其他题名Recent Advances in Big Defensins of Marine Invertebrates
许艳红1,2; 闵军2
; 周洪磊3; 张怡1; 刘卫2; 胡晓珂2发表期刊食品科学
ISSN1002-6630
2021
卷号42期号:15页码:251-260
关键词大防御素无脊椎动物二硫键表达抗菌作用
研究领域Food Science & Technology
英文摘要Big defensins are cysteine-rich cationic antimicrobial peptides(AMPs)formed by serially connecting the N-terminal hydrophobic domain with the C-terminal beta-defensin-like domain.These domains have different antibacterial activities.Moreover,big defensins have conserved salt-stable antimicrobial activity and the N-terminal domain can drive the self-assembly of big defensins into nanonetworks that entrap and kill bacteria.So far,big defensins have been mainly found in the innate immune system of invertebrate animals and amphioxus that is a primitive chordate holding a key phylogenetic position bridging from invertebrates to vertebrates.Moreover,the C-terminal domain of big defensins has similar structure and bioactivity to the beta-defensin of vertebrates,which has aroused interest in investigating the biological evolution and function of defensins and the evolution of the immune system in species related to defensins.Based on the progress that has been made in the identification and characterization of big defensins in recent years,herein we present an integrated review of the molecular structures and evolution of big defensins,together with their antibacterial mechanism and expression regulation as well as their application prospects in the fields of aquaculture and aquatic product safety and in the development of new antimicrobial drugs.This review will provide a reference in the application of big defensins.
中文摘要大防御素是由疏水结构域(N端)和类beta-防御素结构域(C端)这两个抗菌活性不同的结构域串联而成的富含半胱氨酸的阳离子抗菌肽,具有耐盐稳定性以及保守的抗菌活性,且N端结构域可驱动大防御素自组装成纳米网络结构诱捕杀菌。目前,大防御素主要在无脊椎动物以及脊椎动物和无脊椎动物的过渡生物--文昌鱼的先天免疫系统中发现,更因其C端结构域与脊椎动物beta-防御素具有结构和功能相似性,引起了****对防御素的生物进化、物种免疫系统进化以及功能研究的兴趣。针对近年来大防御素在分离鉴定和动物免疫方面的研究进展,本文概述了大防御素的分子结构与进化,总结了大防御素的抗菌活性机制与表达调控,以及在水产养殖、水产品安全领域和抗菌药物研发方面的应用前景,以期为大防御素的应用提供参考。
文章类型Review
资助机构十三五国家重点研发计划重点专项; 烟台市科技发展计划项目; 中国科学院青年创新促进会项目
收录类别CSCD
语种中文
CSCD记录号CSCD:7040774
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/30257
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.福建农林大学食品科学学院,福建福州350002;
2.中国科学院烟台海岸带研究所,海岸带生物学与生物资源利用重点实验室,山东烟台264003;
3.福建省洋泽海洋生物科技有限公司,福建福州350600
推荐引用方式
GB/T 7714许艳红,闵军,周洪磊,等. 海洋无脊椎动物大防御素的研究进展[J]. 食品科学,2021,42(15):251-260.
APA许艳红,闵军,周洪磊,张怡,刘卫,&胡晓珂.(2021).海洋无脊椎动物大防御素的研究进展.食品科学,42(15),251-260.
MLA许艳红,et al."海洋无脊椎动物大防御素的研究进展".食品科学 42.15(2021):251-260.
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