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基本信息 The basic information
姓名: 田野

学院: 生命学院


学历: 博士研究生毕业

学位: 医学博士


职称: 讲师（高校）

职务:


学科: 药学,生物学-生物化学与分子生物学









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工作经历 Work Experience
2016/05-至今，西北工业大学，生命学院，讲师
2013/08-2016/04，空军军医大学，第二附属医院，主管药师
2014/08-2015/10，加州大学戴维斯分校，博士后



May 2016-present, Assistant Professor, School of Life Sciences, Northwestern Polytechnical University
Aug 2013-Apr 2016, Pharmacist, Tangdu Hospital, Air Force Medical University

Aug 2014-Oct 2015, Post Doctor, University of Carlifornia, Davis






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教育经历 Education Experience
2008/09-2013/06，浙江大学，药物化学，博士

2010/11-2011/11, 美国华盛顿大学，联合培养博士研究生
2004/09-2008/06，浙江大学，药学，学士学位



Sep 2008-Jun 2013, PhD. College of Pharmaceutical Sciences, Zhejiang University
Nov 2010-Nov 2011, University of Washington, Joint-PhD
Sep 2004-Jun 2008, College of Pharmaceutical Sciences, Zhejiang University






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教育教学 Education And Teaching
本科生课程：生命科学导论; 生物化学（英）

研究生课程：蛋白质实验技术；航天医学工程


Undergraduate Courses
An introduction to life science, Biochemistry


Graduate Courses
Protein experimental technology, Aerospace medicine






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科学研究 Scientific Research
1 主持科研项目
(1) 国家自然科学基金青年项目：“MACF1通过FOXO1/β-catenin通路调节成骨细胞抗氧化参与模拟失重抑制骨形成的机制研究”（No.**）
(2) 陕西省自然科学基础研究计划一般项目（青年）：“MACF1调控MAP1B参与骨形成的机制研究”（No.2018JQ8032）
(3) 中国博士后科学基金面上项目：“MACF1调节细胞氧化还原平衡参与模拟失重抑制成骨分化”（No.2017M613210）
(4) 陕西省博士后科研资助项目：“重组小RNA的生物合成及其对失重性骨质流失的治疗作用”（No.2017M613210）
(5) 横向项目“重组功能性小RNA生物合成技术”，2017.10-2019.10
(6) 中央高校基本科研业务费“重组功能性小RNA在治疗骨质疏松症中的应用”（No.**zy053）
(7) 西北工业大学引进高层次人才科研启动费资助项目“MACF1调控小鼠成骨细胞分化的分子机制”，2016.1-2017.12
(8) 中国博士后科学基金第12批特别资助（站中），MACF1调控MAP1B参与模拟失重抑制成骨细胞迁移的机制，2019T120947


Fundings
(1) National Natural Science Foundation of China (Grant No. **). 2019.1-2021.12
(2) Natural Science Basic Research Program of Shaanxi Province (Grant No. 2018JQ8032). 2018.1-2019.12
(3) China Postdoctoral Science Foundation (Grant No. 2017M613210). 2017.1-2018.12

(4) Shaanxi Postdoctoral Science Foundation (Grant No. 2017BSHEDZZ13). 2017.1-2018.12
(5) Fundamental Research Funds for the Central Universities (China) (Grant No. **zy053). 2018.1-2019.12
(6) China Postdoctoral Science Foundation (Grant No. 2019T120947). 2019.1-2020.12









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学术成果 Academic Achievements
[1] Chong Yin^#, Ye Tian^#, Yang Yu, Haoyu Wang, Zixiang Wu, Zizhan Huang, Yan Zhang, Dijie Li, Chaofei Yang, Xue Wang, Yu Li*, Airong Qian*, A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation, J Cell Physiol, 2019, 234(7): 11524-11536
[2] Xin Li^#, Ye Tian^#, Meijuan Tu, Pui Yan Ho, Neelu Batra, Ai-Ming Yu*, Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression, Acta Pharmaceutica Sinica B, 2019, 9(3): 639-647
[3] Peihong Su^#, Ye Tian^#, Chaofei Yang, Xiaoli Ma, Xue Wang, Jiawei Pei, Ai-Rong Qian*, Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy, Int J of Mol Sci, 2018, 19(8):2343
[4] Ye Tian, Jiang Zheng*, Metabolic Activation and Toxicities of bis-Benzylisoquinoline Alkaloids, Advances in Molecular Toxicology, Elsevier B.V., Edited by James C. Fishbein and Jacqueline M. Heilman, Volume 11, Chapter Six
[5] Ye Tian, Xiaoli Ma, Chaofei Yang, Peihong Su, Chong Yin, Ai-Rong Qian*, The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment, Int J of Mol Sci, 2017, 18(10): 2132
[6] Joseph L. Jilek^#, Ye Tian^#, Ai-Ming Yu*, Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice, Drug Metab Dispos, 2017, 45(5): 512-522
[7] Ye Tian, Shuijie Shen, Yan Jiang, Qi Shen, Su Zeng*, Jiang Zheng*, CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine, Arch Toxicol, 2016, 90(7): 1737-1748
[8] Ye Tian, Yicong Bian, Yan Jiang, Sainan Qian, Aiming Yu, Su Zeng*, Interplay of Breast Cancer Resistance Protein (BCRP) and metabolizing enzymes, Curr Drug Metab, 2015, 16(10): 877-893
[9] Ye Tian, Sainan Qian, Yan Jiang, Qi Shen, Jiang Zheng, Hui Zhou*, Su Zeng*, The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids, Int J Pharmaceut, 2013, 453(2): 371-379
[10] Ye Tian^#, Ying He^#, Haihong Hu, Lu Wang, Su Zeng*, Determination of the enantioselectivity of six chiral aryloxy aminopropanol drugs transport across Caco-2 cell monolayers, Acta Pharmaceutica Sinica B, 2012, 2(2): 168–173
[11] 田野，屈伯宣，姚艳，曾苏*，LLC-PK1/BCRP细胞系的建立及其生物学特征，药学学报，2012，47(12)：1599-1604
[12] Abdul Qadir^#, Yongguang Gao^#, Patil Suryaji, Ye Tian, Xiao Lin, Kai Dang, Shanfeng Jiang, Yu Li, Zhiping Miao and Airong Qian*, Non-Viral Delivery System and Targeted Bone Disease Therapy. Int J of Mol Sci, 2019, 20: 565
[13] 王威, 李郁, 张文娟, 田野, 骞爱荣*. 深度学习技术在疾病诊断中的应用[J].第二军医大学学报, 2018, 39(8): 852-858
[14] Yong-Guang Gao, Xiao Lin, Kai Dang, Shan-Feng Jiang, Ye Tian, Fen-Li Liu, Di-Jie Li, Yu Li, Zhi-Ping Miao* and Ai-Rong Qian*. Structure-activity relationship of novel low generation dendrimers for gene delivery. Organic & Biomolecular Chemistry, 2018, 16, 7833-7842.
[15] Chong Yin^#, Yan Zhang^#, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang*, Airong Qian*, Cory J. Xian, Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation, J Cell Physiol, 2018, 233(7): 5405-5419
[16] Siyu Li, Zhiping Miao, Ye Tian, Haoyu Wang, Shuai Wang, Tianyuan He, Yue Yang, Peng Wang, Mengyao Ma, Tuanmin Yang, Tao Chen, Zhiyong Liu, Junhong Gao, Chu Chen*, Airong Qian*, Limethason reduces airway inflammation in a murine model of ovalbumin induced chronic asthma without causing side effects, Exp Ther Med, 2018, 15(3): 2269-2276
[17] Ai-Ming Yu*, Ye Tian, Mei-Juan Tu, Pui-Yan Ho, Joseph L. Jilek, MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy, Drug Metab Dispos, 2016, 44(3): 308-319
[18] Qi Shen, Minjuan Zuo, Li Ma, Ye Tian, Lu Wang, Huidi Jiang, Quan Zhou, Hui Zhou*, Lushan Yu*, Su Zeng, Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity, Chem Biol Interact, 2014, 224C: 89-99
[19] Li Li, Qingqing Yao, Siyun Xu, Haihong Hu, Qi Shen, Ye Tian, Lanying Pan, Hui Zhou, Huidi Jiang, Chuang Lu, Lushan Yu*, Su Zeng*, Cyclosporin A affects the bioavailability of ginkgolic acids via inhibition of P-gp and BCRP, Eur J Pharm Biopharm, 2014, 88(3): 759-767
[20] Haihong Hu, Chen Su, Yan Jiang, Lushan Yu, Yao Liu, Ye Tian, Siyun Xu, Hui Zhou, Xin He, Huidi Jiang, Su Zeng*, Construction and application of double-transfected cells expressing the human transporter P-glycoprotein and cytochrome P450 3A4, Pharmazie, 2013, 68(10): 816-820
[21] Siyuan Sun, Zhongjian Chen, Liping Li, Dongli Sun, Ye Tian, Hao Pan, Huichang Bi, Min Huang, Su Zeng, Huidi Jiang*, The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP, Xenobiotica, 2012, 42(12): 1197-1205
[22] 屈伯宣，田野，余露山，蒋惠娣，周权，曾苏*，体外细胞模型中氟伐他汀对映体的手性分离和含量测定方法学研究，浙江大学学报(医学版)，2011，40(1)：12-16
[23] Shuijie Shen, Fan Zhang, Su Zeng, Ye Tian, Xiaojuan Chai, Shirley Gee, Bruce D. Hammock, Jiang Zheng*, Development of enantioselective polyclonal antibodies to detect styrene oxide protein adducts, Anal Chem, 2009, 81(7): 2668-2677



专利 Patent
[1] 邓旭东，田野，尹大川，骞爱荣，高永光，王雪，李瑞云，张托弟。阳离子聚乙烯胺线形高分子作为转基因载体的应用。中国，申请号：9.8
[2] 骞爱荣，田野，程群燕，喻译锋，罗晓庆，裴佳伟，王雪，杨超飞。一种重组小RNA的生产方法及应用。中国，申请号： 9.9
[3] 高永光，骞爱荣，党凯，田野，张文娟，姜山峰，赵欣，罗晓庆，多胺类阳离子脂质、转基因载体及其制备方法[P]，申请号：8.7；
[4] 骞爱荣，高永光，党凯，田野，张文娟，姜山峰，赵欣，罗晓庆，树枝状分子类阳离子脂质、转基因载体及其制备方法[P]，申请号：1.2；
[5] 高永光，骞爱荣，田野，李郁，党凯，姜山峰，罗晓庆，赵欣，杨超飞，萘酰亚胺修饰的树形高分子转基因载体、其制备方法及应用[P]，申请号：4.6；
[6] 骞爱荣，田野，李郁，王威，张文娟，于观贞，罗晓庆，赵欣，一种病理诊断方法及装置，0.6
[7] 骞爱荣，王雪，田野，高永光，李瑞云，裴佳伟，杨超飞，苏佩红，赵欣，罗晓庆，一种筛选miRNA调控剂的细胞模型及应用，申请号：3.5
[8] 骞爱荣、高永光、党凯、李郁、田野、姜山峰、罗晓庆、赵欣；酯键联接的萘酰亚胺大环多胺化合物的合成及应用，申请号：1.9
[9] 高永光、骞爱荣、李郁、田野、党凯、姜山峰、罗晓庆、赵欣；酰胺键联接的萘酰亚胺多功能化合物的合成及应用，申请号：2.3