Wang, Shuang1; Ji, Chenglong1,2,3
; Li, Fei1,3; Zhan, Junfei1,4; Sun, Tao1,4; Tang, Jianhui1,3; Wu, Huifeng1,2,3发表期刊JOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
2021-08-15
卷号416页码:9
关键词Brominated flame retardantsMarine invertebratesEndocrine disruptorSteroids sulfonation
DOI10.1016/j.jhazmat.2021.126228
通讯作者Ji, Chenglong(clji@yic.ac.cn); Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to marine organisms due to its potential endocrine-disrupting effects. However, limited attention of TBBPA's endocrine-disrupting effects has been paid on marine invertebrates. In this work, the reproductive endocrine-disrupting effects of TBBPA were evaluated by observing the gametes development, quantifying the gender-specific gene expression, and determining vertebrate sex hormones in mussels Mytilus galloprovincialis treated with TBBPA for 30 days. Additionally, transcriptomic profiling and enzymes activities were conducted to investigate the potential mechanisms of reproductive endocrine-disrupting effects. We found that promotion of gametogenesis and alterations of vertebrate sex hormones occurred in TBBPA-treated mussels of both sexes. Meanwhile, estrogen sulfotransferase (SULT1E1) and steroid sulfatase (STS) were up-regulated at transcript level as a result of TBBPA treatments, suggesting that TBBPA disrupted the steroidogenesis in mussels through promoting steroids sulfo-nation and hydrolysis of sulfate steroids. The induction of SULTs for TBBPA biotransformation might be responsible for the dysregulation of steroidogenesis and steroids metabolism. Overall, these findings provide a new insight into assessing impact of TBBPA as well as TBBPA biomonitoring in marine environment.
资助机构National Natural Science Foundation of China; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; Youth Innovation Promotion Association CAS; Yantai Science and Technology Development Plan
收录类别SCI
语种英语
关键词[WOS]GENDER-SPECIFIC RESPONSES; SCALLOP CHLAMYS-FARRERI; TESTOSTERONE CONCENTRATIONS; BISPHENOL-A; TBBPA; ESTRADIOL-17-BETA; SEX; GAMETOGENESIS; GLUCURONIDE; SULFATASE
研究领域[WOS]Engineering; Environmental Sciences & Ecology
WOS记录号WOS:000664769200005
引用统计被引频次：1[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/29459
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中科院海岸带环境过程与生态修复重点实验室
通讯作者Ji, Chenglong; Wu, Huifeng作者单位1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Processes, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai Inst Coastal Zone Res,YICCAS, Yantai 264003, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 26071, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Wang, Shuang,Ji, Chenglong,Li, Fei,et al. Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,416:9.
APAWang, Shuang.,Ji, Chenglong.,Li, Fei.,Zhan, Junfei.,Sun, Tao.,...&Wu, Huifeng.(2021).Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,416,9.
MLAWang, Shuang,et al."Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 416(2021):9.
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