Pu, Yang1,3; Wei, Mengjiao1; Witkowski, Andrzej4; Krzywda, Marta4; Wang, Yinchu2
; Li, Wenjun2发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
2020-12-10
卷号533期号:3页码:573-579
关键词Biofunctional biosilicaC-phycocyaninPhycocyanobilinEnhanced photodynamic effectNanocarriers
DOI10.1016/j.bbrc.2020.09.049
通讯作者Pu, Yang(ypu@ldu.edu.cn); Li, Wenjun(wjli@yic.ac.cn)
英文摘要Intricate mesoporous biosilica has many biomedical applications as a nanocarrier. However, its potential use in photodynamic therapy (PDT) has received little attention. This work reports the first fabrication of bio-engineered materials by covalently conjugating C-phycocyanin (C-PC), a natural photosensitizer, to biosilica for the PDT of tumor-associated macrophages. The resulting hybrid material showed outstanding photodynamic activity under 620 nm laser irradiation. Furthermore, it enhanced the relatively weak photodynamic effect of C-PC. This study also explored methods of biofunctionalizing biosilica for cancer phototherapy, a new pharmacological application of non-toxic C-PC. (C) 2020 Elsevier Inc. All rights reserved.
资助机构National Natural Science Foundation of China; Key Research and Development Program of Yantai; TEAM-NET programme of the Foundation for Polish Science; European Union under the European Regional Development Fund
收录类别SCI
语种英语
关键词[WOS]APOPTOSIS; DIATOMS; PHYCOBILIPROTEINS; PHYCOBILISOMES; ANTIOXIDANT; CYCLE; DRUG
研究领域[WOS]Biochemistry & Molecular Biology; Biophysics
WOS记录号WOS:000588268300046
引用统计被引频次：3[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28321
专题海岸带生物学与生物资源利用重点实验室
中国科学院烟台海岸带研究所
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Pu, Yang; Li, Wenjun作者单位1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Ludong Univ, Bionanotechnol Res Inst, Yantai 264025, Peoples R China
4.Univ Szczecin, Inst Marine & Environm Sci, Szczecin, Poland
推荐引用方式
GB/T 7714Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,et al. A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(3):573-579.
APAPu, Yang,Wei, Mengjiao,Witkowski, Andrzej,Krzywda, Marta,Wang, Yinchu,&Li, Wenjun.(2020).A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(3),573-579.
MLAPu, Yang,et al."A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.3(2020):573-579.
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