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基本信息 The basic information
姓名: 张连兵

学院: 生命学院


学历: 博士研究生毕业

学位: 博士


职称: 教授

职务:


学科: 生物医学工程,生物学


邮箱: lbzhang@nwpu.edu.cn




工作经历 Work Experience
2011.07- 2012.01 德国Max Planck Institute of Microstructure Physics, 博士后
2012.02-2016.05 西班牙CIC纳米研究中心,博士后
2016.06 西北工业大学，生命学院，教授



教育经历 Education Experience
1996.09-2000.07 郑州大学, 商用英语, 文学学士
2000.09-2007.07 德国哈勒维滕贝格大学, 生物化学, Diplom
2007.09-2011.07 德国斯图加特大学, 生物化学, 博士



教育教学 Education And Teaching
本科生课程： 生物科学Plus，纳米酶学,细胞生物学前沿（英文）
本科全英文专业课程：Botany， Neuroscience
研究生课程：纳米酶学



荣誉获奖 Awards Information
2010国家优秀自费留学生奖学金

欧洲材料研究学会（European Materials Research Society）2010 Young Scientist Award




科学研究 Scientific Research
主要研究方向：纳米酶；新型功能纳米材料生物医学应用；生物内源分子纳米修饰与仿生；微纳仿生电光效应；生物催化剂分子改造及构效关系分析。
主持科研项目：
国家自然科学基金面上项目（**) 2020-2023

国家自然科学基金面上项目（**) 2018-2019
陕西省自然科学基金面上项目(2018JM3027)
陕西省留学人员科技活动择优资助项目（**）
代表性论文：

1. Fan Yang, Mikel Abadia, Chaoqiu Chen, WeikeWang, Le Li, Lianbing Zhang*, CeliaRogero, Andrey Chuvilin, Mato Knez* Design of active and stable oxygenreduction reaction catalysts by embedding CoxOy nanoparticles intonitrogen-doped carbon. Nano Research 2017,10,97-107.
2.Le Li, Lianbing Zhang*, Mato Knez* Comparison of two endogenous deliveryagents in cancer therapy: Exosomes and ferritin. Pharmacological Research 2016，110,1-9.
3. LeLi, Maider Mu？oz-Culla, Unai Carmona, Maria Paz Lopez, Fan Yang, CesarTrigueros, David Otaegui, LianbingZhang*, Mato Knez* Ferritin-mediated siRNA delivery and gene silencing inhuman tumor and primary cells. Biomaterials 2016，98,143-151.
4. Lianbing Zhang, Le Li, Di Penta, A.;Carmona, U.; Yang, F.; Sch？ps, R.; Brandsch, M.; Zugaza, JL.; Knez, M.* H-ChainFerritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector. AdvancedHealthcare Materials 2015，4, 1305-1310.
5. UnaiCarmona, Le Li, Lianbing Zhang*,Mato Knez* Ferritin light-chain subunits: key elements for the electrontransfer across the protein cage. Chem. Commun. 2014，50,15358-15361.
6. LeLi, Lianbing Zhang*, Unai Carmona,Mato Knez* Semi-Artificial and Bioactive Ferroxidase with Nanoparticles as theActive Sites. Chem. Commun. 2014，50,8021-8023.
7. UnaiCarmona, Lianbing Zhang*, Le Li,Mato Knez* Tuning, Inhibiting and Restoring the Enzyme Mimetic Activities ofPt-Apoferritin. Chem. Commun. 2014，50,701-703.
8. ZhangZhang, Lianbing Zhang*, StephanSenz, Mato Knez, Immobilization of Apoferritin-Templated Seeds for Si NanowireGrowth. Chem. Vapor Deposition, 2011，17, 149-154.
9. Lianbing Zhang*, Wiebek Fischer,Eckhard Pippel, Gerd Hause, Matthias Brandsch, Mato Knez* Receptor-MediatedCellular Uptake of Nanoparticles: a Switchable Delivery System. Small2011，7,1538-1541.
10. Zhang, LB.*; Laug, L.; Münchgesang,W.; Pippel, E.; G？sele, U.; Brandsch, M.; Knez, M.* Reducing Stress on Cellswith Apoferritin-Encapsulated Platinum Nanoparticles. Nano Lett. 2010,10,219-223.
11. Zhang, LB.*;Patil, A. J.; Li, L.; Schierhorn, A.; G？sele, U.; Knez, M.* ChemicalInfiltration during Atomic Layer Deposition: Metalation of Porphyrins as ModelSubstrates. Angew. Chem. Int. Ed. 2009,48, 4892-4895.



社会兼职 Social Appointments
中国生物物理学会 纳米酶分会 副会长（任期 2019.8-2021.8）



团队信息 Team Information

纳米生物医学先进诊疗技术实验室
Laboratory of AdvancedNano-Biomedical Theranostic Technology
本课题组的研究领域是纳米生物材料与纳米医学，是跨越材料、化学、生物医学的新兴交叉学科。我们的目标是开发新型功能纳米材料，通过结构设计、可控合成、合理的表面修饰、利用纳米材料独特的物理与化学性质得到功能丰富的生物仿生纳米材料，研究其在生命体系中的行为，挖掘在生物医学领域的应用潜力。

主要研究方向：
纳米酶；新型功能纳米材料生物医学应用、生物内源分子纳米修饰与仿生、微纳仿生电光效应、生物催化剂分子改造及构效关系分析
课题组成员:
孙乐明 副教授:毕业于美国俄亥俄州立大学，获生物医学工程专业博士学位，2017年入职西北工业大学生命学院。主要研究方向为大分子自组装与改性、生物仿生技术与应用、纳米生物医学。
吴淑琪 副教授:毕业于南开大学化学学院，获分析化学专业理学博士学位，2017年入职西北工业大学生命学院。主要研究方向为多功能纳米复合物构建、仿生修饰与应用、疾病诊疗。
陈 耀 助理教授:毕业于中国科学院山西煤炭化学研究所，获材料物理与化学博士学位。主要研究方向为基于原子层沉积的纳米生物检测和传感材料设计，仿生材料及生物电化学分析。
李爱朋 助理教授:毕业于浙江大学，获化学工程与技术专业博士学位，2017年入职西北工业大学生命学院。主要研究方向为蛋白复合微纳材料、酶工程。
研究生：杨迎春、田庆、李阳、王婷、杨陆秋、杨珂、杨荣、雷扬、王钰妍、王月容、杨雄

毕业生：尉迟庆潇

课题组科研项目：

2 项国家自然科学基金面上项目: **, **
3 项国家自然科学基金青年项目: **; **; **
5 项国家博士后科学基金: 2017M623232; 2018M631197; 2018M633561; 2018M633566; 2018M633581
1 项陕西省自然科学基金面上项目: 2018JM3027
4项陕西省自然科学基金青年项目：2018JQ2038; 2019JQ-034; 2019JQ-231; 2020JQ-145
1 项深圳市科创委计划项目(基础研究—自由探索类): JCYJ20**8207
1 项陕西省留学人员择优资助项目: Nr. **
4 项陕西省博士后科学基金


课题组研究成果：
2021
Yao Chen, Xiaomei Shen, Unai Carmona, Fan Yang, Xingfa Gao*, Mato Knez*, Lianbing Zhang*, Yong Qin, Control of stepwise Hg²⁺reduction on gold to selectively tune its peroxidase and catalase-like activities and the mechanism.Advanced Materials Interfaces2021, 8, **. (IF 4.948)


Yingchun Yang, Qing Tian, Shuqi Wu, Yixiao Li, Ke Yang, Yi Yan, Li Shang, Aipeng Li, Lianbing Zhang*,Blue light-triggered Fe²⁺-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy.Biomaterials2021, 271, 120739. (IF 10.317)


Aipeng Li, Ting Wang, Qing Tian, Xiaohong Yang, Dongming Yin, Yong Qin, Lianbing Zhang*,Single point mutant inverts stereoselectivity of a carbonyl reductase toward β-ketoesters with enhanced activity. Chemistry-A European Journal 2021, 27, 6283. (IF 4.857)


Dingchang Liu,Dongjie Fu, Lianbing Zhang, Leming Sun*,Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticlesfor Alzheimer’s disease diagnosis.Chinese Chemical Letters2021, 32, 1066. (IF 4.632)


Leming Sun*, Dingchang Liu, Dongjie Fu, Tao Yue, Douglas Scharre, Lianbing Zhang*, Fluorescent peptide nanoparticles to detect amyloid-beta aggregation in cerebrospinal fluid and serum for Alzheimer's disease diagnosis and progression monitoring. Chemical Engineering Journal 2021, 405, 126733. (IF 10.652)


Shuqi Wu, YangLi, Ruofei Zhang, Kelong Fan, Weihang Ding, Letong Xu, Lianbing Zhang*,Persistent luminescence-polypyrrole nanocomposite for dual-modal imaging and photothermal therapy of mammary cancer. Talanta 2021, 221, 121435. (IF 5.339)


2020
Dongjie Fu, Dingchang Liu, Lianbing Zhang, Leming Sun*, Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications. Chinese Chemical Letters 2020, 31(12), 3195-3199. (IF 4.632)



Yingchun Yang, Tao Li, Yong Qin, Lianbing Zhang, Yao Chen*, Construct of carbon nanotube-supported Fe₂O₃hybrid nanozyme by atomic layer deposition for highly efficient dopamine sensing. Frontiers in Chemistry 2020, 8:564968. (IF 3.693)


Shuqi Wu, Zihan Qiao, YangLi,Sunpei Hu, Yuan Ma, Siyi Wei, Lianbing Zhang*,Persistent luminescence nanoplatform with Fenton-like catalytic activity for tumor multimodal imaging and photoenhanced combination therapy.ACS Applied Materials & Interfaces2020, 12(23), 25572-25580.(IF 8.758).


Aipeng Li, Xue Li, Wei Pang, Qing Tian, Ting Wang, Lianbing Zhang*, Fine-tuning of the substrate binding mode to enhance the catalytic efficiency of an ortho-haloacetophenone-specific carbonyl reductase. Catalysis Science & Technology 2020, 10, 2462-2472. (IF 5.721)


Shuqi Wu,YangLi,Weihang Ding,Letong Xu, Yuan Ma, Lianbing Zhang*, Recent advancesof persistent luminescence nanoparticles in bioapplications. Nano-MicroLetters2020, 12,70.(IF 12.264).


Yao Chen, Qingxiao Yuchi, Tao Li, Guanghao Yang, Jiaojiao Miao, Chenyang Huang, Jingyi Liu, Aipeng Li, Yong Qin*, Lianbing Zhang*, Precise engineering of ultra-thin Fe₂O₃decorated Pt-based nanozymes via atomic layer deposition to switch off undesired activity for enhanced sensing performance. Sensors and Actuators B: Chemical 2020, 305, 127436. (IF 7.1)


Jiaojiao Miao, Xue Teng, Rui Zhang*, Pengfei Guo, Yao Chen, Xuehua Zhou, Hongqiang Wang*, Xiangnan Sun*, Lianbing Zhang*, "Carbohydrate-universal" electrolyzer for energy-saving hydrogen production with Co₃FeP_x@NF as bifunctional electrocatalysts. Applied Catalysis B: Environmental 2020, 263,118109. (IF 16.683)



2019
Aipeng Li, Qingxiao Yuchi, Xue Li, Wei Pang, Bin Li, Feng Xue*, Lianbing Zhang*, Discovery of a novel ortho-haloacetophenones-specific carbonyl reductase from Bacillus aryabhattai and insight into the molecular basis for its catalytic performance. International Journal of Biological Macromolecules 2019, 138, 781-790.(IF 5.162)


Leming Sun, Aipeng Li, Yanzi Hu, Yang Li, Li Shang, Lianbing Zhang*, Self-assembled fluorescent and antibacterial GHK-Cu nanoparticles for wound healing applications. Particle & Particle Systems Characterization2019, 36(4), **.(IF 4.384)


2018
Leming Sun*, Yanzi Hu, Lianbing Zhang*, Recent trends in nanocrystals for pharmaceutical applications. Current Pharmaceutical Design2018, 24(21), 2394-2402.(IF 2.757)


AipengLi, Qingxiao Yuchi, Lianbing Zhang*, Ferritin: A powerful platform fornanozymes. Progress in Biochemistry and Biophysics2018, 45(2), 193-203.(IF 0.463)


2017
Fan Yang, Mikel Abadia, Chaoqiu Chen,Weike Wang, Le Li, Lianbing Zhang*, Celia Rogero, Andrey Chuvilin, Mato Knez*, Designof active and stable oxygen reduction reaction catalysts by embedding CoxOynanoparticles into nitrogen-doped carbon. Nano Research2017, 10, 97-107. (IF 8.893)


2016
LeLi, Maider Mu？oz-Culla, Unai Carmona, Maria Paz Lopez, Fan Yang, CesarTrigueros, David Otaegui, Lianbing Zhang*, Mato Knez*, Ferritin-mediated siRNAdelivery and gene silencing in human tumor and primary cells. Biomaterials2016, 98, 143-151. (IF 10.317)


Le Li, LianbingZhang*, Mato Knez*, Comparison of two endogenous delivery agents in cancertherapy: Exosomes and ferritin. Pharmacological Research2016, 110, 1-9. （IF 5.893）



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