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基本信息 The basic information
姓名: 张文娟

学院: 生命学院


学历: 博士研究生毕业

学位: 理学博士


职称: 讲师（高校）

职务:


学科: 生物学





工作经历 Work Experience
2020年7月-至今 西北工业大学生命学院，硕士生导师
2017年7月-2020年7月 西北工业大学生命学院，博士后
2017年1月-至今 西北工业大学生命学院 助理教授




Jul 2017-Jul 2020 Postdoctor, School of Life Sciences, Northwestern Polytechnical University
Jul 2020 -now Master’s Supervisor,School of Life Sciences, Northwestern Polytechnical University
Jan 2017-now Assistant Professor, School of Life Sciences, Northwestern Polytechnical University



教育经历 Education Experience
2012/09-2016/12 西北农林科技大学 生物信息学 理学 博士
2009/09-2012/06 西北农林科技大学 环境工程 工学 硕士


2012/09-2016/12，PhD, Bioinformatics, Northwest A&F University
2009/09-2012/06, Master, Environmental Engineering,Northwest A&F University







教育教学 Education And Teaching
本科生全英文课程 《Zoology》（动物学）和《Genetics》（遗传学）
本科生综合素养课程《生命科学导论》
研究生课程 《航天医学工程》


Undergraduate Courses：《Zoology》、《Genetics》
Undergraduate Courses：《Introduction of Life Sciences》
Graduate Courses：《Aerospace Medical Engineering》







招生信息 Admission Information
每年招收对生物信息学、医学大数据分析、骨代谢研究和系统生物学等方向感兴趣的硕士研究生。
欢迎数学、生物、计算机等相关专业的同学加入合作，可先邮件联系wenjuan_zhang2017@nwpu.edu.cn。



科学研究 Scientific Research
1. 主持国家自然基金（青年项目），**，CD40L参与模拟失重促进破骨细胞分化的骨免疫机制研究，2020.01-2022.12，20万元；

2. 主持中国博士后科学基金（面上项目），2017M623249，基于网络药理学探讨黄芪心脑同治的物质基础和作用机制，2017.10-2019.10，5万元；
3. 主持中央高校基本科研业务专项资金资助（科研启动费），**OQD050，黄芪多靶协同心脑同治的物质基础和分子机制，2017.01-2018.12，15万元.
4. 参与国家自然科学基金（面上项目），**，MACF1结合CDK12参与模拟失重抑制骨形成的作用及机制，2018/01-2021/12，55万元


Fundings
1.National Natural Science Foundation of China (Grant No.**). 2020.01-2022.12, RMB 200000
2. China Postdoctoral Science Foundation(Grant No.2017M623249).2017.10-2019.10,RMB 50000
3.The Fundamental Research Funds for the Central Universities (Grant No. **OQD050).2017.01-2018.12, RMB 150000
4.National Natural Science Foundation of China (Grant No.**). 2018.01-2021.12, RMB 550000



学术成果 Academic Achievements
(1)Hong Wang^#, Wenjuan Zhang^#, Jinren Liu, Junhong Gao, Le Fang, Zhiyong Liu, Baoqing Xia, Xiaolin Fan, Cunzhi Li, Qing Lu, Airong Qian*. NF-κB and FosB mediate inflammation and oxidative stress in the blast lung injury of rats exposed to shock waves. Acta Biochim Biophys Sin. 2021,53: 283–293.
(2)Wenjuan Zhang^#,Ying Huai^#, Kai Dang^#, Airong Qian*. Osteoimmunology: the regulatory roles of T lymphocytes in osteoporosis. Frontiers in Endocrinology. 2020,11:465.
(3) Ying Huai^#, Wenjuan Zhang^#, Zhihao Chen,Fan Zhao,Wei Wang,Kai Dang,Kaiyue Xue,Yongguang Gao,Shanfeng Jiang,Zhiping Miao,Meng Li,Qiang Hao,Chu Chen*, Airong Qian*. A Comprehensive Analysis of MicroRNAs in Human Osteoporosis. Frontiers in Endocrinology. 2020,11:116213.
(4) Hong Wang, WenJuan Zhang, JunHong Gao, JinRen Liu, ZhiYong Liu, BaoQing Xia, XiaoLin Fan, CunZhi Li, AiRong Qian*. Global gene expression profiling of blast lung injury of goats exposed to shock wave. Chinese Journal of Traumatology.2020, 23 (5) , 249-257.
(5) Wenjuan Zhang, Ying Huai, Zhiping Miao, Airong Qian*, Yonghua Wang*. Systems Pharmacology for Investigation of the Mechanisms of action of Traditional Chinese Medicine in Drug Discovery. Frontiers in Pharmacology, 2019 July 11, 10:743.
(6)Wenjuan Zhang^#, Kaiyue Xue^#, Yongguang Gao^#, Ying Huai, Wang Wei, Miao Zhiping, Dang Kai, Jiang Shanfeng, Qian Airong*. Systems pharmacology dissection of action mechanisms of Dipsaci Radix for osteoporosis. Life sciences, 2019, Aug 30, 235:116820.
(7)Wenjuan Zhang, Ying Huai, Zhiping Miao, Chu Chen, Mohamed Shahen, Siddiq Ur Rahman, Mahmoud Alagawany, Mohamed E. Abd El-Hack*, Heping Zhao*, Airong Qian*. Systems pharmacology approach to investigate the molecular mechanisms of herb Rhodiola rosea L. radix. Drug Development Industrial Pharmacology, 2018 Nov 17:1-9.
(8)Wenjuan Zhang^#,Ying Huai^#, Wei Wang, Kaiyue Xue, Lei Chen, Chu Chen*, Airong Qian*. A Retrospective Cohort Study on the Risk Factors of Deep Vein Thrombosis (DVT) for Traumatic Fracture Patients at Honghui Hospital. BMJ Open, 2019 Mar 3; 9(3):e024247.
(9) Wenjuan Zhang, Qin Tao, Zihu Guo, Yingxue Fu, Xuetong Chen, Piar Ali Shar, Mohamed Shahen, Jinglin Zhu, Jun Xue, Yaofei Bai, Zhezhong Wang, Wei Xiao*, Yonghua Wang*. Systems Pharmacology Dissection of the Integrated Treatment for Co-Occurring Disorders by Chinese medicine: Cardiovascular and Gastrointestinal Disorders. Scientific Reports, 2016 Sep 6; 6:32400.
(10)Wenjuan Zhang, Yaofei Bai, Yonghua Wang*, Wei Xiao*. Polypharmacology in drug discovery: a review from systems pharmacology perspective. Current Pharmaceutical Design, 2016 22(21):3171-81.
(11)Haixing Yang^#, Wenjuan Zhang^#, Chao Huang, Wei Zhou, Yao Yao, Zhenzhong Wang, Yan Li, Wei Xiao, Yonghua Wang*. A novel systems pharmacology model for herbal medicine injection: a case using reduning injection. BMC Complement Alternative Medicine. 2014 Nov 4; 14:430.
(12) 张文娟, 王永华^*. 系统药理学原理、方法及在中医药中的应用.世界中医药. 2015, 10(2): 280-286.
(13)Jianling Liu^#, Ke Sun^#, Chuli Zheng, Xuetong Chen, Wenjuan Zhang, Zhenzhong Wang, Piar Ali Shar, Wei Xiao, Yonghua Wang*. Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection. PLOS ONE. 2015 Apr 1; 10(4): e**.
(14) Yuan Wang, Zihu Guo, Xuetong Chen, Wenjuan Zhang, Aiping Lu, Yonghua Wang*. Multi-scale modeling of cell survival and death mediated by p53 network: A Systems Pharmacology Framework. Molecular BioSystems. 2015 Nov 11(11):3011-21.
(15) Piar Ali Shar, Weiyang Tao, Shuo Gao, Chao Huang, Bohui Li, Wenjuan Zhang, Mohamed Shahen, Chunli Zheng, Yaofei Bai, Yonghua Wang*. Pred-binding: large-scale protein–ligand binding affinity prediction. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016, Feb 18:1-8.
(16) Weiyang Tao^#, Bohui Li^#, Shuo Gao, Yaofei Bai, Piar Ali Shar, Wenjuan Zhang, Zihu Guo, Ke Sun, Yingxue Fu, Chao Huang, Chunli Zheng, Jiexin Mu, Tianli Pei,Yuan Wang, Yan Li, Yonghua Wang*. CancerHSP: anticancer herbs database of systems pharmacology. Scientific Reports. 2015 Jun 15; 5:11481.
(17) Peng Li^#, Chao Huang^#, Yingxue Fu^#, Jinan Wang^#, Ziyin Wu, Jinlong Ru, Chunli Zheng, Zihu Guo, Xuetong Chen, Wei Zhou, Wenjuan Zhang, Yan Li, Jianxin Chen, Aiping Lu, Yonghua Wang*. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015 Jun 15; 31(12):2007-16.
(18)Bo Zhang^#, Yingxue Fu^#, Chao Huang^#, Chunli Zheng^#, Ziyin Wu^#, Wenjuan Zhang, Xiaoyan Yang, Fukai Gong, Yuerong Li, Xiaoyu Chen, Shuo Gao, Xuetong Chen, Yan Li, Aiping Lu, Yonghua Wang*. New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Scientific Reports. 2016 Feb 25; 6:21872.
(19) Mohamed Shahen#, Zihu Guo#, Akhtar Hussain Shar#, Reham Ebaid, Qin Tao, Wenjuan Zhang, Ziyin Wu, Yaofei Bai, Yingxue Fu, Chunli Zheng, He Wang, Piar Ali Shar, Jianling Liu, Zhenzhong Wang, Wei Xiao*, Yonghua Wang*. Dengue virus causes changes of MicroRNA genes regulatory network revealing potential targets for antiviral drugs. BMC Systems Biology. 2018 12





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