Mi, Yingqi1,2,3; Zhang, Jingjing1,2; Han, Xiangru4; Tan, Wenqiang1,2
; Miao, Qin1,2,3; Cui, Jingmin1,2,3; Li, Qing1,2; Guo, Zhanyong1,2,3发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2021-06-30
卷号181页码:572-581
关键词Carboxymethyl inulinAntioxidantHeterocyclic moieties
DOI10.1016/j.ijbiomac.2021.03.109
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要A series of novel inulin derivatives were designed and synthesized by the introduction of amino heterocyclic moieties onto carboxymethyl inulin with the aid of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hyd roxysucci ni mide. The target products were prepared via three - step chemical synthesis, and structures were identified by FTIR and H-1 NMR spectroscopy. Antioxidant activities of inulin derivatives including DPPH - radical scavenging assay, superoxide - radical scavenging assay, hydroxyl - radical scavenging assay, and reducing power were estimated. Meanwhile, their antifungal activities, including Colletotrichum lagenarium and Bottytis cinerea, were also explored by hyphal measurement. In particular, inulin derivatives bearing heterocyclic moieties exhibited a remarkable improvement over inulin on antioxidant and antifungal activities, and their bioactivities decreased roughly in the order of 2ATCMI > 4APCMI > 3APCMI > 2APCMI > 3ATCMI > CMI > inulin. Furthermore, the cytotoxicities of inulin derivatives against L929 cells were evaluated by CCK-8 in vitro, and all samples showed weak cytotoxicities. In a nutshell, the paper provides a practical approach to synthesize novel inulin derivatives with dramatically enhanced bioactivity and good biocompatibility. The product described in paper might serve as a new leading structure for further design of antioxidants or antifungal agents in biomedicine, cosmetics, and other fields. (C) 2021 Elsevier B.V. All rights reserved.
资助机构National Key Research and Development Program of China; Natural Science Foundation of Shandong Province of China
收录类别SCI
语种英语
关键词[WOS]IN-VITRO; DERIVATIVES; PREDICTION; CHITOSANS
研究领域[WOS]Biochemistry & Molecular Biology; Chemistry; Polymer Science
WOS记录号WOS:000656891400007
引用统计被引频次：2[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/29383
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yantai Univ, Coll Environm & Mat Engn, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714Mi, Yingqi,Zhang, Jingjing,Han, Xiangru,et al. Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,181:572-581.
APAMi, Yingqi.,Zhang, Jingjing.,Han, Xiangru.,Tan, Wenqiang.,Miao, Qin.,...&Guo, Zhanyong.(2021).Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,181,572-581.
MLAMi, Yingqi,et al."Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 181(2021):572-581.
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