He, Na1,4; Wang, Yude1,4; Huang, Yan3; Wang, Xiaoyan3; Chen, Lingxin2,3
; Lv, Changjun1,4发表期刊SENSORS AND ACTUATORS B-CHEMICAL
2020-11-01
卷号322页码:8
关键词Fluorescent probeNear-infraredGlutamyl transpeptidaseIdiopathic pulmonary fibrosisFluorescence imaging
DOI10.1016/j.snb.2020.128565
通讯作者Huang, Yan(huangyanpy@163.com); Chen, Lingxin(lxchen@yic.ac.cn); Lv, Changjun(lucky_lcj@sina.com)
英文摘要Idiopathic pulmonary fibrosis (IPF), whose early diagnosis and effective treatment still remain the focus of clinical studies, is a chronic, irreversible and finally fatal pulmonary disease. Glutamyl transpeptidase (GGT) has a potential relationship with the occurrence and development of IPF. Therefore, explore whether GGT can be applied as a biological indicator for the clinical identification and diagnosis of IPF, sensitive and accurate detection of GGT under physiological conditions is necessary. In this research, a new fluorescent probe Cy-GGT was exhibited for detecting GGT concentrations in pulmonary fibrosis cell and mice models. Cy-GGT was capable of rapidly and selectively detecting GGT in vitro. The probe was successfully applied for visualizing GGT in oxidative stress cell models, pulmonary fibrosis cells and mice models. The results revealed that intracellular GGT increased in the cells and mice models of pulmonary fibrosis. GGT plays a significant part in pulmonary fibrosis, and the GGT level abnormally expressed in the lung tissue may be employed as a potential biological indicator to diagnose IPF lesions. Furthermore, the discovery of the close relationship between IPF and GGT will provide a new idea for effective therapy of IPF in the future.
资助机构National Nature Science Foundation of China; science and technology innovation development plan of Yantai of China; Research Initiation Fund of Binzhou Medical University; Taishan Scholar Project Special Funding
收录类别SCI
语种英语
关键词[WOS]GLUTATHIONE-S-TRANSFERASE; GAMMA-GLUTAMYLTRANSPEPTIDASE; AGGREGATION; ASSOCIATION; LIVER
研究领域[WOS]Chemistry; Electrochemistry; Instruments & Instrumentation
WOS记录号WOS:000573296500018
引用统计被引频次：3[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28491
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
通讯作者Huang, Yan; Chen, Lingxin; Lv, Changjun作者单位1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Binzhou Med Univ, Med Res Ctr, Inst Mol Med, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714He, Na,Wang, Yude,Huang, Yan,et al. A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models[J]. SENSORS AND ACTUATORS B-CHEMICAL,2020,322:8.
APAHe, Na,Wang, Yude,Huang, Yan,Wang, Xiaoyan,Chen, Lingxin,&Lv, Changjun.(2020).A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models.SENSORS AND ACTUATORS B-CHEMICAL,322,8.
MLAHe, Na,et al."A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models".SENSORS AND ACTUATORS B-CHEMICAL 322(2020):8.
PDF全文下载地址:
点我下载PDF
