang Zhao,Tao Wang*, Lin Yuan, Xingwang Jia, Junfeng Zhao*, Oxidative Acylation of Sulfoximines with Methylarenes as Acyl Donor. RSC Adv., 2015, 5, 75386-75389. (SCI三区, IF: 2.936).
1. Jun-Feng Zhao,* Xiao-Hong Zhang, Ying-Jie Ding, Yong-Sheng Yang, Xiao-Bao Bi, Chuan-Fa Liu,* Facile Synthesis of Peptidyl Salicylaldehyde Esters and Its Use in Cyclic Peptide Synthesis, Org. Lett. 2013, 15, 5182-5185. (SCI一区，IF：6.492)
独立工作前：
17. Jun-Feng Zhao, Christian Mück-Lichtenfeld, Amido Studer,* Cooperative N-Heterocyclic Carbene (NHC) and Ruthenium Redox Catalysis: Oxidative Esterification of Aldehydes with Air as the Terminal Oxidant, Adv. Synth. & Catal. 2013, 355, 1098-1106.
16. Ming-Kui Zhu, Jun-Feng Zhao, Teck-Peng Loh, Palladium-Catalyzed C-C Bond Formation of Arylhydrazines with Olefins via Carbon-Nitrogen Bond Cleavage, Org. Lett., 2011, 13, 5714-5716.
15. Jun-Feng Zhao, Boon-Hong Tan, Teck-Peng Loh,* In(III)-pybox complex catalyzed enantioselective Mukaiyama aldol reactions between polymeric or hydrated glyoxylates and enolsilanes derived from aryl ketones, Chem. Sci. 2011, 2, 349-352.
14. Jun-Feng Zhao, Teguh-Budiono Tjan and Teck-Peng Loh, Significant counterion effect of the In(III)-pybox complex in highly enantioselective carbonyl-ene reactions of ethyl glyoxylate, Tetrahedron Lett., 2010, 51, 5649-5652.
13. Ming-Kui Zhu, Jun-Feng Zhao, Teck-Peng Loh,* Palladium-Catalyzed Oxime Assisted Intramolecular Dioxygenation of Alkenes with 1 atm of Air as the Sole Oxidant, J. Am. Chem. Soc., 2010, 132, 6294-6295.
12. Jun-Feng Zhao, Boon-Hong Tan, Teguh-Budiono Tjan, Teck-Peng Loh, Enantioselective Carbonyl-Ene Reactions of Trifluoropyruvate in Ionic Liquid via a Recyclable Indium(III)-Pybox Complex, Adv. Synth. & Catal., 2010, 352, 2085-2088.
11. Jun-Feng Zhao, Teguh-Budiono Tjan, Boon-Hong Tan, Teck-Peng Loh, Highly enantioselective ketone-ene reactions of trifluoropyruvate: Significant Counterion effect of the In(III)-PyBox complex, Org. Lett., 2009, 11, 5714-5716.
10. Jun-Feng Zhao, Teck-Peng Loh,* Acid-Catalyzed Intramolecular [2+2] Cycloaddition of Ene-allenones: Facile Access to Bicyclo[n.2.0] Frameworks, Angew. Chem. Int. Ed., 2009, 48, 7232-7235.
9. Jun-Feng Zhao, Hoi-Yan Tsui, Pei-Jia Wu, Jun Lu, Teck-Peng Loh,* Highly Enantioselective Carbonyl-ene Reactions Catalyzed by In(III)-PyBox Complex, J. Am. Chem. Soc. 2008, 130, 16492-16493. (Highlighted by SYNFACT, 2009, 2, 0187 and 2009, 3, 0283).
8. Jun-Feng Zhao, Yu-Jun Zhao, Teck-Peng Loh, Indium tribromide-promoted arene-terminated epoxy olefin cyclization, Chem. Commun., 2008, 1353-1355.
7. Jun-Feng Zhao, Long He, Jun Jiang, Zhuo Tang, Lin-Feng Cun, Liu-Zhu Gong, Organo-catalyzed highly diastereo- and enantio-selective direct aldol reactions in water, Tetrahedron Lett., 2008, 49, 3372-2275.
6. Jun-Feng Zhao, Chang Xie, Sheng-Zhen Xu, Ming-Wu Ding, Wen-Jing Xiao, Iminophosphorane-mediated efficient synthesis of new tricyclic 3,5-dihydro-1,2,3-triazolo [4,5-d]-1,2,4-triazolo[1,5-a]pyrimidin-9-ones, Org. Bio. Chem., 2006, 4, 130-134.
5. Jun-Feng Zhao, Chang Xie, Ming-Wu Ding, Hong-Wu He, Base-catalyzed, efficient synthesis of 5-substituted 3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-ones, Synthesis, 2005, 15, 2544-2548.
4. Jun-Feng Zhao, Chang Xie, Ming-Wu Ding, Hong-Wu He, A selective synthesis of 3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-ones, Chem. Lett. 2005, 34, 1022-1023.
3. Jun-Feng Zhao, Ming-Wu Ding, Synthesis and crystal structure of 3-benzyl-5- cyclohexylamino-6-phenyl-3,6dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one, Chinese J. Struct. Chem. 2005, 24, 439-444.
2. Jun-Feng Zhao, Yang-Gen Hu, Ming-Wu Ding, Hong-Wu He, 5,6-Dianilino-3-(4-chlorophenyl)-3,6-dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one, Acta. Cryst. 2005, E61, 2791-2792.
1. Ming-Wu Ding,* Shen-Zhen Xu, Jun-Feng Zhao, Application of bis(iminophosphorane) in heterocyclic synthesis: New entries to symmetrically or unsymmetrically substituted thieno[2,3-d : 5,4-d']dipyrimidine-4,5(3H,6H)-diones, J. Org. Chem. 2004, 69, 8366-8371.
授权专利：
1. Junfeng Zhao, Long Hu, Silin Xu, Zhenguang Zhao, Mild and Efficient preparation method for acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide. 美国发明专利，US**B2（授权日期：2020-11-17）。
2. 赵军锋；胡隆；许泗林；赵振光；α-酰氧基烯酰胺类化合物温和高效的制备方法及其在酰胺键和肽键形成中的应用，中国发明专利，专利号：ZL.1（授权日期：2017-11-24）。
3. 赵军锋；胡隆；一种高效制备NH-1,2,3三唑化合物的方法，中国发明专利，专利号：ZL1.9（授权日期：2019-03-01）。
4. 赵军锋，李学荣，范立文；一种由手性酸催化的光学纯萜类生物碱类似物的不对称合成方法，中国发明专利，专利号：ZL7.6（授权日期：2019-03-22）。
5. 赵军锋，涂永良，一种高效制备1,3,5三取代吡唑类化合物的方法，中国发明专利，专利号：ZL6.6（授权日期：2019-11-22）。
6. Chuan-Fa Liu, Jun-Feng Zhao, Method of synthesizing peptides, proteins and bioconjugates, Patent, WO/2013/119184, PCT/SG2013/000052.
7. 赵军锋，涂永良，曾宪柱；一种高效制备炔酰胺类化合物的方法，中国发明专利，专利号：ZL9.8（授权日期：2021-01-26）。
8. 赵军锋，王辉，杨进华，王长流；炔酰胺介导的硫代酰胺制备方法及其在硫代多肽合成中的应用，中国发明专利，专利号：ZL6.3（授权日期：2021-01-26）。
9. 赵军锋，彭志媛，涂永良，曾宪柱；炔酰胺的胺氢化和膦氢化反应，中国发明专利，专利号：ZL1.7（授权日期：2021-01-26）。