Wang, Yude1,2,3; Wei, Yinghui1,2; He, Na4; Zhang, Liangwei3
; You, Jinmao5; Chen, Lingxin3,5; Lv, Changjun1,2发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
2021-07-10
页码8
DOI10.1039/d1tb01307f
通讯作者Zhang, Liangwei(liangweizhang@yic.ac.cn); Chen, Lingxin(lxchen@yic.ac.cn); Lv, Changjun(lucky_lcj@sina.com)
英文摘要Idiopathic pulmonary fibrosis (IPF) is a devastating and fatal interstitial lung disease due to various challenges in diagnosis and treatment. Due to its complicated pathogenesis and difficulty in early diagnosis, there is no effective cure. Cyclooxygenase-2 (COX-2) is inextricably associated with pulmonary fibrosis. The abnormal level of COX-2 leads to extremely exacerbated pulmonary fibrosis. Therefore, we reported a near-infrared fluorescent probe Cy-COX to detect the fluctuation of COX-2 levels during pulmonary fibrosis and explain its important protective effect. The probe Cy-COX showed a significant enhancement of fluorescence signal to COX-2 with excellent selectivity and sensitivity. In order to clarify the relationship between COX-2 and pulmonary fibrosis, we used the probe Cy-COX to detect COX-2 fluctuation in organisms with pulmonary fibrosis. The results showed that the COX-2 level increased in the early stage and decreased in the late stage with the aggravation of pulmonary fibrosis. Furthermore, up-regulation of COX-2 levels can effectively alleviate the severity of pulmonary fibrosis. Therefore, Cy-COX is a fast and convenient imaging tool with great potential to predict the early stage of pulmonary fibrosis and evaluate the therapeutic effects.
资助机构National Natural Science Foundation of China; science and technology innovation development plan of Yantai of China; Research Initiation Fund of Binzhou Medical University; Taishan Scholar Project Special Funding
收录类别SCI
语种英语
关键词[WOS]INTERSTITIAL LUNG-DISEASE; CANCER; COX-2; FIBROBLASTS; PATHOGENESIS; INFLAMMATION; EXPRESSION
研究领域[WOS]Materials Science
WOS记录号WOS:000678242600001
引用统计被引频次：1[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/29549
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
通讯作者Zhang, Liangwei; Chen, Lingxin; Lv, Changjun作者单位1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
2.Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Shandong Univ, Cheelo Coll Med, Qilu Hosp, Rehabil Ctr, Jinan 250100, Peoples R China
5.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
推荐引用方式
GB/T 7714Wang, Yude,Wei, Yinghui,He, Na,et al. Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021:8.
APAWang, Yude.,Wei, Yinghui.,He, Na.,Zhang, Liangwei.,You, Jinmao.,...&Lv, Changjun.(2021).Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models.JOURNAL OF MATERIALS CHEMISTRY B,8.
MLAWang, Yude,et al."Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models".JOURNAL OF MATERIALS CHEMISTRY B (2021):8.
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